| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | tryptophan 2,3-dioxygenase|This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 6999) |
| External Link | https://ncbi.nlm.nih.gov/gene/6999 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the TDO2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IFI27 | interferon, alpha-inducible protein 27 | 0.0187328 |
| ATF3 | activating transcription factor 3 | 0.0140678 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0136144 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.0130094 |
| XIC | X chromosome inactivation center | 0.0127788 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.0126787 |
| DACH1 | dachshund family transcription factor 1 | 0.0125617 |
| ANXA3 | annexin A3 | 0.0125084 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0122791 |
| TFF1 | trefoil factor 1 | 0.0120257 |
| ACKR3 | atypical chemokine receptor 3 | 0.01201 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.0119994 |
| MX1 | MX dynamin-like GTPase 1 | 0.0116417 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.011594 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0115856 |
| GAB2 | GRB2-associated binding protein 2 | 0.0114422 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0114259 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0113637 |
| ABHD4 | abhydrolase domain containing 4 | 0.0111675 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0111626 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0110544 |
| S100A12 | S100 calcium binding protein A12 | 0.0107385 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0107065 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0104416 |
| MGAM | maltase-glucoamylase | 0.0104303 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | 0.0103094 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0102929 |
| HIST1H2AC | histone cluster 1, H2ac | 0.0102534 |
| HSPA2 | heat shock 70kDa protein 2 | 0.0101089 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00984573 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00984038 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0097771 |
| AGR2 | anterior gradient 2 | 0.00977254 |
| INHBA | inhibin, beta A | 0.00969078 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00966282 |
| MMP10 | matrix metallopeptidase 10 | 0.00944345 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00933622 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.00918922 |
| RRAGD | Ras-related GTP binding D | 0.00917702 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00906939 |
| DST | dystonin | 0.00906704 |
| CA12 | carbonic anhydrase XII | 0.00899886 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00899293 |
| LAMC2 | laminin, gamma 2 | 0.00897692 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.0089715 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00890858 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.00888088 |
| HOXB7 | homeobox B7 | 0.00875427 |
| REG1A | regenerating islet-derived 1 alpha | 0.00871072 |
| CLIC5 | chloride intracellular channel 5 | 0.00865397 |
| GALC | galactosylceramidase | 0.00863428 |
| OLFM4 | olfactomedin 4 | 0.00859974 |
| AOC1 | amine oxidase, copper containing 1 | 0.00847623 |
| LCN2 | lipocalin 2 | 0.00844479 |
| CALML4 | calmodulin-like 4 | 0.00840238 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.00836719 |
| FOSL2 | FOS-like antigen 2 | 0.00835427 |
| NEBL | nebulette | 0.00828692 |
| ALDOB | aldolase B, fructose-bisphosphate | 0.00823028 |
| ITM2C | integral membrane protein 2C | 0.00815053 |
| HEPH | hephaestin | 0.00813532 |
| H1-2 | H1.2 linker histone, cluster member | 0.00813009 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0081002 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.0080505 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00803636 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00802307 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00797459 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.00787599 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.00787354 |
| ATXN1 | ataxin 1 | 0.00781514 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0078048 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00779692 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.00779445 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.00777844 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.00770875 |
| MERTK | MER proto-oncogene, tyrosine kinase | 0.00770637 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00766984 |
| OLFML2B | olfactomedin-like 2B | 0.00765077 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00763848 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00761985 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00760397 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00759188 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00756211 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | 0.00755957 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00755494 |
| TPD52L1 | tumor protein D52-like 1 | 0.00755361 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00752556 |
| ZNF165 | zinc finger protein 165 | 0.00749069 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.00748109 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.00748041 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00747632 |
| REG1B | regenerating islet-derived 1 beta | 0.00746975 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00737381 |
| IL33R | interleukin 33 receptor | 0.0073128 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0073092 |
| RCAN1 | regulator of calcineurin 1 | 0.00730361 |
