TAK-901_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in SW1417 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the TAK-901_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.201482
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.138778
FTL ferritin, light polypeptide 0.136487
RPS6 ribosomal protein S6 0.132992
PABPC1 poly(A) binding protein, cytoplasmic 1 0.132721
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.111435
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110662
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.098379
RPS3 ribosomal protein S3 0.0915749
EPS8 epidermal growth factor receptor pathway substrate 8 0.0838242
RPL37A ribosomal protein L37a 0.0758395
TMSB10 thymosin beta 10 0.075839
RPS12 ribosomal protein S12 0.0741592
RPLP2 ribosomal protein, large, P2 0.0736138
VMP1 vacuole membrane protein 1 0.071943
B2M beta-2-microglobulin 0.0704892
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0700528
RPS19 ribosomal protein S19 0.0691972
GOLGA4 golgin A4 0.0674478
RPL12 ribosomal protein L12 0.06347
RPL28 ribosomal protein L28 0.0631195
RPL18 ribosomal protein L18 0.061888
CST3 cystatin C 0.0608073
APLP2 amyloid beta (A4) precursor-like protein 2 0.0583515
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0577317
RPL19 ribosomal protein L19 0.0575778
RPS17 ribosomal protein S17 0.0547993
EEF2 eukaryotic translation elongation factor 2 0.0532902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0529039
SRRM2 serine/arginine repetitive matrix 2 0.0525717
RPL32 ribosomal protein L32 0.0518157
RPL36 ribosomal protein L36 0.0501414
RPS13 ribosomal protein S13 0.0499286
RPS5 ribosomal protein S5 0.0496889
RPL35A ribosomal protein L35a 0.0490527
NEBL nebulette 0.0478045
RPS11 ribosomal protein S11 0.0476145
RPL31 ribosomal protein L31 0.046655
PRRC2C proline-rich coiled-coil 2C 0.0452716
RPS25 ribosomal protein S25 0.0451535
BRD2 bromodomain containing 2 0.0447864
RPL8 ribosomal protein L8 0.0446436
RPL23 ribosomal protein L23 0.044592
EIF1 eukaryotic translation initiation factor 1 0.0441607
RPS29 ribosomal protein S29 0.0436275
ARHGAP26 Rho GTPase activating protein 26 0.0420392
TJP1 tight junction protein 1 0.0418423
RPL26 ribosomal protein L26 0.040885
POTEF POTE ankyrin domain family, member F 0.0407817
EIF5B eukaryotic translation initiation factor 5B 0.0404427
DIAPH1 diaphanous-related formin 1 0.0399833
MYO1E myosin IE 0.0397817
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0397567
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0394889
GSTP1 glutathione S-transferase pi 1 0.0393081
RPS14 ribosomal protein S14 0.0390959
RPS15 ribosomal protein S15 0.038876
SETD5 SET domain containing 5 0.0384732
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0383341
AKAP9 A kinase (PRKA) anchor protein 9 0.0380479
UBE2H ubiquitin-conjugating enzyme E2H 0.0378155
FXR1 fragile X mental retardation, autosomal homolog 1 0.0377993
RACK1 receptor for activated C kinase 1 0.0373514
RPS21 ribosomal protein S21 0.0371897
AKAP13 A kinase (PRKA) anchor protein 13 0.0371623
RPL7A ribosomal protein L7a 0.036958
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0367339
YBX1 Y box binding protein 1 0.0365652
RPS8 ribosomal protein S8 0.0364224
GLS2 glutaminase 2 (liver, mitochondrial) 0.0360311
RPL11 ribosomal protein L11 0.0360081
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0356996
KMT2C lysine (K)-specific methyltransferase 2C 0.0349742
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0348821
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347196
KTN1 kinectin 1 (kinesin receptor) 0.0346445
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0340013
GOLGB1 golgin B1 0.0338203
ATP5F1E ATP synthase F1 subunit epsilon 0.0336913
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0333468
ANKHD1 ankyrin repeat and KH domain containing 1 0.0332006
VEGFA vascular endothelial growth factor A 0.0329375
SIK3 SIK family kinase 3 0.0328048
MACF1 microtubule-actin crosslinking factor 1 0.0326489
RPS23 ribosomal protein S23 0.0325614
SET SET nuclear proto-oncogene 0.0325452
KRT18 keratin 18, type I 0.0323837
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0323248
SON SON DNA binding protein 0.0317716
PNN pinin, desmosome associated protein 0.0316765
ARHGAP42 Rho GTPase activating protein 42 0.0310304
RPL9 ribosomal protein L9 0.0308318
MATR3 matrin 3 0.0307875
YAP1 Yes-associated protein 1 0.0304223
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0301656
ANXA2 annexin A2 0.0301228
TRA2A transformer 2 alpha homolog (Drosophila) 0.0300121
RPS4X ribosomal protein S4, X-linked 0.0298542
TRIM2 tripartite motif containing 2 0.0297751
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.029735

decreased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) -0.0860377
KLF10 Kruppel-like factor 10 -0.075561
ZMYND8 zinc finger, MYND-type containing 8 -0.0636413
ARRDC3 arrestin domain containing 3 -0.0540197
