| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-901_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.161295 |
| IER3 | immediate early response 3 | 0.137961 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.135036 |
| GPHN | gephyrin | 0.122062 |
| RPS6 | ribosomal protein S6 | 0.109772 |
| RPS3 | ribosomal protein S3 | 0.0854839 |
| WDR43 | WD repeat domain 43 | 0.0837166 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0806464 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0771003 |
| RPL26 | ribosomal protein L26 | 0.0755783 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.073879 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0736315 |
| RBM25 | RNA binding motif protein 25 | 0.0683554 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0677118 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0645607 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0637774 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | 0.0632468 |
| RPS12 | ribosomal protein S12 | 0.062554 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0622709 |
| GOLGA4 | golgin A4 | 0.0617169 |
| MED13L | mediator complex subunit 13-like | 0.0611503 |
| RPS19 | ribosomal protein S19 | 0.0601054 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0577989 |
| RPS17 | ribosomal protein S17 | 0.0565346 |
| RBM39 | RNA binding motif protein 39 | 0.0542462 |
| NOP58 | NOP58 ribonucleoprotein | 0.0540384 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0529185 |
| TXNIP | thioredoxin interacting protein | 0.0527768 |
| RLF | rearranged L-myc fusion | 0.0504174 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.049839 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.049379 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0491154 |
| ZNF292 | zinc finger protein 292 | 0.0480246 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0467371 |
| RPL37A | ribosomal protein L37a | 0.0466387 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0463071 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0458985 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0456211 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0449073 |
| RHEB | Ras homolog enriched in brain | 0.0445904 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.04442 |
| AREG | amphiregulin | 0.044178 |
| RPL36 | ribosomal protein L36 | 0.0428947 |
| CCNL1 | cyclin L1 | 0.0427681 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0427139 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0424839 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0423589 |
| RPL5 | ribosomal protein L5 | 0.0413522 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0410751 |
| RPLP2 | ribosomal protein, large, P2 | 0.0409551 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0406135 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0404132 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0398992 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0397703 |
| YBX1 | Y box binding protein 1 | 0.0395174 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0392994 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.03902 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0388947 |
| RPS29 | ribosomal protein S29 | 0.0388705 |
| RAB7A | RAB7A, member RAS oncogene family | 0.038428 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0381917 |
| RPL11 | ribosomal protein L11 | 0.038158 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0377463 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0375042 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0372607 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0372483 |
| MATR3 | matrin 3 | 0.0371939 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0365847 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0353422 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0349791 |
| FOXJ3 | forkhead box J3 | 0.0348077 |
| FAT1 | FAT atypical cadherin 1 | 0.0347011 |
| CEP85L | centrosomal protein 85kDa-like | 0.0345759 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0342545 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0339661 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0337203 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0337033 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0337014 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0334824 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0332965 |
| BRD2 | bromodomain containing 2 | 0.0332021 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0331722 |
| RPS18 | ribosomal protein S18 | 0.0331183 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0327137 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0323687 |
| RPS2 | ribosomal protein S2 | 0.0320655 |
| JMJD1C | jumonji domain containing 1C | 0.031438 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0313301 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0312508 |
| YTHDC1 | YTH domain containing 1 | 0.0312377 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0309824 |
| USP47 | ubiquitin specific peptidase 47 | 0.0309512 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.030878 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0304365 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0303868 |
| CUL3 | cullin 3 | 0.0303425 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0303092 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0303089 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0303006 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0302264 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.246055 |
| HMGA2 | high mobility group AT-hook 2 | -0.086726 |
| PTMA | prothymosin, alpha | -0.0860578 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.078407 |
| FERMT1 | fermitin family member 1 | -0.0651038 |
| LAMB3 | laminin, beta 3 | -0.0646318 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0573801 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0493107 |
| RAD51B | RAD51 paralog B | -0.0491237 |
| LAMA4 | laminin, alpha 4 | -0.0487343 |
| RCOR1 | REST corepressor 1 | -0.0479883 |
| FLOT1 | flotillin 1 | -0.0453007 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0422601 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0414341 |
| VCL | vinculin | -0.0413982 |
| ACTG1 | actin gamma 1 | -0.0392297 |
| CD9 | CD9 molecule | -0.0387991 |
| FHIT | fragile histidine triad | -0.0382807 |
| EGR1 | early growth response 1 | -0.0376359 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0372559 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0370526 |
| EGFR | epidermal growth factor receptor | -0.0363223 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0346109 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0341073 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0310556 |
| CLTC | clathrin, heavy chain (Hc) | -0.0298889 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0284341 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0282589 |
| SERINC5 | serine incorporator 5 | -0.0279629 |
| EHBP1 | EH domain binding protein 1 | -0.0272632 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0270129 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0269596 |
| MTAP | methylthioadenosine phosphorylase | -0.0267728 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0250625 |
| DSPP | dentin sialophosphoprotein | -0.024887 |
| LDHA | lactate dehydrogenase A | -0.023301 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0227377 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0226927 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0223991 |
| GPC5 | glypican 5 | -0.0219223 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0216091 |
| EMP1 | epithelial membrane protein 1 | -0.0205704 |
| DSG2 | desmoglein 2 | -0.02021 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0199221 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0196469 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0195724 |
| CUX1 | cut-like homeobox 1 | -0.0195413 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0193253 |
| TPM4 | tropomyosin 4 | -0.0187053 |
| XYLT1 | xylosyltransferase I | -0.0186825 |
| NDRG1 | N-myc downstream regulated 1 | -0.0185971 |
| DEK | DEK proto-oncogene | -0.0184428 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0182118 |
| CANX | calnexin | -0.0178281 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0177938 |
| TUBB | tubulin, beta class I | -0.0177677 |
| KLF10 | Kruppel-like factor 10 | -0.0177339 |
| PERP | PERP, TP53 apoptosis effector | -0.0177098 |
| LAMC2 | laminin, gamma 2 | -0.0176446 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.017609 |
| EXOC4 | exocyst complex component 4 | -0.0175531 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0174145 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0171719 |
| PGK1 | phosphoglycerate kinase 1 | -0.0170785 |
| PRELID2 | PRELI domain containing 2 | -0.0167342 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0165944 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0164463 |
| ANLN | anillin, actin binding protein | -0.0164318 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0162766 |
| BMP4 | bone morphogenetic protein 4 | -0.0162362 |
| KLK10 | kallikrein-related peptidase 10 | -0.0159855 |
| FHL2 | four and a half LIM domains 2 | -0.0156092 |
| TMEM123 | transmembrane protein 123 | -0.015551 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.0154954 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0154271 |
| ABR | active BCR-related | -0.0153218 |
| DENND1A | DENN/MADD domain containing 1A | -0.0151148 |
| LEMD1 | LEM domain containing 1 | -0.0150129 |
| ITGB4 | integrin, beta 4 | -0.0149973 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0149373 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.0147949 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0147934 |
| SNX14 | sorting nexin 14 | -0.0145195 |
| HDAC2 | histone deacetylase 2 | -0.0142404 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | -0.0142391 |
| HMGB1 | high mobility group box 1 | -0.0141481 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0137839 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0136503 |
| KLF6 | Kruppel-like factor 6 | -0.0135734 |
| CTSB | cathepsin B | -0.0134994 |
| HDAC4 | histone deacetylase 4 | -0.0134236 |
| KRT19 | keratin 19, type I | -0.0133885 |
| EFNB2 | ephrin-B2 | -0.0133237 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | -0.0133221 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0132901 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0132057 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.013202 |
| AOPEP | aminopeptidase O (putative) | -0.0131332 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0128901 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0128747 |