| IRF7 | interferon regulatory factor 7 | 0.00725806 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | 0.00724269 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 0.00721993 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00719213 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00716708 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.00716091 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.00715733 |
| NSG1 | neuron specific gene family member 1 | 0.00713926 |
| REG3A | regenerating islet-derived 3 alpha | 0.00712447 |
| QDPR | quinoid dihydropteridine reductase | 0.00711395 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00707687 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00704707 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00702841 |
| MICA | MHC class I polypeptide-related sequence A | 0.00700558 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00700125 |
| TLCD3A | TLC domain containing 3A | 0.0069898 |
| CLTB | clathrin, light chain B | 0.00694116 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00693407 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00692897 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.00691512 |
| SUCO | SUN domain containing ossification factor | 0.00691134 |
| RNF7 | ring finger protein 7 | 0.00690219 |
| TBX2 | T-box 2 | 0.00684288 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00682959 |
| ZNF267 | zinc finger protein 267 | 0.00682558 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00682029 |
| CDA | cytidine deaminase | 0.00680778 |
| CRY1 | cryptochrome circadian clock 1 | 0.00680057 |
| RIT1 | Ras-like without CAAX 1 | 0.00677539 |
| IFI44 | interferon-induced protein 44 | 0.00673042 |
| S100P | S100 calcium binding protein P | 0.00668903 |
| BMP7 | bone morphogenetic protein 7 | 0.00666325 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | 0.00663691 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.00663118 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.00661597 |
| RGCC | regulator of cell cycle | 0.00659551 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00659388 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.00659376 |
| ZFP36 | ZFP36 ring finger protein | 0.00659162 |
| KLK10 | kallikrein-related peptidase 10 | 0.00655341 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00654436 |
| GCH1 | GTP cyclohydrolase 1 | 0.0065401 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.00653931 |
| COG2 | component of oligomeric golgi complex 2 | 0.00653753 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.00652852 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.00651458 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | 0.00650043 |
| DPEP1 | dipeptidase 1 (renal) | 0.00647137 |
| BTG2 | BTG family, member 2 | 0.00645987 |
| EMX2 | empty spiracles homeobox 2 | 0.00645793 |
| EPHB2 | EPH receptor B2 | 0.00645666 |
| LXN | latexin | 0.00644226 |
| KLK6 | kallikrein-related peptidase 6 | 0.0064354 |
| EGR1 | early growth response 1 | 0.00642297 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.00641266 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00636179 |
| THBD | thrombomodulin | 0.00635714 |
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | 0.00635111 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00634712 |
| MYO1C | myosin IC | 0.00634646 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00633888 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00633624 |
| MSX1 | msh homeobox 1 | 0.00633393 |
| EVI2A | ecotropic viral integration site 2A | 0.00633149 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00633138 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00632307 |
| ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.00631811 |
| TSPAN8 | tetraspanin 8 | 0.00630316 |
| CCDC88C | coiled-coil domain containing 88C | 0.0063005 |
| SRGN | serglycin | 0.00626609 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.00626252 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | 0.0062577 |
| RHOB | ras homolog family member B | 0.00624976 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | 0.00623139 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00622384 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.00620605 |
| KCNN3 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 | 0.00618594 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00615639 |
| MICB | MHC class I polypeptide-related sequence B | 0.00613481 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00613038 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00611478 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.00611263 |
| TXN | thioredoxin | 0.00610582 |
| MMP12 | matrix metallopeptidase 12 | 0.00610142 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.00608064 |
| TDRD7 | tudor domain containing 7 | 0.00606192 |
| C5AR1 | complement component 5a receptor 1 | 0.00605086 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00604823 |
| KIAA0040 | KIAA0040 | 0.00604723 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 0.00601193 |
| KLHL24 | kelch-like family member 24 | 0.00600091 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00599438 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00599309 |
| STK38L | serine/threonine kinase 38 like | 0.00597588 |
| PLSCR1 | phospholipid scramblase 1 | 0.00597495 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.00596756 |
| COPS2 | COP9 signalosome subunit 2 | 0.00594637 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.00591162 |
| FAR2 | fatty acyl CoA reductase 2 | 0.00590599 |
| HOXD3 | homeobox D3 | 0.00590149 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.00589611 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.00588326 |
| MYO5C | myosin VC | 0.0058809 |
