TE10 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Highly differentiated squamous cell carcinoma. TKG0261(Deposited from Tohoku Univ.). (Cell Line Ontology, CLO_0051372)
Similar Terms
Downloads & Tools

Genes

279 gene knockdowns changing fitness of TE10 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
WFDC11 WAP four-disulfide core domain 11 2.16541
OXSR1 oxidative stress responsive 1 2.14294
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 2.1073
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.0243
PAPOLG poly(A) polymerase gamma 1.9717
MAST4 microtubule associated serine/threonine kinase family member 4 1.88584
IFNA6 interferon, alpha 6 1.81152
GALK2 galactokinase 2 1.78987
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 1.75134
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 1.74177
ANXA3 annexin A3 1.73864
ZNF689 zinc finger protein 689 1.73498
FBXO18 F-box protein, helicase, 18 1.70462
ATP11A ATPase, class VI, type 11A 1.7034
ABAT 4-aminobutyrate aminotransferase 1.63628
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 1.62804
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 1.62337
CIB4 calcium and integrin binding family member 4 1.60721
DHRS13 dehydrogenase/reductase (SDR family) member 13 1.58252
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 1.58062
CAPN7 calpain 7 1.53145
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.51455
SH3TC1 SH3 domain and tetratricopeptide repeats 1 1.5107
ADCK1 aarF domain containing kinase 1 1.50916
MBD2 methyl-CpG binding domain protein 2 1.498
DTNB dystrobrevin, beta 1.44436
C17ORF85 chromosome 17 open reading frame 85 1.42766
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 1.41952
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.40331
CABP5 calcium binding protein 5 1.39075
ARG2 arginase 2 1.37792
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 1.35818
FRK fyn-related Src family tyrosine kinase 1.35326
IFNA10 interferon, alpha 10 1.34135
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.29885
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 1.27724
REPIN1 replication initiator 1 1.27131
SLC12A8 solute carrier family 12, member 8 1.27091
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 1.2576
IL17RB interleukin 17 receptor B 1.25046
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 1.24692
CXCR6 chemokine (C-X-C motif) receptor 6 1.23697
SERTAD3 SERTA domain containing 3 1.23284
H1FOO H1 histone family, member O, oocyte-specific 1.22626
ZNF439 zinc finger protein 439 1.22608
XYLB xylulokinase homolog (H. influenzae) 1.21673
IL17C interleukin 17C 1.21456
PDS5B PDS5 cohesin associated factor B 1.21262
TRIM7 tripartite motif containing 7 1.21048
COTL1 coactosin-like F-actin binding protein 1 1.20022
GFPT2 glutamine-fructose-6-phosphate transaminase 2 1.1979
TMEM126B transmembrane protein 126B 1.18282
ZNF282 zinc finger protein 282 1.18038
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.1792
CHRD chordin 1.17458
EFCAB2 EF-hand calcium binding domain 2 1.17133
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 1.16484
AHR aryl hydrocarbon receptor 1.1609
CPB2 carboxypeptidase B2 (plasma) 1.15924
C4BPB complement component 4 binding protein, beta 1.15605
OR4D11 olfactory receptor, family 4, subfamily D, member 11 1.15371
DPYS dihydropyrimidinase 1.14449
PURA purine-rich element binding protein A 1.13266
CCNE2 cyclin E2 1.12499
UBB ubiquitin B 1.11776
TUBB4A tubulin, beta 4A class IVa 1.11248
ADRB2 adrenoceptor beta 2, surface 1.11219
S100B S100 calcium binding protein B 1.10973
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.10937
RHAG Rh-associated glycoprotein 1.10762
MPPED1 metallophosphoesterase domain containing 1 1.10543
GH1 growth hormone 1 1.10327
UHMK1 U2AF homology motif (UHM) kinase 1 1.10216
CST2 cystatin SA 1.0919
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 1.08844
CAPS2 calcyphosine 2 1.08493
PPP1R16A protein phosphatase 1, regulatory subunit 16A 1.0803
ZMYND11 zinc finger, MYND-type containing 11 1.08026
RABGGTA Rab geranylgeranyltransferase, alpha subunit 1.07976
FGF22 fibroblast growth factor 22 1.07695
CD4 CD4 molecule 1.06838
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 1.05932
AVIL advillin 1.04244
PABPN1 poly(A) binding protein, nuclear 1 1.04118
PGM3 phosphoglucomutase 3 1.0336
TMPRSS5 transmembrane protease, serine 5 1.03203
EED embryonic ectoderm development 1.02872
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.02417
AOC2 amine oxidase, copper containing 2 (retina-specific) 1.02261
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.0076
REG1B regenerating islet-derived 1 beta 1.00481
TSPAN17 tetraspanin 17 1.00406
C14ORF39 chromosome 14 open reading frame 39 1.00217

decreased fitness

Symbol Name Standardized Value
