TAK-901_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.164877
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.150666
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.123571
NDRG1 N-myc downstream regulated 1 0.115225
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.110109
LOC102724023 ES1 protein homolog, mitochondrial 0.10312
LAMB3 laminin, beta 3 0.09936
ELL2 elongation factor, RNA polymerase II, 2 0.0906662
ARRDC3 arrestin domain containing 3 0.0864847
BACE2 beta-site APP-cleaving enzyme 2 0.0837329
TSC22D2 TSC22 domain family, member 2 0.083078
TJP1 tight junction protein 1 0.0825455
MYO5B myosin VB 0.0785579
IRS2 insulin receptor substrate 2 0.0724489
GRB10 growth factor receptor-bound protein 10 0.0662884
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.065891
BHLHE40 basic helix-loop-helix family, member e40 0.0654975
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0648751
SPAG9 sperm associated antigen 9 0.0630435
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0614545
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0569084
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.055949
ZNF292 zinc finger protein 292 0.0532623
CXCL8 chemokine (C-X-C motif) ligand 8 0.0521561
KMT2E lysine (K)-specific methyltransferase 2E 0.0520949
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0513321
RUNX1 runt-related transcription factor 1 0.0501227
IFIH1 interferon induced with helicase C domain 1 0.0499489
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0499455
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0493681
NAMPT nicotinamide phosphoribosyltransferase 0.0482464
DSCAM Down syndrome cell adhesion molecule 0.0450526
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0442916
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0440143
SNX9 sorting nexin 9 0.043779
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0437788
HELZ helicase with zinc finger 0.0435288
DTNA dystrobrevin, alpha 0.042672
MTUS1 microtubule associated tumor suppressor 1 0.0423681
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0413384
ANKRD17 ankyrin repeat domain 17 0.0396419
MED13 mediator complex subunit 13 0.0378191
ERRFI1 ERBB receptor feedback inhibitor 1 0.0373393
DUSP10 dual specificity phosphatase 10 0.0370777
ANXA2 annexin A2 0.0370359
CPNE8 copine VIII 0.0364544
MXD1 MAX dimerization protein 1 0.0355986
AKR1C1 aldo-keto reductase family 1, member C1 0.0355723
RYBP RING1 and YY1 binding protein 0.0353391
PTPRM protein tyrosine phosphatase, receptor type, M 0.0351604
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0350583
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0346341
FNDC3A fibronectin type III domain containing 3A 0.0345836
GOLGA4 golgin A4 0.0344758
UGCG UDP-glucose ceramide glucosyltransferase 0.034381
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0337732
USP9X ubiquitin specific peptidase 9, X-linked 0.0336233
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0336144
NAV2 neuron navigator 2 0.0332627
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0331849
ZNFX1 zinc finger, NFX1-type containing 1 0.0329016
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0328916
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0324752
PKN2 protein kinase N2 0.0324583
WAC WW domain containing adaptor with coiled-coil 0.0322303
MCTP2 multiple C2 domains, transmembrane 2 0.0319979
PTK2 protein tyrosine kinase 2 0.0319976
KLF10 Kruppel-like factor 10 0.0317764
RAB1A RAB1A, member RAS oncogene family 0.0317741
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0315398
NPEPPS aminopeptidase puromycin sensitive 0.030988
PRPF3 pre-mRNA processing factor 3 0.0306616
ATF3 activating transcription factor 3 0.0306406
SON SON DNA binding protein 0.030519
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0305164
AKAP13 A kinase (PRKA) anchor protein 13 0.0304123
GLMN glomulin, FKBP associated protein 0.0303719
SMAD3 SMAD family member 3 0.0302418
WDR43 WD repeat domain 43 0.0300768
CCNT2 cyclin T2 0.0300432
SCAF8 SR-related CTD-associated factor 8 0.0299172
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0297927
SHB Src homology 2 domain containing adaptor protein B 0.0296347
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0295917
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0292433
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0289154
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0288396
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0287356
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0286895
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0285517
GMNN geminin, DNA replication inhibitor 0.028357
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0281806
HOOK2 hook microtubule-tethering protein 2 0.0278866
YME1L1 YME1-like 1 ATPase 0.0277968
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0276103
TRIO trio Rho guanine nucleotide exchange factor 0.0274493
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0273312
CUL3 cullin 3 0.0272555
