| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/1235170 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in TCS PIM-1 1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CNTRL | centriolin | 1.65 |
| RAB36 | RAB36, member RAS oncogene family | 1.33 |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 1.21 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.97 |
| COL1A1 | collagen, type I, alpha 1 | 0.8 |
| CCDC28A | coiled-coil domain containing 28A | 0.73 |
| ANGPTL4 | angiopoietin-like 4 | 0.69 |
| MYO3A | myosin IIIA | 0.64 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.6 |
| TSC22D2 | TSC22 domain family, member 2 | 0.58 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 0.58 |
| PLEK | pleckstrin | 0.57 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.55 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.51 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.5 |
| LMTK2 | lemur tyrosine kinase 2 | 0.49 |
| TTC30A | tetratricopeptide repeat domain 30A | 0.48 |
| WDR60 | WD repeat domain 60 | 0.47 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.46 |
| NABP2 | nucleic acid binding protein 2 | 0.46 |
| SLC16A6 | solute carrier family 16, member 6 | 0.46 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.45 |
| CCDC32 | coiled-coil domain containing 32 | 0.45 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.43 |
| JUN | jun proto-oncogene | 0.42 |
| FAT3 | FAT atypical cadherin 3 | 0.41 |
| ZFHX4 | zinc finger homeobox 4 | 0.41 |
| WWC3 | WWC family member 3 | 0.4 |
| ZNF286A | zinc finger protein 286A | 0.4 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.39 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.39 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.39 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.39 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.39 |
| RFLNB | refilin B | 0.38 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 0.38 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.38 |
| RNF13 | ring finger protein 13 | 0.38 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.37 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.37 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.36 |
| VIM | vimentin | 0.36 |
| GTF3A | general transcription factor IIIA | 0.36 |
| ADCK5 | aarF domain containing kinase 5 | 0.35 |
| SYBU | syntabulin (syntaxin-interacting) | 0.35 |
| PCGF5 | polycomb group ring finger 5 | 0.35 |
| EMC10 | ER membrane protein complex subunit 10 | 0.35 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.35 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.35 |
| KIF26A | kinesin family member 26A | 0.35 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | 0.35 |
| HELB | helicase (DNA) B | 0.35 |
| C4ORF33 | chromosome 4 open reading frame 33 | 0.35 |
| UBOX5 | U-box domain containing 5 | 0.35 |
| DOLPP1 | dolichyldiphosphatase 1 | 0.34 |
| MAST1 | microtubule associated serine/threonine kinase 1 | 0.34 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | 0.34 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.34 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.33 |
| SERGEF | secretion regulating guanine nucleotide exchange factor | 0.33 |
| MYBPC1 | myosin binding protein C, slow type | 0.33 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.33 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.33 |
| CCDC112 | coiled-coil domain containing 112 | 0.32 |
| CEP152 | centrosomal protein 152kDa | 0.32 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.32 |
| CDC14A | cell division cycle 14A | 0.32 |
| S100A5 | S100 calcium binding protein A5 | 0.32 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | 0.31 |
| ZNF652 | zinc finger protein 652 | 0.31 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.31 |
| SELENOM | selenoprotein M | 0.31 |
| PNN | pinin, desmosome associated protein | 0.31 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.31 |
| SPPL2A | signal peptide peptidase like 2A | 0.31 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.3 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | 0.3 |
| FAM20C | family with sequence similarity 20, member C | 0.3 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | 0.3 |
| AZI2 | 5-azacytidine induced 2 | 0.3 |
| RNF139 | ring finger protein 139 | 0.3 |
| ODC1 | ornithine decarboxylase 1 | 0.3 |
| TMEM39A | transmembrane protein 39A | 0.29 |
| LPIN2 | lipin 2 | 0.29 |
| ZMYM5 | zinc finger, MYM-type 5 | 0.29 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.29 |
| GPR180 | G protein-coupled receptor 180 | 0.29 |
| ZNF205 | zinc finger protein 205 | 0.29 |
| TESK1 | testis-specific kinase 1 | 0.29 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.28 |
| GTDC1 | glycosyltransferase-like domain containing 1 | 0.28 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.28 |
| LRRC8B | leucine rich repeat containing 8 family, member B | 0.28 |
| ASNSD1 | asparagine synthetase domain containing 1 | 0.28 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.28 |
| NET1 | neuroepithelial cell transforming 1 | 0.28 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.28 |
| CDCA7 | cell division cycle associated 7 | 0.28 |
