TCF12 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcription factor 12|The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6938)
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Genes

357 genes differentially expressed following the TCF12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MMP3 matrix metallopeptidase 3 3.16163
LPO lactoperoxidase 3.16163
TDRD9 tudor domain containing 9 3.16163
TMEM215 transmembrane protein 215 3.16163
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.16163
TEX101 testis expressed 101 3.16163
KRT86 keratin 86, type II 3.16163
HOPX HOP homeobox 3.16163
KLHL1 kelch-like family member 1 3.16163
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.16163
GLOD5 glyoxalase domain containing 5 3.16163
BTC betacellulin 3.16163
ZMYND10 zinc finger, MYND-type containing 10 3.16163
ITSN1 intersectin 1 (SH3 domain protein) 3.16163
MUC6 mucin 6, oligomeric mucus/gel-forming 3.16163
LPA lipoprotein, Lp(a) 3.16163
C5ORF46 chromosome 5 open reading frame 46 3.16163
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.16163
IRX1 iroquois homeobox 1 3.16163
PLAAT4 phospholipase A and acyltransferase 4 3.16163
RHEX regulator of hemoglobinization and erythroid cell expansion 3.16163
DCST1 DC-STAMP domain containing 1 3.16163
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.16163
PDF peptide deformylase (mitochondrial) 3.16163
GLRA3 glycine receptor, alpha 3 3.16163
VEGFD vascular endothelial growth factor D 3.16163
CEMP1 cementum protein 1 3.0656
ADRB2 adrenoceptor beta 2, surface 3.0656
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.0656
NCBP2L nuclear cap binding protein subunit 2-like 3.0656
HLF hepatic leukemia factor 3.0656
SCG2 secretogranin II 3.0656
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.0656
PARP3 poly (ADP-ribose) polymerase family, member 3 3.0656
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.0656
NAPSA napsin A aspartic peptidase 3.0656
ZNF503 zinc finger protein 503 3.0656
CARD18 caspase recruitment domain family, member 18 3.0656
CCR9 chemokine (C-C motif) receptor 9 3.0656
EQTN equatorin, sperm acrosome associated 3.0656
COL20A1 collagen, type XX, alpha 1 3.0656
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.0656
LYZL6 lysozyme-like 6 3.0656
C1ORF146 chromosome 1 open reading frame 146 3.0656
LCN12 lipocalin 12 3.0656
FIMP1 fertilization-influencing membrane protein 1 3.0656
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.0656
DRGX dorsal root ganglia homeobox 3.0656
TREML1 triggering receptor expressed on myeloid cells-like 1 3.0656
OXT oxytocin/neurophysin I prepropeptide 3.0656
LGALS2 lectin, galactoside-binding, soluble, 2 3.0656
CA1 carbonic anhydrase I 3.0656
SHCBP1L SHC SH2-domain binding protein 1-like 3.0656
PCDHB8 protocadherin beta 8 3.0656
HES7 hes family bHLH transcription factor 7 3.0656
MYBPC3 myosin binding protein C, cardiac 3.0656
ADTRP androgen-dependent TFPI-regulating protein 3.0656
CXORF65 chromosome X open reading frame 65 3.0656
SKOR1 SKI family transcriptional corepressor 1 3.0656
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 3.0656
CCL3 chemokine (C-C motif) ligand 3 3.0656
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.0656
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.0656
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 3.0656
GBP3 guanylate binding protein 3 3.0656
YIPF7 Yip1 domain family, member 7 3.0656
ROPN1L rhophilin associated tail protein 1-like 3.0656
HTRA4 HtrA serine peptidase 4 3.0656
HOXC13 homeobox C13 3.0656
ELOVL3 ELOVL fatty acid elongase 3 3.0656
DPP9 dipeptidyl-peptidase 9 3.0656
FMO2 flavin containing monooxygenase 2 (non-functional) 3.0656
LOC124900192 uncharacterized LOC124900192 3.0656
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.0656
FYB1 FYN binding protein 1 3.0656
SMIM40 small integral membrane protein 40 3.0656
CIMIP2B ciliary microtubule inner protein 2B 3.0656
PRR20G proline rich 20G 3.0656
ANKRD42-DT ANKRD42 divergent transcript 3.0656
C17ORF114 chromosome 17 open reading frame 114 3.0656
TMDD1 transmembrane and death domain 1 3.0656
CTXND1 cortexin domain containing 1 3.0656
IHO1 interactor of HORMAD1 1 3.0656
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.0656
TMEM270 transmembrane protein 270 3.0656
LORICRIN loricrin cornified envelope precursor protein 3.0656
