TAK-901_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.140196
MYH9 myosin, heavy chain 9, non-muscle 0.102666
RPS6 ribosomal protein S6 0.0879451
TRIO trio Rho guanine nucleotide exchange factor 0.0873967
EEF2 eukaryotic translation elongation factor 2 0.0849652
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0801067
RPS3 ribosomal protein S3 0.0774883
HDAC9 histone deacetylase 9 0.0740845
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0734392
RPS12 ribosomal protein S12 0.0687376
VEGFA vascular endothelial growth factor A 0.0668027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0666758
B2M beta-2-microglobulin 0.0616267
MT2A metallothionein 2A 0.0609964
RPL37A ribosomal protein L37a 0.0605776
NAV2 neuron navigator 2 0.0578157
NAP1L1 nucleosome assembly protein 1-like 1 0.0565872
IER3 immediate early response 3 0.0543554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0513605
TPT1 tumor protein, translationally-controlled 1 0.0508929
RPL26 ribosomal protein L26 0.0499832
ANXA2 annexin A2 0.0492704
SQSTM1 sequestosome 1 0.0487189
SOD2 superoxide dismutase 2, mitochondrial 0.048703
INTS6 integrator complex subunit 6 0.0463181
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0459753
RPL11 ribosomal protein L11 0.0454368
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0450744
ZSWIM6 zinc finger, SWIM-type containing 6 0.0442722
GOLGB1 golgin B1 0.0433282
ENO1 enolase 1, (alpha) 0.042998
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0425385
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0423566
RPLP2 ribosomal protein, large, P2 0.0408559
FNIP1 folliculin interacting protein 1 0.0407015
ZMIZ1 zinc finger, MIZ-type containing 1 0.0406071
RPS23 ribosomal protein S23 0.0390675
RACK1 receptor for activated C kinase 1 0.0378485
DUSP10 dual specificity phosphatase 10 0.0377578
RPS8 ribosomal protein S8 0.0364563
YBX1 Y box binding protein 1 0.0357622
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351702
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0345372
RPS4X ribosomal protein S4, X-linked 0.03417
MYOF myoferlin 0.0341468
RPS17 ribosomal protein S17 0.0338034
SRRM2 serine/arginine repetitive matrix 2 0.0337291
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0336465
RPL7 ribosomal protein L7 0.0334596
LDHA lactate dehydrogenase A 0.0326293
RPL23 ribosomal protein L23 0.0318653
RAB7A RAB7A, member RAS oncogene family 0.031377
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0312299
ADM adrenomedullin 0.0302816
RPL12 ribosomal protein L12 0.0302366
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0300882
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0299758
FLNA filamin A, alpha 0.0298305
SPAG9 sperm associated antigen 9 0.0297699
RHOBTB3 Rho-related BTB domain containing 3 0.0294654
GOLGA4 golgin A4 0.0292503
AHNAK AHNAK nucleoprotein 0.0287672
RPL9 ribosomal protein L9 0.0279595
RPS10 ribosomal protein S10 0.0274429
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0272361
APLP2 amyloid beta (A4) precursor-like protein 2 0.0264697
RPL7A ribosomal protein L7a 0.0262551
AKAP9 A kinase (PRKA) anchor protein 9 0.0257459
RPL19 ribosomal protein L19 0.0253149
BRD2 bromodomain containing 2 0.0246751
MBNL1 muscleblind-like splicing regulator 1 0.0244045
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0243881
ASPH aspartate beta-hydroxylase 0.024103
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0238958
PHF3 PHD finger protein 3 0.0236133
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0231844
MORF4L2 mortality factor 4 like 2 0.0229662
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.022609
RB1CC1 RB1-inducible coiled-coil 1 0.0224084
RPL36 ribosomal protein L36 0.0224008
KDM3A lysine (K)-specific demethylase 3A 0.022324
RPS27A ribosomal protein S27a 0.0222774
DSTN destrin (actin depolymerizing factor) 0.0217592
RPS25 ribosomal protein S25 0.0217044
PRRC2C proline-rich coiled-coil 2C 0.0215417
HSPA8 heat shock 70kDa protein 8 0.0212357
RPS19 ribosomal protein S19 0.0211773
DSCAM Down syndrome cell adhesion molecule 0.0210846
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0209727
RPS24 ribosomal protein S24 0.0209256
APP amyloid beta (A4) precursor protein 0.0209216
PRELID2 PRELI domain containing 2 0.0208603
TRA2A transformer 2 alpha homolog (Drosophila) 0.020632
RPL37 ribosomal protein L37 0.0206071
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0204384
RPS2 ribosomal protein S2 0.0203542
ATXN1 ataxin 1 0.0203198
ANKHD1 ankyrin repeat and KH domain containing 1 0.0202642
OPTN optineurin 0.0202601
ZBTB38 zinc finger and BTB domain containing 38 0.0201894

decreased expression

Symbol Name Standardized Value
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.103786
NAMPT nicotinamide phosphoribosyltransferase -0.0988286
IGFBP3 insulin-like growth factor binding protein 3 -0.094328
