TAK-901_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.206177
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.147379
B2M beta-2-microglobulin 0.147244
VIM vimentin 0.132574
HLA-B major histocompatibility complex, class I, B 0.130911
CD44 CD44 molecule (Indian blood group) 0.109653
MT2A metallothionein 2A 0.108466
MYO10 myosin X 0.107094
RPS6 ribosomal protein S6 0.103737
NALF1 NALCN channel auxiliary factor 1 0.0929936
TPT1 tumor protein, translationally-controlled 1 0.0872937
MYH9 myosin, heavy chain 9, non-muscle 0.0809044
TMSB10 thymosin beta 10 0.0800915
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0788105
ASPH aspartate beta-hydroxylase 0.0777759
CXCL8 chemokine (C-X-C motif) ligand 8 0.0755672
FTH1 ferritin, heavy polypeptide 1 0.075374
AKAP12 A kinase (PRKA) anchor protein 12 0.0732845
TRIO trio Rho guanine nucleotide exchange factor 0.0717645
ZSWIM6 zinc finger, SWIM-type containing 6 0.0700822
RPL37A ribosomal protein L37a 0.0697792
TIMP1 TIMP metallopeptidase inhibitor 1 0.0695817
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0683495
INHBA inhibin, beta A 0.0672844
TGFBI transforming growth factor, beta-induced, 68kDa 0.0670405
JARID2 jumonji, AT rich interactive domain 2 0.0659573
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0657496
NAV1 neuron navigator 1 0.064636
FNDC3B fibronectin type III domain containing 3B 0.0604488
COL6A1 collagen, type VI, alpha 1 0.059621
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0588039
VEGFA vascular endothelial growth factor A 0.0557209
RPS12 ribosomal protein S12 0.0551158
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0537266
TIMP2 TIMP metallopeptidase inhibitor 2 0.0533033
RPS8 ribosomal protein S8 0.0527771
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0511846
GLIS3 GLIS family zinc finger 3 0.0502256
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0501176
FTL ferritin, light polypeptide 0.0492881
FMNL2 formin-like 2 0.0482831
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0481137
STC1 stanniocalcin 1 0.0479365
INTS6 integrator complex subunit 6 0.047636
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0476268
COL6A2 collagen, type VI, alpha 2 0.0468602
RPL23 ribosomal protein L23 0.0462135
RPS3 ribosomal protein S3 0.0441303
EEF2 eukaryotic translation elongation factor 2 0.0433634
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0423787
LIMS1 LIM and senescent cell antigen-like domains 1 0.0421684
VCL vinculin 0.0420152
RPS19 ribosomal protein S19 0.0417833
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0415942
RPL31 ribosomal protein L31 0.0414688
ENO1 enolase 1, (alpha) 0.0412248
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0410034
RPL9 ribosomal protein L9 0.0404953
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0404641
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0402158
PTK2 protein tyrosine kinase 2 0.0401523
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0397431
RPS17 ribosomal protein S17 0.0396755
PRRC2C proline-rich coiled-coil 2C 0.0395822
PRELID2 PRELI domain containing 2 0.0395265
ANKRD12 ankyrin repeat domain 12 0.0392935
RPL35A ribosomal protein L35a 0.0392798
NAP1L1 nucleosome assembly protein 1-like 1 0.0383997
EIF1 eukaryotic translation initiation factor 1 0.0380862
PRKG1 protein kinase, cGMP-dependent, type I 0.038079
RPLP1 ribosomal protein, large, P1 0.0379864
SRRM2 serine/arginine repetitive matrix 2 0.0379837
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0379562
RACK1 receptor for activated C kinase 1 0.0378654
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0377056
RUNX1 runt-related transcription factor 1 0.0374551
RPL11 ribosomal protein L11 0.035999
IER3 immediate early response 3 0.0352955
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0349671
CALD1 caldesmon 1 0.0348061
KTN1 kinectin 1 (kinesin receptor) 0.0347381
LTBP1 latent transforming growth factor beta binding protein 1 0.0344694
HIPK2 homeodomain interacting protein kinase 2 0.0342508
EGFR epidermal growth factor receptor 0.0342061
RPL19 ribosomal protein L19 0.0336245
CALR calreticulin 0.0332909
NOTCH2 notch 2 0.033186
ACTG1 actin gamma 1 0.0330167
RPL26 ribosomal protein L26 0.0327454
RPL5 ribosomal protein L5 0.0325934
PKM pyruvate kinase, muscle 0.0325816
ZNF638 zinc finger protein 638 0.032403
POTEF POTE ankyrin domain family, member F 0.0319178
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0319088
HMGA2 high mobility group AT-hook 2 0.0312016
RPL28 ribosomal protein L28 0.0303197
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0299617
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0299579
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296083
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.02957

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.129463
MMP1 matrix metallopeptidase 1 -0.127332
COL6A3 collagen, type VI, alpha 3 -0.0653181
