TBX5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description T-box 5|This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6910)
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Genes

365 genes differentially expressed following the TBX5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FOXD1 forkhead box D1 3.1418
ADRB2 adrenoceptor beta 2, surface 3.1418
CELA3A chymotrypsin-like elastase family, member 3A 3.1418
PKP1 plakophilin 1 3.1418
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 3.1418
SLC25A41 solute carrier family 25, member 41 3.1418
GJB1 gap junction protein, beta 1, 32kDa 3.1418
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 3.1418
PAX9 paired box 9 3.1418
EPHX4 epoxide hydrolase 4 3.1418
FOLR2 folate receptor 2 (fetal) 3.1418
ASB10 ankyrin repeat and SOCS box containing 10 3.1418
CD200R1L CD200 receptor 1-like 3.1418
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.1418
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.1418
SLC22A14 solute carrier family 22, member 14 3.1418
SYCP2 synaptonemal complex protein 2 3.1418
KLHL35 kelch-like family member 35 3.1418
TMEM212 transmembrane protein 212 3.1418
HRH4 histamine receptor H4 3.1418
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.1418
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.1418
VTN vitronectin 3.1418
ADGRE1 adhesion G protein-coupled receptor E1 3.1418
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.1418
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.1418
LIM2 lens intrinsic membrane protein 2, 19kDa 3.1418
AVP arginine vasopressin 3.1418
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.1418
NMUR2 neuromedin U receptor 2 3.1418
HIC1 hypermethylated in cancer 1 3.1418
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.1418
CCDC87 coiled-coil domain containing 87 3.1418
RNASE6 ribonuclease, RNase A family, k6 3.1418
PRSS22 protease, serine, 22 3.1418
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.1418
ASCL3 achaete-scute family bHLH transcription factor 3 3.1418
NKPD1 NTPase, KAP family P-loop domain containing 1 3.1418
OXT oxytocin/neurophysin I prepropeptide 3.1418
MUC22 mucin 22 3.1418
CA6 carbonic anhydrase VI 3.1418
SP7 Sp7 transcription factor 3.1418
TRIM74 tripartite motif containing 74 3.1418
UBE2W ubiquitin-conjugating enzyme E2W (putative) 3.1418
LCN15 lipocalin 15 3.1418
RGPD3 RANBP2-like and GRIP domain containing 3 3.1418
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.1418
CELA1 chymotrypsin-like elastase family, member 1 3.1418
C8ORF74 chromosome 8 open reading frame 74 3.1418
YY2 YY2 transcription factor 3.1418
OR1D2 olfactory receptor, family 1, subfamily D, member 2 3.1418
ADAM29 ADAM metallopeptidase domain 29 3.1418
PCDHA3 protocadherin alpha 3 3.1418
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.1418
SMIM38 small integral membrane protein 38 3.1418
EPOP elongin BC and polycomb repressive complex 2 associated protein 3.1418
ERVW-1 endogenous retrovirus group W, member 1 3.1418
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 3.1418
MT3 metallothionein 3 3.1418
PTH1R parathyroid hormone 1 receptor 3.1418
GBP4 guanylate binding protein 4 3.1418
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 3.1418
SIM1 single-minded family bHLH transcription factor 1 3.1418
RHCG Rh family, C glycoprotein 3.1418
LOC122394732 uncharacterized LOC122394732 3.1418
MINAR2 membrane integral NOTCH2 associated receptor 2 3.1418
TAMALIN trafficking regulator and scaffold protein tamalin 3.1418
ZC3H11C zinc finger CCCH-type containing 11C 3.1418
SPEGNB SPEG neighbor 3.1418
AGA-DT AGA divergent transcript 3.1418
CIMAP1D CIMAP1 family member D 3.1418
H2BC12L H2B clustered histone 12 like 3.1418
SMIM43 small integral membrane protein 43 3.1418
H3C3 H3 clustered histone 3 3.1418
MEIOSIN meiosis initiator 3.1418
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.1418
DEUP1 deuterosome assembly protein 1 3.1418
TAFA3 TAFA chemokine like family member 3 3.1418
TMPRSS6 transmembrane protease, serine 6 3.1418
HR hair growth associated 3.1418
RASAL3 RAS protein activator like 3 3.1418
ZNF257 zinc finger protein 257 3.1418
NPIPB9 nuclear pore complex interacting protein family, member B9 3.1418
MSX1 msh homeobox 1 3.1418
C10ORF67 chromosome 10 open reading frame 67 3.1418
AMBP alpha-1-microglobulin/bikunin precursor 3.1418
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.1418
