TCCSUP Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from Bladder Carcinoma Tumour (Cell Model Passports, SIDM01190)
External Link https://depmap.org/portal/cell_line/ACH-000720
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Genes

354 gene knockdowns changing fitness of TCCSUP relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 12.2212
WDCP WD repeat and coiled coil containing 11.3936
SNAI1 snail family zinc finger 1 10.1491
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 7.5821
ATG13 autophagy related 13 7.4813
PSMC3IP PSMC3 interacting protein 7.19243
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 6.94135
RNASE7 ribonuclease, RNase A family, 7 6.59464
KLHL36 kelch-like family member 36 6.33257
FAIM2 Fas apoptotic inhibitory molecule 2 6.0351
RAPSN receptor-associated protein of the synapse 5.92988
RGL3 ral guanine nucleotide dissociation stimulator-like 3 5.90754
PBX1 pre-B-cell leukemia homeobox 1 5.86977
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 5.78286
UBTD1 ubiquitin domain containing 1 5.64742
AHR aryl hydrocarbon receptor 5.58466
OCLN occludin 5.54315
AOC3 amine oxidase, copper containing 3 5.20941
C9ORF50 chromosome 9 open reading frame 50 5.01601
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 4.9419
RAB31 RAB31, member RAS oncogene family 4.90528
RGS11 regulator of G-protein signaling 11 4.88848
MEIS2 Meis homeobox 2 4.88637
GOLT1A golgi transport 1A 4.83523
SOX4 SRY (sex determining region Y)-box 4 4.81911
ZNF157 zinc finger protein 157 4.71426
BBS2 Bardet-Biedl syndrome 2 4.70014
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 4.66822
GATA5 GATA binding protein 5 4.63177
CXCL9 chemokine (C-X-C motif) ligand 9 4.62717
DBF4B DBF4 zinc finger B 4.62164
AIP aryl hydrocarbon receptor interacting protein 4.49371
RESP18 regulated endocrine-specific protein 18 4.408
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 4.36555
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 4.362
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 4.29695
MN1 meningioma (disrupted in balanced translocation) 1 4.29063
CLDN17 claudin 17 4.24486
CCNE2 cyclin E2 4.19592
NR1I2 nuclear receptor subfamily 1, group I, member 2 4.19176
TARBP1 TAR (HIV-1) RNA binding protein 1 4.14526
ATG3 autophagy related 3 4.02293
IQCF6 IQ motif containing F6 4.01811
FADS3 fatty acid desaturase 3 4.00652
ALPI alkaline phosphatase, intestinal 3.97546
C2CD4B C2 calcium-dependent domain containing 4B 3.92055
CXCL5 chemokine (C-X-C motif) ligand 5 3.8946
ZNF462 zinc finger protein 462 3.84646
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 3.8321
RHOXF2B Rhox homeobox family, member 2B 3.82427
ZNF2 zinc finger protein 2 3.77262
CCS copper chaperone for superoxide dismutase 3.69198
TMEM221 transmembrane protein 221 3.66005
PRSS27 protease, serine 27 3.58029
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 3.56877
TMEM234 transmembrane protein 234 3.54169
INPP5K inositol polyphosphate-5-phosphatase K 3.51951
SYNGR3 synaptogyrin 3 3.50105
STIP1 stress-induced phosphoprotein 1 3.49894
MSLN mesothelin 3.49675
IFT54 intraflagellar transport 54 3.47819
PNPLA7 patatin-like phospholipase domain containing 7 3.45743
TRAFD1 TRAF-type zinc finger domain containing 1 3.41032
RPL3L ribosomal protein L3-like 3.39796
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.36807
GUCA1B guanylate cyclase activator 1B (retina) 3.36627
KRT76 keratin 76, type II 3.35802
PF4V1 platelet factor 4 variant 1 3.34498
CDIP1 cell death-inducing p53 target 1 3.30551
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 3.30111
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 3.29702
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.29253
PRR35 proline rich 35 3.26231
SLMAP sarcolemma associated protein 3.25943
MARCHF6 membrane associated ring-CH-type finger 6 3.25014
CPPED1 calcineurin-like phosphoesterase domain containing 1 3.24699
IVD isovaleryl-CoA dehydrogenase 3.23979
TRIM21 tripartite motif containing 21 3.23354
SUCO SUN domain containing ossification factor 3.21767
FGFR1 fibroblast growth factor receptor 1 3.20675
AOC2 amine oxidase, copper containing 2 (retina-specific) 3.19182
FAM91A1 family with sequence similarity 91, member A1 3.17125
SFTPA2 surfactant protein A2 3.14969
ARNT aryl hydrocarbon receptor nuclear translocator 3.14391
