TCS 1102 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/11960895
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Genes

198 proteins with high or low expression in TCS 1102 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
TASP1 taspase, threonine aspartase, 1 0.72
ABHD2 abhydrolase domain containing 2 0.68
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.68
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 0.63
DNAAF2 dynein, axonemal, assembly factor 2 0.59
TMC5 transmembrane channel-like 5 0.57
RPE ribulose-5-phosphate-3-epimerase 0.54
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.53
SLC16A6 solute carrier family 16, member 6 0.52
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 0.51
RPL36A ribosomal protein L36a 0.46
FAM135B family with sequence similarity 135, member B 0.46
SOX12 SRY (sex determining region Y)-box 12 0.45
ZNF273 zinc finger protein 273 0.45
IFIH1 interferon induced with helicase C domain 1 0.44
ZMYM5 zinc finger, MYM-type 5 0.43
ZNF35 zinc finger protein 35 0.43
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.42
FAM241B family with sequence similarity 241 member B 0.42
MCFD2 multiple coagulation factor deficiency 2 0.4
DOLK dolichol kinase 0.39
ASTE1 asteroid homolog 1 (Drosophila) 0.38
FBXW4 F-box and WD repeat domain containing 4 0.37
PANK3 pantothenate kinase 3 0.37
CNTLN centlein, centrosomal protein 0.37
NRP1 neuropilin 1 0.37
DOHH deoxyhypusine hydroxylase/monooxygenase 0.36
DGKE diacylglycerol kinase, epsilon 64kDa 0.36
EPHX4 epoxide hydrolase 4 0.36
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.36
ADM adrenomedullin 0.36
C16ORF72 chromosome 16 open reading frame 72 0.36
ERH enhancer of rudimentary homolog (Drosophila) 0.35
RABEP2 rabaptin, RAB GTPase binding effector protein 2 0.34
FBXW2 F-box and WD repeat domain containing 2 0.34
DYNLRB1 dynein, light chain, roadblock-type 1 0.34
ADGRF1 adhesion G protein-coupled receptor F1 0.34
STX1A syntaxin 1A (brain) 0.34
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 0.33
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 0.33
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.33
RPL34 ribosomal protein L34 0.33
RPL26 ribosomal protein L26 0.32
ZDHHC8 zinc finger, DHHC-type containing 8 0.32
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.32
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.32
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 0.32
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 0.32
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.32
KLF13 Kruppel-like factor 13 0.31
NME6 NME/NM23 nucleoside diphosphate kinase 6 0.31
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.31
RITA1 RBPJ interacting and tubulin associated 1 0.31
HAUS1 HAUS augmin-like complex, subunit 1 0.31
MRPL51 mitochondrial ribosomal protein L51 0.31
JDP2 Jun dimerization protein 2 0.31
ANTKMT adenine nucleotide translocase lysine methyltransferase 0.31
ERP29 endoplasmic reticulum protein 29 0.3
ZNF12 zinc finger protein 12 0.3
FPGT fucose-1-phosphate guanylyltransferase 0.3
FAN1 FANCD2/FANCI-associated nuclease 1 0.3
MRPL53 mitochondrial ribosomal protein L53 0.3
HCFC2 host cell factor C2 0.3
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.3
SLC44A2 solute carrier family 44 (choline transporter), member 2 0.3
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.3
PHF19 PHD finger protein 19 0.3
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.3
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.3
PCSK6 proprotein convertase subtilisin/kexin type 6 0.29
B9D1 B9 protein domain 1 0.29
BORCS6 BLOC-1 related complex subunit 6 0.29
SERINC5 serine incorporator 5 0.29
SPEG SPEG complex locus 0.29
MT-ATP6 ATP synthase F0 subunit 6 0.29
ZNRD1 zinc ribbon domain containing 1 0.29
FBXL16 F-box and leucine-rich repeat protein 16 0.29
PRRX2 paired related homeobox 2 0.29
CLTA clathrin, light chain A 0.28
MID1IP1 MID1 interacting protein 1 0.28
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 0.28
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.28
RPL23 ribosomal protein L23 0.28
SRD5A3 steroid 5 alpha-reductase 3 0.28
ABHD17C abhydrolase domain containing 17C 0.28
NAIF1 nuclear apoptosis inducing factor 1 0.28
ACP1 acid phosphatase 1, soluble 0.28
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 0.28
SGMS2 sphingomyelin synthase 2 0.27
TENT5A terminal nucleotidyltransferase 5A 0.27
ELOB elongin B 0.27
HIKESHI heat shock protein nuclear import factor hikeshi 0.27
FLYWCH1 FLYWCH-type zinc finger 1 0.27
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.27
ASB13 ankyrin repeat and SOCS box containing 13 0.27
STMN3 stathmin-like 3 0.27
UBQLN1 ubiquilin 1 0.27
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 0.27
SYTL2 synaptotagmin-like 2 0.27
C6ORF47 chromosome 6 open reading frame 47 0.27

