TBK1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description TANK-binding kinase 1|The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 29110)
External Link https://ncbi.nlm.nih.gov/gene/29110
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Genes

497 genes differentially expressed following the TBK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
LTF lactotransferrin 0.0199858
DIPK1A divergent protein kinase domain 1A 0.0130427
TNNT1 troponin T type 1 (skeletal, slow) 0.0130264
SCGB2A1 secretoglobin, family 2A, member 1 0.0122359
PEG3 paternally expressed 3 0.0107454
EMX2 empty spiracles homeobox 2 0.0105092
MYBPC1 myosin binding protein C, slow type 0.009821
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00962871
KRT7 keratin 7, type II 0.00958452
GLUL glutamate-ammonia ligase 0.00949372
MUC16 mucin 16, cell surface associated 0.00948285
CLU clusterin 0.00941917
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00925764
CAPG capping protein (actin filament), gelsolin-like 0.00911549
TPM2 tropomyosin 2 (beta) 0.00903484
RCAN1 regulator of calcineurin 1 0.00903007
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00889227
MSMB microseminoprotein, beta- 0.00888347
RAB25 RAB25, member RAS oncogene family 0.00886798
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.00881226
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.0084486
IQCG IQ motif containing G 0.00841948
CTSB cathepsin B 0.00841384
CD9 CD9 molecule 0.00810097
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.00808764
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00804665
NKX3-1 NK3 homeobox 1 0.00796243
TCTA T-cell leukemia translocation altered 0.00793287
TPM4 tropomyosin 4 0.00787778
GUCY2C guanylate cyclase 2C 0.00774803
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.00768791
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.00765563
YBX3 Y box binding protein 3 0.00759304
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.00757697
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.00748465
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.00747575
SEPP1 selenoprotein P, plasma, 1 0.00740296
OAT ornithine aminotransferase 0.00739971
CLDN10 claudin 10 0.00737915
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.00730628
MEIS1 Meis homeobox 1 0.00730226
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00728784
DNTT DNA nucleotidylexotransferase 0.00726339
E2F2 E2F transcription factor 2 0.00722754
SIRT3 sirtuin 3 0.00713949
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.00712837
POSTN periostin, osteoblast specific factor 0.00705991
NUSAP1 nucleolar and spindle associated protein 1 0.00701852
PUF60 poly-U binding splicing factor 60KDa 0.00701004
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.00698969
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.00695792
C9ORF16 chromosome 9 open reading frame 16 0.00693884
AHCY adenosylhomocysteinase 0.00693548
TUBB4B tubulin, beta 4B class IVb 0.00692417
C3 complement component 3 0.00690807
NPTXR neuronal pentraxin receptor 0.00689656
ATF5 activating transcription factor 5 0.0068904
AZIN1 antizyme inhibitor 1 0.00686583
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.00685497
AQP3 aquaporin 3 (Gill blood group) 0.00680484
TYMS thymidylate synthetase 0.00677634
ACTA2 actin, alpha 2, smooth muscle, aorta 0.00677604
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.00676474
PALLD palladin, cytoskeletal associated protein 0.00669976
TUBB2A tubulin, beta 2A class IIa 0.00666339
CLDN3 claudin 3 0.00661251
BPGM 2,3-bisphosphoglycerate mutase 0.00660835
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.00659069
NT5E 5'-nucleotidase, ecto (CD73) 0.00658591
ITM2C integral membrane protein 2C 0.00657116
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.00656362
LCN2 lipocalin 2 0.00656289
DSP desmoplakin 0.00655727
ESRP1 epithelial splicing regulatory protein 1 0.00655079
CSTA cystatin A (stefin A) 0.00653803
ZBED2 zinc finger, BED-type containing 2 0.0065262
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.00650298
MLF1 myeloid leukemia factor 1 0.00649817
S100A14 S100 calcium binding protein A14 0.00646593
TSPAN1 tetraspanin 1 0.00646302
PCYOX1 prenylcysteine oxidase 1 0.00644504
