TAK-901_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.172105
PABPC1 poly(A) binding protein, cytoplasmic 1 0.154323
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.125864
RPS3 ribosomal protein S3 0.125664
RPS6 ribosomal protein S6 0.125536
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.121505
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.117816
LAMB3 laminin, beta 3 0.0998774
FTH1 ferritin, heavy polypeptide 1 0.0992645
RACK1 receptor for activated C kinase 1 0.0914889
B2M beta-2-microglobulin 0.0895436
G0S2 G0/G1 switch 2 0.0890813
RPL37A ribosomal protein L37a 0.0876838
EIF1 eukaryotic translation initiation factor 1 0.0837068
RPS8 ribosomal protein S8 0.0816526
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0811079
PTMA prothymosin, alpha 0.0804798
RPS29 ribosomal protein S29 0.079698
RPS12 ribosomal protein S12 0.077169
ANXA2 annexin A2 0.0770574
LDHA lactate dehydrogenase A 0.0722182
RPS19 ribosomal protein S19 0.0690923
NDRG1 N-myc downstream regulated 1 0.0684165
SQSTM1 sequestosome 1 0.0666397
RPL12 ribosomal protein L12 0.0651151
RPL35A ribosomal protein L35a 0.0647336
RPS13 ribosomal protein S13 0.0643669
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0619182
RPS17 ribosomal protein S17 0.0613868
RPL19 ribosomal protein L19 0.0602427
RPL23 ribosomal protein L23 0.059379
RPL36 ribosomal protein L36 0.0585515
RPS23 ribosomal protein S23 0.0571015
EMP1 epithelial membrane protein 1 0.0563346
RPL26 ribosomal protein L26 0.0560588
KRT18 keratin 18, type I 0.0558951
RPL11 ribosomal protein L11 0.0540464
MYO6 myosin VI 0.0526033
CANX calnexin 0.0522982
RPL32 ribosomal protein L32 0.0519282
RPS15 ribosomal protein S15 0.051821
CALR calreticulin 0.0506319
EZR ezrin 0.0505669
RPL31 ribosomal protein L31 0.0502217
VEGFA vascular endothelial growth factor A 0.0493015
HLA-B major histocompatibility complex, class I, B 0.0492817
TMSB10 thymosin beta 10 0.04883
RPS27A ribosomal protein S27a 0.0485184
PRRC2C proline-rich coiled-coil 2C 0.0484442
APLP2 amyloid beta (A4) precursor-like protein 2 0.0469568
GOLGB1 golgin B1 0.0466419
TXNIP thioredoxin interacting protein 0.0465848
RPL37 ribosomal protein L37 0.0465097
TPI1 triosephosphate isomerase 1 0.0464122
HMGA1 high mobility group AT-hook 1 0.0453439
EEF2 eukaryotic translation elongation factor 2 0.0450788
RPL28 ribosomal protein L28 0.0450487
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0448519
RPL8 ribosomal protein L8 0.044339
KTN1 kinectin 1 (kinesin receptor) 0.043631
RPL9 ribosomal protein L9 0.0431992
PLAU plasminogen activator, urokinase 0.0425919
RPS24 ribosomal protein S24 0.042366
RPS25 ribosomal protein S25 0.0417761
GOLGA4 golgin A4 0.0416636
LOC102724023 ES1 protein homolog, mitochondrial 0.0415759
RAB7A RAB7A, member RAS oncogene family 0.0414757
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0410444
NAP1L1 nucleosome assembly protein 1-like 1 0.0406693
BRD2 bromodomain containing 2 0.0395864
IRS2 insulin receptor substrate 2 0.0393291
FTL ferritin, light polypeptide 0.0389065
RPL7A ribosomal protein L7a 0.0387694
ACTG1 actin gamma 1 0.0386699
INTS6 integrator complex subunit 6 0.0383543
AKAP9 A kinase (PRKA) anchor protein 9 0.0382723
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0379149
DSCAM Down syndrome cell adhesion molecule 0.037848
YBX1 Y box binding protein 1 0.0374759
CD44 CD44 molecule (Indian blood group) 0.0374751
ENO1 enolase 1, (alpha) 0.0362752
HLA-A major histocompatibility complex, class I, A 0.0362094
MYH9 myosin, heavy chain 9, non-muscle 0.0358531
KRT17 keratin 17, type I 0.0354617
RPS5 ribosomal protein S5 0.0346799
NACA nascent polypeptide-associated complex alpha subunit 0.0342818
RPS10 ribosomal protein S10 0.0336994
TRIO trio Rho guanine nucleotide exchange factor 0.0335976
KRT7 keratin 7, type II 0.0334788
TMF1 TATA element modulatory factor 1 0.0329636
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0326922
RPS11 ribosomal protein S11 0.0326413
VIM vimentin 0.0323853
SRRM2 serine/arginine repetitive matrix 2 0.03221
AKAP12 A kinase (PRKA) anchor protein 12 0.0321534
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0320364
PLK2 polo-like kinase 2 0.031666
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0313939
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0311114
UBC ubiquitin C 0.0307883

decreased expression

Symbol Name Standardized Value
MUC4 mucin 4, cell surface associated -0.0872322
LAMA4 laminin, alpha 4 -0.0532854
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0430221
OSMR oncostatin M receptor -0.0420901
EFNA5 ephrin-A5 -0.0386232
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0385621
TNF tumor necrosis factor -0.0308725
