TBP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description TATA box binding protein|Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010] (NCBI Entrez Gene Database, 6908)
External Link http://www.ncbi.nlm.nih.gov/gene/6908
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231 interacting proteins for TBP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABT1 activator of basal transcription 1
AFF1 AF4/FMR2 family, member 1
AFF4 AF4/FMR2 family, member 4
AHR aryl hydrocarbon receptor
AR androgen receptor
ATF4 activating transcription factor 4
ATXN7 ataxin 7
BAX BCL2-associated X protein
BCL3 B-cell CLL/lymphoma 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
BPTF bromodomain PHD finger transcription factor
BRD2 bromodomain containing 2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBX5 chromobox homolog 5
CBX8 chromobox homolog 8
CCNT1 cyclin T1
CCNT2 cyclin T2
CD3EAP CD3e molecule, epsilon associated protein
CDK19 cyclin-dependent kinase 19
CDK8 cyclin-dependent kinase 8
CDK9 cyclin-dependent kinase 9
CENPB centromere protein B, 80kDa
CHD1 chromodomain helicase DNA binding protein 1
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL26A1 collagen, type XXVI, alpha 1
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
CREBBP CREB binding protein
CREG1 cellular repressor of E1A-stimulated genes 1
CREM cAMP responsive element modulator
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CXXC1 CXXC finger protein 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
EAF1 ELL associated factor 1
EAF2 ELL associated factor 2
EDF1 endothelial differentiation-related factor 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELL elongation factor RNA polymerase II
ELL2 elongation factor, RNA polymerase II, 2
ELL3 elongation factor RNA polymerase II-like 3
EP300 E1A binding protein p300
ERCC1 excision repair cross-complementation group 1
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
FATE1 fetal and adult testis expressed 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXF2 forkhead box F2
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GLI2 GLI family zinc finger 2
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2A1L general transcription factor IIA, 1-like
GTF2A2 general transcription factor IIA, 2, 12kDa
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAP1 huntingtin-associated protein 1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGB1 high mobility group box 1
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSF1 heat shock transcription factor 1
HTT huntingtin
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
IPO5 importin 5
JMY junction mediating and regulatory protein, p53 cofactor
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KDM5A lysine (K)-specific demethylase 5A
KLF5 Kruppel-like factor 5 (intestinal)
LARP7 La ribonucleoprotein domain family, member 7
MBD3 methyl-CpG binding domain protein 3
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MED10 mediator complex subunit 10
MED12 mediator complex subunit 12
MED13L mediator complex subunit 13-like
MED14 mediator complex subunit 14
MED16 mediator complex subunit 16
MED17 mediator complex subunit 17
MED20 mediator complex subunit 20
MED21 mediator complex subunit 21
MED23 mediator complex subunit 23
MED25 mediator complex subunit 25
MED26 mediator complex subunit 26
MED27 mediator complex subunit 27
MED4 mediator complex subunit 4
MED8 mediator complex subunit 8
MEF2A myocyte enhancer factor 2A
MKX mohawk homeobox
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MSX1 msh homeobox 1
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTA3 metastasis associated 1 family, member 3
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFYB nuclear transcription factor Y, beta
NFYC nuclear transcription factor Y, gamma
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAX3 paired box 3
PAX5 paired box 5
PAX6 paired box 6
PCGF2 polycomb group ring finger 2
PHF8 PHD finger protein 8
PIAS1 protein inhibitor of activated STAT, 1
PIAS3 protein inhibitor of activated STAT, 3
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POU2F1 POU class 2 homeobox 1
POU2F2 POU class 2 homeobox 2
POU3F2 POU class 3 homeobox 2
PPAN peter pan homolog (Drosophila)
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RING1 ring finger protein 1
RNF4 ring finger protein 4
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
RXRA retinoid X receptor, alpha
SET SET nuclear proto-oncogene
SETD7 SET domain containing (lysine methyltransferase) 7
SIN3A SIN3 transcription regulator family member A
SIRT1 sirtuin 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SUB1 SUB1 homolog (S. cerevisiae)
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBPL1 TBP-like 1
TCEA1 transcription elongation factor A (SII), 1
TCF12 transcription factor 12
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TP53 tumor protein p53
TRAM2 translocation associated membrane protein 2
TRIP4 thyroid hormone receptor interactor 4
TRRAP transformation/transcription domain-associated protein
TTF1 transcription termination factor, RNA polymerase I
TWISTNB TWIST neighbor
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBTF upstream binding transcription factor, RNA polymerase I
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USP11 ubiquitin specific peptidase 11
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR62 WD repeat domain 62
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF76 zinc finger protein 76