TBX6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description T-box 6|This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 6911)
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Genes

298 genes differentially expressed following the TBX6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GRM6 glutamate receptor, metabotropic 6 2.89185
ASB12 ankyrin repeat and SOCS box containing 12 2.89185
C19ORF67 chromosome 19 open reading frame 67 2.89185
SHCBP1L SHC SH2-domain binding protein 1-like 2.89185
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.89185
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 2.89185
ALPK2 alpha-kinase 2 2.89185
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.89185
SLC9C2 solute carrier family 9, member C2 (putative) 2.89185
XCL1 chemokine (C motif) ligand 1 2.89185
PAX9 paired box 9 2.89185
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.89185
NXPH4 neurexophilin 4 2.89185
MAGEA3 melanoma antigen family A3 2.89185
CD163 CD163 molecule 2.89185
RAX retina and anterior neural fold homeobox 2.89185
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.89185
ELSPBP1 epididymal sperm binding protein 1 2.89185
FFAR4 free fatty acid receptor 4 2.89185
GFI1 growth factor independent 1 transcription repressor 2.89185
NCKAP1L NCK-associated protein 1-like 2.89185
LGALS2 lectin, galactoside-binding, soluble, 2 2.89185
TSHZ1 teashirt zinc finger homeobox 1 2.89185
TMC8 transmembrane channel-like 8 2.89185
NMUR1 neuromedin U receptor 1 2.89185
PRDM1 PR domain containing 1, with ZNF domain 2.89185
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.89185
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.89185
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.89185
SETSIP SET-like protein 2.89185
PNOC prepronociceptin 2.89185
GUCY2F guanylate cyclase 2F, retinal 2.89185
TMEM217 transmembrane protein 217 2.89185
OCM2 oncomodulin 2 2.89185
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.89185
ACVRL1 activin A receptor type II-like 1 2.89185
LY6K lymphocyte antigen 6 complex, locus K 2.89185
LGI1 leucine-rich, glioma inactivated 1 2.89185
S100A5 S100 calcium binding protein A5 2.89185
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.89185
MAP3K7CL MAP3K7 C-terminal like 2.89185
OR6N1 olfactory receptor, family 6, subfamily N, member 1 2.89185
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.89185
KRT80 keratin 80, type II 2.89185
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.89185
TMPRSS4 transmembrane protease, serine 4 2.89185
RNF183 ring finger protein 183 2.89185
LRRN4CL LRRN4 C-terminal like 2.89185
TAS1R1 taste receptor, type 1, member 1 2.89185
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.89185
PHF24 PHD finger protein 24 2.89185
SPMAP2L sperm microtubule associated protein 2 like 2.89185
RBM33-DT RBM33 divergent transcript 2.89185
GNG5B G protein subunit gamma 5B 2.89185
FREY1 Frey regulator of sperm-oocyte fusion 1 2.89185
KASH5 KASH domain containing 5 2.89185
ANKRD40CL ANKRD40 C-terminal like 2.89185
ALPG alkaline phosphatase, germ cell 2.89185
VSIR V-set immunoregulatory receptor 2.89185
FGFBP1 fibroblast growth factor binding protein 1 2.89185
FMR1NB fragile X mental retardation 1 neighbor 2.89185
PCDHA7 protocadherin alpha 7 2.89185
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 2.89185
CD300LG CD300 molecule-like family member g 2.89185
PVRIG poliovirus receptor related immunoglobulin domain containing 2.89185
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.89185
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.89185
ASB15 ankyrin repeat and SOCS box containing 15 2.89185
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.89185
PCDHB13 protocadherin beta 13 2.89185
CFAP99 cilia and flagella associated protein 99 2.89185
PTH parathyroid hormone 2.89185
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.89185
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.89185
CFAP45 cilia and flagella associated protein 45 2.89185
C10ORF67 chromosome 10 open reading frame 67 2.89185
OLAH oleoyl-ACP hydrolase 2.89185
SCN10A sodium channel, voltage gated, type X alpha subunit 2.89185
DAO D-amino-acid oxidase 2.89185
LRTM3 leucine rich repeat transmembrane protein 3 2.89185
GOLGA8M golgin A8 family, member M 2.89185
POU2AF1 POU class 2 associating factor 1 2.89185
IRGM immunity-related GTPase family, M 2.89185
CLEC4E C-type lectin domain family 4, member E 2.89185
TREH trehalase (brush-border membrane glycoprotein) 2.89185
CPA2 carboxypeptidase A2 (pancreatic) 2.89185
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.89185
RANBP3L RAN binding protein 3-like 2.89185
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 2.89185
DQX1 DEAQ box RNA-dependent ATPase 1 2.89185
CNTF ciliary neurotrophic factor 2.89185
MRLN myoregulin 2.89185
HAMP hepcidin antimicrobial peptide 2.89185
HBE1 hemoglobin, epsilon 1 2.89185
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.89185
MORC1 MORC family CW-type zinc finger 1 2.89185
PMP2 peripheral myelin protein 2 2.89185
