TAL1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description T-cell acute lymphocytic leukemia 1| (NCBI Entrez Gene Database, 6886)
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Genes

370 genes differentially expressed following the TAL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ASB9 ankyrin repeat and SOCS box containing 9 3.18317
C9ORF152 chromosome 9 open reading frame 152 3.18317
FOXN4 forkhead box N4 3.18317
F2 coagulation factor II (thrombin) 3.18317
NPIPA8 nuclear pore complex interacting protein family, member A8 3.18317
MUC21 mucin 21, cell surface associated 3.18317
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.18317
PRDM16 PR domain containing 16 3.18317
ETV2 ets variant 2 3.18317
USP50 ubiquitin specific peptidase 50 3.18317
ZNF556 zinc finger protein 556 3.18317
SFTPB surfactant protein B 3.18317
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.18317
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.18317
PBOV1 prostate and breast cancer overexpressed 1 3.18317
TFF2 trefoil factor 2 3.18317
HCRTR2 hypocretin (orexin) receptor 2 3.18317
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.18317
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.18317
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.18317
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.18317
FMO1 flavin containing monooxygenase 1 3.18317
FAM181B family with sequence similarity 181, member B 3.18317
RAB7B RAB7B, member RAS oncogene family 3.18317
TTLL8 tubulin tyrosine ligase-like family member 8 3.18317
BANF2 barrier to autointegration factor 2 3.18317
DEFB108B defensin, beta 108B 3.18317
VSIR V-set immunoregulatory receptor 3.18317
PADI1 peptidyl arginine deiminase, type I 3.18317
SDSL serine dehydratase-like 3.18317
ANGPTL8 angiopoietin like 8 3.18317
ANPEP alanyl (membrane) aminopeptidase 3.18317
SELE selectin E 3.18317
NLRP5 NLR family, pyrin domain containing 5 3.18317
SRGN serglycin 3.18317
CXCL13 chemokine (C-X-C motif) ligand 13 3.18317
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.18317
FGF6 fibroblast growth factor 6 3.18317
GIPC3 GIPC PDZ domain containing family, member 3 3.18317
HBG1 hemoglobin, gamma A 3.18317
GALP galanin-like peptide 3.18317
ASCL1 achaete-scute family bHLH transcription factor 1 3.18317
CIB3 calcium and integrin binding family member 3 3.18317
TMEM100 transmembrane protein 100 3.18317
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.18317
RAB11B RAB11B, member RAS oncogene family 3.18317
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.18317
PCDHB13 protocadherin beta 13 3.18317
LRRC72 leucine rich repeat containing 72 3.18317
NKX3-1 NK3 homeobox 1 3.18317
GDF5 growth differentiation factor 5 3.18317
TBX20 T-box 20 3.18317
TMPRSS11F transmembrane protease, serine 11F 3.18317
PTGDR2 prostaglandin D2 receptor 2 3.18317
TMEM178A transmembrane protein 178A 3.18317
AMBP alpha-1-microglobulin/bikunin precursor 3.18317
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.18317
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.18317
LRTM3 leucine rich repeat transmembrane protein 3 3.18317
SCRT2 scratch family zinc finger 2 3.18317
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.18317
MAG myelin associated glycoprotein 3.18317
TACR2 tachykinin receptor 2 3.18317
SAA2 serum amyloid A2 3.18317
HRH4 histamine receptor H4 3.18317
SLFN11 schlafen family member 11 3.18317
CST11 cystatin 11 3.18317
MAGIX MAGI family member, X-linked 3.18317
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.18317
GLUD2 glutamate dehydrogenase 2 3.18317
ZNF467 zinc finger protein 467 3.18317
TM4SF1 transmembrane 4 L six family member 1 3.18317
