TE4 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Esophageal Squamous Cell Carcinoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000917
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Genes

361 gene knockdowns changing fitness of TE4 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 11.6366
ERN1 endoplasmic reticulum to nucleus signaling 1 10.2604
RAI14 retinoic acid induced 14 10.0174
PAX9 paired box 9 9.82533
RAI1 retinoic acid induced 1 9.25597
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 8.80002
HMG20A high mobility group 20A 8.51754
XBP1 X-box binding protein 1 8.33886
ARF5 ADP-ribosylation factor 5 8.21607
AMER2 APC membrane recruitment protein 2 7.88918
TCAP titin-cap 7.78155
EPN2 epsin 2 7.55301
PIH1D1 PIH1 domain containing 1 7.31422
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 6.94974
NPC2 Niemann-Pick disease, type C2 6.92577
PGAP3 post-GPI attachment to proteins 3 6.87575
SYT17 synaptotagmin XVII 6.76262
CD82 CD82 molecule 6.60455
NEUROD2 neuronal differentiation 2 6.58474
C16ORF52 chromosome 16 open reading frame 52 6.54096
WDR13 WD repeat domain 13 6.5375
ZXDA zinc finger, X-linked, duplicated A 6.53541
CDRT15L2 CMT1A duplicated region transcript 15-like 2 6.45607
OR52J3 olfactory receptor, family 52, subfamily J, member 3 6.40947
C11ORF49 chromosome 11 open reading frame 49 6.18411
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 6.11308
NKX2-8 NK2 homeobox 8 5.8847
CDRT1 CMT1A duplicated region transcript 1 5.7982
TOP1MT topoisomerase (DNA) I, mitochondrial 5.69248
USP49 ubiquitin specific peptidase 49 5.6721
OR4L1 olfactory receptor, family 4, subfamily L, member 1 5.48985
EVX2 even-skipped homeobox 2 5.48105
CIDEB cell death-inducing DFFA-like effector b 5.39375
CD46 CD46 molecule, complement regulatory protein 5.37914
FIG4 FIG4 phosphoinositide 5-phosphatase 5.32071
STARD3 StAR-related lipid transfer (START) domain containing 3 5.3172
HOXB8 homeobox B8 5.31611
PLD6 phospholipase D family, member 6 5.26454
CCDC8 coiled-coil domain containing 8 5.15223
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 5.08254
MIEN1 migration and invasion enhancer 1 5.06379
MICU1 mitochondrial calcium uptake 1 4.99221
PDIA6 protein disulfide isomerase family A, member 6 4.96193
PGAP1 post-GPI attachment to proteins 1 4.89103
LRP5 low density lipoprotein receptor-related protein 5 4.82618
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 4.70741
HTRA2 HtrA serine peptidase 2 4.65485
ANXA8 annexin A8 4.65323
PNMT phenylethanolamine N-methyltransferase 4.64419
RNF212B ring finger protein 212B 4.62153
CRYL1 crystallin, lambda 1 4.59299
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 4.57656
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 4.46802
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 4.463
HOXB4 homeobox B4 4.43677
OR4S2 olfactory receptor, family 4, subfamily S, member 2 4.39815
NKX2-1 NK2 homeobox 1 4.39672
ASF1A anti-silencing function 1A histone chaperone 4.39577
ADD2 adducin 2 (beta) 4.37768
MAGEA6 melanoma antigen family A6 4.35567
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 4.35261
UBQLN2 ubiquilin 2 4.33702
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 4.28153
TMEM132E transmembrane protein 132E 4.25172
RXFP3 relaxin/insulin-like family peptide receptor 3 4.2451
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 4.23799
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 4.21923
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 4.21304
FAM219B family with sequence similarity 219, member B 4.1623
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 4.09373
SLF1 SMC5-SMC6 complex localization factor 1 4.02908
OR7C1 olfactory receptor, family 7, subfamily C, member 1 4.01014
GOLM2 golgi membrane protein 2 4.00293
ACVRL1 activin A receptor type II-like 1 4.00069
RABEP2 rabaptin, RAB GTPase binding effector protein 2 3.99159
GOSR1 golgi SNAP receptor complex member 1 3.99145
CLU clusterin 3.98915
TTN titin 3.981
CHRM4 cholinergic receptor, muscarinic 4 3.97874
FOXA1 forkhead box A1 3.94489
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 3.89166
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 3.86558
CA10 carbonic anhydrase X 3.81699
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 3.75905
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 3.75251
RBM47 RNA binding motif protein 47 3.75091
AAGAB alpha- and gamma-adaptin binding protein 3.73503
