TDG Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description thymine-DNA glycosylase|The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6996)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_TDG
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Genes

35 co-expressed genes for TDG from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
CBX3 chromobox homolog 3
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
DEK DEK proto-oncogene
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
EIF3A eukaryotic translation initiation factor 3, subunit A
EXOSC8 exosome component 8
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
NCL nucleolin
NUP153 nucleoporin 153kDa
PAPOLA poly(A) polymerase alpha
PDS5A PDS5 cohesin associated factor A
PTBP1 polypyrimidine tract binding protein 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
RBMX RNA binding motif protein, X-linked
RPA1 replication protein A1, 70kDa
SERBP1 SERPINE1 mRNA binding protein 1
SFPQ splicing factor proline/glutamine-rich
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SRI sorcin
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SUMO2 small ubiquitin-like modifier 2
TARDBP TAR DNA binding protein
TDG thymine-DNA glycosylase
TRA2B transformer 2 beta homolog (Drosophila)
U2SURP U2 snRNP-associated SURP domain containing
XPO1 exportin 1
ZCCHC8 zinc finger, CCHC domain containing 8