MX2 MX dynamin-like GTPase 2 -0.0278741
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0271609
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0268756
RIMKLB ribosomal modification protein rimK-like family member B -0.0251355
TC2N tandem C2 domains, nuclear -0.0249478
SMOC1 SPARC related modular calcium binding 1 -0.0235362
WARS1 tryptophanyl-tRNA synthetase 1 -0.0230854
ACTN4 actinin, alpha 4 -0.0215174
PLSCR1 phospholipid scramblase 1 -0.0212324
F3 coagulation factor III (thromboplastin, tissue factor) -0.0206904
RIGI RNA sensor RIG-I -0.0205867
EPSTI1 epithelial stromal interaction 1 (breast) -0.0198058
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0194722
MYO1E myosin IE -0.0192634
PLAT plasminogen activator, tissue -0.0191382
STS steroid sulfatase (microsomal), isozyme S -0.0175552
LATS2 large tumor suppressor kinase 2 -0.017216
C3 complement component 3 -0.0168564
OXSR1 oxidative stress responsive 1 -0.0167212
SULF2 sulfatase 2 -0.0166345
RNF213 ring finger protein 213 -0.0166063
DPYD dihydropyrimidine dehydrogenase -0.0164389
MAML2 mastermind-like 2 (Drosophila) -0.0160458
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0154263
ETV6 ets variant 6 -0.0153118
C6ORF132 chromosome 6 open reading frame 132 -0.0151008
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0150659
KIF13B kinesin family member 13B -0.0148374
FBXO34 F-box protein 34 -0.0147345
RBM47 RNA binding motif protein 47 -0.0147075
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0141258
ZBTB20 zinc finger and BTB domain containing 20 -0.0139887
RAD51B RAD51 paralog B -0.0139576
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0138747
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0138167
TAS2R14 taste receptor, type 2, member 14 -0.0133425
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0131224
FCHSD2 FCH and double SH3 domains 2 -0.0129786
PLAUR plasminogen activator, urokinase receptor -0.0128846
RAB10 RAB10, member RAS oncogene family -0.0123245
CTSD cathepsin D -0.0122066
BCAR3 breast cancer anti-estrogen resistance 3 -0.0120881
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.012059
TGM2 transglutaminase 2 -0.0119763
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0119074
PLPP3 phospholipid phosphatase 3 -0.0118988
SAMD12 sterile alpha motif domain containing 12 -0.0118574
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0117514
FOXO1 forkhead box O1 -0.0117308
LY6E lymphocyte antigen 6 complex, locus E -0.0115265
FN1 fibronectin 1 -0.0114076
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.0114063
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0112797
OSBPL3 oxysterol binding protein-like 3 -0.0110024
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0109921
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0109396
WWC1 WW and C2 domain containing 1 -0.0108998
TAPBP TAP binding protein (tapasin) -0.0108867
NRP1 neuropilin 1 -0.0107383
TGFA transforming growth factor, alpha -0.0106925
LMO7 LIM domain 7 -0.0106044
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.010579
PICALM phosphatidylinositol binding clathrin assembly protein -0.0105721
RAB31 RAB31, member RAS oncogene family -0.0105312
NT5C2 5'-nucleotidase, cytosolic II -0.0105087
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0104213
TNS4 tensin 4 -0.0103335
VCL vinculin -0.0103311
SORBS2 sorbin and SH3 domain containing 2 -0.0103192
MT1X metallothionein 1X -0.0102911
CCDC91 coiled-coil domain containing 91 -0.0101901
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0101495
PBX1 pre-B-cell leukemia homeobox 1 -0.0100894
ETNK1 ethanolamine kinase 1 -0.0100381
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.00998302
IL1RAP interleukin 1 receptor accessory protein -0.00989196
ASS1 argininosuccinate synthase 1 -0.00989036
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.00981415
ZC3H12C zinc finger CCCH-type containing 12C -0.00976119
USP18 ubiquitin specific peptidase 18 -0.0095127
PLAC8 placenta-specific 8 -0.0095109
SAMHD1 SAM domain and HD domain 1 -0.00949671
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0094689
S100A4 S100 calcium binding protein A4 -0.00929403
PCDH7 protocadherin 7 -0.00928941
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.00910668
TNRC18 trinucleotide repeat containing 18 -0.00908803
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.00904179
CLIC5 chloride intracellular channel 5 -0.00901696
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00900711
STAT1 signal transducer and activator of transcription 1, 91kDa -0.00897471
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00896292
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -0.0089562