TEF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description thyrotrophic embryonic factor|This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 7008)
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Genes

335 genes differentially expressed following the TEF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.70206
CLEC5A C-type lectin domain family 5, member A 3.70206
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 3.70206
TCP11 t-complex 11, testis-specific 3.70206
SPRR2G small proline-rich protein 2G 3.70206
STMN4 stathmin-like 4 3.70206
KRT72 keratin 72, type II 3.70206
TRPC5OS TRPC5 opposite strand 3.70206
BMP5 bone morphogenetic protein 5 3.70206
MYO1A myosin IA 3.70206
FABP12 fatty acid binding protein 12 3.70206
SMIM9 small integral membrane protein 9 3.70206
SSTR5 somatostatin receptor 5 3.70206
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.70206
GPR22 G protein-coupled receptor 22 3.70206
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.70206
GCSAM germinal center-associated, signaling and motility 3.70206
OR13C3 olfactory receptor, family 13, subfamily C, member 3 3.70206
GPR37L1 G protein-coupled receptor 37 like 1 3.70206
BDKRB1 bradykinin receptor B1 3.70206
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.70206
SPEM1 spermatid maturation 1 3.70206
ASGR2 asialoglycoprotein receptor 2 3.70206
SPACA5 sperm acrosome associated 5 3.70206
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.70206
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.70206
TNMD tenomodulin 3.70206
AMDHD1 amidohydrolase domain containing 1 3.70206
BPIFC BPI fold containing family C 3.70206
SPNS3 spinster homolog 3 (Drosophila) 3.70206
ADRA1B adrenoceptor alpha 1B 3.70206
LRRC38 leucine rich repeat containing 38 3.70206
MSLN mesothelin 3.70206
YIPF7 Yip1 domain family, member 7 3.70206
PASD1 PAS domain containing 1 3.70206
PRDM8 PR domain containing 8 3.70206
SPI1 Spi-1 proto-oncogene 3.70206
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.70206
ROPN1L rhophilin associated tail protein 1-like 3.70206
HRG histidine-rich glycoprotein 3.70206
SOST sclerostin 3.70206
TPH1 tryptophan hydroxylase 1 3.70206
NPR3 natriuretic peptide receptor 3 3.70206
CD3G CD3g molecule, gamma (CD3-TCR complex) 3.70206
IL10RA interleukin 10 receptor, alpha 3.70206
SCRT1 scratch family zinc finger 1 3.70206
RGS9BP regulator of G protein signaling 9 binding protein 3.70206
CCR4 chemokine (C-C motif) receptor 4 3.70206
SLC22A10 solute carrier family 22, member 10 3.70206
WEE2 WEE1 homolog 2 (S. pombe) 3.70206
GSC goosecoid homeobox 3.70206
SIX2 SIX homeobox 2 3.70206
UPK3A uroplakin 3A 3.70206
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.70206
LY86 lymphocyte antigen 86 3.70206
PTTG2 pituitary tumor-transforming 2 3.70206
GZMM granzyme M (lymphocyte met-ase 1) 3.70206
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.70206
CD79A CD79a molecule, immunoglobulin-associated alpha 3.70206
ANXA13 annexin A13 3.70206
MAG myelin associated glycoprotein 3.70206
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.70206
ZNF280A zinc finger protein 280A 3.70206
TLR6 toll-like receptor 6 3.70206
GGT5 gamma-glutamyltransferase 5 3.70206
NKX2-2 NK2 homeobox 2 3.70206
SOX1 SRY (sex determining region Y)-box 1 3.70206
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.70206
OR1I1 olfactory receptor, family 1, subfamily I, member 1 3.70206
ADTRP androgen-dependent TFPI-regulating protein 3.70206
GSTM5 glutathione S-transferase mu 5 3.70206
TMEM191B transmembrane protein 191B 3.70206
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.70206
WT1 Wilms tumor 1 3.70206
TMEM100 transmembrane protein 100 3.70206
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.70206
PAX6 paired box 6 3.70206
TYRP1 tyrosinase-related protein 1 3.70206
MYBPC3 myosin binding protein C, cardiac 3.70206
CLEC6A C-type lectin domain family 6, member A 3.70206
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.70206
PI16 peptidase inhibitor 16 3.70206
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 3.70206