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 3.0656
SAG S-antigen; retina and pineal gland (arrestin) 3.0656
GCSAM germinal center-associated, signaling and motility 3.0656
NPIPB9 nuclear pore complex interacting protein family, member B9 3.0656
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.0656
CATSPER1 cation channel, sperm associated 1 3.0656
MAGEB1 melanoma antigen family B1 3.0656
VIT vitrin 3.0656
PCDHB13 protocadherin beta 13 3.0656
DMP1 dentin matrix acidic phosphoprotein 1 3.0656
CD300LG CD300 molecule-like family member g 3.0656
LIPA lipase A, lysosomal acid, cholesterol esterase 3.0656
IZUMO4 IZUMO family member 4 3.0656
C1ORF162 chromosome 1 open reading frame 162 3.0656
SLC45A2 solute carrier family 45, member 2 3.0656
OSTN osteocrin 3.0656
CSAG2 CSAG family, member 2 3.0656
LTB lymphotoxin beta (TNF superfamily, member 3) 3.0656
SMCP sperm mitochondria-associated cysteine-rich protein 3.0656
GPR85 G protein-coupled receptor 85 3.0656
IL1RN interleukin 1 receptor antagonist 3.0656
PLB1 phospholipase B1 3.0656
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.0656
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.0656
GLP2R glucagon-like peptide 2 receptor 3.0656
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.0656
PRSS53 protease, serine, 53 3.0656
CCL25 chemokine (C-C motif) ligand 25 3.0656
ZNF132 zinc finger protein 132 3.0656
RNF112 ring finger protein 112 3.0656
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.0656
CXCR4 chemokine (C-X-C motif) receptor 4 3.0656
PHF21A PHD finger protein 21A 3.0656
ADAM7 ADAM metallopeptidase domain 7 3.0656
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.0656
LRRC46 leucine rich repeat containing 46 3.0656
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.0656
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.0656
KRT16 keratin 16, type I 3.0656
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 3.0656
SLC25A52 solute carrier family 25, member 52 3.0656
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.0656
APOD apolipoprotein D 3.0656
ODAM odontogenic, ameloblast asssociated 3.0656
DUSP26 dual specificity phosphatase 26 (putative) 3.0656
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.0656
CGB2 chorionic gonadotropin, beta polypeptide 2 3.0656
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.0656
PRSS38 protease, serine, 38 3.0656
PENK proenkephalin 3.0656
PGR progesterone receptor 3.0656
TRIM7 tripartite motif containing 7 3.0656
MGP matrix Gla protein 3.0656
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.0656
GOLGA8Q golgin A8 family, member Q 3.0656
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.0656
NTN5 netrin 5 3.0656
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.0656
PCDHGA3 protocadherin gamma subfamily A, 3 3.0656
ALOXE3 arachidonate lipoxygenase 3 3.0656
VWA3A von Willebrand factor A domain containing 3A 3.0656
VWA7 von Willebrand factor A domain containing 7 3.0656
FBXO43 F-box protein 43 3.0656
CFAP47 cilia and flagella associated protein 47 3.0656
EPHA5 EPH receptor A5 3.0656
C7ORF33 chromosome 7 open reading frame 33 3.0656
SEZ6L seizure related 6 homolog (mouse)-like 3.0656
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.0656
HEPN1 hepatocellular carcinoma, down-regulated 1 3.0656
GLT6D1 glycosyltransferase 6 domain containing 1 3.0656
GCM2 glial cells missing homolog 2 (Drosophila) 3.0656
VAV1 vav 1 guanine nucleotide exchange factor 3.0656
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.0656
PASD1 PAS domain containing 1 3.0656
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.0656
IL17B interleukin 17B 3.0656
SHISA3 shisa family member 3 3.0656
MSLN mesothelin 3.0656
CIB3 calcium and integrin binding family member 3 3.0656
XAF1 XIAP associated factor 1 3.0656
SSX1 synovial sarcoma, X breakpoint 1 3.0656
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.0656
MEIG1 meiosis/spermiogenesis associated 1 3.0656
CHRM1 cholinergic receptor, muscarinic 1 3.0656
NUTM2B NUT family member 2B 3.0656
ERAP2 endoplasmic reticulum aminopeptidase 2 3.0656
OR5A2 olfactory receptor, family 5, subfamily A, member 2 3.0656
WFDC10A WAP four-disulfide core domain 10A 3.0656
TECRL trans-2,3-enoyl-CoA reductase-like 3.0656
PXT1 peroxisomal, testis specific 1 3.0656
TBC1D28 TBC1 domain family, member 28 3.0656
