TCF7L2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcription factor 7-like 2 (T-cell specific, HMG-box)|This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 6934)
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Genes

339 genes differentially expressed following the TCF7L2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
VEGFD vascular endothelial growth factor D 2.66548
FOXJ1 forkhead box J1 2.66548
CXORF65 chromosome X open reading frame 65 2.66548
LOC124900192 uncharacterized LOC124900192 2.66548
XKR6 XK, Kell blood group complex subunit-related family, member 6 2.66548
PLN phospholamban 2.66548
NUGGC nuclear GTPase, germinal center associated 2.66548
PDYN prodynorphin 2.66548
MYPN myopalladin 2.66548
SP6 Sp6 transcription factor 2.66548
FAM209A family with sequence similarity 209, member A 2.66548
SLC51B solute carrier family 51, beta subunit 2.66548
MSGN1 mesogenin 1 2.66548
PADI4 peptidyl arginine deiminase, type IV 2.66548
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.66548
NT5C1B 5'-nucleotidase, cytosolic IB 2.66548
ZNF703 zinc finger protein 703 2.66548
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.66548
PRSS54 protease, serine, 54 2.66548
H3-7 H3.7 histone (putative) 2.66548
NPR3 natriuretic peptide receptor 3 2.66548
TENT5D terminal nucleotidyltransferase 5D 2.66548
CFAP206 cilia and flagella associated protein 206 2.66548
THEMIS thymocyte selection associated 2.66548
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.66548
CTSF cathepsin F 2.66548
IL5RA interleukin 5 receptor, alpha 2.58384
NRAP nebulin-related anchoring protein 2.58384
GJA9 gap junction protein, alpha 9, 59kDa 2.58384
COL20A1 collagen, type XX, alpha 1 2.58384
EQTN equatorin, sperm acrosome associated 2.58384
TMPRSS11D transmembrane protease, serine 11D 2.58384
TCHH trichohyalin 2.58384
SOX18 SRY (sex determining region Y)-box 18 2.58384
UPK3A uroplakin 3A 2.58384
NXPH3 neurexophilin 3 2.58384
IGFL2 IGF-like family member 2 2.58384
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.58384
ATOH7 atonal homolog 7 (Drosophila) 2.58384
NPPC natriuretic peptide C 2.58384
GSTM5 glutathione S-transferase mu 5 2.58384
WNT8B wingless-type MMTV integration site family, member 8B 2.58384
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.58384
TBC1D5 TBC1 domain family, member 5 2.58384
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.58384
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.58384
GALR3 galanin receptor 3 2.58384
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.58384
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.58384
COPZ2 coatomer protein complex, subunit zeta 2 2.58384
GMNC geminin coiled-coil domain containing 2.58384
CLEC5A C-type lectin domain family 5, member A 2.58384
DET1 de-etiolated homolog 1 (Arabidopsis) 2.58384
ASB12 ankyrin repeat and SOCS box containing 12 2.58384
RSPO3 R-spondin 3 2.58384
NRROS negative regulator of reactive oxygen species 2.58384
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.58384
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.58384
OTUD6A OTU deubiquitinase 6A 2.58384
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.58384
CIZ1 CDKN1A interacting zinc finger protein 1 2.58384
PIGR polymeric immunoglobulin receptor 2.58384
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.58384
TLE7 TLE family member 7 2.58384
SQOR sulfide quinone oxidoreductase 2.58384
GIPC3 GIPC PDZ domain containing family, member 3 2.58384
ZNF726 zinc finger protein 726 2.58384
VN1R1 vomeronasal 1 receptor 1 2.58384
SPI1 Spi-1 proto-oncogene 2.58384
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.58384
SPATA31C1 SPATA31 subfamily C, member 1 2.58384
TMPRSS6 transmembrane protease, serine 6 2.58384
HTD2 hydroxyacyl-thioester dehydratase type 2 2.58384
FAM237B family with sequence similarity 237 member B 2.58384
FLACC1 flagellum associated containing coiled-coil domains 1 2.58384
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.58384
LINC02268 long intergenic non-protein coding RNA 2268 2.58384
LRRC8C-DT LRRC8C divergent transcript 2.58384
IRF2-DT IRF2 divergent transcript 2.58384
C17ORF113 chromosome 17 open reading frame 113 2.58384
SRARP steroid receptor associated and regulated protein 2.58384
CD8B2 CD8b2 molecule 2.58384
