TERT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description telomerase reverse transcriptase|Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7015)
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Genes

353 genes differentially expressed following the TERT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF534 zinc finger protein 534 3.31731
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.31731
AMIGO3 adhesion molecule with Ig-like domain 3 3.31731
WFDC13 WAP four-disulfide core domain 13 3.31731
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.31731
HRG histidine-rich glycoprotein 3.31731
BTBD16 BTB (POZ) domain containing 16 3.31731
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.31731
SPAG6 sperm associated antigen 6 3.31731
NMUR2 neuromedin U receptor 2 3.31731
THEMIS thymocyte selection associated 3.31731
HMX3 H6 family homeobox 3 3.31731
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.31731
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.31731
TSHZ1 teashirt zinc finger homeobox 1 3.31731
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.31731
PRDM16 PR domain containing 16 3.31731
TRPC5OS TRPC5 opposite strand 3.31731
RDH16 retinol dehydrogenase 16 (all-trans) 3.31731
TMEM52B transmembrane protein 52B 3.31731
MTNR1B melatonin receptor 1B 3.31731
COL22A1 collagen, type XXII, alpha 1 3.31731
WFDC10A WAP four-disulfide core domain 10A 3.31731
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.31731
RUNX3 runt-related transcription factor 3 3.31731
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.31731
TMEM45B transmembrane protein 45B 3.31731
LRRC31 leucine rich repeat containing 31 3.31731
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.31731
PSG11 pregnancy specific beta-1-glycoprotein 11 3.31731
RAI2 retinoic acid induced 2 3.31731
MMEL1 membrane metallo-endopeptidase-like 1 3.31731
UROC1 urocanate hydratase 1 3.31731
CBLN3 cerebellin 3 precursor 3.31731
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.31731
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 3.31731
CFAP99 cilia and flagella associated protein 99 3.31731
CIMIP2A ciliary microtubule inner protein 2A 3.31731
PNOC prepronociceptin 3.31731
DPPA3 developmental pluripotency associated 3 3.31731
PCDHA5 protocadherin alpha 5 3.31731
UPK3A uroplakin 3A 3.31731
PCDHB6 protocadherin beta 6 3.31731
TRIM10 tripartite motif containing 10 3.31731
INHBB inhibin, beta B 3.31731
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.31731
SLC16A11 solute carrier family 16, member 11 3.31731
SPINK4 serine peptidase inhibitor, Kazal type 4 3.31731
ANKRD22 ankyrin repeat domain 22 3.31731
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.31731
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.31731
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.31731
LRRD1 leucine-rich repeats and death domain containing 1 3.31731
CTRC chymotrypsin C (caldecrin) 3.31731
FBXL8 F-box and leucine-rich repeat protein 8 3.31731
SCG2 secretogranin II 3.31731
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.31731
CARD18 caspase recruitment domain family, member 18 3.31731
SOX18 SRY (sex determining region Y)-box 18 3.31731
CLEC19A C-type lectin domain family 19, member A 3.31731
HLX H2.0-like homeobox 3.31731
RAB41 RAB41, member RAS oncogene family 3.31731
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.31731
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.31731
RFPL2 ret finger protein-like 2 3.31731
ARSF arylsulfatase F 3.31731
ACOT4 acyl-CoA thioesterase 4 3.31731
PBOV1 prostate and breast cancer overexpressed 1 3.31731
TLX3 T-cell leukemia homeobox 3 3.31731
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.31731
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 3.31731
SIX6 SIX homeobox 6 3.31731
TMPRSS11B transmembrane protease, serine 11B 3.31731
PRL prolactin 3.31731
TYRP1 tyrosinase-related protein 1 3.31731
FAM90A1 family with sequence similarity 90, member A1 3.31731
ARHGAP36 Rho GTPase activating protein 36 3.31731
PAX8 paired box 8 3.31731
UCN urocortin 3.31731
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.31731
ADGRA1 adhesion G protein-coupled receptor A1 3.31731
PLA2G12B phospholipase A2, group XIIB 3.31731
BNC1 basonuclin 1 3.31731
SPRR2E small proline-rich protein 2E 3.31731
MLN motilin 3.31731