FDFT1 farnesyl-diphosphate farnesyltransferase 1 3.065
SVOP SV2 related protein homolog (rat) 3.0497
SLC10A4 solute carrier family 10, member 4 3.04064
INHA inhibin, alpha 3.04064
NEK4 NIMA-related kinase 4 2.87346
ELL2 elongation factor, RNA polymerase II, 2 2.68013
GEMIN8 gem (nuclear organelle) associated protein 8 2.67749
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.67749
BMP2K BMP2 inducible kinase 2.64599
KIF23 kinesin family member 23 2.59594
KIF3B kinesin family member 3B 2.57936
NCOR2 nuclear receptor corepressor 2 2.55125
TMEM229A transmembrane protein 229A 2.48692
OTX2 orthodenticle homeobox 2 2.4735
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.4735
PGA5 pepsinogen 5, group I (pepsinogen A) 2.41744
EFTUD2 elongation factor Tu GTP binding domain containing 2 2.39897
CES2 carboxylesterase 2 2.37432
RFLNB refilin B 2.3668
PCSK5 proprotein convertase subtilisin/kexin type 5 2.3668
CDK12 cyclin-dependent kinase 12 2.3668
MPLKIP M-phase specific PLK1 interacting protein 2.31671
ZNF462 zinc finger protein 462 2.28294
TTC27 tetratricopeptide repeat domain 27 2.27991
ZBTB3 zinc finger and BTB domain containing 3 2.26946
AKR1C3 aldo-keto reductase family 1, member C3 2.23208
C18ORF32 chromosome 18 open reading frame 32 2.22715
FASN fatty acid synthase 2.22342
CALM1 calmodulin 1 (phosphorylase kinase, delta) 2.22128
ASXL2 additional sex combs like transcriptional regulator 2 2.21723
GBA2 glucosidase, beta (bile acid) 2 2.21169
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 2.2047
MRPS10 mitochondrial ribosomal protein S10 2.20036
RCC1L RCC1 like 2.18795
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.16237
OCIAD1 OCIA domain containing 1 2.13732
CEP350 centrosomal protein 350kDa 2.13526
CLDN20 claudin 20 2.11179
RNF150 ring finger protein 150 2.11073
RBM26 RNA binding motif protein 26 2.11049
GRHL3 grainyhead-like 3 (Drosophila) 2.08559
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.08559
ZNF792 zinc finger protein 792 2.08559
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.08559
NHLH1 nescient helix loop helix 1 2.08559
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 2.08559
VSTM2B V-set and transmembrane domain containing 2B 2.08559
RIPK4 receptor-interacting serine-threonine kinase 4 2.08559
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.08415
CD24 CD24 molecule 2.07169
PRR14 proline rich 14 2.07118
RAD23A RAD23 homolog A (S. cerevisiae) 2.07088
FHL2 four and a half LIM domains 2 2.06626
UBE2D3 ubiquitin-conjugating enzyme E2D 3 2.06626
SEH1L SEH1-like (S. cerevisiae) 2.06626
CYB5A cytochrome b5 type A (microsomal) 2.05439
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 2.03546
RAB3D RAB3D, member RAS oncogene family 2.02198
RBP1 retinol binding protein 1, cellular 2.01613
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 2.01613
MVK mevalonate kinase 2.00791

decreased expression

Symbol Name Standardized Value
TCF12 transcription factor 12 -3.27582
N4BP2L1 NEDD4 binding protein 2-like 1 -3.16163
LAT linker for activation of T cells -3.16163
DRICH1 aspartate-rich 1 -3.1044
NAP1L5 nucleosome assembly protein 1-like 5 -3.1044
MBLAC1 metallo-beta-lactamase domain containing 1 -3.1044
FCRLB Fc receptor-like B -3.1044
LPIN2 lipin 2 -3.0656
TSPAN10 tetraspanin 10 -3.0656
ABR active BCR-related -3.0656
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -3.0656
COL11A2 collagen, type XI, alpha 2 -3.0497
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -3.0497
TNNI1 troponin I type 1 (skeletal, slow) -3.0497
BMX BMX non-receptor tyrosine kinase -3.0497
GP1BA glycoprotein Ib (platelet), alpha polypeptide -3.0497
ZNF98 zinc finger protein 98 -3.0497
SPATA32 spermatogenesis associated 32 -3.0497
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -3.0497
FGF4 fibroblast growth factor 4 -3.0497
C17ORF78 chromosome 17 open reading frame 78 -3.0497
LEP leptin -3.0497
OIT3 oncoprotein induced transcript 3 -3.0497
GMNC geminin coiled-coil domain containing -3.0497
MTTP microsomal triglyceride transfer protein -3.0497
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.0497
SLC25A41 solute carrier family 25, member 41 -3.0497
KIF12 kinesin family member 12 -3.0497
CCDC158 coiled-coil domain containing 158 -3.0497
LBHD1 LBH domain containing 1 -3.0497
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -3.0497