| KLF10 | Kruppel-like factor 10 | 0.00587498 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.00587349 |
| GATA6 | GATA binding protein 6 | 0.00586238 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00585961 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0058578 |
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha | 0.00584224 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.00582868 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.00582419 |
| CYTIP | cytohesin 1 interacting protein | 0.00582229 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.00581355 |
| RARA | retinoic acid receptor, alpha | 0.0058001 |
| PANX1 | pannexin 1 | 0.00579589 |
| BAG3 | BCL2-associated athanogene 3 | 0.00579308 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | 0.00578835 |
| PSMD12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | 0.00577996 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | 0.00577488 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.00577375 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00576566 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00576093 |
| PDCD10 | programmed cell death 10 | 0.00573223 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00573067 |
| RNF43 | ring finger protein 43 | 0.00571191 |
| MECOM | MDS1 and EVI1 complex locus | 0.00567254 |
| CAST | calpastatin | 0.0056668 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00564419 |
| HMOX1 | heme oxygenase 1 | 0.00564258 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00563601 |
| TMEM185B | transmembrane protein 185B | 0.00562408 |
| AFF1 | AF4/FMR2 family, member 1 | 0.00562386 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.00562288 |
| HSP90B2P | heat shock protein 90kDa beta (Grp94), member 2, pseudogene | 0.00561113 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00558934 |
| SMYD3 | SET and MYND domain containing 3 | 0.00557443 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00556949 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00556553 |
| WAC | WW domain containing adaptor with coiled-coil | 0.00556198 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.00556181 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.00554196 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00553905 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00553396 |
| PIR | pirin (iron-binding nuclear protein) | 0.00552809 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.00552102 |
| ZNF423 | zinc finger protein 423 | 0.0055202 |
| VLDLR | very low density lipoprotein receptor | 0.00552018 |
| NOX4 | NADPH oxidase 4 | 0.00551619 |
| ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent | 0.00551302 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.00550407 |
| SLC7A9 | solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 | 0.00550405 |
| MUC13 | mucin 13, cell surface associated | 0.00550007 |
| MME | membrane metallo-endopeptidase | 0.00549575 |
| ITGA6 | integrin, alpha 6 | 0.00549026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0152443 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.0142339 |
| C3 | complement component 3 | -0.0139958 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0136419 |
| A2M | alpha-2-macroglobulin | -0.0128307 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.0112414 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0112002 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0107358 |
| PEG3 | paternally expressed 3 | -0.0105042 |
| STEAP3 | STEAP family member 3, metalloreductase | -0.0103322 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.0103116 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.0101795 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0101264 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0100843 |
| PTN | pleiotrophin | -0.00998604 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00998195 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00964376 |
| BEX1 | brain expressed, X-linked 1 | -0.00960062 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00947516 |
| C7 | complement component 7 | -0.00912808 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.00903198 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0089701 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00894706 |
| SIRT3 | sirtuin 3 | -0.00884724 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00879675 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.008758 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | -0.00858112 |
| NNMT | nicotinamide N-methyltransferase | -0.00857873 |
| RB1 | retinoblastoma 1 | -0.00850748 |
| KRT7 | keratin 7, type II | -0.00845096 |
| FN1 | fibronectin 1 | -0.00840662 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00838343 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00837785 |
| CP | ceruloplasmin (ferroxidase) | -0.00833025 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00830779 |
| NDRG2 | NDRG family member 2 | -0.00828753 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00825976 |
| APOD | apolipoprotein D | -0.00821838 |
| PRR11 | proline rich 11 | -0.00820949 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00815235 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.00804626 |
| ENG | endoglin | -0.00787913 |
| CD52 | CD52 molecule | -0.00784665 |
| ZNF160 | zinc finger protein 160 | -0.00777433 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00773307 |
| H2AX | H2A.X variant histone | -0.00770892 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00756051 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | -0.00755485 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0075395 |
| CBS | cystathionine-beta-synthase | -0.0075161 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.00751589 |
