TAT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tyrosine aminotransferase|This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6898)
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Genes

338 genes differentially expressed following the TAT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ASCL3 achaete-scute family bHLH transcription factor 3 3.01655
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.01655
CALR3 calreticulin 3 3.01655
CXCL16 chemokine (C-X-C motif) ligand 16 3.01655
TMEM233 transmembrane protein 233 3.01655
MAMLD1 mastermind-like domain containing 1 3.01655
BPIFB4 BPI fold containing family B, member 4 3.01655
BAIAP3 BAI1-associated protein 3 3.01655
BTC betacellulin 3.01655
CTF1 cardiotrophin 1 3.01655
PCDHGB7 protocadherin gamma subfamily B, 7 3.01655
SLC16A6 solute carrier family 16, member 6 3.01655
C3ORF22 chromosome 3 open reading frame 22 3.01655
POTEJ POTE ankyrin domain family, member J 3.01655
HHIPL2 HHIP-like 2 3.01655
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.01655
TAS2R19 taste receptor, type 2, member 19 3.01655
IL33 interleukin 33 3.01655
TMPRSS6 transmembrane protease, serine 6 3.01655
SIGLEC15 sialic acid binding Ig-like lectin 15 3.01655
MDFIC2 MyoD family inhibitor domain containing 2 3.01655
DLX3 distal-less homeobox 3 3.01655
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.01655
TMEM270 transmembrane protein 270 3.01655
ZNF441 zinc finger protein 441 3.01655
ZNF467 zinc finger protein 467 2.95837
CRH corticotropin releasing hormone 2.95837
OCM2 oncomodulin 2 2.95837
SMIM35 small integral membrane protein 35 2.95837
ANKRD34A ankyrin repeat domain 34A 2.95837
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.95837
SSTR5 somatostatin receptor 5 2.95837
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.95837
FETUB fetuin B 2.95837
AKAIN1 A-kinase anchor inhibitor 1 2.95837
PDYN prodynorphin 2.95837
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.95837
SKOR2 SKI family transcriptional corepressor 2 2.95837
MYBPC3 myosin binding protein C, cardiac 2.95837
ERN2 endoplasmic reticulum to nucleus signaling 2 2.95837
NCF1 neutrophil cytosolic factor 1 2.95837
HORMAD2 HORMA domain containing 2 2.95837
PAX8 paired box 8 2.95837
SMIM45 small integral membrane protein 45 2.95837
TMA7B translation machinery associated 7 homolog B 2.95837
SPDEF SAM pointed domain containing ETS transcription factor 2.95837
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.95837
PRSS27 protease, serine 27 2.95837
FGF7 fibroblast growth factor 7 2.95837
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.95837
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 2.95837
HES2 hes family bHLH transcription factor 2 2.95837
PNMA6F PNMA family member 6F 2.95837
PLN phospholamban 2.95837
SPACA1 sperm acrosome associated 1 2.95837
MRC1 mannose receptor, C type 1 2.95837
MPO myeloperoxidase 2.95837
LOC122526780 uncharacterized LOC122526780 2.95837
ATOH1 atonal homolog 1 (Drosophila) 2.95837
TMEM82 transmembrane protein 82 2.95837
CPB2 carboxypeptidase B2 (plasma) 2.95837
CPB1 carboxypeptidase B1 (tissue) 2.95837
ANXA2R annexin A2 receptor 2.95837
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.95837
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.95837
RUNX3 runt-related transcription factor 3 2.95837
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.95837
GZMM granzyme M (lymphocyte met-ase 1) 2.95837
GDF10 growth differentiation factor 10 2.95837
ZNF575 zinc finger protein 575 2.95837
HAPLN2 hyaluronan and proteoglycan link protein 2 2.95837
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.95837
ZIC4 Zic family member 4 2.95837
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.95837
UNC93A unc-93 homolog A (C. elegans) 2.95837
CXCL13 chemokine (C-X-C motif) ligand 13 2.95837
PKD2L1 polycystic kidney disease 2-like 1 2.95837
LMNTD1 lamin tail domain containing 1 2.95837
TAS2R60 taste receptor, type 2, member 60 2.95837
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.95837
LOC124909439 uncharacterized LOC124909439 2.95837
BEND2 BEN domain containing 2 2.95837
HNF1A HNF1 homeobox A 2.95837
OTOF otoferlin 2.95837