MUC16 mucin 16, cell surface associated -3.0497
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -3.0497
SIGLEC10 sialic acid binding Ig-like lectin 10 -3.0497
HIGD1C HIG1 hypoxia inducible domain family, member 1C -3.0497
CTSO cathepsin O -3.0497
CDH26 cadherin 26 -3.0497
PRRT1B proline rich transmembrane protein 1B -3.0497
FBP1 fructose-1,6-bisphosphatase 1 -3.0497
DGCR6 DiGeorge syndrome critical region gene 6 -3.0497
C1QTNF1 C1q and tumor necrosis factor related protein 1 -3.0497
ZNF436 zinc finger protein 436 -3.0497
DYDC1 DPY30 domain containing 1 -3.0497
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -3.0497
TNR tenascin R -3.0497
MYH13 myosin, heavy chain 13, skeletal muscle -3.0497
NADK NAD kinase -2.92554
FIBP fibroblast growth factor (acidic) intracellular binding protein -2.87346
FBXL4 F-box and leucine-rich repeat protein 4 -2.75055
HDAC8 histone deacetylase 8 -2.73278
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.71999
NKD2 naked cuticle homolog 2 (Drosophila) -2.71895
SELENOK selenoprotein K -2.71754
UBQLN1 ubiquilin 1 -2.7074
GBA1 glucosylceramidase beta 1 -2.70058
LYN LYN proto-oncogene, Src family tyrosine kinase -2.68116
PPARD peroxisome proliferator-activated receptor delta -2.68013
BTN3A3 butyrophilin, subfamily 3, member A3 -2.67749
ACE angiotensin I converting enzyme -2.67749
VSTM5 V-set and transmembrane domain containing 5 -2.67749
FHL3 four and a half LIM domains 3 -2.63863
BCORL1 BCL6 corepressor-like 1 -2.60379
ZNF597 zinc finger protein 597 -2.57619
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.57619
IL15RA interleukin 15 receptor, alpha -2.57619
SYTL5 synaptotagmin-like 5 -2.57619
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.57619
ZNF491 zinc finger protein 491 -2.57619
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.55093
DDA1 DET1 and DDB1 associated 1 -2.54356
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.54052
DORIP1 dopamine receptor interacting protein 1 -2.50834
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.46649
PON3 paraoxonase 3 -2.4043
COL12A1 collagen, type XII, alpha 1 -2.4043
EBF1 early B-cell factor 1 -2.4043
ZBTB47 zinc finger and BTB domain containing 47 -2.4043
DNAH1 dynein, axonemal, heavy chain 1 -2.4043
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase -2.37444
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.34635
HVCN1 hydrogen voltage gated channel 1 -2.32733
C1QTNF2 C1q and tumor necrosis factor related protein 2 -2.32598
ELL3 elongation factor RNA polymerase II-like 3 -2.32598
TMEM213 transmembrane protein 213 -2.32598
CCDC163 CCDC163 homolog -2.32598
TMEM187 transmembrane protein 187 -2.27703
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.27703
COPG1 coatomer protein complex, subunit gamma 1 -2.26987
GPC4 glypican 4 -2.26977
S100A6 S100 calcium binding protein A6 -2.24538
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.22374
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -2.21308
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -2.21308
TCF15 transcription factor 15 (basic helix-loop-helix) -2.19968
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) -2.19968
SGCE sarcoglycan, epsilon -2.18795
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -2.18185
UBAC1 UBA domain containing 1 -2.1758
CPZ carboxypeptidase Z -2.13794
LGI4 leucine-rich repeat LGI family, member 4 -2.13465
EXOC8 exocyst complex component 8 -2.12156
DCAF17 DDB1 and CUL4 associated factor 17 -2.11617
MDN1 MDN1, midasin homolog (yeast) -2.11284
ETFRF1 electron transfer flavoprotein regulatory factor 1 -2.10119
POLR1G RNA polymerase I subunit G -2.0983
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.08841
ERVH48-1 endogenous retrovirus group 48, member 1 -2.08066
SREK1IP1 SREK1-interacting protein 1 -2.08066
GID4 GID complex subunit 4 -2.07943
GARIN2 golgi associated RAB2 interactor family member 2 -2.05748
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.05748
VILL villin-like -2.05748
LIN54 lin-54 DREAM MuvB core complex component -2.0482
RAD54B RAD54 homolog B (S. cerevisiae) -2.04801
KIRREL1 kirre like nephrin family adhesion molecule 1 -2.03108
LLGL1 lethal giant larvae homolog 1 (Drosophila) -2.02541
BUB3 BUB3 mitotic checkpoint protein -2.012
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -2.00898
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -2.00367