ADAP2 ArfGAP with dual PH domains 2 3.71402
GMDS GDP-mannose 4,6-dehydratase 3.71001
BAZ1A bromodomain adjacent to zinc finger domain, 1A 3.70616
INSM2 insulinoma-associated 2 3.65756
YIPF5 Yip1 domain family, member 5 3.65482
LDLR low density lipoprotein receptor 3.64914
CCDC32 coiled-coil domain containing 32 3.59868
RGN regucalcin 3.59796
JPH4 junctophilin 4 3.59709
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 3.57468
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.56464
ATAD3A ATPase family, AAA domain containing 3A 3.52872
CARNS1 carnosine synthase 1 3.51677
MYH7 myosin, heavy chain 7, cardiac muscle, beta 3.515
TAS2R10 taste receptor, type 2, member 10 3.50492
MTUS1 microtubule associated tumor suppressor 1 3.48244
ACSM5 acyl-CoA synthetase medium-chain family member 5 3.47008
ZAR1 zygote arrest 1 3.46822
MMP15 matrix metallopeptidase 15 (membrane-inserted) 3.42924
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 3.42519
F2 coagulation factor II (thrombin) 3.40811
TAPT1 transmembrane anterior posterior transformation 1 3.40437
TP53I11 tumor protein p53 inducible protein 11 3.36855
FIMP1 fertilization-influencing membrane protein 1 3.33056
TET3 tet methylcytosine dioxygenase 3 3.32662
TBX10 T-box 10 3.28567
CORO1B coronin, actin binding protein, 1B 3.27287
MTMR6 myotubularin related protein 6 3.26864
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 3.26006
NPC1 Niemann-Pick disease, type C1 3.23442
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 3.22278
AGXT2 alanine--glyoxylate aminotransferase 2 3.20855
MRAS muscle RAS oncogene homolog 3.20132
PRRC2B proline-rich coiled-coil 2B 3.17387
SESTD1 SEC14 and spectrin domains 1 3.16714
DLG2 discs, large homolog 2 (Drosophila) 3.16034
HOXA5 homeobox A5 3.15681
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 3.13167
CTSF cathepsin F 3.10605
KRT86 keratin 86, type II 3.10341
PAGE2 P antigen family, member 2 (prostate associated) 3.0997
FAM193A family with sequence similarity 193, member A 3.09793
MYBPC3 myosin binding protein C, cardiac 3.08476
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 3.08153
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 3.04821
KIAA0895 KIAA0895 3.02612
PRAMEF4 PRAME family member 4 3.02127
FCHO2 FCH domain only 2 3.01628
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 3.01015
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 3.00205
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 3.00164
PRR23C proline rich 23C 2.98623
HOXB13 homeobox B13 2.98359
CCDC132 coiled-coil domain containing 132 2.98343
PRKCB protein kinase C, beta 2.9823
SUCO SUN domain containing ossification factor 2.98041
OSBP2 oxysterol binding protein 2 2.97967
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13 2.96377
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.9588
FBXL19 F-box and leucine-rich repeat protein 19 2.95502
BCL2L2 BCL2-like 2 2.95149
NOMO2 NODAL modulator 2 2.9401
TPBG trophoblast glycoprotein 2.93185
PRR15L proline rich 15-like 2.91916
OR6V1 olfactory receptor, family 6, subfamily V, member 1 2.89656
FAM26D family with sequence similarity 26, member D 2.89586
TRIM43 tripartite motif containing 43 2.88525
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 2.88418
SLA Src-like-adaptor 2.8781
MAGOHB mago-nashi homolog B (Drosophila) 2.87393
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.87103
SLC16A11 solute carrier family 16, member 11 2.86673
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.86657
VSX1 visual system homeobox 1 2.86434
PPP1R3E protein phosphatase 1, regulatory subunit 3E 2.84926
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.83975
RBM33 RNA binding motif protein 33 2.83942
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.83846
PRSS8 protease, serine, 8 2.83298
LTB4R2 leukotriene B4 receptor 2 2.81524
FAM189A1 family with sequence similarity 189, member A1 2.81138
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.80166
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.80128
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.80069
IRX3 iroquois homeobox 3 2.78733
BORCS5 BLOC-1 related complex subunit 5 2.77853
BEST4 bestrophin 4 2.77714
RHOD ras homolog family member D 2.7767
FBXW5 F-box and WD repeat domain containing 5 2.77466
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 2.77355
HOMEZ homeobox and leucine zipper encoding 2.77156
