TAK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 7|The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6885)
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100 substrates of the kinase TAK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8
PKP1 plakophilin 1
EPS8L1 EPS8-like 1
EPS8L2 EPS8-like 2
FAM46D family with sequence similarity 46, member D
PALM2-AKAP2 PALM2-AKAP2 readthrough
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
ENAH enabled homolog (Drosophila)
SRI sorcin
NEO1 neogenin 1
ERBB2 erb-b2 receptor tyrosine kinase 2
C11ORF52 chromosome 11 open reading frame 52
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
BIRC5 baculoviral IAP repeat containing 5
RET ret proto-oncogene
CCDC85C coiled-coil domain containing 85C
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
MSN moesin
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2
CDC42 cell division cycle 42
TTN titin
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
AHNAK AHNAK nucleoprotein
SNRPC small nuclear ribonucleoprotein polypeptide C
ARHGAP18 Rho GTPase activating protein 18
RAI14 retinoic acid induced 14
FRMD4B FERM domain containing 4B
VDAC3 voltage-dependent anion channel 3
VDAC2 voltage-dependent anion channel 2
VDAC1 voltage-dependent anion channel 1
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH1 myosin, heavy chain 1, skeletal muscle, adult
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
SOCS6 suppressor of cytokine signaling 6
CEP135 centrosomal protein 135kDa
MTMR10 myotubularin related protein 10
FRAS1 Fraser extracellular matrix complex subunit 1
RDX radixin
PARK7 parkinson protein 7
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
S1PR1 sphingosine-1-phosphate receptor 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
MYH13 myosin, heavy chain 13, skeletal muscle
PCBP1 poly(rC) binding protein 1
STK26 serine/threonine protein kinase 26
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
DOCK10 dedicator of cytokinesis 10
RPL4 ribosomal protein L4
DKC1 dyskeratosis congenita 1, dyskerin
STK11 serine/threonine kinase 11
HDAC5 histone deacetylase 5
SRCAP Snf2-related CREBBP activator protein
PNP purine nucleoside phosphorylase
RFX7 regulatory factor X, 7
INSR insulin receptor
AP2B1 adaptor-related protein complex 2, beta 1 subunit
DENND1A DENN/MADD domain containing 1A
RICTOR RPTOR independent companion of MTOR, complex 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
RASA1 RAS p21 protein activator (GTPase activating protein) 1
EZR ezrin
TPD52L2 tumor protein D52-like 2
AGMO alkylglycerol monooxygenase
SCN1A sodium channel, voltage gated, type I alpha subunit
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
PLD2 phospholipase D2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
BANK1 B-cell scaffold protein with ankyrin repeats 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
ATG4B autophagy related 4B, cysteine peptidase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
SLC44A2 solute carrier family 44 (choline transporter), member 2
ATF4 activating transcription factor 4
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
CD226 CD226 molecule
CARD9 caspase recruitment domain family, member 9
JUP junction plakoglobin
PUM2 pumilio RNA-binding family member 2
REEP3 receptor accessory protein 3
SYNRG synergin, gamma
TTF1 transcription termination factor, RNA polymerase I
HRAS Harvey rat sarcoma viral oncogene homolog
KIF14 kinesin family member 14
PSEN1 presenilin 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
PPAP2A phosphatidic acid phosphatase type 2A