TBX15 T-box 15 3.18317
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.18317
IMPG2 interphotoreceptor matrix proteoglycan 2 3.18317
TMEM176A transmembrane protein 176A 3.18317
SPINK4 serine peptidase inhibitor, Kazal type 4 3.18317
GATA2 GATA binding protein 2 3.18317
ZACN zinc activated ligand-gated ion channel 3.18317
RASL10A RAS-like, family 10, member A 3.18317
FGF21 fibroblast growth factor 21 3.18317
SMCP sperm mitochondria-associated cysteine-rich protein 3.18317
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.18317
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.18317
RXFP2 relaxin/insulin-like family peptide receptor 2 3.18317
OSTN osteocrin 3.18317
OSR2 odd-skipped related transciption factor 2 3.18317
SYTL5 synaptotagmin-like 5 3.18317
BTNL8 butyrophilin-like 8 3.18317
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.18317
PSKH2 protein serine kinase H2 3.18317
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.18317
H3C3 H3 clustered histone 3 3.18317
CIMIP4 ciliary microtubule inner protein 4 3.18317
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.18317
KIAA0753 KIAA0753 3.18317
LOC102723971 beta-lactoglobulin-like 3.18317
TEKT2 tektin 2 (testicular) 3.18317
H2AC1 H2A clustered histone 1 3.18317
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.18317
CPA2 carboxypeptidase A2 (pancreatic) 3.18317
ARR3 arrestin 3, retinal (X-arrestin) 3.18317
CLRN2 clarin 2 3.18317
KRT222 keratin 222, type II 3.18317
H2BC3 H2B clustered histone 3 3.18317
H1-8 H1.8 linker histone 3.18317
HAVCR1 hepatitis A virus cellular receptor 1 3.18317
SERINC4 serine incorporator 4 3.18317
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.18317
CPA3 carboxypeptidase A3 (mast cell) 3.18317
THBD thrombomodulin 3.18317
SPATA31H1 SPATA31 subfamily H member 1 3.18317
LGALS12 lectin, galactoside-binding, soluble, 12 3.18317
FAIM2 Fas apoptotic inhibitory molecule 2 3.18317
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.18317
ADAM12 ADAM metallopeptidase domain 12 3.18317
GBX2 gastrulation brain homeobox 2 3.18317
EVI2A ecotropic viral integration site 2A 3.18317
GJC2 gap junction protein, gamma 2, 47kDa 3.18317
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.18317
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.18317
CFB complement factor B 3.18317
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.18317
TRIM7 tripartite motif containing 7 3.18317
KLK11 kallikrein-related peptidase 11 3.18317
CIMIP2A ciliary microtubule inner protein 2A 3.18317
ZC3H12D zinc finger CCCH-type containing 12D 3.18317
ANKRD55 ankyrin repeat domain 55 3.18317
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.18317
DMRT2 doublesex and mab-3 related transcription factor 2 3.18317
NT5C1B 5'-nucleotidase, cytosolic IB 3.18317
CTSE cathepsin E 3.18317
CSF1R colony stimulating factor 1 receptor 3.18317
SIDT1 SID1 transmembrane family, member 1 3.18317
CALHM5 calcium homeostasis modulator family member 5 3.18317
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.18317
TBC1D26 TBC1 domain family, member 26 3.18317
LORICRIN loricrin cornified envelope precursor protein 3.18317
NTSR2 neurotensin receptor 2 3.18317
CCN5 cellular communication network factor 5 3.18317
FNDC9 fibronectin type III domain containing 9 3.18317
CCDC154 coiled-coil domain containing 154 3.18317
PRSS57 protease, serine, 57 3.18317
VAX2 ventral anterior homeobox 2 3.18317
NPIPB15 nuclear pore complex interacting protein family, member B15 3.18317
FBXO39 F-box protein 39 3.18317
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.18317
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.18317
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.18317
