| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-901_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0939724 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0714127 |
| RASAL2 | RAS protein activator like 2 | 0.0661093 |
| HDAC9 | histone deacetylase 9 | 0.0641587 |
| NAV2 | neuron navigator 2 | 0.0639912 |
| CD44 | CD44 molecule (Indian blood group) | 0.0637902 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.059582 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0594653 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0567245 |
| SMAD3 | SMAD family member 3 | 0.0549882 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.053162 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0501073 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0469475 |
| RPS3 | ribosomal protein S3 | 0.046888 |
| RUNX1 | runt-related transcription factor 1 | 0.0423123 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0419632 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.041648 |
| MSN | moesin | 0.0407736 |
| B2M | beta-2-microglobulin | 0.0396411 |
| VMP1 | vacuole membrane protein 1 | 0.0377252 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0375848 |
| NOTCH2 | notch 2 | 0.0356348 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0350411 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0343593 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0327769 |
| RBM25 | RNA binding motif protein 25 | 0.032113 |
| RNF145 | ring finger protein 145 | 0.0316571 |
| MCL1 | myeloid cell leukemia 1 | 0.0312029 |
| FLNA | filamin A, alpha | 0.0307876 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.030741 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0306719 |
| SON | SON DNA binding protein | 0.0301405 |
| ANO6 | anoctamin 6 | 0.0300279 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0299926 |
| TPM3 | tropomyosin 3 | 0.0299233 |
| MT2A | metallothionein 2A | 0.0298252 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0297106 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0294688 |
| TUSC3 | tumor suppressor candidate 3 | 0.0294084 |
| GOLGB1 | golgin B1 | 0.0293244 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0290721 |
| DIAPH1 | diaphanous-related formin 1 | 0.0290391 |
| MATR3 | matrin 3 | 0.0285885 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0275616 |
| MED13L | mediator complex subunit 13-like | 0.0275353 |
| RPS6 | ribosomal protein S6 | 0.0275146 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0266971 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0265992 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0263077 |
| CLIC4 | chloride intracellular channel 4 | 0.0262979 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0262723 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0261813 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.026053 |
| VEGFA | vascular endothelial growth factor A | 0.0257271 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0255864 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0253233 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0251007 |
| IPO7 | importin 7 | 0.0249432 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.02456 |
| NDRG1 | N-myc downstream regulated 1 | 0.0244199 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0242586 |
| ANXA2 | annexin A2 | 0.0238647 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0238553 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0237889 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.023707 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0235673 |
| ANGPTL4 | angiopoietin-like 4 | 0.0235269 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0233656 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.022985 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0229811 |
| ANXA5 | annexin A5 | 0.0227323 |
| JMJD1C | jumonji domain containing 1C | 0.022511 |
| ATXN1 | ataxin 1 | 0.0225027 |
| OTUD7B | OTU deubiquitinase 7B | 0.0223623 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0223588 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0223231 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0222831 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0220314 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.021998 |
| OGA | O-GlcNAcase | 0.0218689 |
| ADAR | adenosine deaminase, RNA-specific | 0.0216138 |
| EZR | ezrin | 0.0215892 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0215384 |
| ASPH | aspartate beta-hydroxylase | 0.021418 |
| AFDN | afadin, adherens junction formation factor | 0.0212336 |
| RTN4 | reticulon 4 | 0.0211666 |
| OPHN1 | oligophrenin 1 | 0.021075 |
| RPL3 | ribosomal protein L3 | 0.0207258 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0207049 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0206315 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0204751 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.0203924 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.0203225 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0202574 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0202371 |
| CORO1C | coronin, actin binding protein, 1C | 0.0200224 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0199596 |
| TOB2 | transducer of ERBB2, 2 | 0.0199161 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0198222 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0198072 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.356478 |
