TBX3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description T-box 3|This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6926)
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Genes

244 genes differentially expressed following the TBX3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.35593
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.35593
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.35593
PDZD9 PDZ domain containing 9 2.35593
MTTP microsomal triglyceride transfer protein 2.35593
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.35593
ASB17 ankyrin repeat and SOCS box containing 17 2.35593
GYPC glycophorin C (Gerbich blood group) 2.35593
GPR22 G protein-coupled receptor 22 2.35593
MYOM3 myomesin 3 2.35593
TCHH trichohyalin 2.35593
ECEL1 endothelin converting enzyme-like 1 2.35593
IL4I1 interleukin 4 induced 1 2.35593
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.35593
CD274 CD274 molecule 2.35593
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.35593
PTX3 pentraxin 3, long 2.35593
CELF3 CUGBP, Elav-like family member 3 2.35593
TRIM10 tripartite motif containing 10 2.35593
PCDHB1 protocadherin beta 1 2.35593
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.35593
TSC22D1 TSC22 domain family, member 1 2.35593
SFTPD surfactant protein D 2.35593
TDRD6 tudor domain containing 6 2.35593
MRPL22 mitochondrial ribosomal protein L22 2.35593
HMX3 H6 family homeobox 3 2.35593
NMUR2 neuromedin U receptor 2 2.35593
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.35593
PRDM8 PR domain containing 8 2.35593
PMCH pro-melanin-concentrating hormone 2.35593
LHX6 LIM homeobox 6 2.35593
FGF6 fibroblast growth factor 6 2.35593
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.35593
CORO6 coronin 6 2.35593
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.35593
MGARP mitochondria-localized glutamic acid-rich protein 2.35593
RGPD3 RANBP2-like and GRIP domain containing 3 2.35593
OR51L1 olfactory receptor, family 51, subfamily L, member 1 2.35593
CRH corticotropin releasing hormone 2.35593
TTLL2 tubulin tyrosine ligase-like family member 2 2.35593
PCGF2 polycomb group ring finger 2 2.35593
DLL4 delta-like 4 (Drosophila) 2.35593
HEPHL1 hephaestin-like 1 2.35593
U2SURP U2 snRNP-associated SURP domain containing 2.35593
BTBD19 BTB (POZ) domain containing 19 2.35593
SIX1 SIX homeobox 1 2.35593
PPIAP39 peptidylprolyl isomerase A pseudogene 39 2.35593
NSG2 neuronal vesicle trafficking associated 2 2.35593
HBG1 hemoglobin, gamma A 2.35593
MT3 metallothionein 3 2.35593
KY kyphoscoliosis peptidase 2.35593
YPEL4 yippee-like 4 (Drosophila) 2.35593
MCHR1 melanin-concentrating hormone receptor 1 2.35593
GPX5 glutathione peroxidase 5 2.35593
SCEL sciellin 2.35593
FMO1 flavin containing monooxygenase 1 2.35593
PLPP4 phospholipid phosphatase 4 2.35593
RTL5 retrotransposon Gag like 5 2.35593
CSP2 CS pseudogene 2 2.35593
REELD1 reeler domain containing 1 2.35593
H2BK1 H2B.K variant histone 1 2.35593
EZHIP EZH inhibitory protein 2.35593
HOATZ HOATZ cilia and flagella associated protein 2.35593
CFAP107 cilia and flagella associated protein 107 2.35593
ZNF723 zinc finger protein 723 2.35593
DYNLT4 dynein light chain Tctex-type 4 2.35593
RNF227 ring finger protein 227 2.35593
NEURL1 neuralized E3 ubiquitin protein ligase 1 2.35593
OR2I1 olfactory receptor family 2 subfamily I member 1 (gene/pseudogene) 2.35593
SPATA22 spermatogenesis associated 22 2.35593
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.35593
CLEC3A C-type lectin domain family 3, member A 2.35593
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.35593
VIT vitrin 2.35593
TUBA3D tubulin, alpha 3d 2.35593
PCDHB11 protocadherin beta 11 2.35593
PCDHB14 protocadherin beta 14 2.35593
ATP13A5 ATPase type 13A5 2.35593
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.35593
ZIC4 Zic family member 4 2.35593
TFEC transcription factor EC 2.35593
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.35593
