TEF Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description thyrotrophic embryonic factor|This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 7008)
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Genes

50 target genes of the TEF transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
ATF6B activating transcription factor 6 beta
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
CA14 carbonic anhydrase XIV
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CCDC77 coiled-coil domain containing 77
CDH3 cadherin 3, type 1, P-cadherin (placental)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDC4 enhancer of mRNA decapping 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EXD3 exonuclease 3'-5' domain containing 3
FOXS1 forkhead box S1
GDNF-AS1 GDNF antisense RNA 1 (head to head)
GHR growth hormone receptor
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GRM1 glutamate receptor, metabotropic 1
HIC2 hypermethylated in cancer 2
HOXC13 homeobox C13
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUP junction plakoglobin
KIF1C kinesin family member 1C
KRT19 keratin 19, type I
KRT75 keratin 75, type II
LMBR1L limb development membrane protein 1-like
LOC100507156 uncharacterized LOC100507156
LOC645434 uncharacterized LOC645434
MTOR-AS1 MTOR antisense RNA 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NBPF10 neuroblastoma breakpoint family, member 10
NOTCH2NL notch 2 N-terminal like
PLEKHN1 pleckstrin homology domain containing, family N member 1
PTPRJ protein tyrosine phosphatase, receptor type, J
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
SCARF2 scavenger receptor class F, member 2
SFTA2 surfactant associated 2
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNORD112 small nucleolar RNA, C/D box 112
TGM1 transglutaminase 1
THBS1 thrombospondin 1
TP63 tumor protein p63
TRAF4 TNF receptor-associated factor 4
TRIP6 thyroid hormone receptor interactor 6
VIT vitrin
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2