TBK1.DN.48HRS Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/TBK1.DN.48HRS_UP
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Genes

100 genes differentially expressed following the TBK1.DN.48HRS gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
APOE apolipoprotein E
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL4C ADP-ribosylation factor-like 4C
BAMBI BMP and activin membrane-bound inhibitor
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CHMP6 charged multivesicular body protein 6
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CNOT4 CCR4-NOT transcription complex, subunit 4
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CXCL2 chemokine (C-X-C motif) ligand 2
DDR1 discoidin domain receptor tyrosine kinase 1
DUSP3 dual specificity phosphatase 3
ECD ecdysoneless homolog (Drosophila)
EDN1 endothelin 1
FCHO1 FCH domain only 1
FKBP14 FK506 binding protein 14, 22 kDa
FSD1 fibronectin type III and SPRY domain containing 1
IGFBP3 insulin-like growth factor binding protein 3
KIAA0907 KIAA0907
LBR lamin B receptor
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MLEC malectin
MTFR1 mitochondrial fission regulator 1
MYCBP MYC binding protein
MYLK myosin light chain kinase
OXSR1 oxidative stress responsive 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PSRC1 proline/serine-rich coiled-coil 1
PTK2 protein tyrosine kinase 2
RBM15B RNA binding motif protein 15B
RNMT RNA (guanine-7-) methyltransferase
SCP2 sterol carrier protein 2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOX2 SRY (sex determining region Y)-box 2
TEX10 testis expressed 10
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM9SF2 transmembrane 9 superfamily member 2
TMCO1 transmembrane and coiled-coil domains 1
TP53BP1 tumor protein p53 binding protein 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBQLN2 ubiquilin 2
UGDH UDP-glucose 6-dehydrogenase
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
AKAP8 A kinase (PRKA) anchor protein 8
ANKRD10 ankyrin repeat domain 10
ATG3 autophagy related 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL2 B-cell CLL/lymphoma 2
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BPHL biphenyl hydrolase-like (serine hydrolase)
CDK1 cyclin-dependent kinase 1
COASY CoA synthase
COL4A1 collagen, type IV, alpha 1
CPNE3 copine III
CRYZ crystallin, zeta (quinone reductase)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DCK deoxycytidine kinase
DLD dihydrolipoamide dehydrogenase
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
EGF epidermal growth factor
GALE UDP-galactose-4-epimerase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GTF2A2 general transcription factor IIA, 2, 12kDa
H2AFV H2A histone family, member V
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IL13RA1 interleukin 13 receptor, alpha 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB1BP1 integrin beta 1 binding protein 1
KIAA0100 KIAA0100
MAPK9 mitogen-activated protein kinase 9
MSRA methionine sulfoxide reductase A
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PPOX protoporphyrinogen oxidase
PRKCQ protein kinase C, theta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD51C RAD51 paralog C
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
TERF2IP telomeric repeat binding factor 2, interacting protein
TOR1A torsin family 1, member A (torsin A)
TRIB3 tribbles pseudokinase 3
UFM1 ubiquitin-fold modifier 1
XBP1 X-box binding protein 1