| COLEC12 | collectin sub-family member 12 | -0.00751368 |
| MMP7 | matrix metallopeptidase 7 | -0.00749757 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00747359 |
| KRT5 | keratin 5, type II | -0.00744902 |
| L1CAM | L1 cell adhesion molecule | -0.0074411 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00742748 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.00740404 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | -0.00732217 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00731796 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | -0.00724126 |
| RANBP1 | RAN binding protein 1 | -0.00721813 |
| PLK1 | polo-like kinase 1 | -0.0072051 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | -0.00719858 |
| GPX4 | glutathione peroxidase 4 | -0.00717731 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.00716327 |
| HAMP | hepcidin antimicrobial peptide | -0.00715428 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | -0.00714019 |
| IL7R | interleukin 7 receptor | -0.00713693 |
| ALB | albumin | -0.00711668 |
| TARP | TCR gamma alternate reading frame protein | -0.0070621 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00703774 |
| TSPAN4 | tetraspanin 4 | -0.00702998 |
| KRT17 | keratin 17, type I | -0.00698891 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.00698276 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00693769 |
| MELK | maternal embryonic leucine zipper kinase | -0.00693527 |
| FGL1 | fibrinogen-like 1 | -0.00691525 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.0068998 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00684574 |
| DIPK1A | divergent protein kinase domain 1A | -0.0068182 |
| CDC20 | cell division cycle 20 | -0.00676499 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00675795 |
| PSG5 | pregnancy specific beta-1-glycoprotein 5 | -0.00675519 |
| DES | desmin | -0.00675288 |
| GTF2H3 | general transcription factor IIH, polypeptide 3, 34kDa | -0.00672786 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0067035 |
| XYLT1 | xylosyltransferase I | -0.00664265 |
| KIF20A | kinesin family member 20A | -0.00663295 |
| STMN2 | stathmin 2 | -0.00661551 |
| GLTP | glycolipid transfer protein | -0.00659583 |
| NEK2 | NIMA-related kinase 2 | -0.0065832 |
| NFIB | nuclear factor I/B | -0.00657782 |
| GOLGA8A | golgin A8 family, member A | -0.00656268 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -0.00653181 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00648718 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | -0.00647222 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00646874 |
| CYP2A6 | cytochrome P450, family 2, subfamily A, polypeptide 6 | -0.00641342 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00641308 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00637457 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -0.00636173 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00635984 |
| MCM4 | minichromosome maintenance complex component 4 | -0.00634152 |
| DHFR | dihydrofolate reductase | -0.00633164 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.00630989 |
| ADIRF | adipogenesis regulatory factor | -0.00630123 |
| FBXW12 | F-box and WD repeat domain containing 12 | -0.00628852 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00628835 |
| MAGED1 | melanoma antigen family D1 | -0.00628357 |
| FUS | FUS RNA binding protein | -0.00621459 |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | -0.00620755 |
| CHGB | chromogranin B | -0.00620042 |
| GNMT | glycine N-methyltransferase | -0.00619506 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00619142 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | -0.00617741 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00616999 |
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | -0.00616182 |
| NFASC | neurofascin | -0.00616012 |
| SLC35E3 | solute carrier family 35, member E3 | -0.00615128 |
| PEG10 | paternally expressed 10 | -0.00614454 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00613601 |
| MYBPC1 | myosin binding protein C, slow type | -0.00612048 |
| HYOU1 | hypoxia up-regulated 1 | -0.00610213 |
| TSPO | translocator protein (18kDa) | -0.00610012 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.0060855 |
| CD84 | CD84 molecule | -0.00608048 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00606435 |
| SYNC | syncoilin, intermediate filament protein | -0.0060482 |
| IFRD2 | interferon-related developmental regulator 2 | -0.00603513 |
| SYNM | synemin, intermediate filament protein | -0.00599755 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00598767 |
| ASS1 | argininosuccinate synthase 1 | -0.00597975 |
| SOGA1 | suppressor of glucose, autophagy associated 1 | -0.00595894 |
| TNC | tenascin C | -0.00595449 |
| EML3 | echinoderm microtubule associated protein like 3 | -0.0059392 |
| KRT14 | keratin 14, type I | -0.00593567 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.00592601 |
| CPNE1 | copine I | -0.00592189 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.0058915 |
| POLR1B | polymerase (RNA) I polypeptide B, 128kDa | -0.00588595 |
| C1RL | complement component 1, r subcomponent-like | -0.00588319 |
| PCOLCE | procollagen C-endopeptidase enhancer | -0.00586432 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00586055 |
| TMSB15A | thymosin beta 15a | -0.00586019 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.00586012 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.005858 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00584684 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | -0.00583375 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | -0.00582401 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00581192 |
