TCF3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description transcription factor 3|This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 6929)
External Link http://www.ncbi.nlm.nih.gov/gene/6929
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199 interacting proteins for TCF3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTL6A actin-like 6A
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
AEBP1 AE binding protein 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ASB2 ankyrin repeat and SOCS box containing 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASCL3 achaete-scute family bHLH transcription factor 3
ATOH1 atonal homolog 1 (Drosophila)
ATOH8 atonal homolog 8 (Drosophila)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BHLHA15 basic helix-loop-helix family, member a15
BRD8 bromodomain containing 8
C14ORF166 chromosome 14 open reading frame 166
C1QBP complement component 1, q subcomponent binding protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANX calnexin
CASP14 caspase 14, apoptosis-related cysteine peptidase
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCNDBP1 cyclin D-type binding-protein 1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CPD carboxypeptidase D
CREBBP CREB binding protein
CSTA cystatin A (stefin A)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAXX death-domain associated protein
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DMAP1 DNA methyltransferase 1 associated protein 1
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EAF1 ELL associated factor 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EP300 E1A binding protein p300
EPC1 enhancer of polycomb homolog 1 (Drosophila)
EPC2 enhancer of polycomb homolog 2 (Drosophila)
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ERLIN2 ER lipid raft associated 2
ERVK-19 endogenous retrovirus group K, member 19
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBL fibrillarin
FERD3L Fer3-like bHLH transcription factor
FLG2 filaggrin family member 2
FOXH1 forkhead box H1
FUS FUS RNA binding protein
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GATS GATS, stromal antigen 3 opposite strand
GSE1 Gse1 coiled-coil protein
HAND1 heart and neural crest derivatives expressed 1
HAND2 heart and neural crest derivatives expressed 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HES5 hes family bHLH transcription factor 5
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOXA1 homeobox A1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IMMT inner membrane protein, mitochondrial
ING3 inhibitor of growth family, member 3
INO80 INO80 complex subunit
INO80B INO80 complex subunit B
INO80E INO80 complex subunit E
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KDM1A lysine (K)-specific demethylase 1A
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LBR lamin B receptor
LDB1 LIM domain binding 1
LGALS7B lectin, galactoside-binding, soluble, 7B
LMO2 LIM domain only 2 (rhombotin-like 1)
LMX1A LIM homeobox transcription factor 1, alpha
LMX1B LIM homeobox transcription factor 1, beta
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAX MYC associated factor X
MDFI MyoD family inhibitor
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MEN1 multiple endocrine neoplasia I
MORF4L1 mortality factor 4 like 1
MRGBP MRG/MORF4L binding protein
MRPL23 mitochondrial ribosomal protein L23
MRPL37 mitochondrial ribosomal protein L37
MRPL39 mitochondrial ribosomal protein L39
MRPL44 mitochondrial ribosomal protein L44
MRPL49 mitochondrial ribosomal protein L49
MSC musculin
MYF5 myogenic factor 5
MYF6 myogenic factor 6 (herculin)
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYO1B myosin IB
MYOD1 myogenic differentiation 1
MYOG myogenin (myogenic factor 4)
NCOR1 nuclear receptor corepressor 1
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NHLH1 nescient helix loop helix 1
NHLH2 nescient helix loop helix 2
NUCLEOLIN nucleolin multifunctional protein
PARP1 poly (ADP-ribose) polymerase 1
PBX1 pre-B-cell leukemia homeobox 1
PCBP1 poly(rC) binding protein 1
PDX1 pancreatic and duodenal homeobox 1
PIP prolactin-induced protein
PKNOX1 PBX/knotted 1 homeobox 1
PLSCR4 phospholipid scramblase 4
PON2 paraoxonase 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRMT5 protein arginine methyltransferase 5
PRPF8 pre-mRNA processing factor 8
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RB1 retinoblastoma 1
RBM39 RNA binding motif protein 39
RCOR1 REST corepressor 1
RNF14 ring finger protein 14
RPL13 ribosomal protein L13
RPL14 ribosomal protein L14
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL31 ribosomal protein L31
RPL36A ribosomal protein L36a
RPL37 ribosomal protein L37
RPN2 ribophorin II
RPS13 ribosomal protein S13
RUFY1 RUN and FYVE domain containing 1
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SAFB scaffold attachment factor B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SF3A3 splicing factor 3a, subunit 3, 60kDa
SIN3A SIN3 transcription regulator family member A
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SON SON DNA binding protein
SOX2 SRY (sex determining region Y)-box 2
SPIN1 spindlin 1
SRCAP Snf2-related CREBBP activator protein
SRF serum response factor (c-fos serum response element-binding transcription factor)
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSBP2 single-stranded DNA binding protein 2
SSBP3 single stranded DNA binding protein 3
STK38 serine/threonine kinase 38
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TADA2A transcriptional adaptor 2A
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAL1 T-cell acute lymphocytic leukemia 1
TAL2 T-cell acute lymphocytic leukemia 2
TCF12 transcription factor 12
TCF21 transcription factor 21
TCF24 transcription factor 24
TCF4 transcription factor 4
TET2 tet methylcytosine dioxygenase 2
TFF3 trefoil factor 3 (intestinal)
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIM33 tripartite motif containing 33
TRRAP transformation/transcription domain-associated protein
TWIST1 twist family bHLH transcription factor 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USF1 upstream transcription factor 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
YEATS4 YEATS domain containing 4
YY1 YY1 transcription factor
ZNHIT1 zinc finger, HIT-type containing 1