CABP4 calcium binding protein 4 3.70206
WNT9B wingless-type MMTV integration site family, member 9B 3.70206
MAGEA3 melanoma antigen family A3 3.70206
CNTN6 contactin 6 3.70206
CSAG1 chondrosarcoma associated gene 1 3.70206
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.70206
OLIG1 oligodendrocyte transcription factor 1 3.70206
CATSPERZ catsper channel auxiliary subunit zeta 3.70206
MUCL1 mucin-like 1 3.70206
FOXE3 forkhead box E3 3.70206
WNT7B wingless-type MMTV integration site family, member 7B 3.70206
IFITM5 interferon induced transmembrane protein 5 3.70206
GPR119 G protein-coupled receptor 119 3.70206
MUC13 mucin 13, cell surface associated 3.70206
RGCC regulator of cell cycle 3.70206
AIRE autoimmune regulator 3.70206
KLK2 kallikrein-related peptidase 2 3.70206
C22ORF42 chromosome 22 open reading frame 42 3.70206
POU2AF1 POU class 2 associating factor 1 3.70206
TBC1D10C TBC1 domain family, member 10C 3.70206
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.70206
GSTT4 glutathione S-transferase theta 4 3.70206
TPSB2 tryptase beta 2 (gene/pseudogene) 3.70206
FAM177B family with sequence similarity 177, member B 3.70206
SERINC4 serine incorporator 4 3.70206
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.70206
NPBWR1 neuropeptides B/W receptor 1 3.70206
APOC2 apolipoprotein C-II 3.70206
SAMD7 sterile alpha motif domain containing 7 3.70206
HK3 hexokinase 3 (white cell) 3.70206
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.70206
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 3.70206
ADCY4 adenylate cyclase 4 3.70206
IL25 interleukin 25 3.70206
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.70206
CIMIP4 ciliary microtubule inner protein 4 3.70206
LRRN4 leucine rich repeat neuronal 4 3.70206
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.70206
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.70206
EFCC1 EF-hand and coiled-coil domain containing 1 3.70206
LGALS13 lectin, galactoside-binding, soluble, 13 3.70206
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.70206
GARIN6 golgi associated RAB2 interactor family member 6 3.70206
LOC128125822 uncharacterized LOC128125822 3.70206
SIGLEC15 sialic acid binding Ig-like lectin 15 3.70206
SI sucrase-isomaltase (alpha-glucosidase) 3.70206
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.70206
SOSTDC1 sclerostin domain containing 1 3.70206
H2BK1 H2B.K variant histone 1 3.70206
LGALS12 lectin, galactoside-binding, soluble, 12 3.70206
KLK15 kallikrein-related peptidase 15 3.70206
GARIN1A golgi associated RAB2 interactor 1A 3.70206
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.70206
POU3F2 POU class 3 homeobox 2 3.70206
NUTM2D NUT family member 2D 3.70206
DBX2 developing brain homeobox 2 3.70206
FZD1 frizzled class receptor 1 3.70206
CD177 CD177 molecule 3.70206
HCAR1 hydroxycarboxylic acid receptor 1 3.70206
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.70206
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.70206
C8ORF90 chromosome 8 open reading frame 90 3.70206
HBG1 hemoglobin, gamma A 3.70206
GBP3 guanylate binding protein 3 3.70206
LAMP5 lysosomal-associated membrane protein family, member 5 3.70206
RERGL RERG/RAS-like 3.70206
GBP4 guanylate binding protein 4 3.70206
FGF10 fibroblast growth factor 10 3.70206
PLG plasminogen 3.70206
PHF24 PHD finger protein 24 3.70206
ZNF534 zinc finger protein 534 3.70206
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.70206
PTGDR prostaglandin D2 receptor (DP) 3.70206
CH25H cholesterol 25-hydroxylase 3.70206
THTPA thiamine triphosphatase 3.70206
RTL5 retrotransposon Gag like 5 3.70206
AQP7 aquaporin 7 3.70206
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.70206
CCL24 chemokine (C-C motif) ligand 24 3.70206
PALMD palmdelphin 3.70206
SPATA31A1 SPATA31 subfamily A, member 1 3.70206
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 3.70206
OR9A4 olfactory receptor, family 9, subfamily A, member 4 3.70206
PCDHGB2 protocadherin gamma subfamily B, 2 3.70206
GP1BA glycoprotein Ib (platelet), alpha polypeptide 3.70206
CCN5 cellular communication network factor 5 3.70206