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0642792
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0607242
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0485348
COL1A1 collagen, type I, alpha 1 -0.0398033
LOX lysyl oxidase -0.0392938
ATP13A3 ATPase type 13A3 -0.037179
ARHGAP21 Rho GTPase activating protein 21 -0.0359522
PDE4D phosphodiesterase 4D, cAMP-specific -0.0354802
COL4A2 collagen, type IV, alpha 2 -0.0300505
COL1A2 collagen, type I, alpha 2 -0.0278858
H1-0 H1.0 linker histone -0.0245563
HHIP hedgehog interacting protein -0.0233019
ZEB1 zinc finger E-box binding homeobox 1 -0.0231229
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0210855
CAVIN1 caveolae associated protein 1 -0.0209622
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0202483
S100A6 S100 calcium binding protein A6 -0.0202351
LMAN1 lectin, mannose-binding, 1 -0.0169167
NGLY1 N-glycanase 1 -0.0165549
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0163895
VEPH1 ventricular zone expressed PH domain-containing 1 -0.015789
FBN1 fibrillin 1 -0.0155911
CAV1 caveolin 1, caveolae protein, 22kDa -0.0155292
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0154711
BIRC6 baculoviral IAP repeat containing 6 -0.0150128
IL1RAP interleukin 1 receptor accessory protein -0.0143278
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0142091
ARHGAP35 Rho GTPase activating protein 35 -0.0142001
TMEM263 transmembrane protein 263 -0.0140725
AFF3 AF4/FMR2 family, member 3 -0.0140709
SNAI2 snail family zinc finger 2 -0.0137213
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0136648
SASH1 SAM and SH3 domain containing 1 -0.0135363
LCORL ligand dependent nuclear receptor corepressor-like -0.0131674
HAS2 hyaluronan synthase 2 -0.0130604
CHSY3 chondroitin sulfate synthase 3 -0.0127804
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -0.0125571
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0123394
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0121535
USP3 ubiquitin specific peptidase 3 -0.0113675
RAD21 RAD21 homolog (S. pombe) -0.0113441
CLINT1 clathrin interactor 1 -0.0112574
APOLD1 apolipoprotein L domain containing 1 -0.0112172
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -0.011125
MSI2 musashi RNA-binding protein 2 -0.0110502
GREM1 gremlin 1, DAN family BMP antagonist -0.0109707
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0109624
E2F7 E2F transcription factor 7 -0.0108938
PRR11 proline rich 11 -0.0108679
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0107296
PRSS23 protease, serine, 23 -0.0106065
SERINC3 serine incorporator 3 -0.010403
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0103864
CCND1 cyclin D1 -0.0103051
ZNF804A zinc finger protein 804A -0.0102604
GOLT1B golgi transport 1B -0.0102504
AFAP1 actin filament associated protein 1 -0.0101394
CDK17 cyclin-dependent kinase 17 -0.0100156
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.00997226
DLC1 DLC1 Rho GTPase activating protein -0.00979562
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.00978917
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.00978439
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.00976504
INTS10 integrator complex subunit 10 -0.00970835
AK5 adenylate kinase 5 -0.00950656
GDF15 growth differentiation factor 15 -0.0093193
MON2 MON2 homolog (S. cerevisiae) -0.00928613
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.00923115
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.00914048
COL12A1 collagen, type XII, alpha 1 -0.00901414
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.00900853
SORBS2 sorbin and SH3 domain containing 2 -0.00894833
SCFD2 sec1 family domain containing 2 -0.00893245
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.00884849
FBN2 fibrillin 2 -0.00883067
ANLN anillin, actin binding protein -0.00882792
TMEM200A transmembrane protein 200A -0.00857334
NPEPPS aminopeptidase puromycin sensitive -0.00851355
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -0.00847792
BBS9 Bardet-Biedl syndrome 9 -0.00847675
ANKRD28 ankyrin repeat domain 28 -0.00843889
CEP95 centrosomal protein 95kDa -0.00841369
SPRY4 sprouty homolog 4 (Drosophila) -0.0084076
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00839765
RNF169 ring finger protein 169 -0.00836491
RARB retinoic acid receptor, beta -0.00827979
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.00825313
GLI2 GLI family zinc finger 2 -0.00818141
CCN2 cellular communication network factor 2 -0.00809796
FOSL1 FOS-like antigen 1 -0.00802024
CUL4B cullin 4B -0.00800007
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.0079683
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.00796728
PDGFC platelet derived growth factor C -0.00795702
KLF6 Kruppel-like factor 6 -0.00786233
TM9SF3 transmembrane 9 superfamily member 3 -0.00785248
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.00778323