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.35593
CLEC6A C-type lectin domain family 6, member A 2.35593
GPR85 G protein-coupled receptor 85 2.35593
LRRC71 leucine rich repeat containing 71 2.35593
S100G S100 calcium binding protein G 2.35593
EXOC3L1 exocyst complex component 3-like 1 2.35593
PRR18 proline rich 18 2.35593
CFAP45 cilia and flagella associated protein 45 2.35593
HBA2 hemoglobin, alpha 2 2.35593
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.35593
IP6K3 inositol hexakisphosphate kinase 3 2.35593
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.35593
POU2AF1 POU class 2 associating factor 1 2.35593
LGALS12 lectin, galactoside-binding, soluble, 12 2.35593
FOXF1 forkhead box F1 2.35593
WFDC8 WAP four-disulfide core domain 8 2.35593
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.35593
PCDHAC2 protocadherin alpha subfamily C, 2 2.35593
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.35593
KLF2 Kruppel-like factor 2 2.35593
RPP40 ribonuclease P/MRP 40kDa subunit 2.35593
C11ORF97 chromosome 11 open reading frame 97 2.35593
PLA2G5 phospholipase A2, group V 2.35593
KLHL1 kelch-like family member 1 2.35593
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.35593
CDC20B cell division cycle 20B 2.35593
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.35593
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.35593
LEUTX leucine twenty homeobox 2.35593
C17ORF99 chromosome 17 open reading frame 99 2.35593
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.35593
PRSS33 protease, serine, 33 2.35593
NTN5 netrin 5 2.35593
ITGB6 integrin, beta 6 2.35593
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.35593
PSG9 pregnancy specific beta-1-glycoprotein 9 2.35593
HK3 hexokinase 3 (white cell) 2.35593
SAMD5 sterile alpha motif domain containing 5 2.35593
ZNF843 zinc finger protein 843 2.35593
FAM135B family with sequence similarity 135, member B 2.35593
SST somatostatin 2.35593
FAT2 FAT atypical cadherin 2 2.35593
QRFP pyroglutamylated RFamide peptide 2.35593
TRIM7 tripartite motif containing 7 2.35593
CFAP126 cilia and flagella associated protein 126 2.35593
DHH desert hedgehog 2.35593
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.35593
ISL2 ISL LIM homeobox 2 2.35593
SYT5 synaptotagmin V 2.35593
ERICH4 glutamate-rich 4 2.35593
TCEA3 transcription elongation factor A (SII), 3 2.35593
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.35593
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.35593
IL10RB interleukin 10 receptor, beta 2.35593
CCDC166 coiled-coil domain containing 166 2.35593
SDSL serine dehydratase-like 2.35593
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.35593
TRHR thyrotropin-releasing hormone receptor 2.35593
AQP1 aquaporin 1 (Colton blood group) 2.35593
ITGA8 integrin, alpha 8 2.35593
NKPD1 NTPase, KAP family P-loop domain containing 1 2.35593
HMBOX1 homeobox containing 1 2.35593
ANPEP alanyl (membrane) aminopeptidase 2.35593
BOD1L2 biorientation of chromosomes in cell division 1-like 2 2.35593
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.35593
ABRA actin binding Rho activating protein 2.35593
FXYD3 FXYD domain containing ion transport regulator 3 2.35593
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.35593
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.35593
LAMP3 lysosomal-associated membrane protein 3 2.35593
SCIN scinderin 2.35593
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2.35593
CCL27 chemokine (C-C motif) ligand 27 2.35593
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 2.35593
CCDC170 coiled-coil domain containing 170 2.35593
BHLHA15 basic helix-loop-helix family, member a15 2.35593
BRDT bromodomain, testis-specific 2.35593
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.35593
TBC1D26 TBC1 domain family, member 26 2.35593
ITGAD integrin, alpha D 2.35593
STMND1 stathmin domain containing 1 2.35593
PLGLB2 plasminogen-like B2 2.35593
R3HCC1L R3H domain and coiled-coil containing 1-like 2.35593
