| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-901_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.166746 |
| JMJD1C | jumonji domain containing 1C | 0.159872 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.120019 |
| HMGA2 | high mobility group AT-hook 2 | 0.101023 |
| MCL1 | myeloid cell leukemia 1 | 0.0925897 |
| NDRG1 | N-myc downstream regulated 1 | 0.0869478 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0861354 |
| POTEF | POTE ankyrin domain family, member F | 0.0833742 |
| BRD2 | bromodomain containing 2 | 0.081624 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.079752 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0796255 |
| VMP1 | vacuole membrane protein 1 | 0.0757415 |
| ENO1 | enolase 1, (alpha) | 0.0716434 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0693339 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0692432 |
| RPS6 | ribosomal protein S6 | 0.069199 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.068591 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0665214 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0611515 |
| ZNF292 | zinc finger protein 292 | 0.0603377 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0597057 |
| RCOR1 | REST corepressor 1 | 0.058751 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0585894 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0576962 |
| INTS6 | integrator complex subunit 6 | 0.0576206 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0552286 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0551619 |
| JUN | jun proto-oncogene | 0.0542967 |
| STC1 | stanniocalcin 1 | 0.0542123 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0536442 |
| RUNX1 | runt-related transcription factor 1 | 0.0525398 |
| PTK2 | protein tyrosine kinase 2 | 0.0514381 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.049863 |
| NABP1 | nucleic acid binding protein 1 | 0.049764 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0495475 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0494634 |
| ZNF638 | zinc finger protein 638 | 0.0482205 |
| RBM39 | RNA binding motif protein 39 | 0.0479882 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0472611 |
| RTN4 | reticulon 4 | 0.0468921 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0465822 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0463184 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0458194 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.04548 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0453021 |
| ERBIN | erbb2 interacting protein | 0.0451348 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0446905 |
| BBX | bobby sox homolog (Drosophila) | 0.0442261 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.0436254 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0432338 |
| NUP58 | nucleoporin 58 | 0.0431422 |
| TCF12 | transcription factor 12 | 0.043052 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0429766 |
| RBM25 | RNA binding motif protein 25 | 0.0420286 |
| SON | SON DNA binding protein | 0.0418861 |
| SETD5 | SET domain containing 5 | 0.0411738 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0410746 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0390861 |
| FBXO11 | F-box protein 11 | 0.0390769 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0390327 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0387573 |
| USP3 | ubiquitin specific peptidase 3 | 0.0378475 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0375411 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0372975 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0370021 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0360192 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0359178 |
| ANO6 | anoctamin 6 | 0.0355815 |
| SEM1 | SEM1 26S proteasome subunit | 0.0354757 |
| SATB2 | SATB homeobox 2 | 0.0353999 |
| SGMS2 | sphingomyelin synthase 2 | 0.0352252 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0350283 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0346762 |
| FKBP15 | FK506 binding protein 15, 133kDa | 0.0344817 |
| EGR1 | early growth response 1 | 0.0343818 |
| RYBP | RING1 and YY1 binding protein | 0.0342104 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.034203 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0341832 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.0341496 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0340599 |
| KIF5B | kinesin family member 5B | 0.0337889 |
| RPS3 | ribosomal protein S3 | 0.0333602 |
| YTHDC1 | YTH domain containing 1 | 0.0332038 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0331639 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0331055 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0326305 |
| USP34 | ubiquitin specific peptidase 34 | 0.0322196 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0318377 |
| SET | SET nuclear proto-oncogene | 0.0317473 |
| ZNF207 | zinc finger protein 207 | 0.0316501 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0315759 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.031547 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0315445 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0313554 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0312591 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | 0.0309207 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0309033 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0308982 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0307522 |
| RPL3 | ribosomal protein L3 | 0.0306736 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0869337 |
| TTR | transthyretin | -0.080268 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0713347 |
| FHIT | fragile histidine triad | -0.070644 |
| BNC2 | basonuclin 2 | -0.0687497 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.067366 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0655694 |
| CALD1 | caldesmon 1 | -0.0622799 |
| EXOC4 | exocyst complex component 4 | -0.0617556 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0616923 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0590998 |
| RAD51B | RAD51 paralog B | -0.0542519 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0538905 |
| FLNB | filamin B, beta | -0.0492007 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0450764 |
| LAMB3 | laminin, beta 3 | -0.0443913 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0435569 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0379614 |
| AHNAK | AHNAK nucleoprotein | -0.0378921 |
| MTAP | methylthioadenosine phosphorylase | -0.0376913 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0369038 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0358657 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0355552 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0353764 |
| RAB3IP | RAB3A interacting protein | -0.0353661 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0345501 |
| FRMD4A | FERM domain containing 4A | -0.0333184 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0332284 |
| KLF10 | Kruppel-like factor 10 | -0.0330687 |
| CDK6 | cyclin-dependent kinase 6 | -0.0325815 |
| TPM4 | tropomyosin 4 | -0.0319301 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0317602 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0316288 |
| MAP4 | microtubule-associated protein 4 | -0.031366 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0312223 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0306522 |
| WWOX | WW domain containing oxidoreductase | -0.0306021 |
| RPS24 | ribosomal protein S24 | -0.0298943 |
| PCNX4 | pecanex 4 | -0.0297373 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0296111 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0293864 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0289406 |
| DIAPH3 | diaphanous-related formin 3 | -0.0286805 |
| MX1 | MX dynamin-like GTPase 1 | -0.0285364 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0284899 |
| ANK2 | ankyrin 2, neuronal | -0.0283836 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0283361 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0281909 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0280088 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0277015 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0274209 |
| TXNRD1 | thioredoxin reductase 1 | -0.0271131 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0269502 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0269224 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0257586 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0254034 |
| RPL4 | ribosomal protein L4 | -0.0246435 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0244776 |
| ALPK1 | alpha-kinase 1 | -0.0243961 |
| RNF169 | ring finger protein 169 | -0.0243528 |
| RIGI | RNA sensor RIG-I | -0.0237414 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0237354 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0234537 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0228362 |
| FRMD6 | FERM domain containing 6 | -0.0227724 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0226802 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0220929 |
| CALR | calreticulin | -0.0220811 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0215301 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0214555 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0212462 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0211635 |
| ATM | ATM serine/threonine kinase | -0.0211621 |
| HLA-E | major histocompatibility complex, class I, E | -0.0210921 |
| CANX | calnexin | -0.0210263 |
| S100A2 | S100 calcium binding protein A2 | -0.0209049 |
| MX2 | MX dynamin-like GTPase 2 | -0.0205453 |
| PRELID2 | PRELI domain containing 2 | -0.0203674 |
| PLSCR1 | phospholipid scramblase 1 | -0.0199835 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0198956 |
| HMGA1 | high mobility group AT-hook 1 | -0.0197719 |
| RPL12 | ribosomal protein L12 | -0.0197246 |
| SRFBP1 | serum response factor binding protein 1 | -0.0195093 |
| OXR1 | oxidation resistance 1 | -0.0193016 |
| RPS27A | ribosomal protein S27a | -0.0192691 |
| PKP4 | plakophilin 4 | -0.0192654 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0192492 |
| PGK1 | phosphoglycerate kinase 1 | -0.019077 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0189524 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0187196 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0186811 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0186038 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.018577 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0185319 |
| CEP95 | centrosomal protein 95kDa | -0.0182758 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0182595 |
| NFIB | nuclear factor I/B | -0.018249 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0178453 |
| TUBB | tubulin, beta class I | -0.0178017 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0177854 |
