TCF21 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcription factor 21|TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6943)
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Genes

319 genes differentially expressed following the TCF21 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.84957
TTC36 tetratricopeptide repeat domain 36 3.84957
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.84957
TMPRSS4 transmembrane protease, serine 4 3.84957
F2 coagulation factor II (thrombin) 3.84957
ASIC4 acid sensing (proton gated) ion channel family member 4 3.84957
GATA4 GATA binding protein 4 3.84957
C9ORF50 chromosome 9 open reading frame 50 3.84957
HK3 hexokinase 3 (white cell) 3.84957
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.84957
GH2 growth hormone 2 3.84957
VPREB3 pre-B lymphocyte 3 3.84957
NUPR1 nuclear protein, transcriptional regulator, 1 3.84957
BHLHA9 basic helix-loop-helix family, member a9 3.84957
GALR3 galanin receptor 3 3.84957
SIGLECL1 SIGLEC family like 1 3.84957
GOLGA8H golgin A8 family, member H 3.84957
LVRN laeverin 3.84957
TMEM150B transmembrane protein 150B 3.84957
CD6 CD6 molecule 3.84957
SCGN secretagogin, EF-hand calcium binding protein 3.84957
PCDHGB2 protocadherin gamma subfamily B, 2 3.84957
GJB4 gap junction protein, beta 4, 30.3kDa 3.81716
IGFL2 IGF-like family member 2 3.81716
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 3.81716
CES5A carboxylesterase 5A 3.81716
TMEM191B transmembrane protein 191B 3.81716
DNASE1L2 deoxyribonuclease I-like 2 3.81716
GNLY granulysin 3.81716
PNMA5 paraneoplastic Ma antigen family member 5 3.81716
PRSS21 protease, serine, 21 (testisin) 3.81716
TRIM10 tripartite motif containing 10 3.81716
MAGEA3 melanoma antigen family A3 3.81716
HES5 hes family bHLH transcription factor 5 3.81716
NUGGC nuclear GTPase, germinal center associated 3.81716
OR5A2 olfactory receptor, family 5, subfamily A, member 2 3.81716
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.81716
SPDEF SAM pointed domain containing ETS transcription factor 3.81716
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.81716
KCNU1 potassium channel, subfamily U, member 1 3.81716
TPPP tubulin polymerization promoting protein 3.81716
AIRE autoimmune regulator 3.81716
GREM1 gremlin 1, DAN family BMP antagonist 3.81716
BMP5 bone morphogenetic protein 5 3.81716
TAS2R13 taste receptor, type 2, member 13 3.81716
OCM2 oncomodulin 2 3.81716
TDRD9 tudor domain containing 9 3.81716
CD68 CD68 molecule 3.81716
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.81716
ANKRD34C ankyrin repeat domain 34C 3.81716
UNC45B unc-45 homolog B (C. elegans) 3.81716
SPRR1B small proline-rich protein 1B 3.81716
TBC1D3I TBC1 domain family member 3I 3.81716
SPEM1 spermatid maturation 1 3.81716
TCERG1L transcription elongation regulator 1-like 3.81716
FRG2C FSHD region gene 2 family, member C 3.81716
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.81716
MYPN myopalladin 3.81716
GPR37L1 G protein-coupled receptor 37 like 1 3.81716
PRDM7 PR domain containing 7 3.81716
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.81716
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.81716
AVPR1A arginine vasopressin receptor 1A 3.81716
SPAAR small regulatory polypeptide of amino acid response 3.81716
CIBAR2 CBY1 interacting BAR domain containing 2 3.81716
PEAK3 PEAK family member 3 3.81716
RTL5 retrotransposon Gag like 5 3.81716
TBXT T-box transcription factor T 3.81716
CCDC198 coiled-coil domain containing 198 3.81716
DEPP1 DEPP autophagy regulator 1 3.81716
HBG1 hemoglobin, gamma A 3.81716
PCDHGC5 protocadherin gamma subfamily C, 5 3.81716
GPR83 G protein-coupled receptor 83 3.81716
ZAR1L zygote arrest 1-like 3.81716
PDILT protein disulfide isomerase-like, testis expressed 3.81716
HABP2 hyaluronan binding protein 2 3.81716
CFHR5 complement factor H-related 5 3.81716
SIX2 SIX homeobox 2 3.81716
