TCF7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcription factor 7 (T-cell specific, HMG-box)|The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 6932)
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Genes

345 genes differentially expressed following the TCF7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FGD2 FYVE, RhoGEF and PH domain containing 2 3.3202
PLIN1 perilipin 1 3.3202
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.3202
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.3202
TBX10 T-box 10 3.3202
RGCC regulator of cell cycle 3.3202
LY6H lymphocyte antigen 6 complex, locus H 3.3202
TSPAN8 tetraspanin 8 3.3202
PAPOLB poly(A) polymerase beta (testis specific) 3.3202
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.3202
GJD3 gap junction protein, delta 3, 31.9kDa 3.3202
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.3202
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 3.3202
IGFL4 IGF-like family member 4 3.3202
HRH4 histamine receptor H4 3.3202
SCGN secretagogin, EF-hand calcium binding protein 3.3202
SYCP2 synaptonemal complex protein 2 3.3202
RGSL1 regulator of G-protein signaling like 1 3.3202
TFEC transcription factor EC 3.3202
TMPRSS15 transmembrane protease, serine 15 3.3202
LRTM3 leucine rich repeat transmembrane protein 3 3.3202
TMEM176A transmembrane protein 176A 3.3202
TMEM275 transmembrane protein 275 3.3202
DIPK1C divergent protein kinase domain 1C 3.3202
SHE Src homology 2 domain containing E 3.3202
SPEGNB SPEG neighbor 3.3202
H2BK1 H2B.K variant histone 1 3.3202
TDO2 tryptophan 2,3-dioxygenase 3.3202
ANKRD53 ankyrin repeat domain 53 3.3202
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.3202
MUC22 mucin 22 3.19773
ANKK1 ankyrin repeat and kinase domain containing 1 3.19773
GJB5 gap junction protein, beta 5, 31.1kDa 3.19773
DDN dendrin 3.19773
HCRTR1 hypocretin (orexin) receptor 1 3.19773
CASP5 caspase 5, apoptosis-related cysteine peptidase 3.19773
FOXA2 forkhead box A2 3.19773
PCDHB1 protocadherin beta 1 3.19773
CELA3B chymotrypsin-like elastase family, member 3B 3.19773
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.19773
HBZ hemoglobin, zeta 3.19773
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.19773
SPINK4 serine peptidase inhibitor, Kazal type 4 3.19773
TMEM121 transmembrane protein 121 3.19773
S100P S100 calcium binding protein P 3.19773
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.19773
F9 coagulation factor IX 3.19773
OTUD6A OTU deubiquitinase 6A 3.19773
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.19773
STRA8 stimulated by retinoic acid 8 3.19773
ARHGAP36 Rho GTPase activating protein 36 3.19773
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.19773
NCKAP1L NCK-associated protein 1-like 3.19773
C11ORF87 chromosome 11 open reading frame 87 3.19773
TLX3 T-cell leukemia homeobox 3 3.19773
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.19773
LRG1 leucine-rich alpha-2-glycoprotein 1 3.19773
FAM90A1 family with sequence similarity 90, member A1 3.19773
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.19773
GJB4 gap junction protein, beta 4, 30.3kDa 3.19773
ADTRP androgen-dependent TFPI-regulating protein 3.19773
C3ORF22 chromosome 3 open reading frame 22 3.19773
RPE65 retinal pigment epithelium-specific protein 65kDa 3.19773
C1ORF141 chromosome 1 open reading frame 141 3.19773
ADAD2 adenosine deaminase domain containing 2 3.19773
WDR87 WD repeat domain 87 3.19773
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.19773
FYB1 FYN binding protein 1 3.19773
H1-6 H1.6 linker histone, cluster member 3.19773
ALDOB aldolase B, fructose-bisphosphate 3.19773
OTOS otospiralin 3.19773
GBP1 guanylate binding protein 1, interferon-inducible 3.19773
GPX5 glutathione peroxidase 5 3.19773
STX11 syntaxin 11 3.19773
SRGN serglycin 3.19773
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.19773
DERPC DERPC proline and glycine rich nuclear protein 3.19773
CBLIF cobalamin binding intrinsic factor 3.19773
CIMIP4 ciliary microtubule inner protein 4 3.19773
PRR20G proline rich 20G 3.19773
LINC02893 long intergenic non-protein coding RNA 2893 3.19773
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.19773
C17ORF114 chromosome 17 open reading frame 114 3.19773