ALOXE3 arachidonate lipoxygenase 3 2.89185
IL19 interleukin 19 2.89185
COMP cartilage oligomeric matrix protein 2.89185
CXORF58 chromosome X open reading frame 58 2.89185
GJB6 gap junction protein, beta 6, 30kDa 2.89185
ERVV-2 endogenous retrovirus group V, member 2 2.89185
CFAP126 cilia and flagella associated protein 126 2.89185
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.89185
SH2D1B SH2 domain containing 1B 2.89185
CSDC2 cold shock domain containing C2, RNA binding 2.89185
RGS8 regulator of G-protein signaling 8 2.89185
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.89185
RBM24 RNA binding motif protein 24 2.89185
RIPPLY2 ripply transcriptional repressor 2 2.89185
VSTM1 V-set and transmembrane domain containing 1 2.89185
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.89185
KLK15 kallikrein-related peptidase 15 2.89185
KISS1 KiSS-1 metastasis-suppressor 2.89185
NRIP2 nuclear receptor interacting protein 2 2.89185
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.89185
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.89185
DMTN dematin actin binding protein 2.89185
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.89185
NNMT nicotinamide N-methyltransferase 2.89185
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.89185
ZC2HC1B zinc finger, C2HC-type containing 1B 2.89185
ST18 suppression of tumorigenicity 18, zinc finger 2.89185
IL10RA interleukin 10 receptor, alpha 2.89185
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.89185
PADI1 peptidyl arginine deiminase, type I 2.89185
LRRC31 leucine rich repeat containing 31 2.89185
TMEM86A transmembrane protein 86A 2.89185
TMEM86B transmembrane protein 86B 2.89185
SSPN sarcospan 2.89185
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.89185
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.89185
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.89185
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.89185
PDCD1 programmed cell death 1 2.89185
OR51A4 olfactory receptor, family 51, subfamily A, member 4 2.89185
CLCNKA chloride channel, voltage-sensitive Ka 2.89185
PRSS57 protease, serine, 57 2.89185
LIMS3 LIM and senescent cell antigen-like domains 3 2.89185
CD22 CD22 molecule 2.89185
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.88996
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 2.73522
PHLDB2 pleckstrin homology-like domain, family B, member 2 2.71449
UNC5A unc-5 homolog A (C. elegans) 2.69651
KDM4C lysine (K)-specific demethylase 4C 2.64093
FSTL1 follistatin-like 1 2.64093
PROM1 prominin 1 2.64093
GSPT1 G1 to S phase transition 1 2.64082
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.63973
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.60106
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.5879
ILDR1 immunoglobulin-like domain containing receptor 1 2.51488
CRYBB3 crystallin, beta B3 2.49756
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 2.45234
INSL6 insulin-like 6 2.38729
LMX1B LIM homeobox transcription factor 1, beta 2.38729
NPIPB8 nuclear pore complex interacting protein family, member B8 2.38633
PDE4A phosphodiesterase 4A, cAMP-specific 2.28539
HTRA3 HtrA serine peptidase 3 2.2853
PCSK9 proprotein convertase subtilisin/kexin type 9 2.26825
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 2.26044
CCDC146 coiled-coil domain containing 146 2.23456
RAB5IF RAB5 interacting factor 2.21575
USP34 ubiquitin specific peptidase 34 2.19446
CEP295 centrosomal protein 295kDa 2.17048
PFDN1 prefoldin subunit 1 2.12197
TFF3 trefoil factor 3 (intestinal) 2.12197
CEP70 centrosomal protein 70kDa 2.11388
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.09051
STK39 serine threonine kinase 39 2.08366
CREB1 cAMP responsive element binding protein 1 2.08366
NMRK1 nicotinamide riboside kinase 1 2.0626
PARP9 poly (ADP-ribose) polymerase family, member 9 2.0626
NLRC3 NLR family, CARD domain containing 3 2.06048
XKRX XK, Kell blood group complex subunit-related, X-linked 2.06048
TULP2 tubby like protein 2 2.06048
PGAP3 post-GPI attachment to proteins 3 2.05104
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.05104
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.05104
TLE2 transducin-like enhancer of split 2 2.05078
KIAA1614 KIAA1614 2.04341
USP10 ubiquitin specific peptidase 10 2.03627
PDPK1 3-phosphoinositide dependent protein kinase 1 2.03627
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.0319
COPG1 coatomer protein complex, subunit gamma 1 2.0319
HELLS helicase, lymphoid-specific 2.0271
MEST mesoderm specific transcript 2.02251
FGF8 fibroblast growth factor 8 (androgen-induced) 2.01992
C9ORF153 chromosome 9 open reading frame 153 2.01992
TMEM70 transmembrane protein 70 2.01213

decreased expression

Symbol Name Standardized Value
APOM apolipoprotein M -2.89185
HSPB2 heat shock 27kDa protein 2 -2.89185
C19ORF38 chromosome 19 open reading frame 38 -2.89185
INHBA inhibin, beta A -2.89185
SNX31 sorting nexin 31 -2.89185
LEF1 lymphoid enhancer-binding factor 1 -2.89185
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.89185