MAEL maelstrom spermatogenic transposon silencer 3.18317
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.18317
CARNS1 carnosine synthase 1 3.18317
MAMDC4 MAM domain containing 4 3.18317
CST7 cystatin F (leukocystatin) 3.18317
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.18317
ZBED6 zinc finger, BED-type containing 6 3.18317
ZNF541 zinc finger protein 541 3.18317
RGSL1 regulator of G-protein signaling like 1 3.18317
EDN3 endothelin 3 3.18317
ERICH4 glutamate-rich 4 3.18317
CCDC198 coiled-coil domain containing 198 3.18317
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.18317
CCL25 chemokine (C-C motif) ligand 25 3.18317
EPOP elongin BC and polycomb repressive complex 2 associated protein 3.18317
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.18317
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 3.15197
NOS2 nitric oxide synthase 2, inducible 3.07049
RNF14 ring finger protein 14 3.06059
FMO3 flavin containing monooxygenase 3 3.05496
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 3.05496
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa 3.02472
TXNDC9 thioredoxin domain containing 9 3.00605
SSRP1 structure specific recognition protein 1 2.99781
SNX12 sorting nexin 12 2.94905
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 2.90611
STK25 serine/threonine kinase 25 2.86125
CSRP2 cysteine and glycine-rich protein 2 2.76127
CUL7 cullin 7 2.73522
REST RE1-silencing transcription factor 2.66883
ZFP36L2 ZFP36 ring finger protein-like 2 2.66188
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.59529
RPAP1 RNA polymerase II associated protein 1 2.59529
H2AC21 H2A clustered histone 21 2.55448
H3C2 H3 clustered histone 2 2.53429
MARCHF7 membrane associated ring-CH-type finger 7 2.52623
FTO fat mass and obesity associated 2.51169
GOPC golgi-associated PDZ and coiled-coil motif containing 2.46383
GLYATL1 glycine-N-acyltransferase-like 1 2.45835
STK36 serine/threonine kinase 36 2.45835
AMIGO1 adhesion molecule with Ig-like domain 1 2.43382
RHOV ras homolog family member V 2.43382
ZBTB12 zinc finger and BTB domain containing 12 2.40317
TXNDC16 thioredoxin domain containing 16 2.40105
PARD3 par-3 family cell polarity regulator 2.39618
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.36046
MYH10 myosin, heavy chain 10, non-muscle 2.33466
NCEH1 neutral cholesterol ester hydrolase 1 2.33175
CACUL1 CDK2-associated, cullin domain 1 2.326
TP53BP2 tumor protein p53 binding protein 2 2.32593
PPP1R42 protein phosphatase 1, regulatory subunit 42 2.30727
SPMIP3 sperm microtubule inner protein 3 2.30727
RNF39 ring finger protein 39 2.30727
SLC30A6 solute carrier family 30 (zinc transporter), member 6 2.30727
CELF1 CUGBP, Elav-like family member 1 2.27973
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.27973
NLRX1 NLR family member X1 2.27493
BLTP1 bridge-like lipid transfer protein family member 1 2.25228
MMP19 matrix metallopeptidase 19 2.24933
CDKN3 cyclin-dependent kinase inhibitor 3 2.24547
CREG1 cellular repressor of E1A-stimulated genes 1 2.24547
ZSWIM8 zinc finger, SWIM-type containing 8 2.24355
H2BC21 H2B clustered histone 21 2.22636
UBASH3B ubiquitin associated and SH3 domain containing B 2.22402
PUSL1 pseudouridylate synthase-like 1 2.21199
TRIM13 tripartite motif containing 13 2.20949
MMUT methylmalonyl-CoA mutase 2.20949
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.20822
KLHL21 kelch-like family member 21 2.20822
BARD1 BRCA1 associated RING domain 1 2.20822
NFIL3 nuclear factor, interleukin 3 regulated 2.20664
MARCKSL1 MARCKS-like 1 2.18367
LUC7L LUC7-like (S. cerevisiae) 2.1832
BRD4 bromodomain containing 4 2.17932
ANGPTL1 angiopoietin-like 1 2.1786
