TAK-901_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.202146
GRAMD1B GRAM domain containing 1B 0.156386
ERRFI1 ERBB receptor feedback inhibitor 1 0.107207
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0943087
TXNRD1 thioredoxin reductase 1 0.0933217
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0822896
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0778508
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0709922
PDE4D phosphodiesterase 4D, cAMP-specific 0.0687048
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.065072
ELL2 elongation factor, RNA polymerase II, 2 0.0626934
ZFAND3 zinc finger, AN1-type domain 3 0.0605083
TRIO trio Rho guanine nucleotide exchange factor 0.0595343
PDE10A phosphodiesterase 10A 0.0584219
EEF2 eukaryotic translation elongation factor 2 0.0575829
YBX3 Y box binding protein 3 0.057181
MCL1 myeloid cell leukemia 1 0.0570418
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.055523
ATP11A ATPase, class VI, type 11A 0.0549919
THSD4 thrombospondin, type I, domain containing 4 0.0544598
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0520094
DOCK5 dedicator of cytokinesis 5 0.0507974
TFPI2 tissue factor pathway inhibitor 2 0.0500888
TPM3 tropomyosin 3 0.0495596
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0465539
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0461378
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0443842
ANO6 anoctamin 6 0.0431415
JMJD1C jumonji domain containing 1C 0.0426842
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0424775
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0422601
FMNL2 formin-like 2 0.0420561
STYK1 serine/threonine/tyrosine kinase 1 0.0410939
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0406761
RAB7A RAB7A, member RAS oncogene family 0.0403048
RICTOR RPTOR independent companion of MTOR, complex 2 0.0401124
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400568
MYH9 myosin, heavy chain 9, non-muscle 0.0399949
ZNF638 zinc finger protein 638 0.039046
EXT1 exostosin glycosyltransferase 1 0.038724
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0385203
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.037677
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0375107
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0373985
DST dystonin 0.037116
NABP1 nucleic acid binding protein 1 0.0368131
NIPBL Nipped-B homolog (Drosophila) 0.0366782
SFPQ splicing factor proline/glutamine-rich 0.0364805
GPHN gephyrin 0.0363508
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0362764
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0361879
BRD2 bromodomain containing 2 0.0359548
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0353836
HSPA8 heat shock 70kDa protein 8 0.035299
IGF1R insulin-like growth factor 1 receptor 0.0350913
PDLIM5 PDZ and LIM domain 5 0.034586
RBM25 RNA binding motif protein 25 0.034546
PCBP2 poly(rC) binding protein 2 0.0338744
IPO7 importin 7 0.0330217
EML4 echinoderm microtubule associated protein like 4 0.0325084
ZSWIM6 zinc finger, SWIM-type containing 6 0.032332
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0319456
CALD1 caldesmon 1 0.0317345
RBM39 RNA binding motif protein 39 0.0313831
VMP1 vacuole membrane protein 1 0.0311061
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0308585
YAP1 Yes-associated protein 1 0.0306285
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0304393
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0302231
WNK1 WNK lysine deficient protein kinase 1 0.0300886
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0299888
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0298687
SRRM2 serine/arginine repetitive matrix 2 0.0297269
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0296107
EXOC6B exocyst complex component 6B 0.0291769
AFF3 AF4/FMR2 family, member 3 0.0291565
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0288393
ATP13A3 ATPase type 13A3 0.0284602
KTN1 kinectin 1 (kinesin receptor) 0.0282239
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0281429
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0279913
SNAP25 synaptosomal-associated protein, 25kDa 0.0273121
TRIP12 thyroid hormone receptor interactor 12 0.0271715
MARCHF4 membrane associated ring-CH-type finger 4 0.0268555
RUNX1 runt-related transcription factor 1 0.0267694
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0264262
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0263428
ADAR adenosine deaminase, RNA-specific 0.026316
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0263051
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0262604
SMAD3 SMAD family member 3 0.0261436
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0259089
WDR43 WD repeat domain 43 0.0257155
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0254779
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.025439
EIF4B eukaryotic translation initiation factor 4B 0.0251268