low expression

Symbol Name Standardized Value
APOB apolipoprotein B -1.31
ENO1 enolase 1, (alpha) -0.83
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.7
SPRED2 sprouty-related, EVH1 domain containing 2 -0.62
RGN regucalcin -0.61
MYBPC1 myosin binding protein C, slow type -0.59
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -0.58
F10 coagulation factor X -0.57
TMEM63A transmembrane protein 63A -0.55
ALS2CL ALS2 C-terminal like -0.55
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.54
PAH phenylalanine hydroxylase -0.54
TBC1D22A TBC1 domain family, member 22A -0.54
NCOA1 nuclear receptor coactivator 1 -0.53
MDM1 Mdm1 nuclear protein homolog (mouse) -0.51
TCTN1 tectonic family member 1 -0.5
RNF145 ring finger protein 145 -0.5
DNM1L dynamin 1-like -0.49
KLHL25 kelch-like family member 25 -0.48
TBC1D16 TBC1 domain family, member 16 -0.47
RNF13 ring finger protein 13 -0.46
PCLO piccolo presynaptic cytomatrix protein -0.45
NDFIP1 Nedd4 family interacting protein 1 -0.45
VCPKMT valosin containing protein lysine (K) methyltransferase -0.44
CD82 CD82 molecule -0.44
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -0.43
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -0.41
ZNF564 zinc finger protein 564 -0.41
APOE apolipoprotein E -0.39
ZCCHC24 zinc finger, CCHC domain containing 24 -0.39
TOX2 TOX high mobility group box family member 2 -0.38
TSPAN3 tetraspanin 3 -0.38
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -0.36
TACSTD2 tumor-associated calcium signal transducer 2 -0.35
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -0.35
SDF2 stromal cell-derived factor 2 -0.33
ZNF729 zinc finger protein 729 -0.33
TMEM106C transmembrane protein 106C -0.32
HKDC1 hexokinase domain containing 1 -0.32
GSE1 Gse1 coiled-coil protein -0.32
MARCKSL1 MARCKS-like 1 -0.32
MSMO1 methylsterol monooxygenase 1 -0.31
TMEM59 transmembrane protein 59 -0.31
HYKK hydroxylysine kinase -0.31
IFT57 intraflagellar transport 57 -0.31
ARID5B AT rich interactive domain 5B (MRF1-like) -0.31
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -0.3
FUNDC2 FUN14 domain containing 2 -0.3
RABGGTB Rab geranylgeranyltransferase, beta subunit -0.3
LBR lamin B receptor -0.29
DAP death-associated protein -0.29
GEM GTP binding protein overexpressed in skeletal muscle -0.29
TM7SF2 transmembrane 7 superfamily member 2 -0.29
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.29
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.29
CCNQ cyclin Q -0.29
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.29
NEBL nebulette -0.29
NLGN2 neuroligin 2 -0.29
PDIA4 protein disulfide isomerase family A, member 4 -0.29
PUF60 poly-U binding splicing factor 60KDa -0.28
LPIN1 lipin 1 -0.28
DIPK1A divergent protein kinase domain 1A -0.28
ZC4H2 zinc finger, C4H2 domain containing -0.28
PKM pyruvate kinase, muscle -0.28
APLP1 amyloid beta (A4) precursor-like protein 1 -0.28
DMWD dystrophia myotonica, WD repeat containing -0.27
TRIM7 tripartite motif containing 7 -0.27
VASN vasorin -0.27
CRTC1 CREB regulated transcription coactivator 1 -0.27
PIMREG PICALM interacting mitotic regulator -0.27
DIPK1B divergent protein kinase domain 1B -0.27
OASL 2'-5'-oligoadenylate synthetase-like -0.27
SCAP SREBF chaperone -0.26
ITGB8 integrin, beta 8 -0.26
MARCKS myristoylated alanine-rich protein kinase C substrate -0.26
ITM2C integral membrane protein 2C -0.26
NLRC3 NLR family, CARD domain containing 3 -0.26
MDP1 magnesium-dependent phosphatase 1 -0.26
TTC8 tetratricopeptide repeat domain 8 -0.25
TMEM184A transmembrane protein 184A -0.25
BCL6 B-cell CLL/lymphoma 6 -0.25
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.25
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.25
FAM117A family with sequence similarity 117, member A -0.25
PLK2 polo-like kinase 2 -0.25
ZNF597 zinc finger protein 597 -0.25
EGFL7 EGF-like-domain, multiple 7 -0.25
FNTB farnesyltransferase, CAAX box, beta -0.25
PEX14 peroxisomal biogenesis factor 14 -0.24
KLHL26 kelch-like family member 26 -0.24
KCTD18 potassium channel tetramerization domain containing 18 -0.24
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -0.24
HRAS Harvey rat sarcoma viral oncogene homolog -0.24
KIAA0586 KIAA0586 -0.24
GRTP1 growth hormone regulated TBC protein 1 -0.24
FHL1 four and a half LIM domains 1 -0.24
AMDHD2 amidohydrolase domain containing 2 -0.24