CDH9 cadherin 9, type 2 (T1-cadherin) -2.89185
CRIPTO3 cripto, EGF-CFC family member 3 -2.89185
NCEH1 neutral cholesterol ester hydrolase 1 -2.83384
MBLAC2 metallo-beta-lactamase domain containing 2 -2.70005
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.64093
TAS2R31 taste receptor, type 2, member 31 -2.64093
PCDHA9 protocadherin alpha 9 -2.64093
CHRDL2 chordin-like 2 -2.64093
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.64093
THPO thrombopoietin -2.64093
LOXL4 lysyl oxidase-like 4 -2.64093
SCIN scinderin -2.64093
TXNDC11 thioredoxin domain containing 11 -2.64093
RIMBP2 RIMS binding protein 2 -2.64093
KCNRG potassium channel regulator -2.64093
SCAF1 SR-related CTD-associated factor 1 -2.64093
CRIP1 cysteine-rich protein 1 (intestinal) -2.64093
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -2.64093
CD96 CD96 molecule -2.64093
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -2.64093
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 -2.64093
TAS2R46 taste receptor, type 2, member 46 -2.64093
CKM creatine kinase, muscle -2.64093
TRHR thyrotropin-releasing hormone receptor -2.64093
ADCY4 adenylate cyclase 4 -2.64093
ADAP1 ArfGAP with dual PH domains 1 -2.64093
MAMLD1 mastermind-like domain containing 1 -2.64093
THBD thrombomodulin -2.64093
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.64093
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.64093
PFN4 profilin family, member 4 -2.64093
LOXHD1 lipoxygenase homology domains 1 -2.64093
PRDM7 PR domain containing 7 -2.64093
CASS4 Cas scaffolding protein family member 4 -2.64093
CD177 CD177 molecule -2.64093
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -2.64093
LAMP5 lysosomal-associated membrane protein family, member 5 -2.64093
TLR2 toll-like receptor 2 -2.64093
CHAD chondroadherin -2.64093
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.64093
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.64093
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 -2.64093
TMIGD3 transmembrane and immunoglobulin domain containing 3 -2.64093
RUNX3 runt-related transcription factor 3 -2.64093
SMIM36 small integral membrane protein 36 -2.64093
ATAD3A ATPase family, AAA domain containing 3A -2.62253
OCEL1 occludin/ELL domain containing 1 -2.58618
NGEF neuronal guanine nucleotide exchange factor -2.53692
PEX19 peroxisomal biogenesis factor 19 -2.53692
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.51894
WAS Wiskott-Aldrich syndrome -2.51894
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -2.51488
TMEM234 transmembrane protein 234 -2.51488
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.51488
PTGES prostaglandin E synthase -2.49756
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.49756
LEAP2 liver expressed antimicrobial peptide 2 -2.49756
RSPO2 R-spondin 2 -2.49756
ELL3 elongation factor RNA polymerase II-like 3 -2.49541
GLB1L galactosidase, beta 1-like -2.49541
NONO non-POU domain containing, octamer-binding -2.46068
RNF8 ring finger protein 8, E3 ubiquitin protein ligase -2.42674
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -2.40498
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.38729
SKIDA1 SKI/DACH domain containing 1 -2.38517
MED18 mediator complex subunit 18 -2.36264
NRBP2 nuclear receptor binding protein 2 -2.36264
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.3129
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -2.3129
NFRKB nuclear factor related to kappaB binding protein -2.26882
NBPF11 neuroblastoma breakpoint family, member 11 -2.26882
NEFM neurofilament, medium polypeptide -2.26882
FZD4 frizzled class receptor 4 -2.26465
TECR trans-2,3-enoyl-CoA reductase -2.26044
GATD1 glutamine amidotransferase class 1 domain containing 1 -2.25354
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.24433
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.23695
MRPS18C mitochondrial ribosomal protein S18C -2.21603
CCNT2 cyclin T2 -2.21575
NBPF26 neuroblastoma breakpoint family, member 26 -2.20366
PLP1 proteolipid protein 1 -2.18664
ZSWIM4 zinc finger, SWIM-type containing 4 -2.17101
TTC8 tetratricopeptide repeat domain 8 -2.16011
COL9A3 collagen, type IX, alpha 3 -2.12261
TMEM229B transmembrane protein 229B -2.1225
GYPE glycophorin E (MNS blood group) -2.1225
ENOPH1 enolase-phosphatase 1 -2.12197
GLYCTK glycerate kinase -2.07097
DNER delta/notch-like EGF repeat containing -2.06818
CGREF1 cell growth regulator with EF-hand domain 1 -2.06381
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.06145
GPR173 G protein-coupled receptor 173 -2.05104
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -2.03178
LRP11 low density lipoprotein receptor-related protein 11 -2.02647
TANK TRAF family member-associated NFKB activator -2.02573
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.01992
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.01213
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.01213
SUMO4 small ubiquitin-like modifier 4 -2.01213
MMD2 monocyte to macrophage differentiation-associated 2 -2.00168