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.31731
SAMD7 sterile alpha motif domain containing 7 3.31731
MIOX myo-inositol oxygenase 3.31731
SIRPG signal-regulatory protein gamma 3.31731
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.31731
ACVRL1 activin A receptor type II-like 1 3.31731
TTR transthyretin 3.31731
PLA1A phospholipase A1 member A 3.31731
PATE4 prostate and testis expressed 4 3.31731
THBD thrombomodulin 3.31731
TEX19 testis expressed 19 3.31731
TEKT1 tektin 1 3.31731
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.31731
SCEL sciellin 3.31731
PRSS38 protease, serine, 38 3.31731
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.31731
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.31731
CLEC18A C-type lectin domain family 18, member A 3.31731
LOC124906010 uncharacterized LOC124906010 3.31731
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 3.31731
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.31731
CD8B2 CD8b2 molecule 3.31731
SMIM45 small integral membrane protein 45 3.31731
CFAP126 cilia and flagella associated protein 126 3.31731
POU2AF2 POU class 2 homeobox associating factor 2 3.31731
MEIOSIN meiosis initiator 3.31731
TBXT T-box transcription factor T 3.31731
RGS8 regulator of G-protein signaling 8 3.31731
PSG9 pregnancy specific beta-1-glycoprotein 9 3.31731
BCL2L15 BCL2-like 15 3.31731
LHX9 LIM homeobox 9 3.31731
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 3.31731
GPR62 G protein-coupled receptor 62 3.31731
C2CD4A C2 calcium-dependent domain containing 4A 3.31731
DRD2 dopamine receptor D2 3.31731
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.31731
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.31731
EDN2 endothelin 2 3.31731
LTB lymphotoxin beta (TNF superfamily, member 3) 3.31731
FNDC9 fibronectin type III domain containing 9 3.31731
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.31731
DLK2 delta-like 2 homolog (Drosophila) 3.31731
LRRC32 leucine rich repeat containing 32 3.31731
LRRC71 leucine rich repeat containing 71 3.31731
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.31731
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.31731
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.31731
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.31731
GPR50 G protein-coupled receptor 50 3.31731
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.31731
IL12A interleukin 12A 3.31731
MAPK11 mitogen-activated protein kinase 11 3.31731
FZD1 frizzled class receptor 1 3.31731
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 3.31731
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.31731
FATE1 fetal and adult testis expressed 1 3.31731
GC group-specific component (vitamin D binding protein) 3.31731
C10ORF53 chromosome 10 open reading frame 53 3.31731
CPA2 carboxypeptidase A2 (pancreatic) 3.31731
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 3.31731
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.31731
NPFFR1 neuropeptide FF receptor 1 3.31731
TDRD10 tudor domain containing 10 3.31731
GOLGA6D golgin A6 family, member D 3.31731
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 3.31731
OR1M1 olfactory receptor, family 1, subfamily M, member 1 3.31731
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.31731
KLF2 Kruppel-like factor 2 3.31731
FCMR Fc fragment of IgM receptor 3.31731
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 3.31731
CMKLR1 chemerin chemokine-like receptor 1 3.31731
CTAGE9 CTAGE family, member 9 3.31731
KHDC1L KH homology domain containing 1-like 3.31731
STMND1 stathmin domain containing 1 3.31731
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3.27686
SPAG4 sperm associated antigen 4 3.26982
H4C16 H4 histone 16 3.26883
MRPL10 mitochondrial ribosomal protein L10 3.15505
C1ORF210 chromosome 1 open reading frame 210 3.06228
PACC1 proton activated chloride channel 1 3.05001
CREG2 cellular repressor of E1A-stimulated genes 2 2.97674
RACK1 receptor for activated C kinase 1 2.9593
GUK1 guanylate kinase 1 2.93937
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.90856
STMN1 stathmin 1 2.86187
ZNF552 zinc finger protein 552 2.84059
UROS uroporphyrinogen III synthase 2.80197
FAM171A2 family with sequence similarity 171, member A2 2.57591
COMMD4 COMM domain containing 4 2.57591
GPX4 glutathione peroxidase 4 2.54936
