TAK-901_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.159673
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0958742
AKAP12 A kinase (PRKA) anchor protein 12 0.0934481
SMAD3 SMAD family member 3 0.0917923
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0809414
ZEB2 zinc finger E-box binding homeobox 2 0.0734898
NAMPT nicotinamide phosphoribosyltransferase 0.071584
FNDC3B fibronectin type III domain containing 3B 0.0698779
B2M beta-2-microglobulin 0.0694247
FTH1 ferritin, heavy polypeptide 1 0.0685155
GRB10 growth factor receptor-bound protein 10 0.0680929
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0672538
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0626768
VIM vimentin 0.062068
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0577749
RAD51B RAD51 paralog B 0.0518542
ELL2 elongation factor, RNA polymerase II, 2 0.0499951
MAP1B microtubule-associated protein 1B 0.0474495
SOD2 superoxide dismutase 2, mitochondrial 0.0470069
FN1 fibronectin 1 0.0466128
VEGFA vascular endothelial growth factor A 0.0455395
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0455272
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.044543
ANXA2 annexin A2 0.0432967
MYH9 myosin, heavy chain 9, non-muscle 0.0427538
RAB27B RAB27B, member RAS oncogene family 0.0416232
LOXL2 lysyl oxidase-like 2 0.0413103
ENO1 enolase 1, (alpha) 0.0401557
CA12 carbonic anhydrase XII 0.0395013
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0389514
TGM2 transglutaminase 2 0.0377406
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0369604
FAM13A family with sequence similarity 13, member A 0.0355813
ECE1 endothelin converting enzyme 1 0.0353594
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0352815
SYNJ2 synaptojanin 2 0.0351561
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0343986
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0334891
PKM pyruvate kinase, muscle 0.0331433
TXNRD1 thioredoxin reductase 1 0.0330781
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0330754
PCBP2 poly(rC) binding protein 2 0.0313089
EZR ezrin 0.0312242
TIMP1 TIMP metallopeptidase inhibitor 1 0.0308973
ZMYND8 zinc finger, MYND-type containing 8 0.0305841
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0304534
EXT1 exostosin glycosyltransferase 1 0.0304303
FLNB filamin B, beta 0.0300655
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0300079
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0297096
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0290806
ATP13A3 ATPase type 13A3 0.0290242
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0290134
AOPEP aminopeptidase O (putative) 0.0288286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0288049
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0285967
OPTN optineurin 0.0281949
PSD3 pleckstrin and Sec7 domain containing 3 0.0281618
ADD3 adducin 3 (gamma) 0.0279768
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0279491
HIPK2 homeodomain interacting protein kinase 2 0.0279145
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0278811
SYAP1 synapse associated protein 1 0.0277821
FAM107B family with sequence similarity 107, member B 0.0277325
BIRC3 baculoviral IAP repeat containing 3 0.0275801
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0275268
SIK3 SIK family kinase 3 0.0272124
IQGAP1 IQ motif containing GTPase activating protein 1 0.0272031
IER3 immediate early response 3 0.0270703
MYO10 myosin X 0.0267274
KYNU kynureninase 0.0267054
SFTPA2 surfactant protein A2 0.0266948
DST dystonin 0.0266171
TNNC1 troponin C type 1 (slow) 0.026544
PARP14 poly (ADP-ribose) polymerase family, member 14 0.02651
EHBP1 EH domain binding protein 1 0.0264947
ASPH aspartate beta-hydroxylase 0.0264002
FTL ferritin, light polypeptide 0.025981
LRMDA leucine rich melanocyte differentiation associated 0.0258303
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.025609
CDCP1 CUB domain containing protein 1 0.025587
ESYT2 extended synaptotagmin-like protein 2 0.0253122
AHNAK AHNAK nucleoprotein 0.0246342
WLS wntless Wnt ligand secretion mediator 0.0245211
MT2A metallothionein 2A 0.0245025
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0243911
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0242929
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0238501
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0237815
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0236802
MACF1 microtubule-actin crosslinking factor 1 0.0235277
CEP250 centrosomal protein 250kDa 0.0234768
RAI14 retinoic acid induced 14 0.0234241
NTN4 netrin 4 0.0233391
MAST4 microtubule associated serine/threonine kinase family member 4 0.0233038
KTN1 kinectin 1 (kinesin receptor) 0.0227457
DOCK5 dedicator of cytokinesis 5 0.0227404
KIAA1217 KIAA1217 0.0226637
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.022197
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0221935

decreased expression

Symbol Name Standardized Value
SDK1 sidekick cell adhesion molecule 1 -0.107161
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.057891
IGFBP3 insulin-like growth factor binding protein 3 -0.0477028