CD79A CD79a molecule, immunoglobulin-associated alpha 2.95837
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.95837
HPCAL4 hippocalcin like 4 2.95837
DUXA double homeobox A 2.95837
XAF1 XIAP associated factor 1 2.95837
ALOX15 arachidonate 15-lipoxygenase 2.95837
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.95837
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.95837
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 2.95837
CCN6 cellular communication network factor 6 2.95837
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.95837
DEPP1 DEPP autophagy regulator 1 2.95837
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.95837
CFAP65 cilia and flagella associated protein 65 2.95837
CLDN2 claudin 2 2.95837
PCDHA3 protocadherin alpha 3 2.95837
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.95837
FPR3 formyl peptide receptor 3 2.95837
SIX6 SIX homeobox 6 2.95837
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.95837
DEUP1 deuterosome assembly protein 1 2.95837
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.95837
JSRP1 junctional sarcoplasmic reticulum protein 1 2.95837
SPATA3 spermatogenesis associated 3 2.95837
PAGE4 P antigen family, member 4 (prostate associated) 2.95837
CLEC4C C-type lectin domain family 4, member C 2.95837
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.95837
FIBIN fin bud initiation factor homolog (zebrafish) 2.95837
CGB7 chorionic gonadotropin, beta polypeptide 7 2.95837
PCDHGA7 protocadherin gamma subfamily A, 7 2.95837
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.95837
LHX2 LIM homeobox 2 2.95837
GLOD5 glyoxalase domain containing 5 2.95837
CLRN1 clarin 1 2.95837
FBXO39 F-box protein 39 2.95837
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.95837
GLYATL3 glycine-N-acyltransferase-like 3 2.95837
RSAD2 radical S-adenosyl methionine domain containing 2 2.95837
RFPL1 ret finger protein-like 1 2.95837
CNTF ciliary neurotrophic factor 2.95837
CT55 cancer/testis antigen 55 2.95837
EFCAB3 EF-hand calcium binding domain 3 2.95837
S100A14 S100 calcium binding protein A14 2.95837
TEKT1 tektin 1 2.95837
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.95837
IP6K3 inositol hexakisphosphate kinase 3 2.95837
GPR68 G protein-coupled receptor 68 2.95837
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.95837
MNDA myeloid cell nuclear differentiation antigen 2.95837
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.95837
PCDHAC2 protocadherin alpha subfamily C, 2 2.95837
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.95837
ADCY4 adenylate cyclase 4 2.95837
GOLGA8O golgin A8 family, member O 2.95837
VAV1 vav 1 guanine nucleotide exchange factor 2.95837
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.95837
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.95837
RGCC regulator of cell cycle 2.95837
THBD thrombomodulin 2.95837
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.95837
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 2.95837
SPEF1 sperm flagellar 1 2.95837
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.95837
MZB1 marginal zone B and B1 cell-specific protein 2.95837
NT5DC4 5'-nucleotidase domain containing 4 2.95837
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.95837
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.95837
SMYD1 SET and MYND domain containing 1 2.95837
ANKRD62 ankyrin repeat domain 62 2.95837
FIGLA folliculogenesis specific basic helix-loop-helix 2.95837
ZNF396 zinc finger protein 396 2.95837
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.95837
ANGPTL3 angiopoietin-like 3 2.95837
NKPD1 NTPase, KAP family P-loop domain containing 1 2.95837
RUFY4 RUN and FYVE domain containing 4 2.95837
ECM1 extracellular matrix protein 1 2.95837
TBC1D28 TBC1 domain family, member 28 2.95837
C4BPA complement component 4 binding protein, alpha 2.95837
SPRN shadow of prion protein homolog (zebrafish) 2.95837
OR52I2 olfactory receptor, family 52, subfamily I, member 2 2.95837
NGB neuroglobin 2.95837
PITX3 paired-like homeodomain 3 2.95837
ASCL2 achaete-scute family bHLH transcription factor 2 2.95837
NLRP4 NLR family, pyrin domain containing 4 2.95837
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.95837