C20ORF204 chromosome 20 open reading frame 204 2.58384
CPHXL cytoplasmic polyadenylated homeobox like 2.58384
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.58384
SYT15 synaptotagmin XV 2.58384
DTHD1 death domain containing 1 2.58384
PCDHA8 protocadherin alpha 8 2.58384
PCDHA7 protocadherin alpha 7 2.58384
FOXD1 forkhead box D1 2.58384
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2.58384
RS1 retinoschisin 1 2.58384
DNAI2 dynein, axonemal, intermediate chain 2 2.58384
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.58384
TAS2R31 taste receptor, type 2, member 31 2.58384
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.58384
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.58384
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.58384
CCDC42 coiled-coil domain containing 42 2.58384
WNT9B wingless-type MMTV integration site family, member 9B 2.58384
IL1RN interleukin 1 receptor antagonist 2.58384
VCX3B variable charge, X-linked 3B 2.58384
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.58384
PRR4 proline rich 4 (lacrimal) 2.58384
PRR11 proline rich 11 2.58384
CFAP45 cilia and flagella associated protein 45 2.58384
CENPA centromere protein A 2.58384
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.58384
SLC7A4 solute carrier family 7, member 4 2.58384
CALHM1 calcium homeostasis modulator 1 2.58384
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.58384
TMEM207 transmembrane protein 207 2.58384
NPFFR1 neuropeptide FF receptor 1 2.58384
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 2.58384
C16ORF78 chromosome 16 open reading frame 78 2.58384
PAGE4 P antigen family, member 4 (prostate associated) 2.58384
PSKH2 protein serine kinase H2 2.58384
WFDC6 WAP four-disulfide core domain 6 2.58384
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.58384
CDHR4 cadherin-related family member 4 2.58384
NUTM2F NUT family member 2F 2.58384
ANKRD33 ankyrin repeat domain 33 2.58384
TRIM24 tripartite motif containing 24 2.58384
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.58384
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.58384
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.58384
IGFBP1 insulin-like growth factor binding protein 1 2.58384
CPSF4L cleavage and polyadenylation specific factor 4-like 2.58384
SNX30 sorting nexin family member 30 2.58384
PCDHGA2 protocadherin gamma subfamily A, 2 2.58384
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.58384
GPR150 G protein-coupled receptor 150 2.58384
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.58384
CXORF49C chromosome X open reading frame 49C 2.58384
CLEC18B C-type lectin domain family 18, member B 2.58384
CXORF58 chromosome X open reading frame 58 2.58384
CCDC70 coiled-coil domain containing 70 2.58384
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.58384
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.58384
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.58384
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.58384
ISL2 ISL LIM homeobox 2 2.58384
KLK12 kallikrein-related peptidase 12 2.58384
ITGAD integrin, alpha D 2.58384
ASTL astacin-like metallo-endopeptidase (M12 family) 2.58384
IGSF9 immunoglobulin superfamily, member 9 2.58384
AMN amnion associated transmembrane protein 2.58384
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.58384
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.58384
DRC7 dynein regulatory complex subunit 7 2.58384
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.58384
C5ORF46 chromosome 5 open reading frame 46 2.58384
LEP leptin 2.58384
ASCL3 achaete-scute family bHLH transcription factor 3 2.58384
NLRP6 NLR family, pyrin domain containing 6 2.58384
POPDC2 popeye domain containing 2 2.58384
ANXA1 annexin A1 2.58384
MMEL1 membrane metallo-endopeptidase-like 1 2.58384
TMPRSS13 transmembrane protease, serine 13 2.58384
NPC1L1 NPC1-like 1 2.58384
AMPD1 adenosine monophosphate deaminase 1 2.58384
A1CF APOBEC1 complementation factor 2.58384
SPAG6 sperm associated antigen 6 2.58384
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.58384
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.58384
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.58384
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.58384
NFE2 nuclear factor, erythroid 2 2.58384
