TAK-901_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.288294
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.207968
VIM vimentin 0.128852
TPT1 tumor protein, translationally-controlled 1 0.124876
RPS6 ribosomal protein S6 0.123851
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110871
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.11073
PDE10A phosphodiesterase 10A 0.109667
CDH13 cadherin 13 0.0972076
FTH1 ferritin, heavy polypeptide 1 0.0897855
RPL26 ribosomal protein L26 0.0891675
PSD3 pleckstrin and Sec7 domain containing 3 0.0873049
RPL37A ribosomal protein L37a 0.0843536
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0830596
RPS12 ribosomal protein S12 0.0808974
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0799238
COL5A2 collagen, type V, alpha 2 0.077049
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0750855
RPL31 ribosomal protein L31 0.0748465
RPS8 ribosomal protein S8 0.0740156
TMSB10 thymosin beta 10 0.0738108
PM20D1 peptidase M20 domain containing 1 0.0725237
RPS3 ribosomal protein S3 0.0723283
PTPRM protein tyrosine phosphatase, receptor type, M 0.0666274
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.065288
FTL ferritin, light polypeptide 0.0652822
RPLP1 ribosomal protein, large, P1 0.0650932
RPS19 ribosomal protein S19 0.0649751
RPS23 ribosomal protein S23 0.0649263
RPL35A ribosomal protein L35a 0.0627635
ENO1 enolase 1, (alpha) 0.0613235
FN1 fibronectin 1 0.0596734
RPL12 ribosomal protein L12 0.0577587
PRKN parkin RBR E3 ubiquitin protein ligase 0.0547282
EEF2 eukaryotic translation elongation factor 2 0.0544141
NALF1 NALCN channel auxiliary factor 1 0.0540613
PDLIM5 PDZ and LIM domain 5 0.0537639
RPS17 ribosomal protein S17 0.053395
P3H2 prolyl 3-hydroxylase 2 0.0528101
MAP7 microtubule-associated protein 7 0.0518411
RPL19 ribosomal protein L19 0.0516164
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0512988
RPS27A ribosomal protein S27a 0.0511774
RACK1 receptor for activated C kinase 1 0.0510295
RPL11 ribosomal protein L11 0.0507496
RPL9 ribosomal protein L9 0.0505166
RPL7A ribosomal protein L7a 0.0476956
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0475799
DST dystonin 0.0472599
BASP1 brain abundant, membrane attached signal protein 1 0.0471625
PTMA prothymosin, alpha 0.0469862
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0469708
B2M beta-2-microglobulin 0.046636
RPL37 ribosomal protein L37 0.0459863
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0453631
SH3KBP1 SH3-domain kinase binding protein 1 0.0448441
RPS29 ribosomal protein S29 0.0441639
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0439414
RPS27 ribosomal protein S27 0.0437707
RPS24 ribosomal protein S24 0.0436516
RPL23 ribosomal protein L23 0.0432377
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0426714
ANXA2 annexin A2 0.0426428
SQSTM1 sequestosome 1 0.0422238
RPL36A ribosomal protein L36a 0.0422135
RPS14 ribosomal protein S14 0.0418825
RPS4X ribosomal protein S4, X-linked 0.0411518
RPLP2 ribosomal protein, large, P2 0.0409733
KYNU kynureninase 0.0409651
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0407989
EXT1 exostosin glycosyltransferase 1 0.040536
RPL36 ribosomal protein L36 0.0402385
RPLP0 ribosomal protein, large, P0 0.0401664
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0398949
SMOC1 SPARC related modular calcium binding 1 0.0396865
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.039626
LSAMP limbic system-associated membrane protein 0.0395136
LDHA lactate dehydrogenase A 0.0395092
MAML3 mastermind-like 3 (Drosophila) 0.0394507
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0388787
FNDC3A fibronectin type III domain containing 3A 0.0387056
SMAD2 SMAD family member 2 0.0380656
RPL34 ribosomal protein L34 0.0371722
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0370382
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.036273
RPS25 ribosomal protein S25 0.0361506
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0356444
AKAP13 A kinase (PRKA) anchor protein 13 0.0352114
LOC102724023 ES1 protein homolog, mitochondrial 0.0351436
RPS13 ribosomal protein S13 0.0351337
FMNL2 formin-like 2 0.0346609
NAP1L1 nucleosome assembly protein 1-like 1 0.0333989
PKM pyruvate kinase, muscle 0.0332966
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0332524
RPL35 ribosomal protein L35 0.0329882
SRRM2 serine/arginine repetitive matrix 2 0.03238
RAD51B RAD51 paralog B 0.0312845
AGTPBP1 ATP/GTP binding protein 1 0.0305131
TTC28 tetratricopeptide repeat domain 28 0.0301652
AUTS2 autism susceptibility candidate 2 0.0300313

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.0725841
EFNA5 ephrin-A5 -0.0641666
RTN4 reticulon 4 -0.0359212
NEK7 NIMA-related kinase 7 -0.0355101
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0341894
TFPI2 tissue factor pathway inhibitor 2 -0.0308229