| APOE | apolipoprotein E | 0.28 |
| ADCY9 | adenylate cyclase 9 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | -1.75 |
| CASZ1 | castor zinc finger 1 | -0.53 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.5 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.48 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.46 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.45 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.44 |
| EMILIN2 | elastin microfibril interfacer 2 | -0.42 |
| CNTNAP1 | contactin associated protein 1 | -0.42 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | -0.41 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.41 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -0.4 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.4 |
| INO80D | INO80 complex subunit D | -0.4 |
| KIAA1324L | KIAA1324-like | -0.4 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | -0.4 |
| CD46 | CD46 molecule, complement regulatory protein | -0.39 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.37 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.36 |
| FZD1 | frizzled class receptor 1 | -0.36 |
| MBP | myelin basic protein | -0.36 |
| PRMT2 | protein arginine methyltransferase 2 | -0.35 |
| SEPTIN7 | septin 7 | -0.34 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.34 |
| MT1F | metallothionein 1F | -0.34 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.34 |
| OTC | ornithine carbamoyltransferase | -0.33 |
| DMGDH | dimethylglycine dehydrogenase | -0.33 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.31 |
| SLC38A7 | solute carrier family 38, member 7 | -0.31 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.31 |
| METTL26 | methyltransferase like 26 | -0.31 |
| SDF4 | stromal cell derived factor 4 | -0.3 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.3 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.29 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.29 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.27 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.27 |
| BPTF | bromodomain PHD finger transcription factor | -0.27 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.27 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -0.27 |
| CCDC158 | coiled-coil domain containing 158 | -0.27 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.27 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.27 |
| RNF130 | ring finger protein 130 | -0.27 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.26 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.26 |
| FAM210B | family with sequence similarity 210, member B | -0.25 |
| ZNF3 | zinc finger protein 3 | -0.25 |
| SH3BP2 | SH3-domain binding protein 2 | -0.25 |
| MLH3 | mutL homolog 3 | -0.25 |
| DMD | dystrophin | -0.25 |
| KLHL15 | kelch-like family member 15 | -0.25 |
| ACVR1B | activin A receptor, type IB | -0.24 |
| NUDT16 | nudix (nucleoside diphosphate linked moiety X)-type motif 16 | -0.24 |
| TSPAN3 | tetraspanin 3 | -0.24 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.24 |
| HMGB2 | high mobility group box 2 | -0.24 |
| USP48 | ubiquitin specific peptidase 48 | -0.24 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.24 |
| TMC4 | transmembrane channel-like 4 | -0.24 |
| TVP23C | trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) | -0.23 |
| DENND3 | DENN/MADD domain containing 3 | -0.23 |
| WDR20 | WD repeat domain 20 | -0.23 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.23 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -0.23 |
| CD63 | CD63 molecule | -0.23 |
| LIX1L | Lix1 homolog (chicken) like | -0.23 |
| ADCY6 | adenylate cyclase 6 | -0.23 |
| MPZL2 | myelin protein zero-like 2 | -0.22 |
| MIGA1 | mitoguardin 1 | -0.22 |
| AASS | aminoadipate-semialdehyde synthase | -0.22 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.22 |
| TTYH3 | tweety family member 3 | -0.22 |
| ITM2B | integral membrane protein 2B | -0.22 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | -0.22 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | -0.22 |
| PLPP2 | phospholipid phosphatase 2 | -0.22 |
| LPIN1 | lipin 1 | -0.21 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.21 |
| JAK3 | Janus kinase 3 | -0.21 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.21 |
| MPDZ | multiple PDZ domain protein | -0.21 |
| NKD2 | naked cuticle homolog 2 (Drosophila) | -0.21 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.21 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.21 |
| ESAM | endothelial cell adhesion molecule | -0.21 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.21 |
| ABHD13 | abhydrolase domain containing 13 | -0.21 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.2 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | -0.2 |
| PLAUR | plasminogen activator, urokinase receptor | -0.2 |
| MT-CO2 | cytochrome c oxidase subunit II | -0.2 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.2 |
| MOCOS | molybdenum cofactor sulfurase | -0.2 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -0.2 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.2 |
| B2M | beta-2-microglobulin | -0.2 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.2 |