URM1 ubiquitin related modifier 1 -3.33866
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -3.04023
GTF3A general transcription factor IIIA -2.79502
GTSE1 G-2 and S-phase expressed 1 -2.46549
TACC3 transforming, acidic coiled-coil containing protein 3 -2.45528
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -2.4404
SNRPA small nuclear ribonucleoprotein polypeptide A -2.18607
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) -2.14909
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.14016
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.13432
RPN1 ribophorin I -2.09544
NUP54 nucleoporin 54kDa -2.03601
SIN3A SIN3 transcription regulator family member A -1.95146
FAM13A family with sequence similarity 13, member A -1.94093
TPR translocated promoter region, nuclear basket protein -1.92771
GAK cyclin G associated kinase -1.9273
WNT7B wingless-type MMTV integration site family, member 7B -1.91996
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -1.90309
CCNL1 cyclin L1 -1.84422
CKAP5 cytoskeleton associated protein 5 -1.79652
CLNS1A chloride channel, nucleotide-sensitive, 1A -1.78596
ACTB actin, beta -1.73454
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 -1.7035
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 -1.69733
ERCC2 excision repair cross-complementation group 2 -1.69425
RUVBL1 RuvB-like AAA ATPase 1 -1.69162
LRP6 low density lipoprotein receptor-related protein 6 -1.68593
SMAD9 SMAD family member 9 -1.66823
PRPF3 pre-mRNA processing factor 3 -1.66459
NR1I2 nuclear receptor subfamily 1, group I, member 2 -1.6565
ASNS asparagine synthetase (glutamine-hydrolyzing) -1.65303
THOC7 THO complex 7 -1.6522
PMPCA peptidase (mitochondrial processing) alpha -1.64755
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -1.61486
ELP4 elongator acetyltransferase complex subunit 4 -1.60245
TGFBR1 transforming growth factor, beta receptor 1 -1.59398
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -1.58965
LOC442028 uncharacterized LOC442028 -1.55922
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -1.55406
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -1.54587
BTG2 BTG family, member 2 -1.54225
SP8 Sp8 transcription factor -1.53234
TMED3 transmembrane emp24 protein transport domain containing 3 -1.53214
LMNB1 lamin B1 -1.50142
RFC2 replication factor C (activator 1) 2, 40kDa -1.49563
IL20 interleukin 20 -1.48175
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -1.47789
NUPL1 nucleoporin like 1 -1.47781
SEC24B SEC24 family member B -1.47281
SPRYD7 SPRY domain containing 7 -1.47136
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -1.46403
NT5C2 5'-nucleotidase, cytosolic II -1.45416
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -1.44676
SRRM1 serine/arginine repetitive matrix 1 -1.44216
BCAS2 breast carcinoma amplified sequence 2 -1.43626
SPPL2A signal peptide peptidase like 2A -1.43389
CASP7 caspase 7, apoptosis-related cysteine peptidase -1.42051
RRM1 ribonucleotide reductase M1 -1.41785
NME1 NME/NM23 nucleoside diphosphate kinase 1 -1.41738
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -1.39454
RBBP4 retinoblastoma binding protein 4 -1.38806
LENG8 leukocyte receptor cluster (LRC) member 8 -1.3861
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa -1.38505
TXNL4A thioredoxin-like 4A -1.3831
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -1.3824
FUBP3 far upstream element (FUSE) binding protein 3 -1.37579
CTDNEP1 CTD nuclear envelope phosphatase 1 -1.37483
PRMT1 protein arginine methyltransferase 1 -1.3743
FRAS1 Fraser extracellular matrix complex subunit 1 -1.37102
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -1.36218
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -1.35567
HLA-E major histocompatibility complex, class I, E -1.35055
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -1.33586
SLAMF7 SLAM family member 7 -1.33543
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -1.32891
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -1.32724
ETV1 ets variant 1 -1.32463
RBM39 RNA binding motif protein 39 -1.32378
RAB10 RAB10, member RAS oncogene family -1.31302
SMC1A structural maintenance of chromosomes 1A -1.30824
TRIM48 tripartite motif containing 48 -1.30369
WNT2B wingless-type MMTV integration site family, member 2B -1.30015
FBXO11 F-box protein 11 -1.29946
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -1.29707
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -1.29468
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 -1.28344
MMP28 matrix metallopeptidase 28 -1.28256
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -1.27525
FKBP1A FK506 binding protein 1A, 12kDa -1.25415
TOP1 topoisomerase (DNA) I -1.25169
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -1.24591