CLUH clustered mitochondria (cluA/CLU1) homolog 2.76822
CBX6 chromobox homolog 6 2.76209
KLHL26 kelch-like family member 26 2.76011
IFI44 interferon-induced protein 44 2.75126
CHP2 calcineurin-like EF-hand protein 2 2.74961
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 2.74816
AQP3 aquaporin 3 (Gill blood group) 2.74615
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.71326
MYO15A myosin XVA 2.70192
FAM189A2 family with sequence similarity 189, member A2 2.69275
KIF24 kinesin family member 24 2.68981
OR4K13 olfactory receptor, family 4, subfamily K, member 13 2.68073
UBAP2 ubiquitin associated protein 2 2.67567
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.67078
ERBB2 erb-b2 receptor tyrosine kinase 2 2.67053
BMP8A bone morphogenetic protein 8a 2.67019
ARL9 ADP-ribosylation factor-like 9 2.65858
PRAMEF14 PRAME family member 14 2.65663
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.64711
C1QTNF4 C1q and tumor necrosis factor related protein 4 2.63823
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 2.63237
BCAN brevican 2.63234
SBNO2 strawberry notch homolog 2 (Drosophila) 2.62222
GJB2 gap junction protein, beta 2, 26kDa 2.61233
SYCP1 synaptonemal complex protein 1 2.60801
APOA4 apolipoprotein A-IV 2.60243
FOXO3 forkhead box O3 2.59835
SOX14 SRY (sex determining region Y)-box 14 2.59094
MED25 mediator complex subunit 25 2.58969
TBC1D10C TBC1 domain family, member 10C 2.57677
LTB4R leukotriene B4 receptor 2.57393
MFAP4 microfibrillar-associated protein 4 2.5737
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 2.57336
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.57173
EFCC1 EF-hand and coiled-coil domain containing 1 2.55999
MT1A metallothionein 1A 2.5593
REXO2 RNA exonuclease 2 2.53612
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.52818
ALKBH5 AlkB family member 5, RNA demethylase 2.52767
TUBA3C tubulin, alpha 3c 2.52717
BRAP BRCA1 associated protein 2.52501
RASL11A RAS-like, family 11, member A 2.52325
KRT14 keratin 14, type I 2.52263
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.51937
CCDC87 coiled-coil domain containing 87 2.51681
SERTM1 serine-rich and transmembrane domain containing 1 2.5141
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.51222
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.50694
TRIT1 tRNA isopentenyltransferase 1 2.50638
ITPK1 inositol-tetrakisphosphate 1-kinase 2.50507
CR1L complement component (3b/4b) receptor 1-like 2.50465
HPD 4-hydroxyphenylpyruvate dioxygenase 2.50152
ARHGAP30 Rho GTPase activating protein 30 2.48411
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.47977
RBM18 RNA binding motif protein 18 2.47921
IER3IP1 immediate early response 3 interacting protein 1 2.44223
ACSF2 acyl-CoA synthetase family member 2 2.43265
KXD1 KxDL motif containing 1 2.42865
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.42537
KIAA1143 KIAA1143 2.4216
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.41244
ANAPC13 anaphase promoting complex subunit 13 2.40995
PHOSPHO1 phosphatase, orphan 1 2.40511
SCAMP2 secretory carrier membrane protein 2 2.40454
ZNF438 zinc finger protein 438 2.40201
DERL2 derlin 2 2.40193
NOSIP nitric oxide synthase interacting protein 2.39746
PSPC1 paraspeckle component 1 2.39397
EXOC2 exocyst complex component 2 2.39328
ALOXE3 arachidonate lipoxygenase 3 2.39322
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 2.39249
LRRC16B leucine rich repeat containing 16B 2.39237
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.39023
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.3886
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.38072
CGB7 chorionic gonadotropin, beta polypeptide 7 2.37737
RGS7BP regulator of G-protein signaling 7 binding protein 2.3715
RTL8B retrotransposon Gag like 8B 2.3676
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.366
GPR158 G protein-coupled receptor 158 2.36086
RCOR2 REST corepressor 2 2.35943
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.35691
HOXB9 homeobox B9 2.35388
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.34145
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.33759
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 2.3241
KRTAP23-1 keratin associated protein 23-1 2.31942
HSPA13 heat shock protein 70kDa family, member 13 2.31753
COX14 COX14 cytochrome c oxidase assembly factor 2.31393
DTX1 deltex 1, E3 ubiquitin ligase 2.31367
CPNE4 copine IV 2.30703