PADI1 peptidyl arginine deiminase, type I 2.95837
PF4V1 platelet factor 4 variant 1 2.95837
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.95837
STAR steroidogenic acute regulatory protein 2.91646
BGN biglycan 2.91646
RPH3A rabphilin 3A 2.91646
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.91646
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.91646
SGMS2 sphingomyelin synthase 2 2.91646
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.91646
RANGAP1 Ran GTPase activating protein 1 2.87841
ZNF454 zinc finger protein 454 2.87841
UBL3 ubiquitin-like 3 2.77438
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.76833
CGREF1 cell growth regulator with EF-hand domain 1 2.75237
TLE4 transducin-like enhancer of split 4 2.70045
CPLX2 complexin 2 2.6488
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.6437
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.59023
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.53581
NCKAP5L NCK-associated protein 5-like 2.4887
ADPRH ADP-ribosylarginine hydrolase 2.46327
IL21R interleukin 21 receptor 2.46327
FNDC1 fibronectin type III domain containing 1 2.4542
LGALS9 lectin, galactoside-binding, soluble, 9 2.4542
CMKLR1 chemerin chemokine-like receptor 1 2.4542
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.4542
HRK harakiri, BCL2 interacting protein 2.4267
CLSTN2 calsyntenin 2 2.4267
ZDHHC7 zinc finger, DHHC-type containing 7 2.39921
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 2.39921
CFDP1 craniofacial development protein 1 2.39777
DCTN1 dynactin 1 2.37796
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.37421
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 2.37163
TMEM266 transmembrane protein 266 2.35717
CYFIP2 cytoplasmic FMR1 interacting protein 2 2.34847
BMP4 bone morphogenetic protein 4 2.34103
PGAP1 post-GPI attachment to proteins 1 2.34103
UBOX5 U-box domain containing 5 2.33064
BTBD2 BTB (POZ) domain containing 2 2.3278
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2.31143
PRCP prolylcarboxypeptidase (angiotensinase C) 2.27616
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.2713
BCAS4 breast carcinoma amplified sequence 4 2.26868
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.26868
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 2.25719
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.25719
PLPP3 phospholipid phosphatase 3 2.24887
SARS1 seryl-tRNA synthetase 1 2.24156
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.23625
SEPTIN7 septin 7 2.23625
GTF2B general transcription factor IIB 2.22422
PHTF1 putative homeodomain transcription factor 1 2.20604
MCL1 myeloid cell leukemia 1 2.20076
NODAL nodal growth differentiation factor 2.1565
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.14332
KHNYN KH and NYN domain containing 2.14332
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.11945
TRABD TraB domain containing 2.04221
TBCK TBC1 domain containing kinase 2.03868
YIPF1 Yip1 domain family, member 1 2.02239

decreased expression

Symbol Name Standardized Value
HSH2D hematopoietic SH2 domain containing -2.95837
TRMT10B tRNA methyltransferase 10 homolog B (S. cerevisiae) -2.95837
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.95837
FLI1 Fli-1 proto-oncogene, ETS transcription factor -2.95837
CRACD capping protein inhibiting regulator of actin dynamics -2.95837
LRRC3B leucine rich repeat containing 3B -2.95837
ENO3 enolase 3 (beta, muscle) -2.95837
MYO3B myosin IIIB -2.94463
PRB2 proline-rich protein BstNI subfamily 2 -2.92955
MMP19 matrix metallopeptidase 19 -2.92955
CDCP2 CUB domain containing protein 2 -2.92955
LPA lipoprotein, Lp(a) -2.92955
UPK3B uroplakin 3B -2.92955
TXLNB taxilin beta -2.92955
IGFL4 IGF-like family member 4 -2.92955
GLRA3 glycine receptor, alpha 3 -2.92955
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.92955
ADTRP androgen-dependent TFPI-regulating protein -2.92955
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.92955
TRIM73 tripartite motif containing 73 -2.92955
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.92955
ZBTB37 zinc finger and BTB domain containing 37 -2.92955
KCNIP3 Kv channel interacting protein 3, calsenilin -2.92955
