TE11 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Esophageal Squamous Cell Carcinoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000488
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Genes

333 gene knockdowns changing fitness of TE11 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
CAMK1G calcium/calmodulin-dependent protein kinase IG 9.63075
ELN elastin 9.51236
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 9.18014
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 8.87117
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 8.778
NR1H2 nuclear receptor subfamily 1, group H, member 2 7.79074
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 7.15198
NEURL4 neuralized E3 ubiquitin protein ligase 4 6.38435
SMIM20 small integral membrane protein 20 6.34949
MKRN2 makorin ring finger protein 2 6.13679
SLF1 SMC5-SMC6 complex localization factor 1 5.82131
IQGAP1 IQ motif containing GTPase activating protein 1 5.58754
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae) 5.50558
FASTKD2 FAST kinase domains 2 5.23225
RXRA retinoid X receptor, alpha 5.15839
SIX6 SIX homeobox 6 5.14561
FGF19 fibroblast growth factor 19 5.09944
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 5.08246
MTX2 metaxin 2 4.98888
HTRA2 HtrA serine peptidase 2 4.84571
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 4.79934
ADGRE5 adhesion G protein-coupled receptor E5 4.72388
CORO1C coronin, actin binding protein, 1C 4.68286
CORO2A coronin, actin binding protein, 2A 4.61603
QRICH2 glutamine rich 2 4.58103
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 4.5794
PPOX protoporphyrinogen oxidase 4.47638
FGD5 FYVE, RhoGEF and PH domain containing 5 4.45532
GCGR glucagon receptor 4.35821
CLUH clustered mitochondria (cluA/CLU1) homolog 4.3461
HMBS hydroxymethylbilane synthase 4.25798
PRRT3 proline-rich transmembrane protein 3 4.18981
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 4.14732
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 4.04514
ZNF169 zinc finger protein 169 3.97355
CSNK1D casein kinase 1, delta 3.94432
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 3.91292
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.88753
PET100 PET100 homolog (S. cerevisiae) 3.85386
STAU1 staufen double-stranded RNA binding protein 1 3.8383
TRIP4 thyroid hormone receptor interactor 4 3.83134
YBEY ybeY metallopeptidase (putative) 3.80596
CNOT4 CCR4-NOT transcription complex, subunit 4 3.79284
MTCH2 mitochondrial carrier 2 3.75045
NCDN neurochondrin 3.74081
AJUBA ajuba LIM protein 3.73248
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 3.72589
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 3.72402
TMEM41A transmembrane protein 41A 3.6932
COL1A1 collagen, type I, alpha 1 3.66557
ZBTB8B zinc finger and BTB domain containing 8B 3.66475
HCCS holocytochrome c synthase 3.61288
WBP4 WW domain binding protein 4 3.60958
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.58307
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 3.56847
SACK1H scaffolding CK1 anchoring protein H 3.54799
PBRM1 polybromo 1 3.49596
PLAC8 placenta-specific 8 3.47292
PHGR1 proline/histidine/glycine-rich 1 3.44723
COX14 COX14 cytochrome c oxidase assembly factor 3.42241
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 3.39682
MIIP migration and invasion inhibitory protein 3.39163
MRM3 mitochondrial rRNA methyltransferase 3 3.38866
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 3.37715
NKX2-5 NK2 homeobox 5 3.35303
GTF2IRD1 GTF2I repeat domain containing 1 3.33323
USP17L10 ubiquitin specific peptidase 17-like family member 10 3.30726
NUBPL nucleotide binding protein-like 3.30271
MPV17L2 MPV17 mitochondrial membrane protein-like 2 3.30017
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 3.2924
TMEM261 transmembrane protein 261 3.29043
WRAP73 WD repeat containing, antisense to TP73 3.27837
COX19 COX19 cytochrome c oxidase assembly factor 3.27775
KIDINS220 kinase D-interacting substrate, 220kDa 3.27469
LIG3 ligase III, DNA, ATP-dependent 3.27048
MRGPRD MAS-related GPR, member D 3.25936
IREB2 iron-responsive element binding protein 2 3.25492
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 3.24163
CTRC chymotrypsin C (caldecrin) 3.22357