ZNF160 zinc finger protein 160 -1.24343
FDPS farnesyl diphosphate synthase -1.23933
SNRPG small nuclear ribonucleoprotein polypeptide G -1.23852
LIN52 lin-52 DREAM MuvB core complex component -1.23579
CASP6 caspase 6, apoptosis-related cysteine peptidase -1.23527
ANTXR2 anthrax toxin receptor 2 -1.23246
GJC1 gap junction protein, gamma 1, 45kDa -1.22829
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) -1.22617
CPQ carboxypeptidase Q -1.22243
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -1.21983
GTPBP4 GTP binding protein 4 -1.21863
NUP205 nucleoporin 205kDa -1.21514
GPN3 GPN-loop GTPase 3 -1.21244
ZBTB24 zinc finger and BTB domain containing 24 -1.21029
SCRT1 scratch family zinc finger 1 -1.20765
ASGR1 asialoglycoprotein receptor 1 -1.20732
PEX5 peroxisomal biogenesis factor 5 -1.20275
DGKB diacylglycerol kinase, beta 90kDa -1.2022
POLR1B polymerase (RNA) I polypeptide B, 128kDa -1.20117
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -1.19447
BIRC6 baculoviral IAP repeat containing 6 -1.19317
NR0B2 nuclear receptor subfamily 0, group B, member 2 -1.18905
SGK1 serum/glucocorticoid regulated kinase 1 -1.18891
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -1.18689
PRPF8 pre-mRNA processing factor 8 -1.18402
AKR7A2P1 aldo-keto reductase family 7, member A2 pseudogene 1 -1.17941
DMBX1 diencephalon/mesencephalon homeobox 1 -1.17652
ILF2 interleukin enhancer binding factor 2 -1.1572
CWC22 CWC22 spliceosome-associated protein -1.15698
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -1.15495
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -1.15435
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -1.15378
RRM2 ribonucleotide reductase M2 -1.15083
IL4 interleukin 4 -1.13956
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -1.1389
PDAP1 PDGFA associated protein 1 -1.13219
CTR9 CTR9, Paf1/RNA polymerase II complex component -1.13061
EXOSC8 exosome component 8 -1.1269
TBP TATA box binding protein -1.12475
NEK5 NIMA-related kinase 5 -1.12448
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -1.12148
U2AF2 U2 small nuclear RNA auxiliary factor 2 -1.11875
MAT1A methionine adenosyltransferase I, alpha -1.10933
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -1.10931
UBA3 ubiquitin-like modifier activating enzyme 3 -1.10925
BRAP BRCA1 associated protein -1.10643
KAT8 K(lysine) acetyltransferase 8 -1.10573
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -1.10457
LIG3 ligase III, DNA, ATP-dependent -1.10189
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 -1.09895
SAE1 SUMO1 activating enzyme subunit 1 -1.09596
SNRPE small nuclear ribonucleoprotein polypeptide E -1.09262
USPL1 ubiquitin specific peptidase like 1 -1.09044
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.08939
CPPED1 calcineurin-like phosphoesterase domain containing 1 -1.0874
PRPF38B pre-mRNA processing factor 38B -1.08499
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -1.08462
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -1.08326
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -1.08132
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -1.08053
ERH enhancer of rudimentary homolog (Drosophila) -1.07484
HTT huntingtin -1.07442
SMAD4 SMAD family member 4 -1.06467
GLE1 GLE1 RNA export mediator -1.06183
NPC1 Niemann-Pick disease, type C1 -1.06127
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -1.06108
MYL12B myosin, light chain 12B, regulatory -1.05952
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.05752
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -1.05525
RPA3 replication protein A3, 14kDa -1.05403
ZNF681 zinc finger protein 681 -1.05346
RAN RAN, member RAS oncogene family -1.0511
ROGDI rogdi homolog (Drosophila) -1.04882
CHID1 chitinase domain containing 1 -1.04867
CCL5 chemokine (C-C motif) ligand 5 -1.0481
ERCC6L excision repair cross-complementation group 6-like -1.04678
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -1.04549
PHF3 PHD finger protein 3 -1.04297
ZNF140 zinc finger protein 140 -1.04184
ZNF468 zinc finger protein 468 -1.04135
MBNL1 muscleblind-like splicing regulator 1 -1.04048
PRPF31 pre-mRNA processing factor 31 -1.03778
TXN thioredoxin -1.02935
ARF1 ADP-ribosylation factor 1 -1.0266
CARS cysteinyl-tRNA synthetase -1.02582
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -1.0254
PRPF4B pre-mRNA processing factor 4B -1.02515
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -1.01994
SNW1 SNW domain containing 1 -1.01522
ZNF738 zinc finger protein 738 -1.01092
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -1.00822
SRSF3 serine/arginine-rich splicing factor 3 -1.0078
U2SURP U2 snRNP-associated SURP domain containing -1.00394
ZNF701 zinc finger protein 701 -1.00358
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -1.0003