DLK1 delta-like 1 homolog (Drosophila) 0.00642361
MYB v-myb avian myeloblastosis viral oncogene homolog 0.00642284
PADI2 peptidyl arginine deiminase, type II 0.00640531
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00640382
MAGEA3 melanoma antigen family A3 0.00638432
PRPF4 pre-mRNA processing factor 4 0.00637404
NCK1 NCK adaptor protein 1 0.00637209
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.0063547
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.00635326
PRNP prion protein 0.00634835
HIST3H2A histone cluster 3, H2a 0.00634697
ESR1 estrogen receptor 1 0.00632624
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.00630953
GREB1 growth regulation by estrogen in breast cancer 1 0.00625771
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00620834
XPO7 exportin 7 0.00620814
BHLHE41 basic helix-loop-helix family, member e41 0.0061763
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.00617324
IGSF6 immunoglobulin superfamily, member 6 0.00616527
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.00615732
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.00615341
FOXG1 forkhead box G1 0.00610708
ARL3 ADP-ribosylation factor-like 3 0.0061051
NEBL nebulette 0.00610281
RAB40B RAB40B, member RAS oncogene family 0.00610104
PERP PERP, TP53 apoptosis effector 0.00609089
CD59 CD59 molecule, complement regulatory protein 0.00607229
CCK cholecystokinin 0.00600516
ETHE1 ethylmalonic encephalopathy 1 0.00598866
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.00598719
RAB4A RAB4A, member RAS oncogene family 0.00597224
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.00594782
ASRGL1 asparaginase like 1 0.00594316
SPARCL1 SPARC-like 1 (hevin) 0.00593697
RGS10 regulator of G-protein signaling 10 0.00593318
ADAM28 ADAM metallopeptidase domain 28 0.00590578
BLNK B-cell linker 0.00590373
BSPRY B-box and SPRY domain containing 0.00587619
ADD3 adducin 3 (gamma) 0.00584242
TCL1A T-cell leukemia/lymphoma 1A 0.00583725
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.005822
MMP12 matrix metallopeptidase 12 0.00581758
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.00580374
NPY neuropeptide Y 0.00579319
PLPP3 phospholipid phosphatase 3 0.00579315
SERINC5 serine incorporator 5 0.00578323
OSR2 odd-skipped related transciption factor 2 0.00577722
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.00576206
AK4 adenylate kinase 4 0.00574782
CCDC170 coiled-coil domain containing 170 0.00574181
CAB39 calcium binding protein 39 0.00573379
TACSTD2 tumor-associated calcium signal transducer 2 0.00571245
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.00570704
NIP7 NIP7, nucleolar pre-rRNA processing protein 0.00569646
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0056903
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.00568183
CRISP3 cysteine-rich secretory protein 3 0.00567814
HMGA1 high mobility group AT-hook 1 0.00565634
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0.00564566
RBM47 RNA binding motif protein 47 0.00560404
C9ORF116 chromosome 9 open reading frame 116 0.00558957
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.00558244
IL10RB interleukin 10 receptor, beta 0.00557323
ANXA2 annexin A2 0.00556122
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.00556117
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 0.00555454
RBBP8 retinoblastoma binding protein 8 0.00554967
KRT19 keratin 19, type I 0.00553998
IFITM1 interferon induced transmembrane protein 1 0.00553835
PLIN3 perilipin 3 0.00552393
TXN thioredoxin 0.00552203
EXOC5 exocyst complex component 5 0.00550827
ALAD aminolevulinate dehydratase 0.00550011
CREB3L1 cAMP responsive element binding protein 3-like 1 0.00549265
EHF ets homologous factor 0.005489
PSD3 pleckstrin and Sec7 domain containing 3 0.00547266
OXTR oxytocin receptor 0.00545204
HBS1L HBS1-like translational GTPase 0.00544224
BIK BCL2-interacting killer (apoptosis-inducing) 0.0054379
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.0054357
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.00542571
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00541093
SMCO4 single-pass membrane protein with coiled-coil domains 4 0.00540862
NPC2 Niemann-Pick disease, type C2 0.00540102