MAGEB1 melanoma antigen family B1 3.1418
PCDHB10 protocadherin beta 10 3.1418
PCDHB13 protocadherin beta 13 3.1418
TLE6 transducin-like enhancer of split 6 3.1418
EXOC3L4 exocyst complex component 3-like 4 3.1418
SBSN suprabasin 3.1418
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.1418
MAGIX MAGI family member, X-linked 3.1418
GATA3 GATA binding protein 3 3.1418
MLANA melan-A 3.1418
ZNF680 zinc finger protein 680 3.1418
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.1418
ASIC3 acid sensing (proton gated) ion channel 3 3.1418
PNPLA1 patatin-like phospholipase domain containing 1 3.1418
PLEK2 pleckstrin 2 3.1418
TAS1R2 taste receptor, type 1, member 2 3.1418
SAA1 serum amyloid A1 3.1418
PRB4 proline-rich protein BstNI subfamily 4 3.1418
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.1418
KLHL41 kelch-like family member 41 3.1418
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.1418
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.1418
SERINC4 serine incorporator 4 3.1418
MAMLD1 mastermind-like domain containing 1 3.1418
DRD2 dopamine receptor D2 3.1418
C2CD4B C2 calcium-dependent domain containing 4B 3.1418
C2CD4A C2 calcium-dependent domain containing 4A 3.1418
SHISA8 shisa family member 8 3.1418
MUC13 mucin 13, cell surface associated 3.1418
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.1418
KLF2 Kruppel-like factor 2 3.1418
CTAGE9 CTAGE family, member 9 3.1418
S100Z S100 calcium binding protein Z 3.1418
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.1418
PKLR pyruvate kinase, liver and RBC 3.1418
CPZ carboxypeptidase Z 3.1418
KRT3 keratin 3, type II 3.1418
LRRC46 leucine rich repeat containing 46 3.1418
MYF5 myogenic factor 5 3.1418
AKR1B15 aldo-keto reductase family 1, member B15 3.1418
ARHGAP20 Rho GTPase activating protein 20 3.1418
BTNL2 butyrophilin-like 2 3.1418
CXCR5 chemokine (C-X-C motif) receptor 5 3.1418
RANBP3L RAN binding protein 3-like 3.1418
ISL1 ISL LIM homeobox 1 3.1418
KLK12 kallikrein-related peptidase 12 3.1418
SOSTDC1 sclerostin domain containing 1 3.1418
CISH cytokine inducible SH2-containing protein 3.1418
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.1418
FLRT3 fibronectin leucine rich transmembrane protein 3 3.1418
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.1418
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.1418
CNR2 cannabinoid receptor 2 (macrophage) 3.1418
SFTA2 surfactant associated 2 3.1418
NPY2R neuropeptide Y receptor Y2 3.1418
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.1418
CFB complement factor B 3.1418
OR4D2 olfactory receptor, family 4, subfamily D, member 2 3.1418
PENK proenkephalin 3.1418
INSM1 insulinoma-associated 1 3.1418
COL6A5 collagen, type VI, alpha 5 3.1418
UTS2R urotensin 2 receptor 3.1418
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.1418
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.1418
GLRB glycine receptor, beta 3.1418
SMIM17 small integral membrane protein 17 3.1418
FCRLB Fc receptor-like B 3.1418
MAGED4B melanoma antigen family D4B 3.1418
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 3.1418
DLX1 distal-less homeobox 1 3.1418
NT5C1B 5'-nucleotidase, cytosolic IB 3.1418
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.1418
TCF21 transcription factor 21 3.1418
SNTN sentan, cilia apical structure protein 3.1418
CIB4 calcium and integrin binding family member 4 3.1418
CHRM1 cholinergic receptor, muscarinic 1 3.1418
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 3.1418
ABHD1 abhydrolase domain containing 1 3.1418
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.1418
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.1418
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 3.1418
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.1418
A1CF APOBEC1 complementation factor 3.1418
TEX38 testis expressed 38 3.1418
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.1418
PRND prion protein 2 (dublet) 3.1418
ZPLD1 zona pellucida-like domain containing 1 3.1418
AGBL4 ATP/GTP binding protein-like 4 3.1418
TESK1 testis-specific kinase 1 3.1418
CLCA1 chloride channel accessory 1 3.1418
CLPSL1 colipase-like 1 3.1418
ECM1 extracellular matrix protein 1 3.1418
PRSS55 protease, serine, 55 3.1418
ANAPC16 anaphase promoting complex subunit 16 3.12772
HMGN2 high mobility group nucleosomal binding domain 2 3.10215
RAB38 RAB38, member RAS oncogene family 3.09232
