TE9 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Esophageal Squamous Cell Carcinoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000694
Similar Terms
Downloads & Tools

Genes

265 gene knockdowns changing fitness of TE9 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
NLN neurolysin (metallopeptidase M3 family) 12.7005
OMA1 OMA1 zinc metallopeptidase 11.1044
LAP3 leucine aminopeptidase 3 7.25031
ZNF526 zinc finger protein 526 6.30891
CTTN cortactin 6.19828
ZNF219 zinc finger protein 219 6.15681
CUL4B cullin 4B 5.77566
ADCY4 adenylate cyclase 4 5.72337
FGF4 fibroblast growth factor 4 5.62545
ANO1 anoctamin 1, calcium activated chloride channel 5.43879
TBX10 T-box 10 5.11297
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 5.06195
IRF9 interferon regulatory factor 9 4.96613
LTB4R2 leukotriene B4 receptor 2 4.81614
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 4.69247
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.52076
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 4.47687
FGF19 fibroblast growth factor 19 4.42872
UBE2G1 ubiquitin-conjugating enzyme E2G 1 4.37352
TM9SF1 transmembrane 9 superfamily member 1 4.31622
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 4.24118
CST6 cystatin E/M 4.23711
TNNC1 troponin C type 1 (slow) 4.23493
KLHL26 kelch-like family member 26 4.21624
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 4.21111
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 4.19984
PRDX3 peroxiredoxin 3 4.15538
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 4.03999
DCAF11 DDB1 and CUL4 associated factor 11 4.02761
TRADD TNFRSF1A-associated via death domain 3.96246
KIAA1683 KIAA1683 3.95948
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 3.8646
CABP2 calcium binding protein 2 3.84311
EREG epiregulin 3.7848
GCHFR GTP cyclohydrolase I feedback regulator 3.74539
SSH3 slingshot protein phosphatase 3 3.739
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 3.60226
TRIM56 tripartite motif containing 56 3.51722
CERS1 ceramide synthase 1 3.44652
LCN15 lipocalin 15 3.42257
BRMS1L breast cancer metastasis-suppressor 1-like 3.42133
MDP1 magnesium-dependent phosphatase 1 3.41201
PDE8B phosphodiesterase 8B 3.40755
MTL5 metallothionein-like 5, testis-specific (tesmin) 3.35988
CRLF1 cytokine receptor-like factor 1 3.35126
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 3.32884
CLCF1 cardiotrophin-like cytokine factor 1 3.31185
EMC9 ER membrane protein complex subunit 9 3.29396
PARP2 poly (ADP-ribose) polymerase 2 3.28428
TEP1 telomerase-associated protein 1 3.24879
PHGR1 proline/histidine/glycine-rich 1 3.2427
KXD1 KxDL motif containing 1 3.23377
PCGF2 polycomb group ring finger 2 3.20598
SLC43A3 solute carrier family 43, member 3 3.18258
CXXC5 CXXC finger protein 5 3.17987
ABHD10 abhydrolase domain containing 10 3.16503
CCDC36 coiled-coil domain containing 36 3.16089
TPPP2 tubulin polymerization-promoting protein family member 2 3.15111
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 3.14575
TSPAN1 tetraspanin 1 3.13497
CHMP4A charged multivesicular body protein 4A 3.13241
RAD54L RAD54-like (S. cerevisiae) 3.1292
PRAMEF14 PRAME family member 14 3.12223
MTRES1 mitochondrial transcription rescue factor 1 3.12014
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 3.11284
RNASE13 ribonuclease, RNase A family, 13 (non-active) 3.0987
CUL4A cullin 4A 3.09151
TMEM53 transmembrane protein 53 3.06617
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.05224
THNSL2 threonine synthase-like 2 (S. cerevisiae) 3.04863
OR2H1 olfactory receptor, family 2, subfamily H, member 1 3.04227
PPME1 protein phosphatase methylesterase 1 3.04197
POGLUT1 protein O-glucosyltransferase 1 3.03552
MRPL1 mitochondrial ribosomal protein L1 3.03011
CPT1A carnitine palmitoyltransferase 1A (liver) 3.02548
LRP5 low density lipoprotein receptor-related protein 5 3.02319
SEC24D SEC24 family member D 3.01904
COMP cartilage oligomeric matrix protein 2.99825
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.97605
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.96234
KLHL32 kelch-like family member 32 2.96048
GLT6D1 glycosyltransferase 6 domain containing 1 2.93986
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.93345
TGM1 transglutaminase 1 2.92518
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 2.92218
TMEM59L transmembrane protein 59-like 2.87012