| LCAT | lecithin-cholesterol acyltransferase | -0.00580681 |
| PLXNA1 | plexin A1 | -0.00580034 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00579097 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.005781 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | -0.0057693 |
| TMBIM4 | transmembrane BAX inhibitor motif containing 4 | -0.00575809 |
| OSMR | oncostatin M receptor | -0.00574533 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00574041 |
| S100A2 | S100 calcium binding protein A2 | -0.0057287 |
| CNN1 | calponin 1, basic, smooth muscle | -0.0057181 |
| TPM2 | tropomyosin 2 (beta) | -0.00570011 |
| PLCXD1 | phosphatidylinositol-specific phospholipase C, X domain containing 1 | -0.00569695 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00569355 |
| AHSG | alpha-2-HS-glycoprotein | -0.00569275 |
| KIF18B | kinesin family member 18B | -0.00568116 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0056799 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -0.00567775 |
| CD6 | CD6 molecule | -0.00566979 |
| WFDC1 | WAP four-disulfide core domain 1 | -0.00563711 |
| COMT | catechol-O-methyltransferase | -0.00563455 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00563411 |
| SGCE | sarcoglycan, epsilon | -0.00561501 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.00559072 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.00558451 |
| BCAP31 | B-cell receptor-associated protein 31 | -0.0055748 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00557436 |
| LMNB2 | lamin B2 | -0.00556457 |
| BPIFA1 | BPI fold containing family A, member 1 | -0.00555851 |
| NDRG3 | NDRG family member 3 | -0.00555382 |
| PSCA | prostate stem cell antigen | -0.00553981 |
| ACTB | actin, beta | -0.00552629 |
| SUSD4 | sushi domain containing 4 | -0.00551774 |
| CLU | clusterin | -0.00551743 |
| SDC4 | syndecan 4 | -0.0055122 |
| MFSD10 | major facilitator superfamily domain containing 10 | -0.00550544 |
| CNTNAP2 | contactin associated protein-like 2 | -0.00550413 |
| ZNF611 | zinc finger protein 611 | -0.00550233 |
| ANXA10 | annexin A10 | -0.00549599 |
| SAA4 | serum amyloid A4, constitutive | -0.00549586 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00549413 |
| MAOB | monoamine oxidase B | -0.0054709 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.00546242 |
| PAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 | -0.00546065 |
| ZNF721 | zinc finger protein 721 | -0.00546003 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | -0.00545971 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00545902 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00545336 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -0.00544852 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0054326 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00543125 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | -0.00542784 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00542082 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -0.0053991 |
| HSPB7 | heat shock 27kDa protein family, member 7 (cardiovascular) | -0.00539586 |
| CYP1A2 | cytochrome P450, family 1, subfamily A, polypeptide 2 | -0.00532646 |
| SPAG16 | sperm associated antigen 16 | -0.00531982 |
| AFP | alpha-fetoprotein | -0.00531143 |
| PRELP | proline/arginine-rich end leucine-rich repeat protein | -0.0053023 |
| ESRP2 | epithelial splicing regulatory protein 2 | -0.00529153 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.00529044 |
| SNRNP40 | small nuclear ribonucleoprotein 40kDa (U5) | -0.00528801 |
| FOXM1 | forkhead box M1 | -0.00528132 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.00526598 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00525756 |
| GNAS | GNAS complex locus | -0.00524736 |
| MXRA7 | matrix-remodelling associated 7 | -0.00524505 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.0052396 |
| MTERF3 | mitochondrial transcription termination factor 3 | -0.00523804 |
| MMP2 | matrix metallopeptidase 2 | -0.00523427 |
| PAX6 | paired box 6 | -0.00522963 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00522286 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00520655 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -0.00519887 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | -0.00519724 |
| CES1 | carboxylesterase 1 | -0.00519673 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.00518032 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00517816 |
| CD81 | CD81 molecule | -0.00516396 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.005161 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00515489 |
| APOA2 | apolipoprotein A-II | -0.00514571 |
| DMD | dystrophin | -0.00513543 |
| THBS1 | thrombospondin 1 | -0.00513439 |
| CDC7 | cell division cycle 7 | -0.00513386 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00512229 |
| CRLF1 | cytokine receptor-like factor 1 | -0.0051186 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | -0.00511754 |
| KAZN | kazrin, periplakin interacting protein | -0.00511154 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00510765 |
| MSMB | microseminoprotein, beta- | -0.0051067 |
| FST | follistatin | -0.00510087 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.00510057 |
| NLRP2 | NLR family, pyrin domain containing 2 | -0.00509336 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.00509235 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.00509199 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00505492 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00505475 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.00505169 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.00504981 |