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 3.09232
BMP8A bone morphogenetic protein 8a 3.09232
FZD9 frizzled class receptor 9 3.09232
ENOX1 ecto-NOX disulfide-thiol exchanger 1 3.0922
SELENOK selenoprotein K 2.94726
CDH10 cadherin 10, type 2 (T2-cadherin) 2.86689
FBP2 fructose-1,6-bisphosphatase 2 2.86689
FTL ferritin, light polypeptide 2.83707
ATP5MC1 ATP synthase membrane subunit c locus 1 2.74986
SYT4 synaptotagmin IV 2.71014
TGFB3 transforming growth factor, beta 3 2.71014
CGN cingulin 2.70994
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.66932
G6PD glucose-6-phosphate dehydrogenase 2.66201
C9ORF40 chromosome 9 open reading frame 40 2.66201
LRRC40 leucine rich repeat containing 40 2.65988
LPP LIM domain containing preferred translocation partner in lipoma 2.63459
RPL21 ribosomal protein L21 2.63319
TADA1 transcriptional adaptor 1 2.57902
CCDC51 coiled-coil domain containing 51 2.52747
RAB4B RAB4B, member RAS oncogene family 2.52429
UBE2I ubiquitin-conjugating enzyme E2I 2.52278
EBI3 Epstein-Barr virus induced 3 2.51951
MANF mesencephalic astrocyte-derived neurotrophic factor 2.47495
CCNL2 cyclin L2 2.45424
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 2.43331
EPB41L2 erythrocyte membrane protein band 4.1-like 2 2.41638
LIX1L Lix1 homolog (chicken) like 2.41455
GSAP gamma-secretase activating protein 2.41455
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.39922
RPL7 ribosomal protein L7 2.39315
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.34541
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.32688
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.31535
FAM204A family with sequence similarity 204, member A 2.26625
H2AC6 H2A clustered histone 6 2.2584
C1ORF35 chromosome 1 open reading frame 35 2.2584
AFG3L2 AFG3-like AAA ATPase 2 2.25571
PAAF1 proteasomal ATPase-associated factor 1 2.24544
BLCAP bladder cancer associated protein 2.22446
NENF neudesin neurotrophic factor 2.20564
ZNF266 zinc finger protein 266 2.2021
MAP3K13 mitogen-activated protein kinase kinase kinase 13 2.18005
EXOC7 exocyst complex component 7 2.17238
VIPR1 vasoactive intestinal peptide receptor 1 2.14836
ANKRD24 ankyrin repeat domain 24 2.14836
MCOLN1 mucolipin 1 2.14069
EMC7 ER membrane protein complex subunit 7 2.14069
KIF2C kinesin family member 2C 2.12691
CTF1 cardiotrophin 1 2.12646
POU5F2 POU domain class 5, transcription factor 2 2.12646
FSCN3 fascin actin-bundling protein 3, testicular 2.12646
GIPC3 GIPC PDZ domain containing family, member 3 2.12646
KLHL34 kelch-like family member 34 2.12646
DLEC1 deleted in lung and esophageal cancer 1 2.12646
BRI3 brain protein I3 2.12577
FSD2 fibronectin type III and SPRY domain containing 2 2.11172
ZNF45 zinc finger protein 45 2.11172
EXOSC7 exosome component 7 2.11135
MMP9 matrix metallopeptidase 9 2.10442
PYGO1 pygopus family PHD finger 1 2.09836
C17ORF75 chromosome 17 open reading frame 75 2.08676
FBN1 fibrillin 1 2.07908
ETNPPL ethanolamine-phosphate phospho-lyase 2.07896
ZFHX3 zinc finger homeobox 3 2.07361
NRP2 neuropilin 2 2.06514
AMOT angiomotin 2.05075
PARL presenilin associated, rhomboid-like 2.05022
HINT2 histidine triad nucleotide binding protein 2 2.04073
DMAC2L distal membrane arm assembly component 2 like 2.03439
DCAF11 DDB1 and CUL4 associated factor 11 2.01836
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.01518
MRPL24 mitochondrial ribosomal protein L24 2.01337
RPL23A ribosomal protein L23a 2.01256
RPS24 ribosomal protein S24 2.01256
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.00461
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 2.0015

decreased expression

Symbol Name Standardized Value
BROX BRO1 domain and CAAX motif containing -3.1418
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.1418
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -3.1418
NEK5 NIMA-related kinase 5 -3.1418
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.1418
NPB neuropeptide B -3.1418
ZNF571 zinc finger protein 571 -3.1418
C2ORF69 chromosome 2 open reading frame 69 -3.1418
INO80B INO80 complex subunit B -3.1418
WDR5B WD repeat domain 5B -3.1418
SPESP1 sperm equatorial segment protein 1 -3.1418
ARGFX arginine-fifty homeobox -3.1418
MYL7 myosin, light chain 7, regulatory -3.1327
GPR87 G protein-coupled receptor 87 -3.1327
ZNF319 zinc finger protein 319 -3.1327
C17ORF78 chromosome 17 open reading frame 78 -3.1327