CCN6 cellular communication network factor 6 3.70206
NECTIN4 nectin cell adhesion molecule 4 3.70206
DEFB107B defensin, beta 107B 3.70206
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.70206
DEUP1 deuterosome assembly protein 1 3.67156
ZNF446 zinc finger protein 446 3.67156
LRRC32 leucine rich repeat containing 32 3.67156
CFAP54 cilia and flagella associated 54 3.67156
COL12A1 collagen, type XII, alpha 1 3.48379
KLHL12 kelch-like family member 12 3.46994
PTBP2 polypyrimidine tract binding protein 2 3.31247
AGA-DT AGA divergent transcript 3.27463
NRSN1 neurensin 1 3.02614
ATP13A2 ATPase type 13A2 2.95544
NIT1 nitrilase 1 2.95161
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.8556
OBSL1 obscurin-like 1 2.84268
BCORL1 BCL6 corepressor-like 1 2.74612
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.73026
ERICH6 glutamate-rich 6 2.73026
RWDD4 RWD domain containing 4 2.72796
TLCD2 TLC domain containing 2 2.63907
MTSS2 MTSS I-BAR domain containing 2 2.60827
SEC23A Sec23 homolog A (S. cerevisiae) 2.50198
RPUSD1 RNA pseudouridylate synthase domain containing 1 2.45654
ZNF699 zinc finger protein 699 2.4432
AS3MT arsenite methyltransferase 2.42728
CCDC102A coiled-coil domain containing 102A 2.41581
CENPW centromere protein W 2.40297
KIAA1671 KIAA1671 2.39554
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.39307
ASIC3 acid sensing (proton gated) ion channel 3 2.39307
NEK7 NIMA-related kinase 7 2.38114
LBHD1 LBH domain containing 1 2.37954
VPS9D1 VPS9 domain containing 1 2.3483
FMO2 flavin containing monooxygenase 2 (non-functional) 2.33884
SLC9C2 solute carrier family 9, member C2 (putative) 2.33884
SCRT2 scratch family zinc finger 2 2.33884
FGF13 fibroblast growth factor 13 2.2988
DMRT1 doublesex and mab-3 related transcription factor 1 2.2877
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.2877
QPCTL glutaminyl-peptide cyclotransferase-like 2.24419
ENG endoglin 2.23891
TRIM14 tripartite motif containing 14 2.22663
FAM168A family with sequence similarity 168, member A 2.22599
IFT22 intraflagellar transport 22 2.22135
INSIG2 insulin induced gene 2 2.1937
RMP24 ribonuclease MRP subunit p24 2.1937
CGGBP1 CGG triplet repeat binding protein 1 2.19297
TSPAN14 tetraspanin 14 2.18244
KLHL28 kelch-like family member 28 2.16799
NOTCH2NLC notch 2 N-terminal like C 2.15952
ZBED1 zinc finger, BED-type containing 1 2.13946
PPIH peptidylprolyl isomerase H (cyclophilin H) 2.11194
SLC35E1 solute carrier family 35, member E1 2.11065
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.10999
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 2.10999
ATF7 activating transcription factor 7 2.07536
RPL32 ribosomal protein L32 2.0738
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.0683
BOC BOC cell adhesion associated, oncogene regulated 2.05933
LETMD1 LETM1 domain containing 1 2.0573
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 2.05478
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.03933
ANKDD1A ankyrin repeat and death domain containing 1A 2.03887
PHEX phosphate regulating endopeptidase homolog, X-linked 2.03789
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.02182
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.02182

decreased expression

Symbol Name Standardized Value
C10ORF105 chromosome 10 open reading frame 105 -3.70206
PCDHGA7 protocadherin gamma subfamily A, 7 -3.55003
AANAT aralkylamine N-acetyltransferase -3.55003
TMEM236 transmembrane protein 236 -3.55003
SYCE3 synaptonemal complex central element protein 3 -3.55003
PIH1D2 PIH1 domain containing 2 -3.55003
LRRC61 leucine rich repeat containing 61 -3.55003
NANOS3 nanos homolog 3 (Drosophila) -3.55003
DOK7 docking protein 7 -3.55003
COLEC10 collectin sub-family member 10 (C-type lectin) -3.55003
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.55003
CCDC17 coiled-coil domain containing 17 -3.55003
CCR6 chemokine (C-C motif) receptor 6 -3.55003
ITPKA inositol-trisphosphate 3-kinase A -3.55003
DCST1 DC-STAMP domain containing 1 -3.55003
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.55003