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.00538592
FABP7 fatty acid binding protein 7, brain 0.00537927
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 0.00537237
KIAA0226L KIAA0226-like 0.00536302
SYNJ2 synaptojanin 2 0.00535506
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 0.00533774
DNM1L dynamin 1-like 0.00533619
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00533612
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00532607
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.00531505
DLG5 discs, large homolog 5 (Drosophila) 0.00531035
TFDP1 transcription factor Dp-1 0.00530399
COL1A2 collagen, type I, alpha 2 0.00528701
EPHB4 EPH receptor B4 0.00528545
VSNL1 visinin-like 1 0.00528507
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 0.00528291
IFRD2 interferon-related developmental regulator 2 0.00527682
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.00526762
SLC44A4 solute carrier family 44, member 4 0.00526349
METRN meteorin, glial cell differentiation regulator 0.00526193
ANO10 anoctamin 10 0.0052619
UBAC1 UBA domain containing 1 0.0052556
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.00525522
KRT5 keratin 5, type II 0.00525499
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.00525348
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.00522095
CLDN8 claudin 8 0.00521841
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00520045
DOK5 docking protein 5 0.00519827
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.00517563
CBR3 carbonyl reductase 3 0.00516363
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.00515706
KRT15 keratin 15, type I 0.00515102
DENND2D DENN/MADD domain containing 2D 0.00514892
ANXA11 annexin A11 0.00513646
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.00513522
VPREB1 pre-B lymphocyte 1 0.00512552
FPGS folylpolyglutamate synthase 0.00512155
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.00511598
MAP7 microtubule-associated protein 7 0.00511102
IRF6 interferon regulatory factor 6 0.00511068
EIF6 eukaryotic translation initiation factor 6 0.00510597
TRAM1 translocation associated membrane protein 1 0.00510227
CTSH cathepsin H 0.00510174
GCAT glycine C-acetyltransferase 0.00509832
IGLL1 immunoglobulin lambda-like polypeptide 1 0.00507973
TMEM176A transmembrane protein 176A 0.00507809
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.00507012
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.00506562
MPP1 membrane protein, palmitoylated 1, 55kDa 0.00505902
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0050545
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.00504729
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.00504509
NDP Norrie disease (pseudoglioma) 0.00504385
EYA2 EYA transcriptional coactivator and phosphatase 2 0.00503981
LRRC23 leucine rich repeat containing 23 0.00503965
ANTXR1 anthrax toxin receptor 1 0.00503226
ACOX2 acyl-CoA oxidase 2, branched chain 0.00502862
EIF3D eukaryotic translation initiation factor 3, subunit D 0.00502862
MSX1 msh homeobox 1 0.00502359
CCDC81 coiled-coil domain containing 81 0.00501271
COG7 component of oligomeric golgi complex 7 0.00500995
C1RL complement component 1, r subcomponent-like 0.00499785
EIF5A eukaryotic translation initiation factor 5A 0.00499255
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.00498305
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 0.00497493
CHKB choline kinase beta 0.00496408
MAGEA12 melanoma antigen family A12 0.00495828
GMDS GDP-mannose 4,6-dehydratase 0.0049523
CD44 CD44 molecule (Indian blood group) 0.00494739
BAG2 BCL2-associated athanogene 2 0.00493285
PLEKHS1 pleckstrin homology domain containing, family S member 1 0.00492321
FAM169A family with sequence similarity 169, member A 0.00492272
FYB1 FYN binding protein 1 0.00491174
GFAP glial fibrillary acidic protein 0.00490699
SPA17 sperm autoantigenic protein 17 0.00490146
ZYX zyxin 0.00490094
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.00489616
PTBP3 polypyrimidine tract binding protein 3 0.00489338
CLEC11A C-type lectin domain family 11, member A 0.00488588
TFRC transferrin receptor 0.00487095
TANK TRAF family member-associated NFKB activator 0.00486738
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.00485379