ACADL acyl-CoA dehydrogenase, long chain 2.58384
CD34 CD34 molecule 2.58384
ALLC allantoicase 2.58384
C10ORF90 chromosome 10 open reading frame 90 2.58384
ADGRF5 adhesion G protein-coupled receptor F5 2.58384
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.58384
RHAG Rh-associated glycoprotein 2.58384
CLPSL1 colipase-like 1 2.58384
GCM1 glial cells missing homolog 1 (Drosophila) 2.58384
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.58384
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 2.51912
CMKLR1 chemerin chemokine-like receptor 1 2.51912
PM20D1 peptidase M20 domain containing 1 2.51912
DMRT1 doublesex and mab-3 related transcription factor 1 2.50161
ERN2 endoplasmic reticulum to nucleus signaling 2 2.49701
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.48704
PXMP4 peroxisomal membrane protein 4, 24kDa 2.4723
SLC22A15 solute carrier family 22, member 15 2.46699
NPM3 nucleophosmin/nucleoplasmin 3 2.46699
ALDOA aldolase A, fructose-bisphosphate 2.38717
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 2.37406
LUZP1 leucine zipper protein 1 2.36037
C14ORF93 chromosome 14 open reading frame 93 2.36037
MRPS18C mitochondrial ribosomal protein S18C 2.36037
SPATA13 spermatogenesis associated 13 2.35487
LOXL4 lysyl oxidase-like 4 2.32945
GRB10 growth factor receptor-bound protein 10 2.3258
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 2.31414
PRR3 proline rich 3 2.30699
ELMO2 engulfment and cell motility 2 2.30087
CDK15 cyclin-dependent kinase 15 2.30087
PACC1 proton activated chloride channel 1 2.29803
EMP1 epithelial membrane protein 1 2.29078
TET3 tet methylcytosine dioxygenase 3 2.26681
F11R F11 receptor 2.26144
NKAP NFKB activating protein 2.25588
ART5 ADP-ribosyltransferase 5 2.22048
COMMD10 COMM domain containing 10 2.21162
UBE2S ubiquitin-conjugating enzyme E2S 2.20054
DDRGK1 DDRGK domain containing 1 2.18841
GOLM1 golgi membrane protein 1 2.1582
JDP2 Jun dimerization protein 2 2.15435
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.14777
PCBP4 poly(rC) binding protein 4 2.13128
RASIP1 Ras interacting protein 1 2.13094
NBPF12 neuroblastoma breakpoint family, member 12 2.12874
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.09981
TSLIG3B tRNA splicing ligase complex subunit 3B 2.09981
GLB1L2 galactosidase, beta 1-like 2 2.09733
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.09733
DGKH diacylglycerol kinase, eta 2.08741
OAT ornithine aminotransferase 2.08151
TMEM255B transmembrane protein 255B 2.07203
AACS acetoacetyl-CoA synthetase 2.07172
TRPM7 transient receptor potential cation channel, subfamily M, member 7 2.06923
GPR18 G protein-coupled receptor 18 2.03956
RBMS2 RNA binding motif, single stranded interacting protein 2 2.03956
BCL2L1 BCL2-like 1 2.03956
KLHL7 kelch-like family member 7 2.03904

decreased expression

Symbol Name Standardized Value
MAT1A methionine adenosyltransferase I, alpha -2.66548
RAB3A RAB3A, member RAS oncogene family -2.66548
TMEM9B TMEM9 domain family, member B -2.66548
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.59071
CYB561D1 cytochrome b561 family, member D1 -2.59071
OVOL1 ovo-like zinc finger 1 -2.59071
H3C4 H3 clustered histone 4 -2.59071
SYNDIG1L synapse differentiation inducing 1-like -2.59071
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -2.59071
OPN3 opsin 3 -2.58384
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.58384
FICD FIC domain containing -2.58384
RPS21 ribosomal protein S21 -2.58384
MYD88 myeloid differentiation primary response 88 -2.58384
PLIN3 perilipin 3 -2.58384
EPN3 epsin 3 -2.58384
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.58384
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.58384
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.58384
RALB v-ral simian leukemia viral oncogene homolog B -2.58384
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -2.58384
ANKDD1B ankyrin repeat and death domain containing 1B -2.58384
ALS2CL ALS2 C-terminal like -2.58384
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -2.58384
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.5563
NRTN neurturin -2.55121
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -2.53735
CDC25B cell division cycle 25B -2.53447
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.51912