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0269082
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0268177

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126528
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.118712
S100A9 S100 calcium binding protein A9 -0.106147
TMSB10 thymosin beta 10 -0.0886595
AKAP12 A kinase (PRKA) anchor protein 12 -0.0750902
EFNA5 ephrin-A5 -0.0679263
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.066887
FTL ferritin, light polypeptide -0.0648637
TPM4 tropomyosin 4 -0.0641841
RPL35A ribosomal protein L35a -0.0567551
FN1 fibronectin 1 -0.0541078
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0530011
SEC31A SEC31 homolog A (S. cerevisiae) -0.051921
ZBTB20 zinc finger and BTB domain containing 20 -0.051317
PTMA prothymosin, alpha -0.0510436
THBS1 thrombospondin 1 -0.0509123
ZMYND8 zinc finger, MYND-type containing 8 -0.0504396
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0502316
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0483234
HMGA2 high mobility group AT-hook 2 -0.0481569
ASPH aspartate beta-hydroxylase -0.0470041
RBM47 RNA binding motif protein 47 -0.0466335
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0459129
TSHZ2 teashirt zinc finger homeobox 2 -0.0445389
CLIP1 CAP-GLY domain containing linker protein 1 -0.0441901
CEMIP cell migration inducing protein, hyaluronan binding -0.043448
EXOC4 exocyst complex component 4 -0.0433535
RAB10 RAB10, member RAS oncogene family -0.043017
NT5C2 5'-nucleotidase, cytosolic II -0.0426626
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0414376
VIM vimentin -0.0408947
RPS25 ribosomal protein S25 -0.0408406
TPT1 tumor protein, translationally-controlled 1 -0.0405491
MUC16 mucin 16, cell surface associated -0.0404021
LRMDA leucine rich melanocyte differentiation associated -0.0401397
GNAS GNAS complex locus -0.0396661
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0394456
CCNI cyclin I -0.0386601
NKD1 naked cuticle homolog 1 (Drosophila) -0.038388
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0382063
RPS14 ribosomal protein S14 -0.0381716
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0376234
RNF213 ring finger protein 213 -0.0375305
ACTG1 actin gamma 1 -0.0373854
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0368728
PDIA3 protein disulfide isomerase family A, member 3 -0.0366228
PRKCSH protein kinase C substrate 80K-H -0.0361624
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0361411
THSD4 thrombospondin, type I, domain containing 4 -0.0359703
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0359435
ADNP activity-dependent neuroprotector homeobox -0.0359095
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0358135
RPS8 ribosomal protein S8 -0.0356517
CDH13 cadherin 13 -0.035595
KRT17 keratin 17, type I -0.0348191
ARHGAP32 Rho GTPase activating protein 32 -0.0345353
MAP1B microtubule-associated protein 1B -0.0343484
RPS12 ribosomal protein S12 -0.0341399
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0339781
PDE4D phosphodiesterase 4D, cAMP-specific -0.0339014
MBD5 methyl-CpG binding domain protein 5 -0.0336402
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0335696
CADM2 cell adhesion molecule 2 -0.0333475
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0331972
SLC38A2 solute carrier family 38, member 2 -0.0323724
ENO1 enolase 1, (alpha) -0.0317842
EXOC6B exocyst complex component 6B -0.0316996
KDM1A lysine (K)-specific demethylase 1A -0.0315527
JMJD1C jumonji domain containing 1C -0.0315093
FLNB filamin B, beta -0.031332
RAI14 retinoic acid induced 14 -0.0313268
SOS1 son of sevenless homolog 1 (Drosophila) -0.0311778
SEPTIN10 septin 10 -0.0311476
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0310071
SIK3 SIK family kinase 3 -0.0309437
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0308051
CDK13 cyclin-dependent kinase 13 -0.0306312
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0305922
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0305882
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0304639
IGFBP3 insulin-like growth factor binding protein 3 -0.0299256
DIDO1 death inducer-obliterator 1 -0.0297473
CAPN2 calpain 2, (m/II) large subunit -0.0296569
USP34 ubiquitin specific peptidase 34 -0.0295616
RRBP1 ribosome binding protein 1 -0.0295486
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0293081
RCOR1 REST corepressor 1 -0.0292453
ZNF638 zinc finger protein 638 -0.0290315
MAML3 mastermind-like 3 (Drosophila) -0.0289021
PSD3 pleckstrin and Sec7 domain containing 3 -0.0288384
EXT1 exostosin glycosyltransferase 1 -0.0288109
ANKRD11 ankyrin repeat domain 11 -0.0286795
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.028583
NPAS2 neuronal PAS domain protein 2 -0.0281375
TM4SF1 transmembrane 4 L six family member 1 -0.0280405
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0280152
RPS16 ribosomal protein S16 -0.0276482
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0274285
ZEB1 zinc finger E-box binding homeobox 1 -0.0274172
SNX14 sorting nexin 14 -0.0273299