PFN4 profilin family, member 4 -3.55003
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -3.55003
MEPE matrix extracellular phosphoglycoprotein -3.55003
RAPSN receptor-associated protein of the synapse -3.55003
VSTM1 V-set and transmembrane domain containing 1 -3.55003
TMEM255A transmembrane protein 255A -3.55003
VWA3A von Willebrand factor A domain containing 3A -3.55003
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -3.55003
TM4SF1 transmembrane 4 L six family member 1 -3.55003
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -3.44589
DYNLT5 dynein light chain Tctex-type family member 5 -3.29869
CADM3 cell adhesion molecule 3 -3.18803
CBR3 carbonyl reductase 3 -3.15765
BAIAP3 BAI1-associated protein 3 -3.11636
HARS2 histidyl-tRNA synthetase 2, mitochondrial -3.02606
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.96646
PLK5 polo-like kinase 5 -2.89419
PTPRN protein tyrosine phosphatase, receptor type, N -2.80866
TMEM115 transmembrane protein 115 -2.70493
ALG9 ALG9, alpha-1,2-mannosyltransferase -2.55863
SMAD3 SMAD family member 3 -2.53972
TAC1 tachykinin, precursor 1 -2.50777
LASP1NB LASP1 neighbor -2.46896
UBTD1 ubiquitin domain containing 1 -2.45337
ELMO3 engulfment and cell motility 3 -2.42801
ACTL6B actin-like 6B -2.3996
LRPPRC leucine-rich pentatricopeptide repeat containing -2.3809
SARDH sarcosine dehydrogenase -2.35045
AHNAK2 AHNAK nucleoprotein 2 -2.3419
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.3419
CCDC88A coiled-coil domain containing 88A -2.3419
EGF epidermal growth factor -2.33884
POU2AF3 POU class 2 homeobox associating factor 3 -2.33884
ATXN7L1 ataxin 7-like 1 -2.32439
SECISBP2 SECIS binding protein 2 -2.32439
EFNA1 ephrin-A1 -2.31925
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -2.31645
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -2.311
DENND6B DENN/MADD domain containing 6B -2.30162
ECE1 endothelin converting enzyme 1 -2.29765
STOM stomatin -2.26301
BRDT bromodomain, testis-specific -2.24416
VEGFD vascular endothelial growth factor D -2.24416
ACBD7 acyl-CoA binding domain containing 7 -2.24041
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.24013
TICAM2 toll-like receptor adaptor molecule 2 -2.23891
MAPK9 mitogen-activated protein kinase 9 -2.2376
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.22663
KLHDC8B kelch domain containing 8B -2.2056
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -2.2045
HIRIP3 HIRA interacting protein 3 -2.19819
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.17667
ENTR1 endosome associated trafficking regulator 1 -2.16103
BICC1 BicC family RNA binding protein 1 -2.14474
RALY RALY heterogeneous nuclear ribonucleoprotein -2.11696
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -2.11194
FBXO32 F-box protein 32 -2.11065
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -2.11065
NME5 NME/NM23 family member 5 -2.11065
RLN1 relaxin 1 -2.11065
INPP1 inositol polyphosphate-1-phosphatase -2.11065
MYOCD myocardin -2.10975
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -2.08962
TMED3 transmembrane emp24 protein transport domain containing 3 -2.06314
YLPM1 YLP motif containing 1 -2.06272
ANKRD24 ankyrin repeat domain 24 -2.0608
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.05933
SHANK2 SH3 and multiple ankyrin repeat domains 2 -2.05933
AMDHD2 amidohydrolase domain containing 2 -2.05933
MPST mercaptopyruvate sulfurtransferase -2.05478
MCRS1 microspherule protein 1 -2.05422
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.04476
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B -2.03933
GLIPR1L1 GLI pathogenesis-related 1 like 1 -2.03887
F3 coagulation factor III (thromboplastin, tissue factor) -2.03451
FILIP1 filamin A interacting protein 1 -2.03265
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.02623
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa -2.02482
RIMS4 regulating synaptic membrane exocytosis 4 -2.02182
RREB1 ras responsive element binding protein 1 -2.01932
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 -2.01398
GANC glucosidase, alpha; neutral C -2.00274