TCF7L2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description transcription factor 7-like 2 (T-cell specific, HMG-box)|This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] (NCBI Entrez Gene Database, 6934)
External Link http://www.ncbi.nlm.nih.gov/gene/6934
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186 interacting proteins for TCF7L2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRF5 adhesion G protein-coupled receptor F5
AES amino-terminal enhancer of split
AFG3L2 AFG3-like AAA ATPase 2
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHCTF1 AT hook containing transcription factor 1
AKAP8 A kinase (PRKA) anchor protein 8
ALB albumin
ALPI alkaline phosphatase, intestinal
ATAD3A ATPase family, AAA domain containing 3A
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CCDC9 coiled-coil domain containing 9
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLASP1 cytoplasmic linker associated protein 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
DAXX death-domain associated protein
DAZAP2 DAZ associated protein 2
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DHCR7 7-dehydrocholesterol reductase
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DOCK8 dedicator of cytokinesis 8
E2F3 E2F transcription factor 3
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFTUD2 elongation factor Tu GTP binding domain containing 2
ELAVL1 ELAV like RNA binding protein 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EP300 E1A binding protein p300
FBLN1 fibulin 1
FOXM1 forkhead box M1
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GTPBP2 GTP binding protein 2
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC8 histone deacetylase 8
HELLS helicase, lymphoid-specific
HIC1 hypermethylated in cancer 1
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H2AA4 histone cluster 2, H2aa4
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
HLTF helicase-like transcription factor
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
IMMT inner membrane protein, mitochondrial
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INTS3 integrator complex subunit 3
INTS5 integrator complex subunit 5
INTS6 integrator complex subunit 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JRK Jrk homolog (mouse)
JUN jun proto-oncogene
JUP junction plakoglobin
KAT2A K(lysine) acetyltransferase 2A
KDM1A lysine (K)-specific demethylase 1A
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT9 keratin 9, type I
L3MBTL3 l(3)mbt-like 3 (Drosophila)
LBR lamin B receptor
LMNA lamin A/C
LRPPRC leucine-rich pentatricopeptide repeat containing
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MATR3 matrin 3
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
MYO1B myosin IB
MYO1C myosin IC
MYO6 myosin VI
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAPG non-SMC condensin I complex, subunit G
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NLK nemo-like kinase
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH3 notch 3
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
NUP205 nucleoporin 205kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
PARP1 poly (ADP-ribose) polymerase 1
PCLO piccolo presynaptic cytomatrix protein
PGAP1 post-GPI attachment to proteins 1
PMM1 phosphomannomutase 1
POLG polymerase (DNA directed), gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSEN1 presenilin 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RAB13 RAB13, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RB1 retinoblastoma 1
RBSN rabenosyn, RAB effector
RFC1 replication factor C (activator 1) 1, 145kDa
RHOT1 ras homolog family member T1
RHOT2 ras homolog family member T2
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RUNX3 runt-related transcription factor 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SFMBT1 Scm-like with four mbt domains 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SP1 Sp1 transcription factor
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUMO2 small ubiquitin-like modifier 2
SUN2 Sad1 and UNC84 domain containing 2
TCERG1 transcription elongation regulator 1
TECR trans-2,3-enoyl-CoA reductase
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TLE6 transducin-like enhancer of split 6
TMEM33 transmembrane protein 33
TNIK TRAF2 and NCK interacting kinase
TNXB tenascin XB
TRIM23 tripartite motif containing 23
TRIM28 tripartite motif containing 28
TRRAP transformation/transcription domain-associated protein
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
WRN Werner syndrome, RecQ helicase-like
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBED4 zinc finger, BED-type containing 4
ZBTB33 zinc finger and BTB domain containing 33
ZC3H11A zinc finger CCCH-type containing 11A
ZNF148 zinc finger protein 148
ZNF300 zinc finger protein 300