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.29589
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.295
STK40 serine/threonine kinase 40 2.29303
LCE6A late cornified envelope 6A 2.2861
SREBF1 sterol regulatory element binding transcription factor 1 2.28496
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 2.27923
PODN podocan 2.27638
MVB12A multivesicular body subunit 12A 2.27066
C19ORF47 chromosome 19 open reading frame 47 2.26747
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.26676
SOAT1 sterol O-acyltransferase 1 2.26636
AP2B1 adaptor-related protein complex 2, beta 1 subunit 2.26107
DAO D-amino-acid oxidase 2.25313
TMEM167A transmembrane protein 167A 2.24904
MSRB2 methionine sulfoxide reductase B2 2.24424
RCAN1 regulator of calcineurin 1 2.2441
RASA4B RAS p21 protein activator 4B 2.24324
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.24162
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.23956
GOLGA6L6 golgin A6 family-like 6 2.23303
AQP10 aquaporin 10 2.23022
FAM135B family with sequence similarity 135, member B 2.22026
HOXB6 homeobox B6 2.21557
RTL8C retrotransposon Gag like 8C 2.21383
ZNF575 zinc finger protein 575 2.21209
RIPK3 receptor-interacting serine-threonine kinase 3 2.20831
MCTS1 malignant T cell amplified sequence 1 2.2065
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.2052
MDK midkine (neurite growth-promoting factor 2) 2.2049
SGO2 shugoshin 2 2.19593
SELENOM selenoprotein M 2.19348
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.19338
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.18883
NFE2L1 nuclear factor, erythroid 2-like 1 2.18487
RABIF RAB interacting factor 2.18319
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.17635
CXXC1 CXXC finger protein 1 2.17418
PIKFYVE phosphoinositide kinase, FYVE finger containing 2.17108
NPAP1 nuclear pore associated protein 1 2.16181
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 2.1582
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 2.15442
PDZRN4 PDZ domain containing ring finger 4 2.15322
TSNAXIP1 translin-associated factor X interacting protein 1 2.15292
GDI2 GDP dissociation inhibitor 2 2.15156
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 2.12964
NGFR nerve growth factor receptor 2.12311
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.12274
PTGDR prostaglandin D2 receptor (DP) 2.12015
HIBADH 3-hydroxyisobutyrate dehydrogenase 2.11959
OOEP oocyte expressed protein 2.11776
NCK2 NCK adaptor protein 2 2.11483
HES7 hes family bHLH transcription factor 7 2.11217
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.11175
CCDC105 coiled-coil domain containing 105 2.10713
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.10673
TAL1 T-cell acute lymphocytic leukemia 1 2.10356
CCL22 chemokine (C-C motif) ligand 22 2.09712
FYB1 FYN binding protein 1 2.09398
GLI2 GLI family zinc finger 2 2.09138
LLGL1 lethal giant larvae homolog 1 (Drosophila) 2.09069
CISD1 CDGSH iron sulfur domain 1 2.09018
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.08724
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.08705
CHD8 chromodomain helicase DNA binding protein 8 2.08381
CD8A CD8a molecule 2.08195
STXBP3 syntaxin binding protein 3 2.08182
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.07397
RNF17 ring finger protein 17 2.07217
OTUD1 OTU deubiquitinase 1 2.06981
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.06934
KEAP1 kelch-like ECH-associated protein 1 2.06887
A4GALT alpha 1,4-galactosyltransferase 2.06611
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.06035
TBC1D28 TBC1 domain family, member 28 2.05907
CEP97 centrosomal protein 97kDa 2.05381
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 2.05204
ERI1 exoribonuclease 1 2.0479
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.04757
ARHGAP1 Rho GTPase activating protein 1 2.04454
ARF1 ADP-ribosylation factor 1 2.04205
WASF2 WAS protein family, member 2 2.04128
CSMD2 CUB and Sushi multiple domains 2 2.03429
ITGB8 integrin, beta 8 2.02961
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.0287
IREB2 iron-responsive element binding protein 2 2.02703
ZFPL1 zinc finger protein-like 1 2.02662
ELK1 ELK1, member of ETS oncogene family 2.0207
BCL9L B-cell CLL/lymphoma 9-like 2.0152
CENPV centromere protein V 2.00205
TMEM143 transmembrane protein 143 2.00169
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) 2.00105
COX18 COX18 cytochrome c oxidase assembly factor 2.00091