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa -2.51912
WDR64 WD repeat domain 64 -2.51912
DUSP10 dual specificity phosphatase 10 -2.51912
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.51912
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -2.51912
FAM216B family with sequence similarity 216, member B -2.51912
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.51912
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.51912
PTPRB protein tyrosine phosphatase, receptor type, B -2.51912
CALML4 calmodulin-like 4 -2.51912
LCN10 lipocalin 10 -2.51912
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.51912
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.51912
ATG9B autophagy related 9B -2.51912
TACR2 tachykinin receptor 2 -2.51912
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.51912
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.51912
MPL MPL proto-oncogene, thrombopoietin receptor -2.51912
ACSS1 acyl-CoA synthetase short-chain family member 1 -2.51912
KLF9 Kruppel-like factor 9 -2.51912
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.51912
RUMY3 RUMY family member 3 -2.51912
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.51912
CCDC194 coiled-coil domain containing 194 -2.51912
TMSB15C thymosin beta 15C -2.51912
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) -2.51912
MSMP microseminoprotein, prostate associated -2.51912
SLA2 Src-like-adaptor 2 -2.51912
CLCF1 cardiotrophin-like cytokine factor 1 -2.51912
AHNAK2 AHNAK nucleoprotein 2 -2.51912
PRAM1 PML-RARA regulated adaptor molecule 1 -2.51912
SP100 SP100 nuclear antigen -2.51912
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.51912
CFAP157 cilia and flagella associated protein 157 -2.51912
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.51912
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.49701
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.47438
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 -2.4499
LHFPL6 LHFPL tetraspan subfamily member 6 -2.41769
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.41682
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.40843
CIRBP cold inducible RNA binding protein -2.38717
LRRC9 leucine rich repeat containing 9 -2.37542
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.37542
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.37542
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -2.36682
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.36037
SLC16A13 solute carrier family 16, member 13 -2.35461
RINL Ras and Rab interactor-like -2.33455
ICMT isoprenylcysteine carboxyl methyltransferase -2.3258
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -2.29397
TMEM178B transmembrane protein 178B -2.25307
STX6 syntaxin 6 -2.22208
CKS1B CDC28 protein kinase regulatory subunit 1B -2.22131
GUSB glucuronidase, beta -2.22048
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -2.21162
RIOK1 RIO kinase 1 -2.20054
PIGC phosphatidylinositol glycan anchor biosynthesis, class C -2.18321
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -2.17928
SIVA1 SIVA1, apoptosis-inducing factor -2.16593
SYCE2 synaptonemal complex central element protein 2 -2.15549
OSBP oxysterol binding protein -2.12874
DMAC2 distal membrane arm assembly component 2 -2.12874
PKNOX2 PBX/knotted 1 homeobox 2 -2.11216
GOLGA3 golgin A3 -2.11183
EID3 EP300 interacting inhibitor of differentiation 3 -2.09299
RLN2 relaxin 2 -2.08741
POMK protein-O-mannose kinase -2.08741
C3ORF52 chromosome 3 open reading frame 52 -2.08741
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -2.06133
SHISA4 shisa family member 4 -2.05515
NDC80 NDC80 kinetochore complex component -2.05195
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -2.05195
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -2.05195
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.03956
RPL34 ribosomal protein L34 -2.03956
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.03956
GTF2IRD2 GTF2I repeat domain containing 2 -2.03956
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.03904
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) -2.03668
ARMCX1 armadillo repeat containing, X-linked 1 -2.02847
SOX4 SRY (sex determining region Y)-box 4 -2.02247
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -2.01569