| NLGN1 | neuroligin 1 | -0.25311 |
| LSAMP | limbic system-associated membrane protein | -0.212764 |
| VIM | vimentin | -0.16452 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.115776 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.112147 |
| NRG3 | neuregulin 3 | -0.100389 |
| FRMD4A | FERM domain containing 4A | -0.0902979 |
| RAD51B | RAD51 paralog B | -0.0832559 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0788189 |
| TNNC1 | troponin C type 1 (slow) | -0.0749542 |
| FHIT | fragile histidine triad | -0.0685621 |
| PGK1 | phosphoglycerate kinase 1 | -0.056766 |
| PRELID2 | PRELI domain containing 2 | -0.0485373 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.043504 |
| PTMA | prothymosin, alpha | -0.0419867 |
| DST | dystonin | -0.0403491 |
| VDAC1 | voltage-dependent anion channel 1 | -0.036579 |
| EXOC4 | exocyst complex component 4 | -0.0344555 |
| LDHA | lactate dehydrogenase A | -0.0339581 |
| FMN1 | formin 1 | -0.0338497 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0320891 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0320405 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0320126 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0306128 |
| SMYD3 | SET and MYND domain containing 3 | -0.0287148 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0285068 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0278667 |
| CFAP20DC | CFAP20 domain containing | -0.0276193 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0274558 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0274319 |
| MACROD2 | MACRO domain containing 2 | -0.0272411 |
| CADM1 | cell adhesion molecule 1 | -0.0268305 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0266893 |
| MSI2 | musashi RNA-binding protein 2 | -0.0264852 |
| WWOX | WW domain containing oxidoreductase | -0.0260792 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0251468 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0242764 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0239515 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.022835 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0224685 |
| ACTG1 | actin gamma 1 | -0.022075 |
| HLA-E | major histocompatibility complex, class I, E | -0.0216435 |
| EGR1 | early growth response 1 | -0.0213443 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0209209 |
| RPL38 | ribosomal protein L38 | -0.0206305 |
| NRXN3 | neurexin 3 | -0.0202261 |
| MITF | microphthalmia-associated transcription factor | -0.0201451 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0198353 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0197586 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0196118 |
| CTSD | cathepsin D | -0.0194638 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0190436 |
| KAZN | kazrin, periplakin interacting protein | -0.0186369 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0185309 |
| LDLRAD3 | low density lipoprotein receptor class A domain containing 3 | -0.0181745 |
| CNKSR3 | CNKSR family member 3 | -0.0181452 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0180541 |
| KIAA1549L | KIAA1549-like | -0.0179324 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0176949 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0176311 |
| DIAPH2 | diaphanous-related formin 2 | -0.0174224 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0174133 |
| PLAT | plasminogen activator, tissue | -0.017375 |
| EHBP1 | EH domain binding protein 1 | -0.0170859 |
| KLF10 | Kruppel-like factor 10 | -0.0168043 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0167734 |
| HMGA1 | high mobility group AT-hook 1 | -0.0165102 |
| DPP6 | dipeptidyl-peptidase 6 | -0.016471 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0164407 |
| RPS24 | ribosomal protein S24 | -0.0162742 |
| RPS21 | ribosomal protein S21 | -0.0162505 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0161985 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0158542 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.015802 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0156184 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0156183 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0156039 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0155731 |
| TPM4 | tropomyosin 4 | -0.015498 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.015391 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0152961 |
| HLA-B | major histocompatibility complex, class I, B | -0.0151898 |
| NBPF8 | neuroblastoma breakpoint family, member 8 | -0.0150027 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0146917 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0146145 |
| RPL27A | ribosomal protein L27a | -0.0145413 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0145264 |
| HLA-A | major histocompatibility complex, class I, A | -0.014438 |
| TMSB10 | thymosin beta 10 | -0.0144377 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0140478 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0140149 |
| SHTN1 | shootin 1 | -0.0134931 |
| NRN1 | neuritin 1 | -0.0134887 |
| ARF1 | ADP-ribosylation factor 1 | -0.0134753 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.0134037 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0133433 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0132177 |
| TUBB | tubulin, beta class I | -0.0129503 |
| STK4 | serine/threonine kinase 4 | -0.0129321 |