SCO1 SCO1 cytochrome c oxidase assembly protein 3.21977
MTERF3 mitochondrial transcription termination factor 3 3.21049
GJD3 gap junction protein, delta 3, 31.9kDa 3.19729
HAX1 HCLS1 associated protein X-1 3.18882
CCDC77 coiled-coil domain containing 77 3.17547
ZC3H4 zinc finger CCCH-type containing 4 3.16111
NFU1 NFU1 iron-sulfur cluster scaffold 3.14306
LARP7 La ribonucleoprotein domain family, member 7 3.13821
CARTPT CART prepropeptide 3.13753
PGPEP1 pyroglutamyl-peptidase I 3.13246
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 3.12527
CEP44 centrosomal protein 44kDa 3.12133
REXO2 RNA exonuclease 2 3.10995
OR1G1 olfactory receptor, family 1, subfamily G, member 1 3.09928
PRR22 proline rich 22 3.09225
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 3.09138
PDE2A phosphodiesterase 2A, cGMP-stimulated 3.08218
MTF1 metal-regulatory transcription factor 1 3.08131
TFB1M transcription factor B1, mitochondrial 3.07964
G6PD glucose-6-phosphate dehydrogenase 3.03808
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 3.01553
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 3.01453
PDLIM7 PDZ and LIM domain 7 (enigma) 2.99619
ERBB3 erb-b2 receptor tyrosine kinase 3 2.97378
SRRD SRR1 domain containing 2.97236
UROS uroporphyrinogen III synthase 2.96453
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.96358
CTTN cortactin 2.95572
IFI27L1 interferon, alpha-inducible protein 27-like 1 2.95303
FAM131C family with sequence similarity 131, member C 2.94922
AMBRA1 autophagy/beclin-1 regulator 1 2.92654
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 2.91896
MED16 mediator complex subunit 16 2.90642
JPH4 junctophilin 4 2.89817
PET117 PET117 homolog (S. cerevisiae) 2.87136
FOXRED1 FAD-dependent oxidoreductase domain containing 1 2.86628
MTO1 mitochondrial tRNA translation optimization 1 2.86538
THAP12 THAP domain containing 12 2.86471
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.85041
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.84676
GTPBP8 GTP-binding protein 8 (putative) 2.84272
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.83432
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 2.82937
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 2.82155
NINJ2 ninjurin 2 2.81505
GRSF1 G-rich RNA sequence binding factor 1 2.80356
TMSB4X thymosin beta 4, X-linked 2.80335
RERE arginine-glutamic acid dipeptide (RE) repeats 2.80236
COX18 COX18 cytochrome c oxidase assembly factor 2.80197
FLYWCH1 FLYWCH-type zinc finger 1 2.79901
FDX1 ferredoxin 1 2.79659
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 2.77284
TTC7A tetratricopeptide repeat domain 7A 2.7722
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.76866
MRPL30 mitochondrial ribosomal protein L30 2.76227
MED25 mediator complex subunit 25 2.75563
SIRT1 sirtuin 1 2.75085
STEEP1 STING1 ER exit protein 1 2.74245
RPUSD3 RNA pseudouridylate synthase domain containing 3 2.74052
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 2.73919
EXTL1 exostosin-like glycosyltransferase 1 2.73719
BIRC2 baculoviral IAP repeat containing 2 2.72523
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.72249
USP1 ubiquitin specific peptidase 1 2.71737
GIGYF2 GRB10 interacting GYF protein 2 2.70809
FASTKD5 FAST kinase domains 5 2.70749
MTIF2 mitochondrial translational initiation factor 2 2.70127
C19ORF38 chromosome 19 open reading frame 38 2.69184
STARD9 StAR-related lipid transfer (START) domain containing 9 2.67166
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.66806
RTN4IP1 reticulon 4 interacting protein 1 2.66153
C20ORF27 chromosome 20 open reading frame 27 2.65737
XCL2 chemokine (C motif) ligand 2 2.65342
MRC2 mannose receptor, C type 2 2.65
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 2.64509
ARSG arylsulfatase G 2.62706
TCEA3 transcription elongation factor A (SII), 3 2.62393
KLHDC4 kelch domain containing 4 2.61259
NSRP1 nuclear speckle splicing regulatory protein 1 2.61175
WDR4 WD repeat domain 4 2.61129
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.59201
DMAC2 distal membrane arm assembly component 2 2.58842
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.58415
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.57297
