TBK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description TANK-binding kinase 1|The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 29110)
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100 substrates of the kinase TBK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
SQSTM1 sequestosome 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
LIMA1 LIM domain and actin binding 1
CASP9 caspase 9, apoptosis-related cysteine peptidase
ZNF462 zinc finger protein 462
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
MUC1 mucin 1, cell surface associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
N4BP3 NEDD4 binding protein 3
CHAMP1 chromosome alignment maintaining phosphoprotein 1
LMO7 LIM domain 7
TRAFD1 TRAF-type zinc finger domain containing 1
TTN titin
NECAP2 NECAP endocytosis associated 2
NES nestin
CCNE1 cyclin E1
RABGAP1L RAB GTPase activating protein 1-like
CEP97 centrosomal protein 97kDa
PER2 period circadian clock 2
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
SCAF1 SR-related CTD-associated factor 1
OFD1 oral-facial-digital syndrome 1
ARHGAP31 Rho GTPase activating protein 31
HTT huntingtin
TERF2IP telomeric repeat binding factor 2, interacting protein
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
ARHGAP17 Rho GTPase activating protein 17
COPA coatomer protein complex, subunit alpha
NCAPD3 non-SMC condensin II complex, subunit D3
DOK3 docking protein 3
BLM Bloom syndrome, RecQ helicase-like
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
CEP170B centrosomal protein 170B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
ZYX zyxin
NUPL2 nucleoporin like 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
FGD5 FYVE, RhoGEF and PH domain containing 5
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
TPRN taperin
MLPH melanophilin
RAB11FIP2 RAB11 family interacting protein 2 (class I)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
MTMR4 myotubularin related protein 4
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
FKBP4 FK506 binding protein 4, 59kDa
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
CLUH clustered mitochondria (cluA/CLU1) homolog
SYNPO synaptopodin
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
DCAF5 DDB1 and CUL4 associated factor 5
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
HOOK2 hook microtubule-tethering protein 2
EPRS glutamyl-prolyl-tRNA synthetase
ADGRA2 adhesion G protein-coupled receptor A2
SYNE2 spectrin repeat containing, nuclear envelope 2
UBL7 ubiquitin-like 7
DENND1C DENN/MADD domain containing 1C
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
INF2 inverted formin, FH2 and WH2 domain containing
TAGLN transgelin
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
MAP1B microtubule-associated protein 1B
TMC5 transmembrane channel-like 5
ESPNL espin-like
PHF20 PHD finger protein 20
DOCK5 dedicator of cytokinesis 5
CAMSAP1 calmodulin regulated spectrin-associated protein 1
ITGB4 integrin, beta 4
ZNF598 zinc finger protein 598
FLNA filamin A, alpha
RGS19 regulator of G-protein signaling 19
JMJD1C jumonji domain containing 1C
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
MCMBP minichromosome maintenance complex binding protein
RNF31 ring finger protein 31
MAP2K2 mitogen-activated protein kinase kinase 2
SDK2 sidekick cell adhesion molecule 2
CFLAR CASP8 and FADD-like apoptosis regulator
WRAP53 WD repeat containing, antisense to TP53
FAM189A2 family with sequence similarity 189, member A2
PPP1R3D protein phosphatase 1, regulatory subunit 3D
GSTP1 glutathione S-transferase pi 1
CDC25B cell division cycle 25B
NOP2 NOP2 nucleolar protein
C6ORF25 chromosome 6 open reading frame 25
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
BAIAP2 BAI1-associated protein 2
DIABLO diablo, IAP-binding mitochondrial protein
ARMCX3 armadillo repeat containing, X-linked 3
WARS tryptophanyl-tRNA synthetase
PARP4 poly (ADP-ribose) polymerase family, member 4
BCAS1 breast carcinoma amplified sequence 1
SVIL supervillin
U2SURP U2 snRNP-associated SURP domain containing