CCDC51 coiled-coil domain containing 51 2.86463
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.84743
REX1BD required for excision 1-B domain containing 2.8243
FADD Fas (TNFRSF6)-associated via death domain 2.80429
SALL2 spalt-like transcription factor 2 2.77166
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2.76165
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 2.76135
KNCN kinocilin 2.7517
CTSG cathepsin G 2.73725
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 2.72246
GLYCTK glycerate kinase 2.69132
RBM23 RNA binding motif protein 23 2.69116
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 2.68598
PSMC3IP PSMC3 interacting protein 2.68338
DERL3 derlin 3 2.68192
SHBG sex hormone-binding globulin 2.68176
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.67512
PEX11B peroxisomal biogenesis factor 11 beta 2.67423
C15ORF62 chromosome 15 open reading frame 62 2.66531
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.6651
TMEM151A transmembrane protein 151A 2.66161
SLC39A2 solute carrier family 39 (zinc transporter), member 2 2.66102
TTBK1 tau tubulin kinase 1 2.65896
FBXO24 F-box protein 24 2.65497
IDE insulin-degrading enzyme 2.65465
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.65218
STEEP1 STING1 ER exit protein 1 2.65024
PCM1 pericentriolar material 1 2.64621
CABP4 calcium binding protein 4 2.63953
KIF12 kinesin family member 12 2.61183
UBE3D ubiquitin protein ligase E3D 2.60329
LIMS2 LIM and senescent cell antigen-like domains 2 2.6016
C12ORF65 chromosome 12 open reading frame 65 2.60076
MRM3 mitochondrial rRNA methyltransferase 3 2.5966
CCDC113 coiled-coil domain containing 113 2.59363
HIST1H4E histone cluster 1, H4e 2.58533
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.58288
ADGRL1 adhesion G protein-coupled receptor L1 2.58272
TBC1D4 TBC1 domain family, member 4 2.57382
TEX37 testis expressed 37 2.57349
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.57243
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.55644
CDHR4 cadherin-related family member 4 2.55422
STK10 serine/threonine kinase 10 2.53593
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.52981
TMEM165 transmembrane protein 165 2.52818
LRRC16B leucine rich repeat containing 16B 2.52771
XCL1 chemokine (C motif) ligand 1 2.52188
RASL11B RAS-like, family 11, member B 2.52157
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.51187
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.51112
REXO2 RNA exonuclease 2 2.51038
PCDHB2 protocadherin beta 2 2.51022
XXYLT1 xyloside xylosyltransferase 1 2.5084
SPATA24 spermatogenesis associated 24 2.50621
SLC30A9 solute carrier family 30 (zinc transporter), member 9 2.49438
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.49095
GRSF1 G-rich RNA sequence binding factor 1 2.48884
KIF2C kinesin family member 2C 2.48647
CKAP2L cytoskeleton associated protein 2-like 2.48204
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.47227
GTPBP8 GTP-binding protein 8 (putative) 2.47003
MEPE matrix extracellular phosphoglycoprotein 2.46183
FKBP8 FK506 binding protein 8, 38kDa 2.42521
FAM178B family with sequence similarity 178, member B 2.41603
ERBB2 erb-b2 receptor tyrosine kinase 2 2.41438
MUC16 mucin 16, cell surface associated 2.40749
IZUMO1 izumo sperm-egg fusion 1 2.3891
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.38725
SPHK1 sphingosine kinase 1 2.38575
CSAD cysteine sulfinic acid decarboxylase 2.3831
PDZK1IP1 PDZK1 interacting protein 1 2.37823
TMEM62 transmembrane protein 62 2.37521
PABIR1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 2.37366
GPR179 G protein-coupled receptor 179 2.36476
RAD18 RAD18 E3 ubiquitin protein ligase 2.364
LIN28A lin-28 homolog A (C. elegans) 2.3572
CST1 cystatin SN 2.35292
KCTD16 potassium channel tetramerization domain containing 16 2.35185
ARHGAP31 Rho GTPase activating protein 31 2.35174
FITM1 fat storage-inducing transmembrane protein 1 2.34904
PGPEP1 pyroglutamyl-peptidase I 2.34447
EXOC4 exocyst complex component 4 2.34163
REC8 REC8 meiotic recombination protein 2.34059
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.33446
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 2.33133
TAGLN3 transgelin 3 2.331
DAGLA diacylglycerol lipase, alpha 2.32745
TMEM179B transmembrane protein 179B 2.32031
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 2.3172