CDH13 cadherin 13 -0.0474636
NRG1 neuregulin 1 -0.0416487
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0415791
PDE4D phosphodiesterase 4D, cAMP-specific -0.0415437
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.039461
MTSS1 metastasis suppressor 1 -0.0392563
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0371358
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0336487
GLCCI1 glucocorticoid induced 1 -0.0326123
EFCAB13 EF-hand calcium binding domain 13 -0.0280748
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.024988
NHSL1 NHS-like 1 -0.0246034
INTS6 integrator complex subunit 6 -0.0238856
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0236089
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0233802
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0227683
FAM20C family with sequence similarity 20, member C -0.022223
SEC31A SEC31 homolog A (S. cerevisiae) -0.0221925
DNER delta/notch-like EGF repeat containing -0.0217189
GPC6 glypican 6 -0.0215204
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.021478
MRPS6 mitochondrial ribosomal protein S6 -0.0209682
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0199685
PID1 phosphotyrosine interaction domain containing 1 -0.0199625
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.019297
TTC3 tetratricopeptide repeat domain 3 -0.0191464
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0181174
NLK nemo-like kinase -0.0176835
TAS2R14 taste receptor, type 2, member 14 -0.0174966
GMDS GDP-mannose 4,6-dehydratase -0.0169493
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0166598
MAML3 mastermind-like 3 (Drosophila) -0.0160601
DTNA dystrobrevin, alpha -0.0159523
DLG1 discs, large homolog 1 (Drosophila) -0.0159015
SH3RF3 SH3 domain containing ring finger 3 -0.0158312
HEATR5A HEAT repeat containing 5A -0.0156455
PMM2 phosphomannomutase 2 -0.0153185
GREB1L growth regulation by estrogen in breast cancer-like -0.0152225
PRRX1 paired related homeobox 1 -0.0151537
IGF1R insulin-like growth factor 1 receptor -0.0151146
ZFAND3 zinc finger, AN1-type domain 3 -0.0150235
CEMIP cell migration inducing protein, hyaluronan binding -0.0149858
TRPS1 trichorhinophalangeal syndrome I -0.0149247
AVIL advillin -0.0148669
LIMCH1 LIM and calponin homology domains 1 -0.0146423
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0145113
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0143244
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -0.0142336
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0141931
MBD5 methyl-CpG binding domain protein 5 -0.0139511
CDK14 cyclin-dependent kinase 14 -0.0137766
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0137308
SERTAD2 SERTA domain containing 2 -0.0137237
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0136068
PCNX4 pecanex 4 -0.0136049
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0134926
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0133227
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0132302
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -0.0129252
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -0.0129124
PRR16 proline rich 16 -0.0127638
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0126441
FANK1 fibronectin type III and ankyrin repeat domains 1 -0.0126184
CFAP20DC CFAP20 domain containing -0.0125682
LARP1B La ribonucleoprotein domain family, member 1B -0.0123902
SPDYA speedy/RINGO cell cycle regulator family member A -0.0123626
CP ceruloplasmin (ferroxidase) -0.0122061
ANXA10 annexin A10 -0.0121824
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0120868
SNX14 sorting nexin 14 -0.0120667
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.01199
LOX lysyl oxidase -0.011979
PRH1 proline-rich protein HaeIII subfamily 1 -0.0118384
CMIP c-Maf inducing protein -0.011705
PHF3 PHD finger protein 3 -0.0116799
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0116511
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0116202
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0115778
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0115377
TMED3 transmembrane emp24 protein transport domain containing 3 -0.0111492
KCTD16 potassium channel tetramerization domain containing 16 -0.0111446
DDIT3 DNA-damage-inducible transcript 3 -0.0110946
IQCJ IQ motif containing J -0.0110727
HDLBP high density lipoprotein binding protein -0.0110215
NBAS neuroblastoma amplified sequence -0.0109551
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0109005
ARHGAP32 Rho GTPase activating protein 32 -0.0108618
OVCH1 ovochymase 1 -0.0108152
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0107509
ANKRD17 ankyrin repeat domain 17 -0.0106884
AEBP2 AE binding protein 2 -0.0106227
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0104956
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0102792
HM13 histocompatibility (minor) 13 -0.0102566
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0101383
PTPRB protein tyrosine phosphatase, receptor type, B -0.0100876
WNT2B wingless-type MMTV integration site family, member 2B -0.00996617