LOC124903372 uncharacterized LOC124903372 3.19773
DNAAF6 dynein axonemal assembly factor 6 3.19773
GARIN1A golgi associated RAB2 interactor 1A 3.19773
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.19773
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.19773
F5 coagulation factor V (proaccelerin, labile factor) 3.19773
TUBA3D tubulin, alpha 3d 3.19773
RAB44 RAB44, member RAS oncogene family 3.19773
FPR2 formyl peptide receptor 2 3.19773
ACR acrosin 3.19773
RNF151 ring finger protein 151 3.19773
PDILT protein disulfide isomerase-like, testis expressed 3.19773
SRPX2 sushi-repeat containing protein, X-linked 2 3.19773
FOLR1 folate receptor 1 (adult) 3.19773
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.19773
TRIM67 tripartite motif containing 67 3.19773
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.19773
GATA2 GATA binding protein 2 3.19773
RNF183 ring finger protein 183 3.19773
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.19773
LGSN lengsin, lens protein with glutamine synthetase domain 3.19773
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.19773
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.19773
PLD4 phospholipase D family, member 4 3.19773
MYOT myotilin 3.19773
MYH13 myosin, heavy chain 13, skeletal muscle 3.19773
PROKR2 prokineticin receptor 2 3.19773
MT1A metallothionein 1A 3.19773
LRCOL1 leucine rich colipase-like 1 3.19773
PALMD palmdelphin 3.19773
RSAD2 radical S-adenosyl methionine domain containing 2 3.19773
INSM1 insulinoma-associated 1 3.19773
DNAH10 dynein, axonemal, heavy chain 10 3.19773
AQP2 aquaporin 2 (collecting duct) 3.19773
NANOGNB NANOG neighbor homeobox 3.19773
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.19773
CALHM3 calcium homeostasis modulator 3 3.19773
PHOSPHO1 phosphatase, orphan 1 3.19773
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.19773
NUTM2A NUT family member 2A 3.19773
TBC1D28 TBC1 domain family, member 28 3.19773
KIF4B kinesin family member 4B 3.19773
ZMYND10 zinc finger, MYND-type containing 10 3.19773
MAGEB17 melanoma antigen family B17 3.19773
PHOX2A paired-like homeobox 2a 3.19773
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.19773
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.19773
PLA2G4E phospholipase A2, group IVE 3.19773
APOC4 apolipoprotein C-IV 3.19773
CYS1 cystin 1 3.19773
GSTA1 glutathione S-transferase alpha 1 3.19773
RETN resistin 3.19773
SLC38A8 solute carrier family 38, member 8 3.19773
PSG2 pregnancy specific beta-1-glycoprotein 2 3.19773
CSF1R colony stimulating factor 1 receptor 3.19773
EFCC1 EF-hand and coiled-coil domain containing 1 3.19773
RASA4 RAS p21 protein activator 4 3.19773
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.19773
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.19773
SIGLEC11 sialic acid binding Ig-like lectin 11 3.19773
RBM24 RNA binding motif protein 24 3.19773
NUPR1 nuclear protein, transcriptional regulator, 1 3.19773
VWA3B von Willebrand factor A domain containing 3B 3.19773
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 3.19773
FBXO47 F-box protein 47 3.19773
ILDR2 immunoglobulin-like domain containing receptor 2 3.19773
UTS2R urotensin 2 receptor 3.19773
ANTXRL anthrax toxin receptor-like 3.19773
CALR3 calreticulin 3 3.19773
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.19773
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.19773
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.19773
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.19773
SLC38A11 solute carrier family 38, member 11 3.19773
BANF2 barrier to autointegration factor 2 3.19773
HIC1 hypermethylated in cancer 1 3.19773
ANGPTL3 angiopoietin-like 3 3.19773
STEAP4 STEAP family member 4 3.19773
SPAG8 sperm associated antigen 8 3.19773
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.19773
OR4M2 olfactory receptor, family 4, subfamily M, member 2 3.19773
GALP galanin-like peptide 3.19773
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.19773
TLDC2 TBC/LysM-associated domain containing 2 3.19773
PCDHGA12 protocadherin gamma subfamily A, 12 3.19773
XCR1 chemokine (C motif) receptor 1 3.19773
TGM7 transglutaminase 7 3.19773
CD8A CD8a molecule 3.19773
ACOT12 acyl-CoA thioesterase 12 3.19773