COA3 cytochrome c oxidase assembly factor 3 2.54888
GMEB2 glucocorticoid modulatory element binding protein 2 2.54628
DLG4 discs, large homolog 4 (Drosophila) 2.53952
PSKH2 protein serine kinase H2 2.53509
TOMM70 translocase of outer mitochondrial membrane 70 2.52481
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.51727
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.51607
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.51429
WNT10B wingless-type MMTV integration site family, member 10B 2.50873
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 2.49114
COQ3 coenzyme Q3 methyltransferase 2.48464
GPR176 G protein-coupled receptor 176 2.48025
NFE2L2 nuclear factor, erythroid 2-like 2 2.4772
MCRIP1 MAPK regulated corepressor interacting protein 1 2.46732
AK1 adenylate kinase 1 2.46224
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.46099
ASCC2 activating signal cointegrator 1 complex subunit 2 2.44694
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.44542
ADPRHL1 ADP-ribosylhydrolase like 1 2.44179
SMOX spermine oxidase 2.43652
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.43031
TRIM28 tripartite motif containing 28 2.4282
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.41788
PDE12 phosphodiesterase 12 2.41716
TMEM242 transmembrane protein 242 2.41705
MTFMT mitochondrial methionyl-tRNA formyltransferase 2.41612
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.41332
SLC30A9 solute carrier family 30 (zinc transporter), member 9 2.41037
TASOR2 transcription activation suppressor family member 2 2.40741
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.40441
ADCY4 adenylate cyclase 4 2.39869
TRNP1 TMF1-regulated nuclear protein 1 2.39798
COA6 cytochrome c oxidase assembly factor 6 2.39501
TMCO6 transmembrane and coiled-coil domains 6 2.38707
PITRM1 pitrilysin metallopeptidase 1 2.38481
C1ORF64 chromosome 1 open reading frame 64 2.38358
CFAP410 cilia and flagella associated protein 410 2.38127
BLM Bloom syndrome, RecQ helicase-like 2.37743
POC1A POC1 centriolar protein A 2.3661
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.36526
BRD7 bromodomain containing 7 2.36429
FAM194C family with sequence similarity 149 member C 2.36312
GTPBP10 GTP-binding protein 10 (putative) 2.36239
MRPL22 mitochondrial ribosomal protein L22 2.36169
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 2.35877
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 2.35522
NEURL2 neuralized E3 ubiquitin protein ligase 2 2.34618
NOA1 nitric oxide associated 1 2.339
RHPN1 rhophilin, Rho GTPase binding protein 1 2.33712
ALAD aminolevulinate dehydratase 2.33257
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 2.33251
NPB neuropeptide B 2.33246
YME1L1 YME1-like 1 ATPase 2.3318
MTG1 mitochondrial ribosome-associated GTPase 1 2.31958
ADAT2 adenosine deaminase, tRNA-specific 2 2.31904
E2F2 E2F transcription factor 2 2.31761
RBM18 RNA binding motif protein 18 2.31479
APTX aprataxin 2.31213
ECSIT ECSIT signalling integrator 2.30863
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2.30843
GPS2 G protein pathway suppressor 2 2.30758
TMOD2 tropomodulin 2 (neuronal) 2.30545
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.30044
SREBF1 sterol regulatory element binding transcription factor 1 2.29931
SRSF9 serine/arginine-rich splicing factor 9 2.29781
SNRPA small nuclear ribonucleoprotein polypeptide A 2.2964
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.29493
TRIM46 tripartite motif containing 46 2.2925
CCDC177 coiled-coil domain containing 177 2.29249
MRPL44 mitochondrial ribosomal protein L44 2.29047
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.28939
NKAPD1 NKAP domain containing 1 2.28506
SLC39A11 solute carrier family 39, member 11 2.28063
ARID4B AT rich interactive domain 4B (RBP1-like) 2.27477
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 2.26696
RIPPLY3 ripply transcriptional repressor 3 2.26654
USP54 ubiquitin specific peptidase 54 2.26312
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2.26159
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.26053
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.25872
FGF1 fibroblast growth factor 1 (acidic) 2.25786
ZNF683 zinc finger protein 683 2.25427
