TAK-901_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.226362
PDE4D phosphodiesterase 4D, cAMP-specific 0.211335
HDAC9 histone deacetylase 9 0.131379
RPS6 ribosomal protein S6 0.10717
FOXP1 forkhead box P1 0.0931236
CPED1 cadherin-like and PC-esterase domain containing 1 0.0929152
RPS8 ribosomal protein S8 0.0687053
AHNAK AHNAK nucleoprotein 0.068103
SOX6 SRY (sex determining region Y)-box 6 0.0677609
TPT1 tumor protein, translationally-controlled 1 0.0657396
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0642316
EGFR epidermal growth factor receptor 0.0620501
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0585707
PTMA prothymosin, alpha 0.0578852
GLI3 GLI family zinc finger 3 0.0537567
RPL31 ribosomal protein L31 0.053023
PKM pyruvate kinase, muscle 0.0524941
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0521114
NPAS2 neuronal PAS domain protein 2 0.0513177
RPL35A ribosomal protein L35a 0.0510967
PDGFC platelet derived growth factor C 0.0506139
ZNF608 zinc finger protein 608 0.0504145
ANXA1 annexin A1 0.0502911
EZR ezrin 0.0499272
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0478609
EEF2 eukaryotic translation elongation factor 2 0.0472221
RPL37A ribosomal protein L37a 0.046455
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0462816
ENO1 enolase 1, (alpha) 0.0445337
VCL vinculin 0.0437549
RPS3 ribosomal protein S3 0.0404463
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0401092
FER1L6 fer-1-like family member 6 0.0398799
ASCC3 activating signal cointegrator 1 complex subunit 3 0.039823
RPL9 ribosomal protein L9 0.0395133
SRRM2 serine/arginine repetitive matrix 2 0.0388692
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0374314
EXT1 exostosin glycosyltransferase 1 0.0371638
FAT1 FAT atypical cadherin 1 0.0367952
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0367515
LOC102724023 ES1 protein homolog, mitochondrial 0.0355669
GLI2 GLI family zinc finger 2 0.0355126
RPL26 ribosomal protein L26 0.0345413
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0343334
DSCAM Down syndrome cell adhesion molecule 0.0341968
RPS12 ribosomal protein S12 0.0341295
RPS13 ribosomal protein S13 0.0340521
VIM vimentin 0.0328417
TACC2 transforming, acidic coiled-coil containing protein 2 0.032056
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0319422
MYL12B myosin, light chain 12B, regulatory 0.0318756
ARL4C ADP-ribosylation factor-like 4C 0.0316752
CCND1 cyclin D1 0.0312679
NFE2L2 nuclear factor, erythroid 2-like 2 0.0311249
ARRDC3 arrestin domain containing 3 0.0309678
AEBP2 AE binding protein 2 0.0306614
RAB7A RAB7A, member RAS oncogene family 0.0303962
RPS25 ribosomal protein S25 0.0302777
TM4SF1 transmembrane 4 L six family member 1 0.030012
RPL19 ribosomal protein L19 0.0298323
BPTF bromodomain PHD finger transcription factor 0.0298171
RPL23 ribosomal protein L23 0.0292208
INTS6 integrator complex subunit 6 0.0289845
DUSP4 dual specificity phosphatase 4 0.0289326
SLC38A2 solute carrier family 38, member 2 0.0288377
PTPRG protein tyrosine phosphatase, receptor type, G 0.0288253
RPL11 ribosomal protein L11 0.0287259
BRD2 bromodomain containing 2 0.0282354
RPL37 ribosomal protein L37 0.0281718
TRIO trio Rho guanine nucleotide exchange factor 0.0280088
TJP1 tight junction protein 1 0.0279557
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0279272
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0278222
BMP10 bone morphogenetic protein 10 0.0277525
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0277492
ZMYND8 zinc finger, MYND-type containing 8 0.027673
EPS8 epidermal growth factor receptor pathway substrate 8 0.0272828
GPATCH8 G patch domain containing 8 0.0272725
RPL7A ribosomal protein L7a 0.0271291
ZFAND3 zinc finger, AN1-type domain 3 0.0270606
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0270178
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0269026
RPS23 ribosomal protein S23 0.0268332
TAS2R14 taste receptor, type 2, member 14 0.0268086
MLIP muscular LMNA-interacting protein 0.0266825
GSE1 Gse1 coiled-coil protein 0.0265723
SEPTIN9 septin 9 0.0262643
KLF10 Kruppel-like factor 10 0.0262428
MYO5C myosin VC 0.0262125
RPS17 ribosomal protein S17 0.0261338
RPS29 ribosomal protein S29 0.0260207
RPLP2 ribosomal protein, large, P2 0.0258838
CUX1 cut-like homeobox 1 0.0258652
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0256569
MYOF myoferlin 0.0254672
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0251658
SGMS2 sphingomyelin synthase 2 0.0250939
TMSB10 thymosin beta 10 0.024978
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0249687
RPS14 ribosomal protein S14 0.0247649

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0746729
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0615488
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0588271
S100A6 S100 calcium binding protein A6 -0.0372214