SHISAL2A shisa like 2A 2.52595
IFT22 intraflagellar transport 22 2.49927
POGLUT1 protein O-glucosyltransferase 1 2.48056
CHP1 calcineurin-like EF-hand protein 1 2.45072
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.44826
TMEM88 transmembrane protein 88 2.44826
PDK2 pyruvate dehydrogenase kinase, isozyme 2 2.44826
RFESD Rieske (Fe-S) domain containing 2.43139
THTPA thiamine triphosphatase 2.42327
SOSTDC1 sclerostin domain containing 1 2.42327
CFAP61 cilia and flagella associated protein 61 2.42327
RPL7A ribosomal protein L7a 2.42008
SF3B4 splicing factor 3b, subunit 4, 49kDa 2.41814
TUBA1A tubulin, alpha 1a 2.41814
TMPPE transmembrane protein with metallophosphoesterase domain 2.41133
CDH22 cadherin 22, type 2 2.41133
PCDHGB7 protocadherin gamma subfamily B, 7 2.41133
ZBBX zinc finger, B-box domain containing 2.41133
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.41133
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.41133
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.41133
SRSF9 serine/arginine-rich splicing factor 9 2.38738
SAMD15 sterile alpha motif domain containing 15 2.38595
OSBPL5 oxysterol binding protein-like 5 2.37161
MRPL11 mitochondrial ribosomal protein L11 2.36305
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.32814
ZNF587B zinc finger protein 587B 2.31229
CMIP c-Maf inducing protein 2.30914
DPF2 D4, zinc and double PHD fingers family 2 2.30314
DNM3 dynamin 3 2.29444
H2AC6 H2A clustered histone 6 2.29181
CD81 CD81 molecule 2.27417
GOLGA5 golgin A5 2.23924
ZNF608 zinc finger protein 608 2.2338
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.23086
DBP D site of albumin promoter (albumin D-box) binding protein 2.20864
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.20287
CUL2 cullin 2 2.19677
APP amyloid beta (A4) precursor protein 2.17471
TUBB6 tubulin, beta 6 class V 2.17367
C3ORF70 chromosome 3 open reading frame 70 2.16418
ZNF787 zinc finger protein 787 2.15615
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 2.15615
SCML2 sex comb on midleg-like 2 (Drosophila) 2.15344
MAP2K5-DT MAP2K5 divergent transcript 2.1368
ACP2 acid phosphatase 2, lysosomal 2.11717
IFITM1 interferon induced transmembrane protein 1 2.11279
OPTC opticin 2.10183
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.09899
BCL7B B-cell CLL/lymphoma 7B 2.0886
RAMAC RNA guanine-7 methyltransferase activating subunit 2.08787
FBXO8 F-box protein 8 2.08318
RBM27 RNA binding motif protein 27 2.08018
CDH23 cadherin-related 23 2.07951
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 2.05035
BCL7C B-cell CLL/lymphoma 7C 2.04906
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 2.04648
CBX3 chromobox homolog 3 2.03647
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.0228
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.0228
APC2 adenomatosis polyposis coli 2 2.0228
HSF5 heat shock transcription factor family member 5 2.0228
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.01793
NOL7 nucleolar protein 7, 27kDa 2.00549
GOLGA6L9 golgin A6 family-like 9 2.00549

decreased expression

Symbol Name Standardized Value
LSMEM1 leucine-rich single-pass membrane protein 1 -3.31731
HIP1 huntingtin interacting protein 1 -3.31731
OCA2 oculocutaneous albinism II -3.31731
ZNF446 zinc finger protein 446 -3.31731
TMC8 transmembrane channel-like 8 -3.31731
ADGRG1 adhesion G protein-coupled receptor G1 -3.31731
FPGT fucose-1-phosphate guanylyltransferase -3.31731
CA4 carbonic anhydrase IV -3.31731
H4C1 H4 clustered histone 1 -3.31731
SCN3A sodium channel, voltage gated, type III alpha subunit -3.11064
RUFY4 RUN and FYVE domain containing 4 -3.11064
GDF6 growth differentiation factor 6 -3.11064
MYH15 myosin, heavy chain 15 -3.11064
CNTFR ciliary neurotrophic factor receptor -3.11064
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -3.11064
CLIP4 CAP-GLY domain containing linker protein family, member 4 -3.11064
THPO thrombopoietin -3.11064
GADL1 glutamate decarboxylase-like 1 -3.11064
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -3.11064
IZUMO4 IZUMO family member 4 -3.11064
RGPD4 RANBP2-like and GRIP domain containing 4 -3.11064
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -3.11064
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -3.11064
ADAMTSL5 ADAMTS-like 5 -3.11064
SDSL serine dehydratase-like -3.11064