CAMTA1 calmodulin binding transcription activator 1 0.0247978
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0247951
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0247524
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0245396

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.288721
VIM vimentin -0.11326
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.106548
PTMA prothymosin, alpha -0.0856029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0780386
TMSB10 thymosin beta 10 -0.0764381
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0602169
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0570742
RPS21 ribosomal protein S21 -0.03971
RPL35A ribosomal protein L35a -0.0362035
HLA-B major histocompatibility complex, class I, B -0.035909
IFI6 interferon, alpha-inducible protein 6 -0.0358493
RPLP1 ribosomal protein, large, P1 -0.029906
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0291122
GNAS GNAS complex locus -0.0289212
MYL12B myosin, light chain 12B, regulatory -0.0284879
CANX calnexin -0.0284562
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0284178
RPS8 ribosomal protein S8 -0.0279371
TPM4 tropomyosin 4 -0.0276571
S100A6 S100 calcium binding protein A6 -0.0274842
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0267925
EGR1 early growth response 1 -0.026527
RPL34 ribosomal protein L34 -0.0264863
H1-0 H1.0 linker histone -0.0257742
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0251968
MT2A metallothionein 2A -0.025003
TPT1 tumor protein, translationally-controlled 1 -0.0243405
ACTG1 actin gamma 1 -0.0241451
PDIA4 protein disulfide isomerase family A, member 4 -0.0238915
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.023869
CALR calreticulin -0.0231296
UBC ubiquitin C -0.0220286
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0219212
RPS24 ribosomal protein S24 -0.0215404
RPS19 ribosomal protein S19 -0.021466
IGF2 insulin-like growth factor 2 -0.0213194
RPLP0 ribosomal protein, large, P0 -0.0209088
RPL23 ribosomal protein L23 -0.0207821
FTL ferritin, light polypeptide -0.0204413
RPS27 ribosomal protein S27 -0.0200933
LMAN1 lectin, mannose-binding, 1 -0.0192498
CAVIN1 caveolae associated protein 1 -0.0191858
RAD51B RAD51 paralog B -0.0191101
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0190979
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0190611
RPL31 ribosomal protein L31 -0.0190359
TMEM263 transmembrane protein 263 -0.0189057
FMN1 formin 1 -0.0188923
RPL19 ribosomal protein L19 -0.0186794
UBB ubiquitin B -0.0186651
S100A10 S100 calcium binding protein A10 -0.0186369
RYR3 ryanodine receptor 3 -0.0184714
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0184382
RPL12 ribosomal protein L12 -0.0180925
RPL8 ribosomal protein L8 -0.0176663
ZMYND8 zinc finger, MYND-type containing 8 -0.0174441
FSCN1 fascin actin-bundling protein 1 -0.0171186
RPS25 ribosomal protein S25 -0.0170679
SMC4 structural maintenance of chromosomes 4 -0.0168136
WSB1 WD repeat and SOCS box containing 1 -0.0166125
TUBA1B tubulin, alpha 1b -0.0162042
EIF1 eukaryotic translation initiation factor 1 -0.0158954
KPNB1 karyopherin (importin) beta 1 -0.0158232
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0157179
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0156481
ARHGAP5 Rho GTPase activating protein 5 -0.0155071
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0154941
PFN1 profilin 1 -0.0153895
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0153272
RPL38 ribosomal protein L38 -0.0149074
TPM2 tropomyosin 2 (beta) -0.0145452
HLA-E major histocompatibility complex, class I, E -0.0145436
RPS15 ribosomal protein S15 -0.01441
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0142008
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0140763
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.013871
LDHA lactate dehydrogenase A -0.0138591
BSG basigin (Ok blood group) -0.0137045
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0136463
PDIA3 protein disulfide isomerase family A, member 3 -0.0135727
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0133512
RSF1 remodeling and spacing factor 1 -0.0131064
WASF2 WAS protein family, member 2 -0.0130005
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0129941
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0128648
RPS27A ribosomal protein S27a -0.012429
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.012423
RPS14 ribosomal protein S14 -0.0124055
NIPSNAP2 nipsnap homolog 2 -0.0123558
PREPL prolyl endopeptidase-like -0.0122982
LMNA lamin A/C -0.0121863
TUBB tubulin, beta class I -0.0119904
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0119829
DEK DEK proto-oncogene -0.0118598
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0118238
SGO2 shugoshin 2 -0.0118217
RPL32 ribosomal protein L32 -0.011778
NCOA7 nuclear receptor coactivator 7 -0.0117767
RPS13 ribosomal protein S13 -0.0117629