UBE2B ubiquitin-conjugating enzyme E2B 3.12882
C19ORF24 chromosome 19 open reading frame 24 3.10319
PUS3 pseudouridylate synthase 3 3.09307
AGMAT agmatine ureohydrolase (agmatinase) 3.08745
GNS glucosamine (N-acetyl)-6-sulfatase 3.06963
PDS5B PDS5 cohesin associated factor B 3.06534
GRAMD1C GRAM domain containing 1C 3.03494
PDLIM5 PDZ and LIM domain 5 3.03325
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 3.03158
LRRC8B leucine rich repeat containing 8 family, member B 3.02435
PDX1 pancreatic and duodenal homeobox 1 3.01963
RAD51B RAD51 paralog B 3.01667
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.01201
TMEM223 transmembrane protein 223 3.00338
KYAT1 kynurenine aminotransferase 1 2.99188
RNF25 ring finger protein 25 2.98868
ZNF341 zinc finger protein 341 2.97786
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.9724
SCAPER S-phase cyclin A-associated protein in the ER 2.93886
SLC25A43 solute carrier family 25, member 43 2.93681
SSTR5 somatostatin receptor 5 2.93456
OR10AD1 olfactory receptor, family 10, subfamily AD, member 1 2.92949
NDNF neuron-derived neurotrophic factor 2.92771
RNF114 ring finger protein 114 2.91989
MESD mesoderm development LRP chaperone 2.91663
COL5A1 collagen, type V, alpha 1 2.88678
LRRC7 leucine rich repeat containing 7 2.88394
ARTN artemin 2.87807
C4ORF48 chromosome 4 open reading frame 48 2.87702
WFDC2 WAP four-disulfide core domain 2 2.8741
TMEM94 transmembrane protein 94 2.86118
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 2.85978
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.85616
SP2 Sp2 transcription factor 2.8545
ZNF224 zinc finger protein 224 2.85375
PPIAL4G peptidylprolyl isomerase A (cyclophilin A)-like 4G 2.84698
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 2.84273
HIST1H4F histone cluster 1, H4f 2.8345
BMPR1A bone morphogenetic protein receptor, type IA 2.83297
TLR7 toll-like receptor 7 2.82485
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa 2.82325
DNAH10 dynein, axonemal, heavy chain 10 2.8205
LRP1B low density lipoprotein receptor-related protein 1B 2.80549
SIX6 SIX homeobox 6 2.80382
TTLL4 tubulin tyrosine ligase-like family member 4 2.80331
TSSK4 testis-specific serine kinase 4 2.79707
SIX5 SIX homeobox 5 2.7902
RTL8C retrotransposon Gag like 8C 2.78607
HAGH hydroxyacylglutathione hydrolase 2.78386
CXCR6 chemokine (C-X-C motif) receptor 6 2.7809
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.77982
HLA-C major histocompatibility complex, class I, C 2.77232
ART3 ADP-ribosyltransferase 3 2.76139
CHRM3 cholinergic receptor, muscarinic 3 2.7453
TIPE1 TNF alpha induced protein 8 like 1 2.74449
HCRT hypocretin (orexin) neuropeptide precursor 2.71736
ASXL3 additional sex combs like transcriptional regulator 3 2.70817
TBKBP1 TBK1 binding protein 1 2.70443
ZNF442 zinc finger protein 442 2.70361
IRF2BPL interferon regulatory factor 2 binding protein-like 2.69087
EPN3 epsin 3 2.68718
MYBPC3 myosin binding protein C, cardiac 2.68607
EXD3 exonuclease 3'-5' domain containing 3 2.68554
ETAA1 Ewing tumor-associated antigen 1 2.68399
LTC4S leukotriene C4 synthase 2.68317
DGCR2 DiGeorge syndrome critical region gene 2 2.68259
SWI5 SWI5 recombination repair homolog (yeast) 2.66789
KPNA4 karyopherin alpha 4 (importin alpha 3) 2.65562
B3GAT3 beta-1,3-glucuronyltransferase 3 2.65413
EFNA3 ephrin-A3 2.65399
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.63104
MRPL13 mitochondrial ribosomal protein L13 2.6266
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.62277
RALBP1 ralA binding protein 1 2.62041
APIP APAF1 interacting protein 2.61613
DEDD2 death effector domain containing 2 2.60606
GPR176 G protein-coupled receptor 176 2.60504
IP6K3 inositol hexakisphosphate kinase 3 2.59747
FERMT3 fermitin family member 3 2.58432
MATR3 matrin 3 2.58398
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 2.58183
ZNF646 zinc finger protein 646 2.57809
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.57766
GNG11 guanine nucleotide binding protein (G protein), gamma 11 2.57269
ARSJ arylsulfatase family, member J 2.55739
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.55649
MIB1 mindbomb E3 ubiquitin protein ligase 1 2.55506
ELF5 E74-like factor 5 (ets domain transcription factor) 2.54996
AAMDC adipogenesis associated, Mth938 domain containing 2.54134
RCAN1 regulator of calcineurin 1 2.54008