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.81716
YIPF7 Yip1 domain family, member 7 3.81716
LRRD1 leucine-rich repeats and death domain containing 1 3.81716
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.81716
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.81716
SLC22A25 solute carrier family 22, member 25 3.81716
MTMR11 myotubularin related protein 11 3.81716
C7ORF57 chromosome 7 open reading frame 57 3.81716
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.81716
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.81716
GZMM granzyme M (lymphocyte met-ase 1) 3.81716
TLR4 toll-like receptor 4 3.81716
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.81716
ULBP1 UL16 binding protein 1 3.81716
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.81716
DMRTA2 DMRT-like family A2 3.81716
JSRP1 junctional sarcoplasmic reticulum protein 1 3.81716
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 3.81716
CTAGE9 CTAGE family, member 9 3.81716
DEFB107B defensin, beta 107B 3.81716
PLA2G2C phospholipase A2, group IIC 3.81716
ARHGAP40 Rho GTPase activating protein 40 3.81716
LCT lactase 3.81716
RGS11 regulator of G-protein signaling 11 3.81716
SHOX2 short stature homeobox 2 3.81716
CNR2 cannabinoid receptor 2 (macrophage) 3.81716
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.81716
ZMYND15 zinc finger, MYND-type containing 15 3.81716
ANKRD62 ankyrin repeat domain 62 3.81716
CLEC18B C-type lectin domain family 18, member B 3.81716
NTSR2 neurotensin receptor 2 3.81716
GPR149 G protein-coupled receptor 149 3.81716
DCT dopachrome tautomerase 3.81716
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.81716
IL1A interleukin 1, alpha 3.81716
COMP cartilage oligomeric matrix protein 3.81716
VWA7 von Willebrand factor A domain containing 7 3.81716
DLX5 distal-less homeobox 5 3.81716
VWA3B von Willebrand factor A domain containing 3B 3.81716
PRSS37 protease, serine, 37 3.81716
DRD2 dopamine receptor D2 3.81716
C22ORF42 chromosome 22 open reading frame 42 3.81716
IRGM immunity-related GTPase family, M 3.81716
PSKH2 protein serine kinase H2 3.81716
CBX8 chromobox homolog 8 3.81716
HKDC1 hexokinase domain containing 1 3.81716
DEFB4A defensin, beta 4A 3.81716
CALHM3 calcium homeostasis modulator 3 3.81716
ALOX15B arachidonate 15-lipoxygenase, type B 3.81716
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.81716
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.81716
GJC2 gap junction protein, gamma 2, 47kDa 3.81716
GOLGA8R golgin A8 family, member R 3.81716
KRTAP8-1 keratin associated protein 8-1 3.81716
LYZL1 lysozyme-like 1 3.81716
IFNE interferon, epsilon 3.81716
ZPLD1 zona pellucida-like domain containing 1 3.81716
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.81716
NKPD1 NTPase, KAP family P-loop domain containing 1 3.81716
RNF224 ring finger protein 224 3.81716
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.81716
KIF19 kinesin family member 19 3.81716
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.81716
FAM25C family with sequence similarity 25, member C 3.81716
C22ORF31 chromosome 22 open reading frame 31 3.81716
EPO erythropoietin 3.81716
NLRP3 NLR family, pyrin domain containing 3 3.81716
AMER2 APC membrane recruitment protein 2 3.81716
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.81716
NR2E3 nuclear receptor subfamily 2, group E, member 3 3.81705
MRPS33 mitochondrial ribosomal protein S33 3.04445
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.83744
C2ORF72 chromosome 2 open reading frame 72 2.74633
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 2.73859
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.66204
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.53258
TMOD4 tropomodulin 4 (muscle) 2.53258
NCF2 neutrophil cytosolic factor 2 2.53258
DPF3 D4, zinc and double PHD fingers, family 3 2.53258
ANGPT4 angiopoietin 4 2.53258