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.35593
FBXL14 F-box and leucine-rich repeat protein 14 2.35593
USPL1 ubiquitin specific peptidase like 1 2.35224
RPP30 ribonuclease P/MRP 30kDa subunit 2.33224
DLAT dihydrolipoamide S-acetyltransferase 2.32824
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 2.2437
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 2.23966
ING4 inhibitor of growth family, member 4 2.22112
CNTNAP3 contactin associated protein-like 3 2.2092
KCTD2 potassium channel tetramerization domain containing 2 2.20078
INSR insulin receptor 2.19047
SPATA1 spermatogenesis associated 1 2.18536
ANGPT1 angiopoietin 1 2.16588
BOC BOC cell adhesion associated, oncogene regulated 2.1658
SCAF11 SR-related CTD-associated factor 11 2.15908
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.15192
CCNT1 cyclin T1 2.14838
EOLA2 endothelium and lymphocyte associated ASCH domain 2 2.14533
ZSCAN5A zinc finger and SCAN domain containing 5A 2.1005
ZNF33B zinc finger protein 33B 2.09931
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.094
MAP3K12 mitogen-activated protein kinase kinase kinase 12 2.094
TOP1 topoisomerase (DNA) I 2.094
MAML3 mastermind-like 3 (Drosophila) 2.094
MLPH melanophilin 2.08399
ANKRD13A ankyrin repeat domain 13A 2.07278
GPS2 G protein pathway suppressor 2 2.06905
UBE2K ubiquitin-conjugating enzyme E2K 2.05035
TMEM65 transmembrane protein 65 2.04602
EIF3C eukaryotic translation initiation factor 3, subunit C 2.02293
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.01306
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 2.01306

decreased expression

Symbol Name Standardized Value
FCSK fucose kinase -2.35593
NBPF9 neuroblastoma breakpoint family, member 9 -2.35593
PIF1 PIF1 5'-to-3' DNA helicase -2.35593
RHOU ras homolog family member U -2.35593
ZBTB16 zinc finger and BTB domain containing 16 -2.35593
HBEGF heparin-binding EGF-like growth factor -2.35593
FAM229A family with sequence similarity 229, member A -2.35593
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 -2.35593
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.35593
UNC13B unc-13 homolog B (C. elegans) -2.35593
RIGI RNA sensor RIG-I -2.35593
CD7 CD7 molecule -2.35593
SBK2 SH3 domain binding kinase family, member 2 -2.35593
TUFM Tu translation elongation factor, mitochondrial -2.35593
NPIPB11 nuclear pore complex interacting protein family, member B11 -2.35593
JMJD7 jumonji domain containing 7 -2.35593
GLB1 galactosidase, beta 1 -2.35593
TIGD6 tigger transposable element derived 6 -2.35593
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.35593
SRSF11 serine/arginine-rich splicing factor 11 -2.35593
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.35593
PECR peroxisomal trans-2-enoyl-CoA reductase -2.35593
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -2.35593
TNXB tenascin XB -2.35593
NANS N-acetylneuraminic acid synthase -2.35593
KDM5C lysine (K)-specific demethylase 5C -2.33224
SDC3 syndecan 3 -2.33224
MAT2A methionine adenosyltransferase II, alpha -2.27
MEN1 multiple endocrine neoplasia I -2.21859
LMBR1L limb development membrane protein 1-like -2.18684
SFN stratifin -2.16831
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.16831
GTPBP1 GTP binding protein 1 -2.15908
GSK3A glycogen synthase kinase 3 alpha -2.11928
ZNF664-RFLNA ZNF664-RFLNA readthrough -2.1005
MAML1 mastermind-like 1 (Drosophila) -2.09467
COL10A1 collagen, type X, alpha 1 -2.094
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -2.08535
ATXN2L ataxin 2-like -2.08044
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) -2.07971
RNF170 ring finger protein 170 -2.07833
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.04516
TMEM107 transmembrane protein 107 -2.02368
MAP2K5 mitogen-activated protein kinase kinase 5 -2.02067
DAXX death-domain associated protein -2.02001
MZF1 myeloid zinc finger 1 -2.0086
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -2.00604