| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11634725 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in TCS ERK 11e relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | 15.77 |
| MYH4 | myosin, heavy chain 4, skeletal muscle | 8.13 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 7.85 |
| ACTN2 | actinin, alpha 2 | 6.46 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 6.43 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | 6.4 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 5.71 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 4.6 |
| DES | desmin | 3.03 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 2.65 |
| SYNPO | synaptopodin | 2.4 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 2.28 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 2.14 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 2.11 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 2.09 |
| ARG2 | arginase 2 | 2.06 |
| PRSS23 | protease, serine, 23 | 1.87 |
| SEPSECS | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase | 1.86 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 1.83 |
| PGK2 | phosphoglycerate kinase 2 | 1.78 |
| METTL7A | methyltransferase like 7A | 1.78 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 1.75 |
| AHNAK2 | AHNAK nucleoprotein 2 | 1.73 |
| TJP3 | tight junction protein 3 | 1.7 |
| CPA4 | carboxypeptidase A4 | 1.67 |
| ABAT | 4-aminobutyrate aminotransferase | 1.64 |
| CLU | clusterin | 1.63 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1.6 |
| HMOX1 | heme oxygenase 1 | 1.59 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 1.59 |
| LAMB2 | laminin, beta 2 (laminin S) | 1.59 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 1.56 |
| PPL | periplakin | 1.54 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 1.49 |
| ABHD2 | abhydrolase domain containing 2 | 1.48 |
| NOTCH3 | notch 3 | 1.47 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 1.44 |
| CERCAM | cerebral endothelial cell adhesion molecule | 1.42 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 1.41 |
| L1CAM | L1 cell adhesion molecule | 1.38 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 1.36 |
| AASS | aminoadipate-semialdehyde synthase | 1.32 |
| FTL | ferritin, light polypeptide | 1.32 |
| CCDC102A | coiled-coil domain containing 102A | 1.32 |
| OPTN | optineurin | 1.31 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | 1.29 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 1.27 |
| VASN | vasorin | 1.26 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 1.26 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 1.26 |
| RBL2 | retinoblastoma-like 2 | 1.25 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | 1.25 |
| TSPAN15 | tetraspanin 15 | 1.25 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 1.24 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 1.24 |
| UNC13D | unc-13 homolog D (C. elegans) | 1.24 |
| RBM47 | RNA binding motif protein 47 | 1.22 |
| SYBU | syntabulin (syntaxin-interacting) | 1.22 |
| DPP4 | dipeptidyl-peptidase 4 | 1.21 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 1.2 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 1.18 |
| PGM2L1 | phosphoglucomutase 2-like 1 | 1.18 |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | 1.18 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 1.17 |
| SAMD9 | sterile alpha motif domain containing 9 | 1.16 |
| PLCD1 | phospholipase C, delta 1 | 1.16 |
| KLHDC8B | kelch domain containing 8B | 1.16 |
| HID1 | HID1 domain containing | 1.16 |
| GSDME | gasdermin E | 1.16 |
| LAMA5 | laminin, alpha 5 | 1.16 |
| CRIP2 | cysteine-rich protein 2 | 1.15 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 1.14 |
| NPTXR | neuronal pentraxin receptor | 1.13 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | 1.13 |
| VWA5A | von Willebrand factor A domain containing 5A | 1.12 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 1.11 |
| CRYM | crystallin, mu | 1.11 |
| NIPSNAP3A | nipsnap homolog 3A (C. elegans) | 1.11 |
| TP53I3 | tumor protein p53 inducible protein 3 | 1.11 |
| CDK18 | cyclin-dependent kinase 18 | 1.1 |
| CAPN5 | calpain 5 | 1.1 |
| CDA | cytidine deaminase | 1.1 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 1.09 |
| GRN | granulin | 1.09 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 1.09 |
| C4ORF33 | chromosome 4 open reading frame 33 | 1.09 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 1.09 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 1.08 |
| MISP3 | MISP family member 3 | 1.08 |
| ABHD4 | abhydrolase domain containing 4 | 1.07 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | 1.07 |
| CGN | cingulin | 1.07 |
| EPS8L1 | EPS8-like 1 | 1.06 |
| ALS2CL | ALS2 C-terminal like | 1.06 |
| ABHD3 | abhydrolase domain containing 3 | 1.05 |
| DENND5A | DENN/MADD domain containing 5A | 1.04 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 1.03 |