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.53258
HCK HCK proto-oncogene, Src family tyrosine kinase 2.53258
MST1 macrophage stimulating 1 2.53258
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.53258
SLC35E1 solute carrier family 35, member E1 2.43823
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.4223
GSDME gasdermin E 2.40962
CYB5D1 cytochrome b5 domain containing 1 2.38985
PRDX4 peroxiredoxin 4 2.366
KCNK17 potassium channel, two pore domain subfamily K, member 17 2.33829
CALD1 caldesmon 1 2.33829
ATCAY ataxia, cerebellar, Cayman type 2.32962
GLA galactosidase, alpha 2.32962
WDR44 WD repeat domain 44 2.32962
LTO1 LTO1 maturation factor of ABCE1 2.32891
VPS13B vacuolar protein sorting 13 homolog B (yeast) 2.32703
ASB7 ankyrin repeat and SOCS box containing 7 2.32129
ZNF664-RFLNA ZNF664-RFLNA readthrough 2.31492
TTBK1 tau tubulin kinase 1 2.30244
FADS1 fatty acid desaturase 1 2.29036
SPEG SPEG complex locus 2.27937
PGM3 phosphoglucomutase 3 2.27374
UMPS uridine monophosphate synthetase 2.26288
VAV1 vav 1 guanine nucleotide exchange factor 2.24883
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.24104
CD177 CD177 molecule 2.24104
NALCN sodium leak channel, non selective 2.18324
RECQL4 RecQ protein-like 4 2.18324
DENND5B DENN/MADD domain containing 5B 2.18016
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 2.17441
FREM2 FRAS1 related extracellular matrix protein 2 2.17339
NT5C1B 5'-nucleotidase, cytosolic IB 2.17339
RTBDN retbindin 2.17339
TPH1 tryptophan hydroxylase 1 2.17339
BDH2 3-hydroxybutyrate dehydrogenase, type 2 2.15243
PTGFRN prostaglandin F2 receptor inhibitor 2.14574
VGLL3 vestigial-like family member 3 2.12455
A1CF APOBEC1 complementation factor 2.12016
CCKBR cholecystokinin B receptor 2.12016
C10ORF67 chromosome 10 open reading frame 67 2.12016
OSCP1 organic solute carrier partner 1 2.12016
SPATA6L spermatogenesis associated 6-like 2.11984
ELOVL1 ELOVL fatty acid elongase 1 2.11967
PTN pleiotrophin 2.10423
PHTF2 putative homeodomain transcription factor 2 2.09708
ZNF280B zinc finger protein 280B 2.09434
NFE2L2 nuclear factor, erythroid 2-like 2 2.07364
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 2.07364
CRTC1 CREB regulated transcription coactivator 1 2.06328
ARHGAP8 Rho GTPase activating protein 8 2.0628
TMEM151B transmembrane protein 151B 2.0628
SAMD12 sterile alpha motif domain containing 12 2.05592
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.03831
FNDC4 fibronectin type III domain containing 4 2.02701
CC2D2A coiled-coil and C2 domain containing 2A 2.01677

decreased expression

Symbol Name Standardized Value
CSDC2 cold shock domain containing C2, RNA binding -3.84957
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.81716
TMIE transmembrane inner ear -3.81716
EQTN equatorin, sperm acrosome associated -3.81716
MROH5 maestro heat-like repeat family member 5 -3.81716
LURAP1L leucine rich adaptor protein 1-like -3.81716
ZNF703 zinc finger protein 703 -3.81716
SLA2 Src-like-adaptor 2 -3.81716
PCDHGB1 protocadherin gamma subfamily B, 1 -3.81716
IL5RA interleukin 5 receptor, alpha -3.81716
PDZD9 PDZ domain containing 9 -3.81716
EBI3 Epstein-Barr virus induced 3 -3.81716
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.81716
APOL6 apolipoprotein L, 6 -3.81716
CD86 CD86 molecule -3.81716
NELL1 NEL-like 1 (chicken) -3.81716
ADAM20 ADAM metallopeptidase domain 20 -3.81716
CLEC2A C-type lectin domain family 2, member A -3.81716
CHI3L2 chitinase 3-like 2 -3.81716
CCR8 chemokine (C-C motif) receptor 8 -3.81716
DUSP8 dual specificity phosphatase 8 -3.81716
KLF1 Kruppel-like factor 1 (erythroid) -3.81716
ERVV-2 endogenous retrovirus group V, member 2 -3.81716
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -3.81716
SPHKAP SPHK1 interactor, AKAP domain containing -3.81716
DMRT1 doublesex and mab-3 related transcription factor 1 -3.81716
PRRT1B proline rich transmembrane protein 1B -3.81716
