TCF4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description transcription factor 4|This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 6925)
External Link http://www.ncbi.nlm.nih.gov/gene/6925
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Genes

91 interacting proteins for TCF4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTL6A actin-like 6A
AR androgen receptor
ASCL1 achaete-scute family bHLH transcription factor 1
ASCL3 achaete-scute family bHLH transcription factor 3
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL9 B-cell CLL/lymphoma 9
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBX1 chromobox homolog 1
CBX3 chromobox homolog 3
CBX8 chromobox homolog 8
CDC73 cell division cycle 73
CHD4 chromodomain helicase DNA binding protein 4
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAXX death-domain associated protein
DGCR6 DiGeorge syndrome critical region gene 6
DOT1L DOT1-like histone H3K79 methyltransferase
EGR1 early growth response 1
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
FERMT2 fermitin family member 2
FUS FUS RNA binding protein
GSK3B glycogen synthase kinase 3 beta
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HBP1 HMG-box transcription factor 1
HIC1 hypermethylated in cancer 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JUN jun proto-oncogene
JUP junction plakoglobin
LDB1 LIM domain binding 1
LEF1 lymphoid enhancer-binding factor 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MBD3 methyl-CpG binding domain protein 3
MEN1 multiple endocrine neoplasia I
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSC musculin
MVP major vault protein
MYOD1 myogenic differentiation 1
NEUROD1 neuronal differentiation 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PBRM1 polybromo 1
PIAS4 protein inhibitor of activated STAT, 4
PML promyelocytic leukemia
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF14 ring finger protein 14
RSF1 remodeling and spacing factor 1
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUVBL1 RuvB-like AAA ATPase 1
SAP30 Sin3A-associated protein, 30kDa
SETD8 SET domain containing (lysine methyltransferase) 8
SKIL SKI-like proto-oncogene
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SSBP2 single-stranded DNA binding protein 2
SSBP3 single stranded DNA binding protein 3
SSBP4 single stranded DNA binding protein 4
SSRP1 structure specific recognition protein 1
SUMO1 small ubiquitin-like modifier 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TAL1 T-cell acute lymphocytic leukemia 1
TAL2 T-cell acute lymphocytic leukemia 2
TCF12 transcription factor 12
TCF21 transcription factor 21
TCF3 transcription factor 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM33 tripartite motif containing 33
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAF2 YY1 associated factor 2
YEATS4 YEATS domain containing 4