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 2.1786
TRIM24 tripartite motif containing 24 2.1786
CEP83 centrosomal protein 83kDa 2.16842
RRAS related RAS viral (r-ras) oncogene homolog 2.1556
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.15424
C19ORF84 chromosome 19 open reading frame 84 2.15089
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 2.14983
NKX1-2 NK1 homeobox 2 2.13142
GHR growth hormone receptor 2.11399
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.11399
TMSB15B thymosin beta 15B 2.11087
AKR1D1 aldo-keto reductase family 1, member D1 2.11087
PROKR1 prokineticin receptor 1 2.11087
RGS22 regulator of G-protein signaling 22 2.11087
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.11087
MAP6 microtubule-associated protein 6 2.11087
RPL31 ribosomal protein L31 2.11087
NAGS N-acetylglutamate synthase 2.11087
DNAH1 dynein, axonemal, heavy chain 1 2.11087
DLG2 discs, large homolog 2 (Drosophila) 2.11087
TGFB3 transforming growth factor, beta 3 2.11087
NTSR1 neurotensin receptor 1 (high affinity) 2.11087
BTBD3 BTB (POZ) domain containing 3 2.09901
ABTB3 ankyrin repeat and BTB domain containing 3 2.06867
TRPC1 transient receptor potential cation channel, subfamily C, member 1 2.06778
NOSTRIN nitric oxide synthase trafficking 2.04202
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.02664
ZCWPW2 zinc finger, CW type with PWWP domain 2 2.0248
NHLRC2 NHL repeat containing 2 2.01315
RAB9B RAB9B, member RAS oncogene family 2.00252

decreased expression

Symbol Name Standardized Value
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -3.18317
THEM6 thioesterase superfamily member 6 -3.18317
TICAM1 toll-like receptor adaptor molecule 1 -3.18317
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -3.18317
BOLL boule-like RNA-binding protein -3.18317
FPR1 formyl peptide receptor 1 -3.18317
ZC3H11C zinc finger CCCH-type containing 11C -3.18317
BTK Bruton agammaglobulinemia tyrosine kinase -3.18317
ARHGAP20 Rho GTPase activating protein 20 -3.18317
C1QL3 complement component 1, q subcomponent-like 3 -3.18317
LCNL1 lipocalin-like 1 -3.18317
MUC1 mucin 1, cell surface associated -3.18317
NRGN neurogranin (protein kinase C substrate, RC3) -3.18317
RSPO2 R-spondin 2 -3.18317
NNT nicotinamide nucleotide transhydrogenase -3.18317
MOGAT3 monoacylglycerol O-acyltransferase 3 -3.18317
CHGB chromogranin B -3.18317
ZNF268 zinc finger protein 268 -3.18317
LIN37 lin-37 DREAM MuvB core complex component -3.18317
FAM161B family with sequence similarity 161, member B -3.18317
ZNF568 zinc finger protein 568 -3.18317
CCL5 chemokine (C-C motif) ligand 5 -3.18317
TBL2 transducin (beta)-like 2 -3.18317
EFCAB9 EF-hand calcium binding domain 9 -3.18317
GPR12 G protein-coupled receptor 12 -3.18317
NUTM1 NUT midline carcinoma, family member 1 -3.18317
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -3.18317
MR1 major histocompatibility complex, class I-related -3.18317
FAM131C family with sequence similarity 131, member C -3.18317
IL9R interleukin 9 receptor -3.18317
BARX1 BARX homeobox 1 -3.18317
CRYBA1 crystallin, beta A1 -3.18317
NBPF14 neuroblastoma breakpoint family, member 14 -3.18317
LOXHD1 lipoxygenase homology domains 1 -3.18317
MINAR2 membrane integral NOTCH2 associated receptor 2 -3.18317
VXN vexin -3.18317
PCP4L1 Purkinje cell protein 4 like 1 -3.18317
PRM1 protamine 1 -3.18317
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -3.18317
PCDHGA1 protocadherin gamma subfamily A, 1 -3.18317
KLK8 kallikrein-related peptidase 8 -3.14719
FOXO6 forkhead box O6 -3.14719
GSTM4 glutathione S-transferase mu 4 -3.09989
STARD8 StAR-related lipid transfer (START) domain containing 8 -3.08384