EIF4B eukaryotic translation initiation factor 4B 0.0048521

decreased expression

Symbol Name Standardized Value
ADIRF adipogenesis regulatory factor -0.0158202
SLC38A1 solute carrier family 38, member 1 -0.0144087
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.0140586
CXCL14 chemokine (C-X-C motif) ligand 14 -0.013838
NPTX2 neuronal pentraxin II -0.0123763
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0122896
FRZB frizzled-related protein -0.0112532
JCHAIN joining chain of multimeric IgA and IgM -0.0107717
TPSAB1 tryptase alpha/beta 1 -0.0100889
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0100126
STK10 serine/threonine kinase 10 -0.00956528
TXNDC9 thioredoxin domain containing 9 -0.00933633
TFPI2 tissue factor pathway inhibitor 2 -0.00927771
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.00921554
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -0.00917248
CADM1 cell adhesion molecule 1 -0.00885026
ADGRF5 adhesion G protein-coupled receptor F5 -0.00857856
ZBTB20 zinc finger and BTB domain containing 20 -0.00827572
TMEM45A transmembrane protein 45A -0.00818467
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0081714
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00779066
PLIN2 perilipin 2 -0.00777736
PDE10A phosphodiesterase 10A -0.00773385
ADGRG6 adhesion G protein-coupled receptor G6 -0.00772982
SPINK1 serine peptidase inhibitor, Kazal type 1 -0.00769604
DCHS1 dachsous cadherin-related 1 -0.00766706
AIM2 absent in melanoma 2 -0.00766221
CLEC2B C-type lectin domain family 2, member B -0.00765544
GPX2 glutathione peroxidase 2 -0.00760974
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.00756612
MFSD10 major facilitator superfamily domain containing 10 -0.00754449
SOX11 SRY (sex determining region Y)-box 11 -0.00751706
ADGRL2 adhesion G protein-coupled receptor L2 -0.00750779
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 -0.00750763
CRABP1 cellular retinoic acid binding protein 1 -0.00749454
GPM6B glycoprotein M6B -0.00745223
CENPE centromere protein E, 312kDa -0.00740336
PCDH17 protocadherin 17 -0.00725138
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.00723772
LOC283683 uncharacterized LOC283683 -0.00719642
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.00714222
FABP4 fatty acid binding protein 4, adipocyte -0.0070527
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -0.00701381
MFAP4 microfibrillar-associated protein 4 -0.00700964
GLS glutaminase -0.00695554
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00695134
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.00694618
KIAA0100 KIAA0100 -0.00693038
GAL galanin/GMAP prepropeptide -0.00687443
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.00674814
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.00674226
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -0.00672461
BANP BTG3 associated nuclear protein -0.0067061
NVL nuclear VCP-like -0.00668288
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -0.00667822
GPX3 glutathione peroxidase 3 -0.00661711
GSTA1 glutathione S-transferase alpha 1 -0.00658709
LIMCH1 LIM and calponin homology domains 1 -0.00658072
HOXD1 homeobox D1 -0.00655557
SPINK4 serine peptidase inhibitor, Kazal type 4 -0.00654915
MBNL2 muscleblind-like splicing regulator 2 -0.00653374
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00650703
RASIP1 Ras interacting protein 1 -0.00639464
ZNF512B zinc finger protein 512B -0.00637292
REG1A regenerating islet-derived 1 alpha -0.00635886
GUSB glucuronidase, beta -0.00633988
NID1 nidogen 1 -0.00633419
NDNF neuron-derived neurotrophic factor -0.00633391
KIF20A kinesin family member 20A -0.00629667
TENT5A terminal nucleotidyltransferase 5A -0.00629053
DYNLL1 dynein, light chain, LC8-type 1 -0.00628976
FBLN1 fibulin 1 -0.00628714
KDR kinase insert domain receptor -0.00628369
TSPYL2 TSPY-like 2 -0.00627303
CD34 CD34 molecule -0.00627073
CLEC3B C-type lectin domain family 3, member B -0.00625841
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00625553
NIT1 nitrilase 1 -0.00623292
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.00622515
ARID4B AT rich interactive domain 4B (RBP1-like) -0.00621544
HSPB8 heat shock 22kDa protein 8 -0.00620287
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -0.00620172
