| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-901_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.261968 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.13977 |
| HDAC9 | histone deacetylase 9 | 0.0991164 |
| COL11A1 | collagen, type XI, alpha 1 | 0.096777 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0913704 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0827702 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0731153 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0630256 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0592093 |
| TENM3 | teneurin transmembrane protein 3 | 0.0581396 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0536672 |
| DST | dystonin | 0.051754 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0469935 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0460709 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.046039 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0456845 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0438372 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0436256 |
| PEG10 | paternally expressed 10 | 0.0432326 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0428351 |
| HMCN1 | hemicentin 1 | 0.0423685 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.042111 |
| RPS3 | ribosomal protein S3 | 0.0413568 |
| RPL18 | ribosomal protein L18 | 0.0413449 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0412289 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0407573 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0397262 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0382064 |
| TMSB4X | thymosin beta 4, X-linked | 0.0373973 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.037196 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0370334 |
| MATR3 | matrin 3 | 0.0369883 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0360365 |
| RPS6 | ribosomal protein S6 | 0.0353591 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0347009 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0334729 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0329236 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0325847 |
| YBX1 | Y box binding protein 1 | 0.0317584 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0313868 |
| EVI5 | ecotropic viral integration site 5 | 0.0310595 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0309919 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0308279 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0307095 |
| CDH19 | cadherin 19, type 2 | 0.0304348 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0298236 |
| RPL12 | ribosomal protein L12 | 0.0292007 |
| NCKAP1 | NCK-associated protein 1 | 0.0290188 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0289977 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0289036 |
| RASAL2 | RAS protein activator like 2 | 0.0285507 |
| UTRN | utrophin | 0.0284853 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0280196 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0278234 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0277277 |
| CORO1C | coronin, actin binding protein, 1C | 0.0272599 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0272098 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0269481 |
| ANK2 | ankyrin 2, neuronal | 0.0266292 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0261409 |
| ITGAV | integrin, alpha V | 0.0261364 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0259267 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0259141 |
| LIN28B | lin-28 homolog B (C. elegans) | 0.0258975 |
| QKI | QKI, KH domain containing, RNA binding | 0.0256649 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0255968 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0253104 |
| POTEF | POTE ankyrin domain family, member F | 0.0250539 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0248627 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0246375 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0245945 |
| ENO1 | enolase 1, (alpha) | 0.0245778 |
| ZNF608 | zinc finger protein 608 | 0.024464 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0244595 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0243262 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0243033 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0242655 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0242058 |
| RPS2 | ribosomal protein S2 | 0.0241696 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0239703 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0238423 |
| TSPAN12 | tetraspanin 12 | 0.0238395 |
| SHROOM3 | shroom family member 3 | 0.0236816 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0236142 |
| NEMF | nuclear export mediator factor | 0.02359 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0235501 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0232932 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0232588 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0228209 |
| RDX | radixin | 0.0226858 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0226439 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0223041 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0221774 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0220802 |
| MYO10 | myosin X | 0.0217842 |
| RBM26 | RNA binding motif protein 26 | 0.0217792 |
| RBM20 | RNA binding motif protein 20 | 0.02161 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0216014 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0215386 |
| APP | amyloid beta (A4) precursor protein | 0.021374 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.121546 |
| RPS16 | ribosomal protein S16 | -0.0768399 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0708218 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0705321 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0674419 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0662849 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0558339 |
| COL3A1 | collagen, type III, alpha 1 | -0.0531109 |
| RIGI | RNA sensor RIG-I | -0.0528173 |
| RPS8 | ribosomal protein S8 | -0.0507902 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0506335 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.050486 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.047048 |
| RPL35A | ribosomal protein L35a | -0.0431374 |
| FNDC3A | fibronectin type III domain containing 3A | -0.04164 |
| CAVIN1 | caveolae associated protein 1 | -0.0406614 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0406611 |
| SPAG9 | sperm associated antigen 9 | -0.0380142 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0368342 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.035707 |
| ZNF217 | zinc finger protein 217 | -0.0334234 |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | -0.0330002 |
| GNAS | GNAS complex locus | -0.0328993 |
| RPS24 | ribosomal protein S24 | -0.03221 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0308528 |
| CENPF | centromere protein F, 350/400kDa | -0.0307079 |
| S100A10 | S100 calcium binding protein A10 | -0.0298085 |
| GSE1 | Gse1 coiled-coil protein | -0.0295914 |
| ANKRD12 | ankyrin repeat domain 12 | -0.029418 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0290989 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0287955 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0287597 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.028578 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0282661 |
| PCDH7 | protocadherin 7 | -0.0273325 |
| MPG | N-methylpurine-DNA glycosylase | -0.0268253 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0263954 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0262876 |
| FGF13 | fibroblast growth factor 13 | -0.0260965 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0260622 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0257357 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0252311 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0251483 |
| RPLP1 | ribosomal protein, large, P1 | -0.0250457 |
| NXN | nucleoredoxin | -0.0247771 |
| PDS5A | PDS5 cohesin associated factor A | -0.0246972 |
| FOXN3 | forkhead box N3 | -0.0246466 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0245944 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0244739 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0242252 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0242241 |
| IGF2 | insulin-like growth factor 2 | -0.0242169 |
| RHOH | ras homolog family member H | -0.0241606 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0240757 |
| MORF4L2 | mortality factor 4 like 2 | -0.0239152 |
| CCNI | cyclin I | -0.0238342 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0235901 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0230436 |
| MT2A | metallothionein 2A | -0.0227015 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0223343 |
| URI1 | URI1, prefoldin-like chaperone | -0.0222704 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | -0.022218 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0221033 |
| LATS2 | large tumor suppressor kinase 2 | -0.0219077 |
| CCNY | cyclin Y | -0.0218974 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0218703 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.021718 |
| HMGB1 | high mobility group box 1 | -0.0217171 |
| CENPE | centromere protein E, 312kDa | -0.0216841 |
| FBXO17 | F-box protein 17 | -0.0216271 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0213272 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0212588 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0212255 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0211304 |
| SMIM44 | small integral membrane protein 44 | -0.0211073 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.021032 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0209448 |
| H1-0 | H1.0 linker histone | -0.0208059 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0207561 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0207526 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0206668 |
| HES4 | hes family bHLH transcription factor 4 | -0.0206494 |
| TPM1 | tropomyosin 1 (alpha) | -0.0205615 |
| GAB2 | GRB2-associated binding protein 2 | -0.0205268 |
| S100A6 | S100 calcium binding protein A6 | -0.0204131 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0202894 |
| CADM2 | cell adhesion molecule 2 | -0.0201787 |
| COL1A2 | collagen, type I, alpha 2 | -0.0201749 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0201009 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0200952 |
| RAD51B | RAD51 paralog B | -0.0200934 |
| APOE | apolipoprotein E | -0.02006 |
| RPL23 | ribosomal protein L23 | -0.0200313 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0200017 |
| RPL4 | ribosomal protein L4 | -0.0199219 |
| RPL36A | ribosomal protein L36a | -0.0198839 |
| TUT4 | terminal uridylyl transferase 4 | -0.019768 |
| RCOR1 | REST corepressor 1 | -0.019752 |
| HLA-B | major histocompatibility complex, class I, B | -0.0196433 |
| SEPTIN2 | septin 2 | -0.0195125 |
