TAK-901_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.136906
PABPC1 poly(A) binding protein, cytoplasmic 1 0.135304
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.128386
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.119262
FTL ferritin, light polypeptide 0.113817
FTH1 ferritin, heavy polypeptide 1 0.104694
PTMA prothymosin, alpha 0.104457
FN1 fibronectin 1 0.0995193
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.098042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0866817
RPS3 ribosomal protein S3 0.0815716
TPT1 tumor protein, translationally-controlled 1 0.0771827
LMO7 LIM domain 7 0.0750782
RPS6 ribosomal protein S6 0.0743106
ALCAM activated leukocyte cell adhesion molecule 0.0738381
TMSB10 thymosin beta 10 0.0688598
ACTG1 actin gamma 1 0.0683125
EIF1 eukaryotic translation initiation factor 1 0.0675899
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0670532
RACK1 receptor for activated C kinase 1 0.0667605
TRIO trio Rho guanine nucleotide exchange factor 0.0662913
RPS23 ribosomal protein S23 0.0648289
G0S2 G0/G1 switch 2 0.0644658
MYO6 myosin VI 0.0631701
RPS8 ribosomal protein S8 0.0598349
ASPH aspartate beta-hydroxylase 0.0596305
POTEF POTE ankyrin domain family, member F 0.0595869
FNDC3B fibronectin type III domain containing 3B 0.058973
PRRC2C proline-rich coiled-coil 2C 0.0585865
ERBIN erbb2 interacting protein 0.0583345
ENO1 enolase 1, (alpha) 0.0580807
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0567473
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0555715
RPL8 ribosomal protein L8 0.0547541
TXNRD1 thioredoxin reductase 1 0.054362
EEF2 eukaryotic translation elongation factor 2 0.0530975
CANX calnexin 0.0527055
RPL35A ribosomal protein L35a 0.051812
RBM25 RNA binding motif protein 25 0.0510726
TMSB4X thymosin beta 4, X-linked 0.050956
S100A6 S100 calcium binding protein A6 0.0501544
RPL23 ribosomal protein L23 0.0498708
ANXA2 annexin A2 0.0494536
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0491026
RPLP2 ribosomal protein, large, P2 0.0487437
PTK2 protein tyrosine kinase 2 0.0484792
SQSTM1 sequestosome 1 0.0480738
RPS29 ribosomal protein S29 0.0477497
RPL37A ribosomal protein L37a 0.0476678
TOP1 topoisomerase (DNA) I 0.0475393
RPS13 ribosomal protein S13 0.0471706
RPS12 ribosomal protein S12 0.0465188
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0463687
RPLP1 ribosomal protein, large, P1 0.0459514
EXT1 exostosin glycosyltransferase 1 0.045908
MYH9 myosin, heavy chain 9, non-muscle 0.0456868
RPL19 ribosomal protein L19 0.04494
CD2AP CD2-associated protein 0.0448652
RPS17 ribosomal protein S17 0.0445377
AKAP13 A kinase (PRKA) anchor protein 13 0.0441909
RPS19 ribosomal protein S19 0.0438942
SETD5 SET domain containing 5 0.0437418
VEGFA vascular endothelial growth factor A 0.0429915
FBXO32 F-box protein 32 0.0429342
RPL32 ribosomal protein L32 0.0425354
RPL11 ribosomal protein L11 0.0423927
DSCAM Down syndrome cell adhesion molecule 0.0422161
GOLGA4 golgin A4 0.0416087
VIM vimentin 0.0412174
RPL9 ribosomal protein L9 0.0411931
APLP2 amyloid beta (A4) precursor-like protein 2 0.0406501
DSPP dentin sialophosphoprotein 0.0403959
UBC ubiquitin C 0.0402109
CALR calreticulin 0.0401354
NPEPPS aminopeptidase puromycin sensitive 0.0399731
KRT7 keratin 7, type II 0.0398571
RPLP0 ribosomal protein, large, P0 0.0398246
RPL12 ribosomal protein L12 0.0393088
RPL37 ribosomal protein L37 0.0392685
TPM3 tropomyosin 3 0.0390437
LDHA lactate dehydrogenase A 0.0380641
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0379529
GOLGB1 golgin B1 0.0378705
LAMB3 laminin, beta 3 0.0376062
MACF1 microtubule-actin crosslinking factor 1 0.0370533
S100A10 S100 calcium binding protein A10 0.0368883
ZSWIM6 zinc finger, SWIM-type containing 6 0.0363584
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0361885
GPBP1 GC-rich promoter binding protein 1 0.0360891
LAMC2 laminin, gamma 2 0.0359757
SLC38A1 solute carrier family 38, member 1 0.0357973
CSTB cystatin B (stefin B) 0.0357117
TM4SF1 transmembrane 4 L six family member 1 0.0353378
RPL7 ribosomal protein L7 0.0351534
RPS25 ribosomal protein S25 0.0351212
RICTOR RPTOR independent companion of MTOR, complex 2 0.0348885
RPS27A ribosomal protein S27a 0.034721
RNF145 ring finger protein 145 0.034326
RPL34 ribosomal protein L34 0.0343096
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0340762

decreased expression

Symbol Name Standardized Value
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.137079
EGR1 early growth response 1 -0.0261713
NOCT nocturnin -0.0132782
EDN1 endothelin 1 -0.0130251
ZBTB10 zinc finger and BTB domain containing 10 -0.0112356
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0108858
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.00988287
GRB10 growth factor receptor-bound protein 10 -0.00950386