CTSA cathepsin A -0.00620026
ANK2 ankyrin 2, neuronal -0.00615051
DUSP1 dual specificity phosphatase 1 -0.00612985
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.00612823
CIDEC cell death-inducing DFFA-like effector c -0.00612182
MYLK myosin light chain kinase -0.00608348
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -0.00605581
GOLGA8H golgin A8 family, member H -0.00601775
OLFML2A olfactomedin-like 2A -0.00601483
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.00600826
TASOR2 transcription activation suppressor family member 2 -0.00600318
GUSBP3 glucuronidase, beta pseudogene 3 -0.00599728
TMEM204 transmembrane protein 204 -0.00599518
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.00599032
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -0.00598711
PFDN4 prefoldin subunit 4 -0.00598669
DDR2 discoidin domain receptor tyrosine kinase 2 -0.00597881
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -0.00597675
NDE1 nudE neurodevelopment protein 1 -0.0059722
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -0.00597019
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.00595992
THBD thrombomodulin -0.00594383
MYH11 myosin, heavy chain 11, smooth muscle -0.00593258
FLT1 fms-related tyrosine kinase 1 -0.00591954
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.00586819
CRYAB crystallin, alpha B -0.00585267
TSC22D2 TSC22 domain family, member 2 -0.005845
CLC Charcot-Leyden crystal galectin -0.0058175
SOD3 superoxide dismutase 3, extracellular -0.00580372
ZNF532 zinc finger protein 532 -0.00579945
ADIPOQ adiponectin, C1Q and collagen domain containing -0.00579899
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -0.00578794
PTGER4 prostaglandin E receptor 4 (subtype EP4) -0.00577914
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00576594
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00575988
DDIT3 DNA-damage-inducible transcript 3 -0.00574137
ABLIM3 actin binding LIM protein family, member 3 -0.00569696
MGLL monoglyceride lipase -0.00568056
DEFA5 defensin, alpha 5, Paneth cell-specific -0.00566603
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.00566305
ECHDC3 enoyl CoA hydratase domain containing 3 -0.005643
MALL mal, T-cell differentiation protein-like -0.00562315
CCDC92 coiled-coil domain containing 92 -0.0056113
CAVIN3 caveolae associated protein 3 -0.00560348
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -0.00558516
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.00558367
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -0.00557461
RGS16 regulator of G-protein signaling 16 -0.00555603
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.00554291
CREM cAMP responsive element modulator -0.00553396
GTPBP2 GTP binding protein 2 -0.00552118
TM4SF1 transmembrane 4 L six family member 1 -0.00550744
CIT citron rho-interacting serine/threonine kinase -0.00550408
MIA melanoma inhibitory activity -0.00550291
ZNF160 zinc finger protein 160 -0.00549255
MMP2 matrix metallopeptidase 2 -0.00548601
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.00547606
TEK TEK tyrosine kinase, endothelial -0.00546051
PDE4D phosphodiesterase 4D, cAMP-specific -0.00545818
DEFB4A defensin, beta 4A -0.00544529
LONP2 lon peptidase 2, peroxisomal -0.00544364
DCT dopachrome tautomerase -0.00544327
PFDN2 prefoldin subunit 2 -0.00544077
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.00543885
CREBBP CREB binding protein -0.00543598
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 -0.00543372
RPL10 ribosomal protein L10 -0.00542843
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -0.00542553
SLC16A4 solute carrier family 16, member 4 -0.0054211
CYFIP2 cytoplasmic FMR1 interacting protein 2 -0.00541928
CHIC2 cysteine-rich hydrophobic domain 2 -0.00541495
EFS embryonal Fyn-associated substrate -0.00540963
DACH1 dachshund family transcription factor 1 -0.00540178
EMP2 epithelial membrane protein 2 -0.00538635
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.00538338
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -0.0053739
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -0.00537043
PLXND1 plexin D1 -0.00536857
SRRM2 serine/arginine repetitive matrix 2 -0.00534365
TLE4 transducin-like enhancer of split 4 -0.00533309