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.25314
FUBP1 far upstream element (FUSE) binding protein 1 2.25313
DCTN1 dynactin 1 2.25123
MRPL2 mitochondrial ribosomal protein L2 2.25041
GCKR glucokinase (hexokinase 4) regulator 2.25019
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.24959
PYURF PIGY upstream reading frame 2.24669
HEBP1 heme binding protein 1 2.24139
THRAP3 thyroid hormone receptor associated protein 3 2.24024
LDB3 LIM domain binding 3 2.23519
TJAP1 tight junction associated protein 1 (peripheral) 2.23309
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 2.23261
MRM2 mitochondrial rRNA methyltransferase 2 2.21698
MT1G metallothionein 1G 2.21213
MIPEP mitochondrial intermediate peptidase 2.21153
IKZF4 IKAROS family zinc finger 4 (Eos) 2.19715
TRAF2 TNF receptor-associated factor 2 2.18579
RGS14 regulator of G-protein signaling 14 2.18119
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 2.1768
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.17647
PPIH peptidylprolyl isomerase H (cyclophilin H) 2.17368
PTDSS1 phosphatidylserine synthase 1 2.17291
UBE2K ubiquitin-conjugating enzyme E2K 2.17164
TRUB2 TruB pseudouridine (psi) synthase family member 2 2.16363
ZFP36L1 ZFP36 ring finger protein-like 1 2.16122
FOXK1 forkhead box K1 2.1597
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.15838
SCO2 SCO2 cytochrome c oxidase assembly protein 2.15567
CIITA class II, major histocompatibility complex, transactivator 2.15434
FLII flightless I homolog (Drosophila) 2.1536
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.15179
DNAAF5 dynein, axonemal, assembly factor 5 2.14979
CMC1 C-x(9)-C motif containing 1 2.14815
UCN2 urocortin 2 2.14738
UBB ubiquitin B 2.14681
WIZ widely interspaced zinc finger motifs 2.14671
SELENOI selenoprotein I 2.13534
LRRC43 leucine rich repeat containing 43 2.13255
UBA6 ubiquitin-like modifier activating enzyme 6 2.12043
DLL4 delta-like 4 (Drosophila) 2.11413
RRAGC Ras-related GTP binding C 2.11325
FAM92B family with sequence similarity 92, member B 2.11089
TRIT1 tRNA isopentenyltransferase 1 2.10882
AHDC1 AT hook, DNA binding motif, containing 1 2.10805
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.10351
IFNA21 interferon, alpha 21 2.10311
MTRF1L mitochondrial translational release factor 1-like 2.09703
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.09604
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.0938
GLRX3 glutaredoxin 3 2.08996
CCDC6 coiled-coil domain containing 6 2.08779
CLDN16 claudin 16 2.08016
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 2.07842
ARHGAP23 Rho GTPase activating protein 23 2.0784
PLA2G3 phospholipase A2, group III 2.07268
CHD8 chromodomain helicase DNA binding protein 8 2.07102
CCDC51 coiled-coil domain containing 51 2.06935
CCNC cyclin C 2.06827
CDK8 cyclin-dependent kinase 8 2.06777
PIH1D1 PIH1 domain containing 1 2.06505
HARS2 histidyl-tRNA synthetase 2, mitochondrial 2.05639
ZNHIT1 zinc finger, HIT-type containing 1 2.05584
DPH1 diphthamide biosynthesis 1 2.05215
C12ORF65 chromosome 12 open reading frame 65 2.04714
XPR1 xenotropic and polytropic retrovirus receptor 1 2.04639
GFM2 G elongation factor, mitochondrial 2 2.04462
NGRN neugrin, neurite outgrowth associated 2.04166
PTCD1 pentatricopeptide repeat domain 1 2.03904
VRTN vertebrae development associated 2.03842
MRPL20 mitochondrial ribosomal protein L20 2.03571
FKBPL FK506 binding protein like 2.0353
RASAL3 RAS protein activator like 3 2.03188
MRPS18C mitochondrial ribosomal protein S18C 2.0308
RMI2 RecQ mediated genome instability 2 2.02448
ELL2 elongation factor, RNA polymerase II, 2 2.02425
GGT5 gamma-glutamyltransferase 5 2.02126
IFNA1 interferon, alpha 1 2.02069
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.0199
CIDEC cell death-inducing DFFA-like effector c 2.01558
CAMK1 calcium/calmodulin-dependent protein kinase I 2.01451
COX4I1 cytochrome c oxidase subunit IV isoform 1 2.01388
MT1X metallothionein 1X 2.01338
BIRC6 baculoviral IAP repeat containing 6 2.01065
MCPH1 microcephalin 1 2.00971
TADA2B transcriptional adaptor 2B 2.00431
TRIP12 thyroid hormone receptor interactor 12 2.00269
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.00062
ZNF224 zinc finger protein 224 2.00046