LRRC74B leucine rich repeat containing 74B 3.19773
PRAP1 proline-rich acidic protein 1 3.19773
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.19773
MPO myeloperoxidase 3.19773
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 3.19773
ALLC allantoicase 3.19773
SP9 Sp9 transcription factor 3.19773
HHIPL2 HHIP-like 2 3.19773
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.96028
DRD4 dopamine receptor D4 2.93817
MEIKIN meiotic kinetochore factor 2.93697
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.6451
BSN bassoon presynaptic cytomatrix protein 2.60295
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.58779
CC2D1B coiled-coil and C2 domain containing 1B 2.55223
CARMIL2 capping protein regulator and myosin 1 linker 2 2.55223
TULP3 tubby like protein 3 2.54198
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.53922
DCPH1 damage control phosphatase 1 2.50739
ATCAY ataxia, cerebellar, Cayman type 2.46716
PAIP1 poly(A) binding protein interacting protein 1 2.43732
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.42663
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2.39352
CALM2 calmodulin 2 (phosphorylase kinase, delta) 2.32174
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 2.32174
CNGB1 cyclic nucleotide gated channel beta 1 2.31666
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.31666
CSP2 CS pseudogene 2 2.31666
TMEM143 transmembrane protein 143 2.31471
HSPB11 heat shock protein family B (small), member 11 2.28024
SPX spexin hormone 2.27769
SEPHS2 selenophosphate synthetase 2 2.27769
ADAM8 ADAM metallopeptidase domain 8 2.27769
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.27769
TUBA1A tubulin, alpha 1a 2.27769
RAD1 RAD1 checkpoint DNA exonuclease 2.274
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.26534
PRR13 proline rich 13 2.2452
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 2.24305
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.24103
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 2.2323
DVL1 dishevelled segment polarity protein 1 2.2323
STAT1 signal transducer and activator of transcription 1, 91kDa 2.22905
CZIB CXXC motif containing zinc binding protein 2.2283
MTCH1 mitochondrial carrier 1 2.20393
IFT52 intraflagellar transport 52 2.19338
NBPF1 neuroblastoma breakpoint family, member 1 2.18772
LYPLAL1 lysophospholipase-like 1 2.17687
VIM vimentin 2.17686
DERL1 derlin 1 2.16378
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 2.11146
RPS28 ribosomal protein S28 2.10129
RAB31 RAB31, member RAS oncogene family 2.0892
LRGUK leucine-rich repeats and guanylate kinase domain containing 2.08452
ZNF750 zinc finger protein 750 2.0699
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 2.0699
ATP13A4 ATPase type 13A4 2.0699
LEF1 lymphoid enhancer-binding factor 1 2.0699
ZEB2 zinc finger E-box binding homeobox 2 2.0699
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 2.06887
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.06198
ACSL4 acyl-CoA synthetase long-chain family member 4 2.05522
TRIM65 tripartite motif containing 65 2.05522
BEND4 BEN domain containing 4 2.05522
SYNE1 spectrin repeat containing, nuclear envelope 1 2.05522
FTSJ3 FtsJ homolog 3 (E. coli) 2.03953
CLEC16A C-type lectin domain family 16, member A 2.01409
APP amyloid beta (A4) precursor protein 2.01409
NTNG1 netrin G1 2.01408
ANO1 anoctamin 1, calcium activated chloride channel 2.00873
KRTCAP3 keratinocyte associated protein 3 2.0048

decreased expression

Symbol Name Standardized Value
DACT2 dishevelled-binding antagonist of beta-catenin 2 -3.3202
IQSEC3 IQ motif and Sec7 domain 3 -3.3202
MYOCOS myocilin opposite strand -3.3202
CA2 carbonic anhydrase II -3.3171
TMPRSS4 transmembrane protease, serine 4 -3.19773
LRRC66 leucine rich repeat containing 66 -3.19773
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) -3.19773
C16ORF54 chromosome 16 open reading frame 54 -3.19773
DEFB131B defensin beta 131B -3.19773
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -3.19773
CLNK cytokine-dependent hematopoietic cell linker -3.19773
LRRC38 leucine rich repeat containing 38 -3.19773
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -3.19773
CRIP1 cysteine-rich protein 1 (intestinal) -3.19773
