| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-901_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.105893 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.103295 |
| MCL1 | myeloid cell leukemia 1 | 0.101951 |
| PDE10A | phosphodiesterase 10A | 0.100176 |
| STC1 | stanniocalcin 1 | 0.0941617 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0934589 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0917554 |
| NBEA | neurobeachin | 0.0813087 |
| NRG1 | neuregulin 1 | 0.0793402 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0754696 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0659285 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.063214 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0606497 |
| ASPH | aspartate beta-hydroxylase | 0.06031 |
| INHBA | inhibin, beta A | 0.0601114 |
| SNTG1 | syntrophin, gamma 1 | 0.0592676 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0587275 |
| EFNA5 | ephrin-A5 | 0.0564163 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0546155 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.054232 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0513327 |
| NCKAP5 | NCK-associated protein 5 | 0.0492294 |
| SCG2 | secretogranin II | 0.0489479 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.048685 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0483874 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0482442 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0465785 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0458109 |
| KIF26B | kinesin family member 26B | 0.0457096 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0438074 |
| VEGFA | vascular endothelial growth factor A | 0.043782 |
| ZFHX3 | zinc finger homeobox 3 | 0.0434037 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0431692 |
| SIK2 | salt-inducible kinase 2 | 0.0428513 |
| PTCHD4 | patched domain containing 4 | 0.0426631 |
| NDRG1 | N-myc downstream regulated 1 | 0.0415908 |
| RORA | RAR-related orphan receptor A | 0.0412535 |
| SMYD3 | SET and MYND domain containing 3 | 0.0406219 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.04042 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0395443 |
| ENO1 | enolase 1, (alpha) | 0.0388575 |
| NAV2 | neuron navigator 2 | 0.0385416 |
| LSAMP | limbic system-associated membrane protein | 0.038352 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0381682 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0378317 |
| CHGB | chromogranin B | 0.0378175 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | 0.0378053 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0375772 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0369834 |
| TOP1 | topoisomerase (DNA) I | 0.0367047 |
| EGFR | epidermal growth factor receptor | 0.0344272 |
| SETX | senataxin | 0.0341211 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0339158 |
| MAP7 | microtubule-associated protein 7 | 0.0338806 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0328196 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0328135 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0327206 |
| SP100 | SP100 nuclear antigen | 0.0318512 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0314431 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.0313567 |
| SVIL | supervillin | 0.0313386 |
| FGF14 | fibroblast growth factor 14 | 0.030774 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0303265 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0301638 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0301012 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0299316 |
| RNF213 | ring finger protein 213 | 0.0296731 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0294278 |
| CDK13 | cyclin-dependent kinase 13 | 0.0291938 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | 0.0288904 |
| VMP1 | vacuole membrane protein 1 | 0.0288672 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0286825 |
| VGF | VGF nerve growth factor inducible | 0.0283403 |
| FAM13A | family with sequence similarity 13, member A | 0.0282136 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0281439 |
| TOX | thymocyte selection-associated high mobility group box | 0.0281087 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0279951 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0277865 |
| TPM3 | tropomyosin 3 | 0.0275876 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0275258 |
| DST | dystonin | 0.027417 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.0273986 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0272392 |
| HOMER1 | homer scaffolding protein 1 | 0.0271826 |
| SIK3 | SIK family kinase 3 | 0.027071 |
| DENND4A | DENN/MADD domain containing 4A | 0.0268962 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0263096 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0263049 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0262922 |
| AHR | aryl hydrocarbon receptor | 0.0261769 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0257863 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0256228 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0254874 |
| GOLGB1 | golgin B1 | 0.0254797 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0253284 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0251715 |
| NANOS1 | nanos homolog 1 (Drosophila) | 0.0249222 |
| TUSC3 | tumor suppressor candidate 3 | 0.0246154 |
| HM13 | histocompatibility (minor) 13 | 0.024434 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0241528 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.110567 |
| TENM1 | teneurin transmembrane protein 1 | -0.103919 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0915708 |
| CENPF | centromere protein F, 350/400kDa | -0.087074 |
| PEG10 | paternally expressed 10 | -0.0803705 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.044653 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0412645 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0407373 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0396189 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0390172 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0330784 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0320884 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0315498 |
| MKI67 | marker of proliferation Ki-67 | -0.0311171 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0310235 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0307997 |
| CALCA | calcitonin-related polypeptide alpha | -0.0298501 |
| HMGB2 | high mobility group box 2 | -0.0287822 |
| ECT2 | epithelial cell transforming 2 | -0.0280854 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0280716 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -0.0270547 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0269792 |
| FOXC1 | forkhead box C1 | -0.026726 |
| TPD52 | tumor protein D52 | -0.0265394 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0265195 |
| TPX2 | TPX2, microtubule-associated | -0.026495 |
| KNL1 | kinetochore scaffold 1 | -0.0262807 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0262584 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0254783 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0254296 |
| SGO2 | shugoshin 2 | -0.0248166 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0247883 |
| PBK | PDZ binding kinase | -0.0247236 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0246245 |
| LIFR | leukemia inhibitory factor receptor alpha | -0.0244814 |
| XPO1 | exportin 1 | -0.0239286 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0234221 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.02321 |
| CADM1 | cell adhesion molecule 1 | -0.0231363 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0225492 |
| TTK | TTK protein kinase | -0.0217581 |
| HMGB1 | high mobility group box 1 | -0.0215871 |
| NFIA | nuclear factor I/A | -0.0213019 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0208904 |
| CDCA2 | cell division cycle associated 2 | -0.0205249 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0204129 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.020289 |
| TUBB | tubulin, beta class I | -0.0199718 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.019764 |
| H1-0 | H1.0 linker histone | -0.0196551 |
| WDR45B | WD repeat domain 45B | -0.019608 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.019455 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0193883 |
| FTL | ferritin, light polypeptide | -0.0193237 |
| KANTR | KDM5C adjacent non-coding transcript | -0.0190765 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0188987 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0187449 |
| FOXN3 | forkhead box N3 | -0.0185403 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.018457 |
| JAM3 | junctional adhesion molecule 3 | -0.01827 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0181856 |
| NCAM1 | neural cell adhesion molecule 1 | -0.017953 |
| RPS21 | ribosomal protein S21 | -0.0177749 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0177486 |
| STMN1 | stathmin 1 | -0.017459 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0174377 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.0174306 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0173798 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0171698 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0171649 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0170055 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0169592 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0168299 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0166158 |
| OGA | O-GlcNAcase | -0.0165479 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0165358 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0164244 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0163457 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.01633 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0163201 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0162126 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.0160141 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0160126 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0159786 |
| DIAPH3 | diaphanous-related formin 3 | -0.0159516 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0157972 |
| ZNF292 | zinc finger protein 292 | -0.0157458 |
| RIT2 | Ras-like without CAAX 2 | -0.0156238 |
| CENPE | centromere protein E, 312kDa | -0.0154566 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | -0.0154134 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0154077 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0153851 |
| UBB | ubiquitin B | -0.0152971 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0152497 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0151999 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0151992 |
| ANLN | anillin, actin binding protein | -0.0150832 |
| CA8 | carbonic anhydrase VIII | -0.015074 |
| S100A9 | S100 calcium binding protein A9 | -0.0149621 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0149349 |