| FN1 | fibronectin 1 | 1.03 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | 1.03 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DUSP4 | dual specificity phosphatase 4 | -3.76 |
| CCNB1 | cyclin B1 | -3.13 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.82 |
| RRM2 | ribonucleotide reductase M2 | -2.81 |
| TPX2 | TPX2, microtubule-associated | -2.75 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -2.73 |
| PLK1 | polo-like kinase 1 | -2.62 |
| FOSL1 | FOS-like antigen 1 | -2.61 |
| CDCA2 | cell division cycle associated 2 | -2.58 |
| ANLN | anillin, actin binding protein | -2.57 |
| PTTG1 | pituitary tumor-transforming 1 | -2.54 |
| TNS4 | tensin 4 | -2.53 |
| WDR76 | WD repeat domain 76 | -2.45 |
| SGO1 | shugoshin 1 | -2.45 |
| KIF2C | kinesin family member 2C | -2.44 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.42 |
| C5ORF34 | chromosome 5 open reading frame 34 | -2.41 |
| CLSPN | claspin | -2.38 |
| CKAP2 | cytoskeleton associated protein 2 | -2.38 |
| AURKA | aurora kinase A | -2.36 |
| CCNF | cyclin F | -2.35 |
| MLPH | melanophilin | -2.34 |
| GMNN | geminin, DNA replication inhibitor | -2.32 |
| EXO1 | exonuclease 1 | -2.29 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.26 |
| AURKB | aurora kinase B | -2.26 |
| INCENP | inner centromere protein antigens 135/155kDa | -2.25 |
| MCM10 | minichromosome maintenance complex component 10 | -2.23 |
| KIF11 | kinesin family member 11 | -2.21 |
| CDC20 | cell division cycle 20 | -2.21 |
| TTK | TTK protein kinase | -2.2 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -2.19 |
| LRR1 | leucine rich repeat protein 1 | -2.17 |
| PRR11 | proline rich 11 | -2.17 |
| KIF20A | kinesin family member 20A | -2.14 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -2.14 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -2.11 |
| TK1 | thymidine kinase 1, soluble | -2.1 |
| ARHGAP19 | Rho GTPase activating protein 19 | -2.1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -2.1 |
| PRC1 | protein regulator of cytokinesis 1 | -2.08 |
| CDC7 | cell division cycle 7 | -2.08 |
| CKAP2L | cytoskeleton associated protein 2-like | -2.05 |
| KIF20B | kinesin family member 20B | -2.03 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.03 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -2.02 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -2.02 |
| GTSE1 | G-2 and S-phase expressed 1 | -2.01 |
| KIF22 | kinesin family member 22 | -2.01 |
| CCNB2 | cyclin B2 | -1.99 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -1.99 |
| NET1 | neuroepithelial cell transforming 1 | -1.98 |
| PIMREG | PICALM interacting mitotic regulator | -1.98 |
| CCNA2 | cyclin A2 | -1.98 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -1.96 |
| DBF4 | DBF4 zinc finger | -1.94 |
| USP37 | ubiquitin specific peptidase 37 | -1.93 |
| ARHGAP11A | Rho GTPase activating protein 11A | -1.93 |
| CENPF | centromere protein F, 350/400kDa | -1.93 |
| CDCA5 | cell division cycle associated 5 | -1.91 |
| ECT2 | epithelial cell transforming 2 | -1.91 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -1.91 |
| SACK1D | scaffolding CK1 anchoring protein D | -1.9 |
| CDCA3 | cell division cycle associated 3 | -1.88 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -1.84 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -1.82 |
| SKA2 | spindle and kinetochore associated complex subunit 2 | -1.82 |
| GDF15 | growth differentiation factor 15 | -1.82 |
| SLBP | stem-loop binding protein | -1.82 |
| DUSP6 | dual specificity phosphatase 6 | -1.81 |
| KIFC1 | kinesin family member C1 | -1.8 |
| TROAP | trophinin associated protein | -1.79 |
| ORC6 | origin recognition complex, subunit 6 | -1.79 |
| CDCA7 | cell division cycle associated 7 | -1.78 |
| KNL1 | kinetochore scaffold 1 | -1.77 |
| CCND1 | cyclin D1 | -1.77 |
| PCLAF | PCNA clamp associated factor | -1.76 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -1.75 |
| EPHA2 | EPH receptor A2 | -1.75 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -1.75 |
| KIF18A | kinesin family member 18A | -1.75 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -1.75 |
| STIL | SCL/TAL1 interrupting locus | -1.73 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -1.72 |
| ATAD2 | ATPase family, AAA domain containing 2 | -1.7 |
| ADAM19 | ADAM metallopeptidase domain 19 | -1.69 |
| SASS6 | spindle assembly 6 homolog (C. elegans) | -1.68 |
| MAPK1 | mitogen-activated protein kinase 1 | -1.68 |
| CDC6 | cell division cycle 6 | -1.68 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -1.66 |
| CEP55 | centrosomal protein 55kDa | -1.66 |
| RAD51 | RAD51 recombinase | -1.66 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -1.65 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -1.65 |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | -1.64 |
| BRCA1 | breast cancer 1, early onset | -1.61 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -1.6 |
| UBE2T | ubiquitin-conjugating enzyme E2T | -1.6 |
| RUNX1 | runt-related transcription factor 1 | -1.59 |