INSIG1 insulin induced gene 1 2.53745
FOXL2NB FOXL2 neighbor 2.53339
C19ORF25 chromosome 19 open reading frame 25 2.52637
C15ORF61 chromosome 15 open reading frame 61 2.52061
ZNF284 zinc finger protein 284 2.51901
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.51851
C11ORF74 chromosome 11 open reading frame 74 2.51581
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 2.5068
ZSWIM3 zinc finger, SWIM-type containing 3 2.50674
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.50519
CFAP70 cilia and flagella associated protein 70 2.49733
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.49392
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.49109
TTL tubulin tyrosine ligase 2.48491
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 2.48078
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.48057
PER2 period circadian clock 2 2.47347
SMIM24 small integral membrane protein 24 2.47292
AMIGO1 adhesion molecule with Ig-like domain 1 2.4728
MRGPRX3 MAS-related GPR, member X3 2.4665
NTN3 netrin 3 2.4646
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.46414
ATG9A autophagy related 9A 2.45937
GLUL glutamate-ammonia ligase 2.45773
TRIM26 tripartite motif containing 26 2.44951
NXNL1 nucleoredoxin-like 1 2.44935
LDLR low density lipoprotein receptor 2.44719
INPP5J inositol polyphosphate-5-phosphatase J 2.44202
RPGR retinitis pigmentosa GTPase regulator 2.43446
ADNP activity-dependent neuroprotector homeobox 2.43265
SLC35A4 solute carrier family 35, member A4 2.42777
MAP1B microtubule-associated protein 1B 2.42538
INTU inturned planar cell polarity protein 2.41942
TNC tenascin C 2.4176
MTMR14 myotubularin related protein 14 2.41067
UBALD1 UBA-like domain containing 1 2.40726
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.40352
DRAXIN dorsal inhibitory axon guidance protein 2.3999
SIRAL2 SIR2 antiphage like 2 2.39675
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.39643
EFNB3 ephrin-B3 2.39192
ASCC1 activating signal cointegrator 1 complex subunit 1 2.39156
VASN vasorin 2.38716
LRRC46 leucine rich repeat containing 46 2.38632
C3ORF38 chromosome 3 open reading frame 38 2.383
ACOT2 acyl-CoA thioesterase 2 2.37611
ROM1 retinal outer segment membrane protein 1 2.37087
VWCE von Willebrand factor C and EGF domains 2.36296
ITGB7 integrin, beta 7 2.35706
DRG2 developmentally regulated GTP binding protein 2 2.35492
GJB4 gap junction protein, beta 4, 30.3kDa 2.35478
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 2.35329
SCUBE3 signal peptide, CUB domain, EGF-like 3 2.35242
USP44 ubiquitin specific peptidase 44 2.3496
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 2.34565
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.3453
LIPG lipase, endothelial 2.34043
EMX2 empty spiracles homeobox 2 2.33706
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.33365
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.33275
E2F3 E2F transcription factor 3 2.33156
OXLD1 oxidoreductase-like domain containing 1 2.32343
OR5M3 olfactory receptor, family 5, subfamily M, member 3 2.31747
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 2.31498
PYCR3 pyrroline-5-carboxylate reductase 3 2.31453
RAB5C RAB5C, member RAS oncogene family 2.30921
QPCTL glutaminyl-peptide cyclotransferase-like 2.30571
SCX scleraxis basic helix-loop-helix transcription factor 2.2995
C5 complement component 5 2.28696
ATOH8 atonal homolog 8 (Drosophila) 2.28202
SELENOI selenoprotein I 2.27674
MAL mal, T-cell differentiation protein 2.27668
DOT1L DOT1-like histone H3K79 methyltransferase 2.26957
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 2.26601
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.26461
C15ORF40 chromosome 15 open reading frame 40 2.263
JADE2 jade family PHD finger 2 2.2616
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.25625
FAM47E family with sequence similarity 47, member E 2.2552
C1ORF95 chromosome 1 open reading frame 95 2.25175
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.24314
GPR20 G protein-coupled receptor 20 2.24242
ATG4B autophagy related 4B, cysteine peptidase 2.24202
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.23166
CDK16 cyclin-dependent kinase 16 2.2275
CTRL chymotrypsin-like 2.22698
NCOA5 nuclear receptor coactivator 5 2.21833
LAD1 ladinin 1 2.21732
EPCAM epithelial cell adhesion molecule 2.20307