GARS1 glycyl-tRNA synthetase 1 -0.0353425
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.032317
NAMPT nicotinamide phosphoribosyltransferase -0.0306277
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0276405
KDM3A lysine (K)-specific demethylase 3A -0.027064
USP3 ubiquitin specific peptidase 3 -0.0255171
RNF145 ring finger protein 145 -0.0244791
GOLGA4 golgin A4 -0.0243044
TXNIP thioredoxin interacting protein -0.0229249
TMEM41B transmembrane protein 41B -0.0224824
NUP58 nucleoporin 58 -0.0213971
LMAN1 lectin, mannose-binding, 1 -0.0213595
NBAS neuroblastoma amplified sequence -0.0211729
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.019965
TFG TRK-fused gene -0.0196535
XPO1 exportin 1 -0.0193717
SEC23A Sec23 homolog A (S. cerevisiae) -0.0192722
RAB6A RAB6A, member RAS oncogene family -0.0191443
CDC73 cell division cycle 73 -0.0186194
LCORL ligand dependent nuclear receptor corepressor-like -0.0182818
COPA coatomer protein complex, subunit alpha -0.0178656
PHIP pleckstrin homology domain interacting protein -0.0178117
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0173447
EVI5 ecotropic viral integration site 5 -0.0172377
PDIA6 protein disulfide isomerase family A, member 6 -0.0170745
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0170162
FAM162A family with sequence similarity 162, member A -0.0169692
BRWD1 bromodomain and WD repeat domain containing 1 -0.0169205
TMEM39A transmembrane protein 39A -0.0164629
PTBP2 polypyrimidine tract binding protein 2 -0.0164443
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0163928
PRRC1 proline-rich coiled-coil 1 -0.0163643
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.016311
ADAM10 ADAM metallopeptidase domain 10 -0.0162121
COG6 component of oligomeric golgi complex 6 -0.0161561
ZMYM2 zinc finger, MYM-type 2 -0.016081
PREPL prolyl endopeptidase-like -0.0158904
TMEM123 transmembrane protein 123 -0.0158359
ANK2 ankyrin 2, neuronal -0.0158097
HDLBP high density lipoprotein binding protein -0.0156284
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0150863
WSB1 WD repeat and SOCS box containing 1 -0.0150756
SEC63 SEC63 homolog (S. cerevisiae) -0.0150639
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0150124
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0149102
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0148915
UFM1 ubiquitin-fold modifier 1 -0.0147694
DCAF6 DDB1 and CUL4 associated factor 6 -0.0146846
CCNI cyclin I -0.0145851
TMEM263 transmembrane protein 263 -0.0145041
CLINT1 clathrin interactor 1 -0.0140591
EPB41 erythrocyte membrane protein band 4.1 -0.0139963
SKIC3 SKI3 subunit of superkiller complex -0.0139616
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0139576
RAD21 RAD21 homolog (S. pombe) -0.0139555
PNISR PNN-interacting serine/arginine-rich protein -0.0138381
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0138368
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0135318
SEC24D SEC24 family member D -0.0134499
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0133302
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.013076
TMSB4X thymosin beta 4, X-linked -0.0129942
TPD52 tumor protein D52 -0.0128292
KIF13A kinesin family member 13A -0.0127838
NUP54 nucleoporin 54kDa -0.0127662
ELP2 elongator acetyltransferase complex subunit 2 -0.0127087
SESN2 sestrin 2 -0.0126543
NCKAP1 NCK-associated protein 1 -0.0126217
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0124172
HILPDA hypoxia inducible lipid droplet-associated -0.0124072
MORF4L2 mortality factor 4 like 2 -0.0123576
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0122437
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0120719
TEC tec protein tyrosine kinase -0.0120404
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0120282
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0118796
EMSY EMSY transcriptional repressor, BRCA2 interacting -0.0117081
SUCO SUN domain containing ossification factor -0.0116914
NEK7 NIMA-related kinase 7 -0.0116499
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0115424
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0113214
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0112905
DDIT4 DNA-damage-inducible transcript 4 -0.0112873
ACACA acetyl-CoA carboxylase alpha -0.0112618
CCNG1 cyclin G1 -0.0110511
ABHD12 abhydrolase domain containing 12 -0.0110303
HMGA1 high mobility group AT-hook 1 -0.0109082
PICALM phosphatidylinositol binding clathrin assembly protein -0.0108617
CSDE1 cold shock domain containing E1, RNA-binding -0.0108117
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0107916
GOLM2 golgi membrane protein 2 -0.0107002
GOLT1B golgi transport 1B -0.010691
DYM dymeclin -0.0106815
PSAT1 phosphoserine aminotransferase 1 -0.0105699
RCOR3 REST corepressor 3 -0.0105651
TTK TTK protein kinase -0.0105195