ADRA2A adrenoceptor alpha 2A -3.81716
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -3.81716
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -3.81716
EEF1G eukaryotic translation elongation factor 1 gamma -3.64108
MAOB monoamine oxidase B -3.35391
DNAI3 dynein axonemal intermediate chain 3 -3.29824
TM7SF2 transmembrane 7 superfamily member 2 -3.29824
PCDHB16 protocadherin beta 16 -3.29081
TMEM144 transmembrane protein 144 -3.21613
MMRN2 multimerin 2 -3.10152
ECEL1 endothelin converting enzyme-like 1 -3.10152
HTRA3 HtrA serine peptidase 3 -3.10152
ZBBX zinc finger, B-box domain containing -2.98759
PACRG PARK2 co-regulated -2.91266
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.80042
TAPT1 transmembrane anterior posterior transformation 1 -2.74828
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.74633
MOGS mannosyl-oligosaccharide glucosidase -2.72384
FCSK fucose kinase -2.57042
NELFA negative elongation factor complex member A -2.56059
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.55927
DRC4 dynein regulatory complex subunit 4 -2.5503
SRBD1 S1 RNA binding domain 1 -2.549
LCA5L Leber congenital amaurosis 5-like -2.53258
RUVBL1 RuvB-like AAA ATPase 1 -2.53258
COPRS coordinator of PRMT5, differentiation stimulator -2.44596
GYPE glycophorin E (MNS blood group) -2.4223
TUBA1B tubulin, alpha 1b -2.40496
TBCC tubulin folding cofactor C -2.38322
CIRBP cold inducible RNA binding protein -2.38239
STIL SCL/TAL1 interrupting locus -2.33829
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) -2.33829
RAB40A RAB40A, member RAS oncogene family -2.32962
GLDN gliomedin -2.32962
HCST hematopoietic cell signal transducer -2.32962
MMP19 matrix metallopeptidase 19 -2.32962
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.32962
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.32962
CLSTN2 calsyntenin 2 -2.32962
ZNF253 zinc finger protein 253 -2.32962
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.32962
APH1A APH1A gamma secretase subunit -2.32703
SHISA9 shisa family member 9 -2.32129
TRAF3 TNF receptor-associated factor 3 -2.31883
NUBP1 nucleotide binding protein 1 -2.31882
CCDC157 coiled-coil domain containing 157 -2.30234
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -2.28712
NKAP NFKB activating protein -2.28525
DBT dihydrolipoamide branched chain transacylase E2 -2.28513
TSC2 tuberous sclerosis 2 -2.27374
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.24815
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.24552
MOCOS molybdenum cofactor sulfurase -2.24104
C1ORF50 chromosome 1 open reading frame 50 -2.21519
ARID4A AT rich interactive domain 4A (RBP1-like) -2.19228
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.18391
ZNF469 zinc finger protein 469 -2.17339
ZNF572 zinc finger protein 572 -2.17339
PUM2 pumilio RNA-binding family member 2 -2.17312
EMC2 ER membrane protein complex subunit 2 -2.15959
C1QTNF6 C1q and tumor necrosis factor related protein 6 -2.15301
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.14134
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13492
RETREG3 reticulophagy regulator family member 3 -2.12355
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.12134
TM9SF2 transmembrane 9 superfamily member 2 -2.09373
AAGAB alpha- and gamma-adaptin binding protein -2.08974
FZD2 frizzled class receptor 2 -2.08119
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.07877
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.07496
EXOC6B exocyst complex component 6B -2.07364
FBXO41 F-box protein 41 -2.06328
TUFM Tu translation elongation factor, mitochondrial -2.06052
GOLT1B golgi transport 1B -2.03212
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like -2.03212
ZNF414 zinc finger protein 414 -2.01912
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -2.01313
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C -2.01313
SELENOK selenoprotein K -2.01244