TXNRD1 thioredoxin reductase 1 -0.0297135
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0239272
OGA O-GlcNAcase -0.0224291
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0215867
CENPF centromere protein F, 350/400kDa -0.0212778
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0201756
GRAMD1B GRAM domain containing 1B -0.0192223
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0188341
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0183633
ELL2 elongation factor, RNA polymerase II, 2 -0.01791
USP3 ubiquitin specific peptidase 3 -0.0176612
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0175232
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0169209
ANLN anillin, actin binding protein -0.0169084
ANKRD28 ankyrin repeat domain 28 -0.0166874
MFF mitochondrial fission factor -0.016545
AVL9 AVL9 homolog (S. cerevisiase) -0.016308
WDFY2 WD repeat and FYVE domain containing 2 -0.0161057
ARHGAP29 Rho GTPase activating protein 29 -0.0158097
SUCO SUN domain containing ossification factor -0.0157315
BRWD3 bromodomain and WD repeat domain containing 3 -0.0154382
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0152629
AGFG1 ArfGAP with FG repeats 1 -0.0152235
NUP58 nucleoporin 58 -0.0151812
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0149813
ZFC3H1 zinc finger, C3H1-type containing -0.0147694
ECT2 epithelial cell transforming 2 -0.0147092
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0147024
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0141745
ATP13A3 ATPase type 13A3 -0.0140228
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0138125
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0137258
MKI67 marker of proliferation Ki-67 -0.0137101
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0136324
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0134141
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0134014
GDA guanine deaminase -0.0132062
CDK17 cyclin-dependent kinase 17 -0.0131715
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0130025
WDR45B WD repeat domain 45B -0.0129355
TM4SF1 transmembrane 4 L six family member 1 -0.0128847
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0128377
CFLAR CASP8 and FADD-like apoptosis regulator -0.0128063
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0127824
PDGFA platelet-derived growth factor alpha polypeptide -0.0127802
NRCAM neuronal cell adhesion molecule -0.0127622
RBM39 RNA binding motif protein 39 -0.0126483
SRPK2 SRSF protein kinase 2 -0.0125756
KIF14 kinesin family member 14 -0.0125726
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0124197
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0122958
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0122901
NCKAP1 NCK-associated protein 1 -0.0122172
PTGR1 prostaglandin reductase 1 -0.0119869
FAM13A family with sequence similarity 13, member A -0.0119728
POU2F1 POU class 2 homeobox 1 -0.0118178
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0117114
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0117016
RAI1 retinoic acid induced 1 -0.0115601
SPAG9 sperm associated antigen 9 -0.0115507
COG5 component of oligomeric golgi complex 5 -0.0115485
PHIP pleckstrin homology domain interacting protein -0.0114823
LIMCH1 LIM and calponin homology domains 1 -0.0114774
NBAS neuroblastoma amplified sequence -0.0113809
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0113506
ADAM9 ADAM metallopeptidase domain 9 -0.0113258
DPY19L1 dpy-19-like 1 (C. elegans) -0.0112957
CENPE centromere protein E, 312kDa -0.0112116
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.0109423
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0108852
SFPQ splicing factor proline/glutamine-rich -0.0108553
FLNB filamin B, beta -0.0107422
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0106943
ADAM17 ADAM metallopeptidase domain 17 -0.0105968
DPYD dihydropyrimidine dehydrogenase -0.0105951
TPD52 tumor protein D52 -0.0105405
TPX2 TPX2, microtubule-associated -0.0104289
DIAPH3 diaphanous-related formin 3 -0.01036
BIRC2 baculoviral IAP repeat containing 2 -0.0103023
MIS18BP1 MIS18 binding protein 1 -0.0101928
TGFBI transforming growth factor, beta-induced, 68kDa -0.010163
TMX4 thioredoxin-related transmembrane protein 4 -0.0099578
TM9SF3 transmembrane 9 superfamily member 3 -0.00984626
PUM2 pumilio RNA-binding family member 2 -0.00981733
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00980064
XPO1 exportin 1 -0.00972015
CEP170 centrosomal protein 170kDa -0.00969766
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.00962911
MON2 MON2 homolog (S. cerevisiae) -0.00962463
CARD16 caspase recruitment domain family, member 16 -0.00960003
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00952432
WDR26 WD repeat domain 26 -0.00933044
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.00928946
SRP54 signal recognition particle 54kDa -0.00925933