RB1CC1 RB1-inducible coiled-coil 1 2.20292
PIANP PILR alpha associated neural protein 2.20013
FBXO42 F-box protein 42 2.19899
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 2.19799
FKBP4 FK506 binding protein 4, 59kDa 2.19478
IFNA1 interferon, alpha 1 2.19161
SCRN2 secernin 2 2.19089
PLAUR plasminogen activator, urokinase receptor 2.19074
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.18889
LGALS12 lectin, galactoside-binding, soluble, 12 2.1857
C6ORF47 chromosome 6 open reading frame 47 2.18002
PRRX2 paired related homeobox 2 2.17877
MAST1 microtubule associated serine/threonine kinase 1 2.17802
TMSB4X thymosin beta 4, X-linked 2.175
KLF3 Kruppel-like factor 3 (basic) 2.17326
TMEM212 transmembrane protein 212 2.16386
JTB jumping translocation breakpoint 2.16088
TEC tec protein tyrosine kinase 2.158
C3ORF62 chromosome 3 open reading frame 62 2.15791
CKB creatine kinase, brain 2.15707
FAM92B family with sequence similarity 92, member B 2.15692
SLTM SAFB-like, transcription modulator 2.15384
DOCK6 dedicator of cytokinesis 6 2.14482
RASA4 RAS p21 protein activator 4 2.14408
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 2.14268
TRIM67 tripartite motif containing 67 2.1416
FBXO7 F-box protein 7 2.141
MAGED1 melanoma antigen family D1 2.13947
FAM89B family with sequence similarity 89, member B 2.13425
CPN2 carboxypeptidase N, polypeptide 2 2.13017
PDYN prodynorphin 2.11987
SFR1 SWI5-dependent recombination repair 1 2.11499
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 2.1145
METRN meteorin, glial cell differentiation regulator 2.11401
CCDC28B coiled-coil domain containing 28B 2.11363
MYO3A myosin IIIA 2.11362
CHD5 chromodomain helicase DNA binding protein 5 2.11311
RASAL3 RAS protein activator like 3 2.11248
ZNF517 zinc finger protein 517 2.11199
CUL4B cullin 4B 2.11187
EYA2 EYA transcriptional coactivator and phosphatase 2 2.10958
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.10679
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.10626
TRIO trio Rho guanine nucleotide exchange factor 2.10233
ADAT2 adenosine deaminase, tRNA-specific 2 2.1005
CALR calreticulin 2.09983
RNASE8 ribonuclease, RNase A family, 8 2.09289
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.0922
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.09134
LSMEM2 leucine-rich single-pass membrane protein 2 2.09035
PLA2G1B phospholipase A2, group IB (pancreas) 2.08836
FKBP1A FK506 binding protein 1A, 12kDa 2.08109
GLMP glycosylated lysosomal membrane protein 2.08096
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 2.07919
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.07725
ASNSD1 asparagine synthetase domain containing 1 2.07385
FGD2 FYVE, RhoGEF and PH domain containing 2 2.0736
C6ORF25 chromosome 6 open reading frame 25 2.07193
NGB neuroglobin 2.07171
ASB16 ankyrin repeat and SOCS box containing 16 2.07079
PLAC9 placenta-specific 9 2.06791
ZNF408 zinc finger protein 408 2.06325
SLC35G6 solute carrier family 35, member G6 2.05348
SLC48A1 solute carrier family 48 (heme transporter), member 1 2.05341
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.05321
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.05299
FAM78B family with sequence similarity 78, member B 2.05256
TBC1D2B TBC1 domain family, member 2B 2.05149
ADAMDEC1 ADAM-like, decysin 1 2.04783
ZBTB26 zinc finger and BTB domain containing 26 2.04502
RCOR1 REST corepressor 1 2.04444
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.03936
GDF5 growth differentiation factor 5 2.03881
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.03667
RASEF RAS and EF-hand domain containing 2.02749
RTBDN retbindin 2.02743
NT5C3B 5'-nucleotidase, cytosolic IIIB 2.02639
IFNA6 interferon, alpha 6 2.02469
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.02296
XYLT2 xylosyltransferase II 2.0222
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.02037
OPRL1 opiate receptor-like 1 2.01875
TRIM47 tripartite motif containing 47 2.0166
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 2.013
YLPM1 YLP motif containing 1 2.01056
TDO2 tryptophan 2,3-dioxygenase 2.00906
ITGA11 integrin, alpha 11 2.0076
NICN1 nicolin 1 2.00386
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.00313
KAT14 lysine acetyltransferase 14 2.00104
C3ORF84 chromosome 3 open reading frame 84 2.00064