TC-N 22A Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/46836562
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Genes

199 proteins with high or low expression in TC-N 22A relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 1.19
SBSN suprabasin 1.01
DNAH2 dynein, axonemal, heavy chain 2 0.96
CLK1 CDC-like kinase 1 0.92
PIP prolactin-induced protein 0.88
VGF VGF nerve growth factor inducible 0.77
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.75
TIGD1 tigger transposable element derived 1 0.69
HAS3 hyaluronan synthase 3 0.66
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.61
SLC2A4RG SLC2A4 regulator 0.55
CLK4 CDC-like kinase 4 0.53
MT2A metallothionein 2A 0.51
TSC22D2 TSC22 domain family, member 2 0.5
ZBED6 zinc finger, BED-type containing 6 0.5
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.49
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.49
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 0.48
ADGRF1 adhesion G protein-coupled receptor F1 0.46
GAS6 growth arrest-specific 6 0.45
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.44
PEX26 peroxisomal biogenesis factor 26 0.43
FOSL1 FOS-like antigen 1 0.43
ZNF503 zinc finger protein 503 0.42
HPCAL1 hippocalcin-like 1 0.41
BCAR3 breast cancer anti-estrogen resistance 3 0.41
STOML1 stomatin (EPB72)-like 1 0.4
KLHDC8B kelch domain containing 8B 0.4
OTUD5 OTU deubiquitinase 5 0.4
RAET1G retinoic acid early transcript 1G 0.39
FAM89A family with sequence similarity 89, member A 0.39
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.39
CCDC88A coiled-coil domain containing 88A 0.38
KCTD17 potassium channel tetramerization domain containing 17 0.37
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.37
ACD adrenocortical dysplasia homolog (mouse) 0.37
MAP2 microtubule-associated protein 2 0.37
USP37 ubiquitin specific peptidase 37 0.36
CCDC85B coiled-coil domain containing 85B 0.36
NQO1 NAD(P)H dehydrogenase, quinone 1 0.36
CCDC14 coiled-coil domain containing 14 0.35
GRAMD2B GRAM domain containing 2B 0.35
ANKRD24 ankyrin repeat domain 24 0.35
CCN3 cellular communication network factor 3 0.35
HIST2H2AA3 histone cluster 2, H2aa3 0.35
ZNF286B zinc finger protein 286B 0.35
MT1E metallothionein 1E 0.35
TPGS1 tubulin polyglutamylase complex subunit 1 0.35
MIEN1 migration and invasion enhancer 1 0.35
EGR1 early growth response 1 0.35
XBP1 X-box binding protein 1 0.35
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.35
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 0.34
CCND3 cyclin D3 0.34
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.33
ZNF449 zinc finger protein 449 0.33
FRMD6 FERM domain containing 6 0.33
SAMD12 sterile alpha motif domain containing 12 0.33
NTSR1 neurotensin receptor 1 (high affinity) 0.33
TCP11L1 t-complex 11, testis-specific-like 1 0.32
TIPE1 TNF alpha induced protein 8 like 1 0.32
UBE2B ubiquitin-conjugating enzyme E2B 0.32
KIF21B kinesin family member 21B 0.32
SNX15 sorting nexin 15 0.31
SDHAF4 succinate dehydrogenase complex assembly factor 4 0.31
ZNF721 zinc finger protein 721 0.31
DUOX1 dual oxidase 1 0.31
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.31
CLK3 CDC-like kinase 3 0.31
MOCS2 molybdenum cofactor synthesis 2 0.31
EPDR1 ependymin related 1 0.3
SRXN1 sulfiredoxin 1 0.3
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.3
GDA guanine deaminase 0.3
ACTBL2 actin, beta-like 2 0.3
TSPYL2 TSPY-like 2 0.3
BMPR1B bone morphogenetic protein receptor, type IB 0.29
WDR25 WD repeat domain 25 0.29
SPC24 SPC24, NDC80 kinetochore complex component 0.29
PRELID1 PRELI domain containing 1 0.29
TPST2 tyrosylprotein sulfotransferase 2 0.29
STARD3NL STARD3 N-terminal like 0.29
CCAR2 cell cycle and apoptosis regulator 2 0.29
AUNIP aurora kinase A and ninein interacting protein 0.28
C11ORF68 chromosome 11 open reading frame 68 0.28
PDE8A phosphodiesterase 8A 0.28
MERTK MER proto-oncogene, tyrosine kinase 0.28
TRIM15 tripartite motif containing 15 0.28
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.27
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.27
ABHD4 abhydrolase domain containing 4 0.27
KLHL29 kelch-like family member 29 0.27
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.27
BSN bassoon presynaptic cytomatrix protein 0.27
FBXO41 F-box protein 41 0.27
VIM vimentin 0.27
NQO2 NAD(P)H dehydrogenase, quinone 2 0.27
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.27
C1ORF43 chromosome 1 open reading frame 43 0.26
ANTKMT adenine nucleotide translocase lysine methyltransferase 0.26