GLRA3 glycine receptor, alpha 3 -3.19773
GC group-specific component (vitamin D binding protein) -3.19773
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.19773
ZAR1L zygote arrest 1-like -3.19773
NPNT nephronectin -3.19773
LDHAL6A lactate dehydrogenase A-like 6A -3.19773
IZUMO3 IZUMO family member 3 -3.19773
GDNF glial cell derived neurotrophic factor -3.19773
SPI1 Spi-1 proto-oncogene -3.19773
FADS6 fatty acid desaturase 6 -3.19773
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -3.19773
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -3.19773
TMPPE transmembrane protein with metallophosphoesterase domain -3.19773
PRTN3 proteinase 3 -3.19773
GOLGA6C golgin A6 family, member C -3.19773
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -3.19773
ADAM12 ADAM metallopeptidase domain 12 -3.19773
ADAP1 ArfGAP with dual PH domains 1 -3.19773
CTXN2 cortexin 2 -3.19773
CCNA1 cyclin A1 -3.19773
SNUPN snurportin 1 -2.93606
ARL3 ADP-ribosylation factor-like 3 -2.89261
ZMYM2 zinc finger, MYM-type 2 -2.80994
SYCP3 synaptonemal complex protein 3 -2.74609
RAB3A RAB3A, member RAS oncogene family -2.72962
PCDHA12 protocadherin alpha 12 -2.70722
ZNF266 zinc finger protein 266 -2.69659
TENT4B terminal nucleotidyltransferase 4B -2.58966
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.55223
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.55223
C7orf78 chromosome 7 open reading frame 78 -2.55223
EBF2 early B-cell factor 2 -2.55223
DIO1 deiodinase, iodothyronine, type I -2.55223
AFAP1L1 actin filament associated protein 1-like 1 -2.54208
NTSR1 neurotensin receptor 1 (high affinity) -2.52187
ZFC3H1 zinc finger, C3H1-type containing -2.50781
SHCBP1 SHC SH2-domain binding protein 1 -2.50739
TSC2 tuberous sclerosis 2 -2.46959
UHMK1 U2AF homology motif (UHM) kinase 1 -2.46921
ATP5F1E ATP synthase F1 subunit epsilon -2.44181
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -2.42625
SEC16A SEC16 homolog A (S. cerevisiae) -2.40598
TPP1 tripeptidyl peptidase I -2.38333
HMBS hydroxymethylbilane synthase -2.38333
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.36517
RBM42 RNA binding motif protein 42 -2.35907
PROCR protein C receptor, endothelial -2.34345
WIZ widely interspaced zinc finger motifs -2.31471
ZBTB17 zinc finger and BTB domain containing 17 -2.28953
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -2.28024
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.28024
MARCHF10 membrane associated ring-CH-type finger 10 -2.28024
CD48 CD48 molecule -2.28024
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -2.28024
KISS1R KISS1 receptor -2.28024
IRX3 iroquois homeobox 3 -2.28024
SREBF1 sterol regulatory element binding transcription factor 1 -2.274
ZNF141 zinc finger protein 141 -2.26534
PXDC1 PX domain containing 1 -2.2484
EPN3 epsin 3 -2.2484
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.24695
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.2452
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -2.2452
ARG1 arginase 1 -2.2452
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.2323
PADI4 peptidyl arginine deiminase, type IV -2.2323
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.2323
GPHA2 glycoprotein hormone alpha 2 -2.23193
LENG9 leukocyte receptor cluster (LRC) member 9 -2.22905
DTD1 D-tyrosyl-tRNA deacylase 1 -2.21446
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -2.20755
SLFN5 schlafen family member 5 -2.19628
RRM2 ribonucleotide reductase M2 -2.1924
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -2.18743
PNMA2 paraneoplastic Ma antigen 2 -2.17686
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 -2.15816
DOHH deoxyhypusine hydroxylase/monooxygenase -2.12061
EPN1 epsin 1 -2.0699
SP3 Sp3 transcription factor -2.06611
PID1 phosphotyrosine interaction domain containing 1 -2.05365
NEMP1 nuclear envelope integral membrane protein 1 -2.05336
H1-5 H1.5 linker histone, cluster member -2.03127
CEP170 centrosomal protein 170kDa -2.02695
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.02593
KIF24 kinesin family member 24 -2.01291
TATDN2 TatD DNase domain containing 2 -2.01291
AMZ2 archaelysin family metallopeptidase 2 -2.00873
FRS2 fibroblast growth factor receptor substrate 2 -2.00873