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.00530775
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00529307
RELN reelin -0.00529267
HK2 hexokinase 2 -0.00529159
SYNPO synaptopodin -0.00528644
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -0.00528458
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.00527965
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.00526676
KDM5D lysine (K)-specific demethylase 5D -0.00524703
REG1B regenerating islet-derived 1 beta -0.00523491
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -0.00522439
SOX10 SRY (sex determining region Y)-box 10 -0.00522019
PLIN1 perilipin 1 -0.00519866
ANXA4 annexin A4 -0.00517346
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.00516446
RCAN2 regulator of calcineurin 2 -0.00515833
GPC3 glypican 3 -0.00515519
KRT20 keratin 20, type I -0.0051503
SORBS1 sorbin and SH3 domain containing 1 -0.0051364
COL14A1 collagen, type XIV, alpha 1 -0.0051158
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -0.00511456
MT1M metallothionein 1M -0.00509346
PTCH1 patched 1 -0.00508627
PRRC2C proline-rich coiled-coil 2C -0.00508519
SFRP1 secreted frizzled-related protein 1 -0.00505758
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.00503697
CAV1 caveolin 1, caveolae protein, 22kDa -0.00502978
CD200 CD200 molecule -0.00502282
FAM13B family with sequence similarity 13, member B -0.00499709
NCAM1 neural cell adhesion molecule 1 -0.00498782
NOTCH2NL notch 2 N-terminal like -0.004978
HSPG2 heparan sulfate proteoglycan 2 -0.00497202
GSTA4 glutathione S-transferase alpha 4 -0.00497032
CDK11A cyclin-dependent kinase 11A -0.00495816
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.00495544
ZEB1 zinc finger E-box binding homeobox 1 -0.00495477
EFNA5 ephrin-A5 -0.00493066
ATP9A ATPase, class II, type 9A -0.00492865
RGS13 regulator of G-protein signaling 13 -0.00492791
AKAP8 A kinase (PRKA) anchor protein 8 -0.00492584
STMN2 stathmin 2 -0.00492025
PAN2 PAN2 poly(A) specific ribonuclease subunit -0.00491863
NEMP1 nuclear envelope integral membrane protein 1 -0.00491625
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.00491245
P3H2 prolyl 3-hydroxylase 2 -0.00490425
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.00490333
RGS5 regulator of G-protein signaling 5 -0.00489613
MX2 MX dynamin-like GTPase 2 -0.0048856
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00488282
TWIST1 twist family bHLH transcription factor 1 -0.0048819
RGS1 regulator of G-protein signaling 1 -0.00485776
FBXW12 F-box and WD repeat domain containing 12 -0.00485548
TSPYL5 TSPY-like 5 -0.00483189
TRIO trio Rho guanine nucleotide exchange factor -0.00482929
ACACB acetyl-CoA carboxylase beta -0.00482366
DUOX2 dual oxidase 2 -0.00481804
YTHDC2 YTH domain containing 2 -0.00481534
CDH5 cadherin 5, type 2 (vascular endothelium) -0.00480913
ZFAND6 zinc finger, AN1-type domain 6 -0.00480192
LRRC32 leucine rich repeat containing 32 -0.00480166
TRIB3 tribbles pseudokinase 3 -0.00479676
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.00479375
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.00478907
TUBB2B tubulin, beta 2B class IIb -0.00478854
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.00478652
PMEL premelanosome protein -0.00477742
XPO6 exportin 6 -0.00477149
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -0.0047583
CHRDL1 chordin-like 1 -0.00475055
ADCY9 adenylate cyclase 9 -0.0047505
SLC38A2 solute carrier family 38, member 2 -0.00474785
SRSF7 serine/arginine-rich splicing factor 7 -0.00473157
TNS2 tensin 2 -0.00472926
MEIS2 Meis homeobox 2 -0.0047237
COMP cartilage oligomeric matrix protein -0.00471796
XYLT1 xylosyltransferase I -0.00468913
PRELP proline/arginine-rich end leucine-rich repeat protein -0.00465772
MN1 meningioma (disrupted in balanced translocation) 1 -0.00464822
EDNRB endothelin receptor type B -0.00463214
REV1 REV1, polymerase (DNA directed) -0.00461276
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.0046095
PDZD2 PDZ domain containing 2 -0.00459885
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.00459598
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.00458771
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.00458758
JADE1 jade family PHD finger 1 -0.00458521