low expression

Symbol Name Standardized Value
AHR aryl hydrocarbon receptor -1.1
TYSND1 trypsin domain containing 1 -0.96
ATF3 activating transcription factor 3 -0.66
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.65
BTBD3 BTB (POZ) domain containing 3 -0.64
RNF185 ring finger protein 185 -0.64
RAB40C RAB40C, member RAS oncogene family -0.6
KLK6 kallikrein-related peptidase 6 -0.56
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.54
TMEM135 transmembrane protein 135 -0.54
FN1 fibronectin 1 -0.53
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.52
CUX2 cut-like homeobox 2 -0.52
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -0.51
TP53 tumor protein p53 -0.51
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.5
PRMT6 protein arginine methyltransferase 6 -0.5
ABHD13 abhydrolase domain containing 13 -0.49
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.48
SVIP small VCP/p97-interacting protein -0.48
BCAM basal cell adhesion molecule (Lutheran blood group) -0.47
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -0.45
AP1AR adaptor-related protein complex 1 associated regulatory protein -0.44
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.43
CNTNAP3 contactin associated protein-like 3 -0.42
EPHA5 EPH receptor A5 -0.42
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -0.42
C17ORF53 chromosome 17 open reading frame 53 -0.41
OTX1 orthodenticle homeobox 1 -0.41
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.41
TRIB1 tribbles pseudokinase 1 -0.4
SIAH1 siah E3 ubiquitin protein ligase 1 -0.39
TMEM177 transmembrane protein 177 -0.39
ATP9A ATPase, class II, type 9A -0.38
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.38
VSIR V-set immunoregulatory receptor -0.37
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D -0.37
FAM53C family with sequence similarity 53, member C -0.37
SGSH N-sulfoglucosamine sulfohydrolase -0.37
SNX21 sorting nexin family member 21 -0.37
PLIN2 perilipin 2 -0.36
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B -0.36
F3 coagulation factor III (thromboplastin, tissue factor) -0.36
HBA1 hemoglobin, alpha 1 -0.36
SC5D sterol-C5-desaturase -0.36
CCDC170 coiled-coil domain containing 170 -0.35
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.35
GSE1 Gse1 coiled-coil protein -0.34
AASS aminoadipate-semialdehyde synthase -0.34
CARD19 caspase recruitment domain family member 19 -0.34
CPA4 carboxypeptidase A4 -0.34
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.34
CLTCL1 clathrin, heavy chain-like 1 -0.34
SLC38A2 solute carrier family 38, member 2 -0.34
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.33
INPP5J inositol polyphosphate-5-phosphatase J -0.33
FAM49B family with sequence similarity 49, member B -0.33
LYN LYN proto-oncogene, Src family tyrosine kinase -0.33
USP53 ubiquitin specific peptidase 53 -0.33
CCDC71 coiled-coil domain containing 71 -0.32
STYK1 serine/threonine/tyrosine kinase 1 -0.32
ASTE1 asteroid homolog 1 (Drosophila) -0.32
FGFR4 fibroblast growth factor receptor 4 -0.31
LTN1 listerin E3 ubiquitin protein ligase 1 -0.31
FAR1 fatty acyl CoA reductase 1 -0.31
TSPAN31 tetraspanin 31 -0.31
GLMP glycosylated lysosomal membrane protein -0.3
STEAP3 STEAP family member 3, metalloreductase -0.3
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.3
ZNF584 zinc finger protein 584 -0.3
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.29
SNAP91 synaptosomal-associated protein, 91kDa -0.29
CD58 CD58 molecule -0.29
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -0.29
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.29
MITD1 MIT, microtubule interacting and transport, domain containing 1 -0.29
CC2D2A coiled-coil and C2 domain containing 2A -0.29
ELF1 E74-like factor 1 (ets domain transcription factor) -0.28
TDRKH tudor and KH domain containing -0.28
ZNF57 zinc finger protein 57 -0.28
PUS10 pseudouridylate synthase 10 -0.28
KITLG KIT ligand -0.28
MRPS14 mitochondrial ribosomal protein S14 -0.27
MT-ND1 NADH dehydrogenase, subunit 1 (complex I) -0.27
ZFP64 ZFP64 zinc finger protein -0.27
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 -0.27
MAST3 microtubule associated serine/threonine kinase 3 -0.27
ELF4 E74-like factor 4 (ets domain transcription factor) -0.27
GORASP1 golgi reassembly stacking protein 1, 65kDa -0.27
R3HDM4 R3H domain containing 4 -0.27
MPZL2 myelin protein zero-like 2 -0.27
IFITM3 interferon induced transmembrane protein 3 -0.27
FUNDC2 FUN14 domain containing 2 -0.27
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.26
HPCAL4 hippocalcin like 4 -0.26
PSEN2 presenilin 2 -0.26
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -0.26
DCLRE1C DNA cross-link repair 1C -0.26
FRY furry homolog (Drosophila) -0.26