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0091115
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.00838127
FOSL1 FOS-like antigen 1 -0.00829348
NR1D1 nuclear receptor subfamily 1, group D, member 1 -0.00767525
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00759179
EFNB2 ephrin-B2 -0.00757203
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0071245
ANKRD33B ankyrin repeat domain 33B -0.00669442
DTNA dystrobrevin, alpha -0.00646195
AGRN agrin -0.00635067
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.00595835
TAPBP TAP binding protein (tapasin) -0.00558987
ICAM1 intercellular adhesion molecule 1 -0.0055434
CHSY3 chondroitin sulfate synthase 3 -0.00525936
TET3 tet methylcytosine dioxygenase 3 -0.00521211
MCTP1 multiple C2 domains, transmembrane 1 -0.00495768
KDM7A lysine (K)-specific demethylase 7A -0.00490359
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.00490044
MRPS6 mitochondrial ribosomal protein S6 -0.00467311
TTLL11 tubulin tyrosine ligase-like family member 11 -0.00455029
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00454397
MIMS1 mitochondrial inner membrane scaffold 1 -0.00449398
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -0.00448205
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00448073
MT1X metallothionein 1X -0.00448018
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -0.00440982
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0043171
DENND3 DENN/MADD domain containing 3 -0.00431615
RAD51B RAD51 paralog B -0.00428577
TMEM80 transmembrane protein 80 -0.00427047
NECTIN1 nectin cell adhesion molecule 1 -0.00424955
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -0.00415929
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K -0.00412305
ADNP2 ADNP homeobox 2 -0.00407402
PER1 period circadian clock 1 -0.00407235
FGF12 fibroblast growth factor 12 -0.00405596
RAB1B RAB1B, member RAS oncogene family -0.00404452
RHOB ras homolog family member B -0.00404176
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00400827
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -0.00397869
CD83 CD83 molecule -0.00395672
MIDEAS mitotic deacetylase associated SANT domain protein -0.00393835
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.00393018
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00392891
FOSL2 FOS-like antigen 2 -0.0039204
LINGO2 leucine rich repeat and Ig domain containing 2 -0.00390783
CYLD cylindromatosis (turban tumor syndrome) -0.00389617
PKP3 plakophilin 3 -0.00386975
RFTN1 raftlin, lipid raft linker 1 -0.00385844
LAMP3 lysosomal-associated membrane protein 3 -0.00384822
SEC24A SEC24 family member A -0.00384047
ZNF267 zinc finger protein 267 -0.00381583
ZBTB25 zinc finger and BTB domain containing 25 -0.00380669
LAMA5 laminin, alpha 5 -0.0038004
RNASEH2A ribonuclease H2, subunit A -0.00377846
CSRNP1 cysteine-serine-rich nuclear protein 1 -0.0037542
ZBED6 zinc finger, BED-type containing 6 -0.00375298
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.00373571
WDR27 WD repeat domain 27 -0.00370139
CCR3 chemokine (C-C motif) receptor 3 -0.00369065
SORBS1 sorbin and SH3 domain containing 1 -0.0036809
LRP1B low density lipoprotein receptor-related protein 1B -0.00363033
GOPC golgi-associated PDZ and coiled-coil motif containing -0.00362284
EPSTI1 epithelial stromal interaction 1 (breast) -0.00362281
FASN fatty acid synthase -0.00361473
INF2 inverted formin, FH2 and WH2 domain containing -0.00358703
HFE hemochromatosis -0.00358702
ZBTB21 zinc finger and BTB domain containing 21 -0.0035832
ITGB4 integrin, beta 4 -0.0035645
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -0.00354391
ZNF280C zinc finger protein 280C -0.00353438
FAM20C family with sequence similarity 20, member C -0.00352387
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.00351166
CSRP2 cysteine and glycine-rich protein 2 -0.00349486
JAG2 jagged 2 -0.00349088
PTX3 pentraxin 3, long -0.00348698
MMP7 matrix metallopeptidase 7 -0.00347124
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.00346874
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -0.00346497
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -0.00345655
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.00344757
PLXNA1 plexin A1 -0.00343358
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -0.00342074
COPG2 coatomer protein complex, subunit gamma 2 -0.00341972
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.00341372
CYBC1 cytochrome b-245 chaperone 1 -0.00341187
EHD1 EH-domain containing 1 -0.00341055
KAT2B K(lysine) acetyltransferase 2B -0.00340915
BTN3A1 butyrophilin, subfamily 3, member A1 -0.00340145
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -0.00339332
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.00338331
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1 -0.00336301