GLIS3 GLIS family zinc finger 3 -0.0780629
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0684735
ZMYND8 zinc finger, MYND-type containing 8 -0.0681685
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0530324
EGR1 early growth response 1 -0.0513062
FRMD4A FERM domain containing 4A -0.0465867
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0448055
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0419854
VIM vimentin -0.038562
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0374606
TPM4 tropomyosin 4 -0.0366895
CTSD cathepsin D -0.0366587
HLA-E major histocompatibility complex, class I, E -0.0340506
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0333814
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0324469
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0314711
RAI14 retinoic acid induced 14 -0.0312096
C3 complement component 3 -0.0291229
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0284678
CLMP CXADR-like membrane protein -0.028275
AKAP12 A kinase (PRKA) anchor protein 12 -0.0281936
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0273597
BASP1 brain abundant, membrane attached signal protein 1 -0.0272841
COL6A3 collagen, type VI, alpha 3 -0.0270232
COL1A2 collagen, type I, alpha 2 -0.0263669
VCAN versican -0.0261642
FOSL1 FOS-like antigen 1 -0.025767
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0257486
ATP13A3 ATPase type 13A3 -0.0238542
FN1 fibronectin 1 -0.0234473
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0233025
PGK1 phosphoglycerate kinase 1 -0.0228814
LOX lysyl oxidase -0.0228715
RTN4 reticulon 4 -0.0224345
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0221548
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0215852
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0215167
SLC38A1 solute carrier family 38, member 1 -0.020804
SFRP1 secreted frizzled-related protein 1 -0.0200164
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0198869
KPNB1 karyopherin (importin) beta 1 -0.0198255
HLA-A major histocompatibility complex, class I, A -0.0196284
ELL2 elongation factor, RNA polymerase II, 2 -0.0189222
ADAM12 ADAM metallopeptidase domain 12 -0.0186544
NRN1 neuritin 1 -0.0185343
SOX5 SRY (sex determining region Y)-box 5 -0.0184293
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0183632
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0183113
TAPBP TAP binding protein (tapasin) -0.0182574
NRP1 neuropilin 1 -0.0182344
ICAM1 intercellular adhesion molecule 1 -0.0182049
SLC35F3 solute carrier family 35, member F3 -0.0177652
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0177648
PRR16 proline rich 16 -0.0177477
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0177088
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0176842
GNAS GNAS complex locus -0.0175882
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0174398
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0172116
HLA-B major histocompatibility complex, class I, B -0.0168044
LRRC7 leucine rich repeat containing 7 -0.0166305
ZFAND3 zinc finger, AN1-type domain 3 -0.0165762
TMEM41B transmembrane protein 41B -0.0164455
KRT19 keratin 19, type I -0.0164362
MAML2 mastermind-like 2 (Drosophila) -0.016403
CNTN6 contactin 6 -0.0162651
PHF21A PHD finger protein 21A -0.0162141
GSK3B glycogen synthase kinase 3 beta -0.0158999
SAMD3 sterile alpha motif domain containing 3 -0.0158109
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0157738
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0155589
UGCG UDP-glucose ceramide glucosyltransferase -0.0153362
MT1X metallothionein 1X -0.0151646
CPPED1 calcineurin-like phosphoesterase domain containing 1 -0.0151136
EFNA5 ephrin-A5 -0.0148952
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0148487
TMSB10 thymosin beta 10 -0.0148093
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0147857
ZBTB2 zinc finger and BTB domain containing 2 -0.0147349
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0146969
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.0146485
RNF24 ring finger protein 24 -0.0146421
OSMR oncostatin M receptor -0.0146347
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0145933
DLG1 discs, large homolog 1 (Drosophila) -0.0144837
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0144833
S100A6 S100 calcium binding protein A6 -0.0144529
IFI6 interferon, alpha-inducible protein 6 -0.0143373
ARL4C ADP-ribosylation factor-like 4C -0.0139203
ETV6 ets variant 6 -0.0138293
DIAPH2 diaphanous-related formin 2 -0.0138156
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0136214
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.013524
RIGI RNA sensor RIG-I -0.0135222
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0134148
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0133474
THBS1 thrombospondin 1 -0.0132491