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.92955
CCDC177 coiled-coil domain containing 177 -2.92955
GOLGA6L7 golgin A6 family like 7 -2.92955
LRRC19 leucine rich repeat containing 19 -2.92955
PDF peptide deformylase (mitochondrial) -2.92955
VWA7 von Willebrand factor A domain containing 7 -2.92955
BPIFB1 BPI fold containing family B, member 1 -2.92955
HSPA1L heat shock 70kDa protein 1-like -2.92955
MYPN myopalladin -2.92955
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.92955
GLT6D1 glycosyltransferase 6 domain containing 1 -2.92955
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.92955
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.92955
FAM131C family with sequence similarity 131, member C -2.92955
POU5F1 POU class 5 homeobox 1 -2.91646
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.86609
PTPRR protein tyrosine phosphatase, receptor type, R -2.80642
ZNF688 zinc finger protein 688 -2.80642
NPEPPS aminopeptidase puromycin sensitive -2.80569
GDPGP1 GDP-D-glucose phosphorylase 1 -2.79602
FOXI3 forkhead box I3 -2.79602
NPY neuropeptide Y -2.79602
TOMM70 translocase of outer mitochondrial membrane 70 -2.71607
NSD1 nuclear receptor binding SET domain protein 1 -2.54045
RAB8B RAB8B, member RAS oncogene family -2.53581
RNF166 ring finger protein 166 -2.45511
YES1 YES proto-oncogene 1, Src family tyrosine kinase -2.39028
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.37359
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.35132
INO80B INO80 complex subunit B -2.33809
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.30109
ARHGAP11B Rho GTPase activating protein 11B -2.25719
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.25719
RBM18 RNA binding motif protein 18 -2.25719
TTPAL tocopherol (alpha) transfer protein-like -2.25498
UBALD1 UBA-like domain containing 1 -2.24676
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.24156
CDK18 cyclin-dependent kinase 18 -2.23625
CCDC93 coiled-coil domain containing 93 -2.23625
WDR20 WD repeat domain 20 -2.23625
GPR137B G protein-coupled receptor 137B -2.23625
ACTN1 actinin, alpha 1 -2.22235
TRIM32 tripartite motif containing 32 -2.22235
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -2.20812
C4ORF33 chromosome 4 open reading frame 33 -2.17651
FAM114A2 family with sequence similarity 114, member A2 -2.17498
MED8 mediator complex subunit 8 -2.17458
FAM3B family with sequence similarity 3, member B -2.17458
NHLRC2 NHL repeat containing 2 -2.17444
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like -2.16788
TUBG1 tubulin, gamma 1 -2.16767
FAF2 Fas associated factor family member 2 -2.16519
PCGF2 polycomb group ring finger 2 -2.16116
CCBE1 collagen and calcium binding EGF domains 1 -2.1548
RPL24 ribosomal protein L24 -2.15165
ARHGAP17 Rho GTPase activating protein 17 -2.15165
TAFA4 TAFA chemokine like family member 4 -2.14332
AKR1D1 aldo-keto reductase family 1, member D1 -2.14332
ELOVL5 ELOVL fatty acid elongase 5 -2.14332
NBEAL2 neurobeachin-like 2 -2.14332
ZNF70 zinc finger protein 70 -2.14332
TRAPPC1 trafficking protein particle complex 1 -2.14332
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -2.13499
DGAT1 diacylglycerol O-acyltransferase 1 -2.13499
FAM13B family with sequence similarity 13, member B -2.13347
ZNF500 zinc finger protein 500 -2.12786
KMT2D lysine (K)-specific methyltransferase 2D -2.12409
ELP5 elongator acetyltransferase complex subunit 5 -2.12359
MAP6D1 MAP6 domain containing 1 -2.11692
SEC11A SEC11 homolog A (S. cerevisiae) -2.09582
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -2.09237
DYNC2I2 dynein 2 intermediate chain 2 -2.0818
OTUD5 OTU deubiquitinase 5 -2.07423
ZNF776 zinc finger protein 776 -2.06561
PARP11 poly (ADP-ribose) polymerase family, member 11 -2.06561
COL5A3 collagen, type V, alpha 3 -2.05809
JDP2 Jun dimerization protein 2 -2.05669
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.04924
ETV1 ets variant 1 -2.04924
SPDYA speedy/RINGO cell cycle regulator family member A -2.04221
TMEM237 transmembrane protein 237 -2.04221
ERMP1 endoplasmic reticulum metallopeptidase 1 -2.03594
H1-4 H1.4 linker histone, cluster member -2.01467
LYRM7 LYR motif containing 7 -2.01342