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.3171
QRICH1 glutamine-rich 1 2.31171
MRPL44 mitochondrial ribosomal protein L44 2.30463
NKAPL NFKB activating protein-like 2.30025
TNS2 tensin 2 2.29899
MIPOL1 mirror-image polydactyly 1 2.29674
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.28622
CCL4 chemokine (C-C motif) ligand 4 2.28055
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.27618
MADD MAP-kinase activating death domain 2.27555
MTERF3 mitochondrial transcription termination factor 3 2.2744
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.26635
LCE3B late cornified envelope 3B 2.26423
HOXB9 homeobox B9 2.26315
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.26021
DUOXA2 dual oxidase maturation factor 2 2.24335
TRABD2A TraB domain containing 2A 2.23908
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.22899
GTPBP10 GTP-binding protein 10 (putative) 2.22691
ZNF2 zinc finger protein 2 2.22124
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.21687
DEPDC1 DEP domain containing 1 2.20375
AGFG2 ArfGAP with FG repeats 2 2.20302
TLR9 toll-like receptor 9 2.20152
RIPK3 receptor-interacting serine-threonine kinase 3 2.20151
SLC12A9 solute carrier family 12, member 9 2.19624
LIN37 lin-37 DREAM MuvB core complex component 2.19601
CEP295 centrosomal protein 295kDa 2.19141
GJC3 gap junction protein, gamma 3, 30.2kDa 2.18515
SOWAHC sosondowah ankyrin repeat domain family member C 2.18368
PYURF PIGY upstream reading frame 2.1836
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.18273
TEKT2 tektin 2 (testicular) 2.17587
RNF212B ring finger protein 212B 2.17555
CARNS1 carnosine synthase 1 2.17463
WRAP73 WD repeat containing, antisense to TP73 2.16782
PRDX1 peroxiredoxin 1 2.16431
PARL presenilin associated, rhomboid-like 2.16396
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 2.16226
JPH4 junctophilin 4 2.15876
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.15182
ANXA8L1 annexin A8-like 1 2.14618
GAL galanin/GMAP prepropeptide 2.14193
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.13749
SFR1 SWI5-dependent recombination repair 1 2.13693
ISYNA1 inositol-3-phosphate synthase 1 2.1286
ARMC10 armadillo repeat containing 10 2.12476
RDM1 RAD52 motif containing 1 2.12443
KIAA1143 KIAA1143 2.11503
FLII flightless I homolog (Drosophila) 2.10698
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.10642
HAGH hydroxyacylglutathione hydrolase 2.10636
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.10122
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 2.09647
NOA1 nitric oxide associated 1 2.09588
ZDHHC23 zinc finger, DHHC-type containing 23 2.09177
AJUBA ajuba LIM protein 2.0873
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.08727
SIVA1 SIVA1, apoptosis-inducing factor 2.08552
FIGLA folliculogenesis specific basic helix-loop-helix 2.08106
NKX2-8 NK2 homeobox 8 2.07969
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.0777
METTL12 methyltransferase like 12 2.07313
ZNF662 zinc finger protein 662 2.07289
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.07214
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.06974
IL11RA interleukin 11 receptor, alpha 2.0684
MRGPRD MAS-related GPR, member D 2.05759
OR6C2 olfactory receptor, family 6, subfamily C, member 2 2.05677
SLC38A11 solute carrier family 38, member 11 2.05132
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.05118
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.04984
THTPA thiamine triphosphatase 2.04799
MCRIP1 MAPK regulated corepressor interacting protein 1 2.04182
COX18 COX18 cytochrome c oxidase assembly factor 2.03936
VAX2 ventral anterior homeobox 2 2.03897
OR51B4 olfactory receptor, family 51, subfamily B, member 4 2.03035
ARPP19 cAMP-regulated phosphoprotein, 19kDa 2.02922
PDLIM7 PDZ and LIM domain 7 (enigma) 2.02824
STAT2 signal transducer and activator of transcription 2, 113kDa 2.02559
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.02393
CDH24 cadherin 24, type 2 2.02237
JPT1 Jupiter microtubule associated homolog 1 2.01826
BEND3 BEN domain containing 3 2.01486
CFAP57 cilia and flagella associated protein 57 2.0109
NDFIP1 Nedd4 family interacting protein 1 2.00937
ANKRD23 ankyrin repeat domain 23 2.00876
CDADC1 cytidine and dCMP deaminase domain containing 1 2.00794
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.00231