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0468578
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.042075
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0418163
TMCC1 transmembrane and coiled-coil domain family 1 -0.0414316
TMEM123 transmembrane protein 123 -0.0394275
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0372448
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0347373
NKD1 naked cuticle homolog 1 (Drosophila) -0.0341849
LOC102724023 ES1 protein homolog, mitochondrial -0.034144
EHBP1 EH domain binding protein 1 -0.0327413
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0312664
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0283349
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0271942
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0268888
KDM7A lysine (K)-specific demethylase 7A -0.0268033
PGK1 phosphoglycerate kinase 1 -0.0265135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0261391
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0260059
IER3 immediate early response 3 -0.0259545
SDC4 syndecan 4 -0.0256345
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.025144
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0248273
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0241473
ZBTB20 zinc finger and BTB domain containing 20 -0.0240289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0236538
SDK1 sidekick cell adhesion molecule 1 -0.0231006
MX2 MX dynamin-like GTPase 2 -0.0226334
SMAD7 SMAD family member 7 -0.0226105
NDRG1 N-myc downstream regulated 1 -0.0223677
AXIN2 axin 2 -0.0220537
MYL12B myosin, light chain 12B, regulatory -0.0219804
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0218124
AHNAK AHNAK nucleoprotein -0.0214306
LARS1 leucyl-tRNA synthetase 1 -0.020859
STAU1 staufen double-stranded RNA binding protein 1 -0.0204276
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0203517
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0200686
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0194304
HLA-E major histocompatibility complex, class I, E -0.0191767
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0190607
KDM3A lysine (K)-specific demethylase 3A -0.0185583
TRIM56 tripartite motif containing 56 -0.0182406
BCL2L1 BCL2-like 1 -0.018234
ARL4C ADP-ribosylation factor-like 4C -0.0181261
CCND1 cyclin D1 -0.0177961
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0177678
EDN1 endothelin 1 -0.0174708
PLSCR1 phospholipid scramblase 1 -0.0173482
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0171055
FOSL1 FOS-like antigen 1 -0.016812
KLK10 kallikrein-related peptidase 10 -0.0166897
CTSD cathepsin D -0.0166502
RIGI RNA sensor RIG-I -0.0164285
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0163225
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0162683
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0157129
CD2AP CD2-associated protein -0.0156948
GTF2IRD1 GTF2I repeat domain containing 1 -0.0155374
ARHGAP35 Rho GTPase activating protein 35 -0.0152636
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0152105
NR1D1 nuclear receptor subfamily 1, group D, member 1 -0.0151365
PLAUR plasminogen activator, urokinase receptor -0.0150662
TRIB1 tribbles pseudokinase 1 -0.0147834
ITGB4 integrin, beta 4 -0.0146615
GCC2 GRIP and coiled-coil domain containing 2 -0.0145832
KPNB1 karyopherin (importin) beta 1 -0.0145309
ITPKC inositol-trisphosphate 3-kinase C -0.0145134
SOX9 SRY (sex determining region Y)-box 9 -0.0145101
TMEM41B transmembrane protein 41B -0.0144404
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0144332
NFIA nuclear factor I/A -0.014163
ARF1 ADP-ribosylation factor 1 -0.0139359
IRF3 interferon regulatory factor 3 -0.0139101
DLG1 discs, large homolog 1 (Drosophila) -0.0138765
OSER1 oxidative stress responsive serine-rich 1 -0.0137498
ZNF33A zinc finger protein 33A -0.0135778
ZBTB46 zinc finger and BTB domain containing 46 -0.0135372
S100A6 S100 calcium binding protein A6 -0.0134556
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -0.013282
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.0132001
EXOC4 exocyst complex component 4 -0.0131373
NUAK2 NUAK family, SNF1-like kinase, 2 -0.01308
MIDEAS mitotic deacetylase associated SANT domain protein -0.0130265
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0129763
SLC38A1 solute carrier family 38, member 1 -0.0129177
RPL6 ribosomal protein L6 -0.0128558
BHLHE40 basic helix-loop-helix family, member e40 -0.012845
PATJ PATJ crumbs cell polarity complex component -0.0128356
TPM4 tropomyosin 4 -0.0128315
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0128315
ZNF217 zinc finger protein 217 -0.0128177
APCDD1 adenomatosis polyposis coli down-regulated 1 -0.0127763
UBE2I ubiquitin-conjugating enzyme E2I -0.0127029
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0126711
NRIP1 nuclear receptor interacting protein 1 -0.0123718
THSD4 thrombospondin, type I, domain containing 4 -0.0123207