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -3.1327
OIT3 oncoprotein induced transcript 3 -3.1327
MTMR11 myotubularin related protein 11 -3.1327
DCST1 DC-STAMP domain containing 1 -3.1327
PLGLB1 plasminogen-like B1 -3.1327
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -3.1327
PARVG parvin, gamma -3.1327
FAM181B family with sequence similarity 181, member B -3.1327
CATSPERQ catsper channel auxiliary subunit theta -3.1327
RASA4 RAS p21 protein activator 4 -3.1327
PAQR9 progestin and adipoQ receptor family member IX -3.1327
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -3.1327
MOG myelin oligodendrocyte glycoprotein -3.1327
TMEM191C transmembrane protein 191C -3.1327
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.1327
SFTPB surfactant protein B -3.1327
MIXL1 Mix paired-like homeobox -3.1327
GLRA3 glycine receptor, alpha 3 -3.1327
LTB4R2 leukotriene B4 receptor 2 -3.1327
ALX3 ALX homeobox 3 -3.1327
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -3.1327
PCDHGA4 protocadherin gamma subfamily A, 4 -3.1327
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -3.1327
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.09139
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.98869
CAMLG calcium modulating ligand -2.86468
NRXN1 neurexin 1 -2.81655
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like -2.79219
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -2.76749
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.76749
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.72144
FGF12 fibroblast growth factor 12 -2.65988
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -2.65524
CTSV cathepsin V -2.65191
RAB40C RAB40C, member RAS oncogene family -2.60303
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -2.59155
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -2.52429
RHD Rh blood group, D antigen -2.4982
FOXN2 forkhead box N2 -2.47495
UBP1 upstream binding protein 1 (LBP-1a) -2.45424
EPAS1 endothelial PAS domain protein 1 -2.44639
KIF1C kinesin family member 1C -2.39311
AOPEP aminopeptidase O (putative) -2.35206
POLK polymerase (DNA directed) kappa -2.35206
ZSWIM8 zinc finger, SWIM-type containing 8 -2.34674
NUP133 nucleoporin 133kDa -2.34541
RUFY3 RUN and FYVE domain containing 3 -2.31509
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 -2.31179
HAUS7 HAUS augmin-like complex, subunit 7 -2.28293
AFAP1 actin filament associated protein 1 -2.20978
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.20978
MAST2 microtubule associated serine/threonine kinase 2 -2.20467
MBTPS2 membrane-bound transcription factor peptidase, site 2 -2.20467
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) -2.20467
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.18231
ATXN7L3B ataxin 7-like 3B -2.18005
SVOPL SVOP-like -2.17391
GPNMB glycoprotein (transmembrane) nmb -2.17298
TAC1 tachykinin, precursor 1 -2.16906
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -2.15387
CLCC1 chloride channel CLIC-like 1 -2.14069
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.14069
ZNF41 zinc finger protein 41 -2.13324
VEPH1 ventricular zone expressed PH domain-containing 1 -2.12691
SOD3 superoxide dismutase 3, extracellular -2.12598
TMEM219 transmembrane protein 219 -2.10762
PGRMC2 progesterone receptor membrane component 2 -2.09208
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.08676
GAL3ST3 galactose-3-O-sulfotransferase 3 -2.08212
EXD2 exonuclease 3'-5' domain containing 2 -2.07004
MRPS6 mitochondrial ribosomal protein S6 -2.05221
DGCR2 DiGeorge syndrome critical region gene 2 -2.05134
CFAP144 cilia and flagella associated protein 144 -2.05022
CDH26 cadherin 26 -2.05022
CCDC194 coiled-coil domain containing 194 -2.05022
SLC26A5 solute carrier family 26 (anion exchanger), member 5 -2.05022
COL11A2 collagen, type XI, alpha 2 -2.05022
LMO2 LIM domain only 2 (rhombotin-like 1) -2.05022
IRX3 iroquois homeobox 3 -2.05022
FBXL13 F-box and leucine-rich repeat protein 13 -2.05021
LOC124904942 uncharacterized LOC124904942 -2.04962
DST dystonin -2.03789
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -2.03757
TTC21B tetratricopeptide repeat domain 21B -2.03497
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -2.02018
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.02018
UTRN utrophin -2.01979
IFT54 intraflagellar transport 54 -2.01969
HK2 hexokinase 2 -2.01337