TCEAL1 transcription elongation factor A (SII)-like 1 -3.02585
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 -2.78531
BEX4 brain expressed, X-linked 4 -2.76122
SNX13 sorting nexin 13 -2.75919
MAPKBP1 mitogen-activated protein kinase binding protein 1 -2.72436
KCTD3 potassium channel tetramerization domain containing 3 -2.71143
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.7113
PCDHGA6 protocadherin gamma subfamily A, 6 -2.70717
KDM6B lysine (K)-specific demethylase 6B -2.67727
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.66525
DVL1 dishevelled segment polarity protein 1 -2.63854
CST3 cystatin C -2.52623
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.51958
PCDHGA10 protocadherin gamma subfamily A, 10 -2.45835
NBPF3 neuroblastoma breakpoint family, member 3 -2.45835
GIGYF2 GRB10 interacting GYF protein 2 -2.45393
NASP nuclear autoantigenic sperm protein (histone-binding) -2.4125
POGLUT3 protein O-glucosyltransferase 3 -2.40326
DAZL deleted in azoospermia-like -2.39374
BCL7B B-cell CLL/lymphoma 7B -2.38385
PACS2 phosphofurin acidic cluster sorting protein 2 -2.35344
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -2.34892
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.31273
VAMP7 vesicle-associated membrane protein 7 -2.30959
GNMT glycine N-methyltransferase -2.26578
FBP2 fructose-1,6-bisphosphatase 2 -2.26578
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 -2.24745
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -2.24355
TSPAN18 tetraspanin 18 -2.24355
PVALEF parvalbumin like EF-hand containing -2.22443
CSF1 colony stimulating factor 1 (macrophage) -2.22443
DNAI2 dynein, axonemal, intermediate chain 2 -2.22443
CDCA7L cell division cycle associated 7-like -2.22443
CLCN4 chloride channel, voltage-sensitive 4 -2.22443
ENKUR enkurin, TRPC channel interacting protein -2.22443
LRATD2 LRAT domain containing 2 -2.22443
PPP1R36 protein phosphatase 1, regulatory subunit 36 -2.22443
COL12A1 collagen, type XII, alpha 1 -2.22443
PTPRF protein tyrosine phosphatase, receptor type, F -2.22402
C9ORF153 chromosome 9 open reading frame 153 -2.20822
HHIP hedgehog interacting protein -2.20717
KIDINS220 kinase D-interacting substrate, 220kDa -2.20619
RDH16 retinol dehydrogenase 16 (all-trans) -2.20136
SLC30A10 solute carrier family 30, member 10 -2.20136
XXYLT1 xyloside xylosyltransferase 1 -2.1982
DENND1B DENN/MADD domain containing 1B -2.19505
USP48 ubiquitin specific peptidase 48 -2.1811
AFG1L AFG1 like ATPase -2.1811
MEGF11 multiple EGF-like-domains 11 -2.161
ZNF385A zinc finger protein 385A -2.1556
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.15089
NEK8 NIMA-related kinase 8 -2.15089
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.15089
ANOS1 anosmin 1 -2.14758
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K -2.12157
ZNF707 zinc finger protein 707 -2.11087
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.11087
LGMN legumain -2.10215
RALBP1 ralA binding protein 1 -2.10215
COMTD1 catechol-O-methyltransferase domain containing 1 -2.06778
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.06591
ZNF148 zinc finger protein 148 -2.06482
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -2.06482
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.05324
PCDHGA8 protocadherin gamma subfamily A, 8 -2.05324
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.03394
EMID1 EMI domain containing 1 -2.03319
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.03298
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.02664
TMEM200A transmembrane protein 200A -2.02664
ZNF891 zinc finger protein 891 -2.01803
ELL elongation factor RNA polymerase II -2.00662