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.11064
PGLYRP1 peptidoglycan recognition protein 1 -3.11064
KLHL6 kelch-like family member 6 -3.11064
RBM24 RNA binding motif protein 24 -3.11064
PROZ protein Z, vitamin K-dependent plasma glycoprotein -3.11064
VXN vexin -3.11064
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.11064
ACP3 acid phosphatase 3 -3.11064
ERFE erythroferrone -3.11064
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -3.11064
DNAAF6 dynein axonemal assembly factor 6 -3.11064
H3-7 H3.7 histone (putative) -3.11064
INSYN1 inhibitory synaptic factor 1 -3.11064
PCDHGA9 protocadherin gamma subfamily A, 9 -3.11064
DDTL D-dopachrome tautomerase-like -3.11064
ITGB7 integrin, beta 7 -3.11064
ERVV-2 endogenous retrovirus group V, member 2 -3.11064
CFAP210 cilia and flagella associated protein 210 -3.00997
PRMT3 protein arginine methyltransferase 3 -3.00153
C17ORF100 chromosome 17 open reading frame 100 -2.97529
MKX mohawk homeobox -2.97529
ECHDC3 enoyl CoA hydratase domain containing 3 -2.86187
SKA1 spindle and kinetochore associated complex subunit 1 -2.83999
TTYH1 tweety family member 1 -2.78783
NREP neuronal regeneration related protein -2.78064
ATG2A autophagy related 2A -2.75659
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.65705
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -2.63264
GSE1 Gse1 coiled-coil protein -2.61634
LTBP2 latent transforming growth factor beta binding protein 2 -2.53697
CD200R1L CD200 receptor 1-like -2.53697
H1-3 H1.3 linker histone, cluster member -2.51423
WDR5 WD repeat domain 5 -2.50122
SNX10 sorting nexin 10 -2.44496
CCNJL cyclin J-like -2.42949
MPPED2 metallophosphoesterase domain containing 2 -2.4169
ARHGAP21 Rho GTPase activating protein 21 -2.39604
CHM choroideremia (Rab escort protein 1) -2.38738
ACOX3 acyl-CoA oxidase 3, pristanoyl -2.38738
BCL9L B-cell CLL/lymphoma 9-like -2.38701
SPRED2 sprouty-related, EVH1 domain containing 2 -2.37377
INTS1 integrator complex subunit 1 -2.37377
PEA15 phosphoprotein enriched in astrocytes 15 -2.3627
PCDHAC1 protocadherin alpha subfamily C, 1 -2.35206
MSC musculin -2.35206
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.35206
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa -2.33858
SH2D4B SH2 domain containing 4B -2.33553
MKRN2 makorin ring finger protein 2 -2.32814
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.32777
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2 -2.30874
IGHMBP2 immunoglobulin mu binding protein 2 -2.29444
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.29346
CD276 CD276 molecule -2.24364
CXXC5 CXXC finger protein 5 -2.2398
PGBD1 piggyBac transposable element derived 1 -2.23905
BIRC2 baculoviral IAP repeat containing 2 -2.23016
IL18 interleukin 18 -2.22033
RAB33A RAB33A, member RAS oncogene family -2.22009
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.21356
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.20153
C22ORF15 chromosome 22 open reading frame 15 -2.17669
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.17471
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.16418
PUM1 pumilio RNA-binding family member 1 -2.15844
KCTD12 potassium channel tetramerization domain containing 12 -2.15615
PPP1R16B protein phosphatase 1, regulatory subunit 16B -2.1461
EEA1 early endosome antigen 1 -2.13482
ZNF680 zinc finger protein 680 -2.13482
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -2.1266
PTPRR protein tyrosine phosphatase, receptor type, R -2.12434
PTOV1 prostate tumor overexpressed 1 -2.12352
PLEKHO2 pleckstrin homology domain containing, family O member 2 -2.12055
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 -2.10915
SBF2 SET binding factor 2 -2.10866
GK5 glycerol kinase 5 (putative) -2.09595
COL5A1 collagen, type V, alpha 1 -2.0886
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.0886
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.08793
GPR157 G protein-coupled receptor 157 -2.0571
EIF1 eukaryotic translation initiation factor 1 -2.05316
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -2.05316
NPIPA1 nuclear pore complex interacting protein family, member A1 -2.03971
FBXO4 F-box protein 4 -2.0228
DPYS dihydropyrimidinase -2.02149
PLAA phospholipase A2-activating protein -2.01106
MRPL14 mitochondrial ribosomal protein L14 -2.00549
SPRING1 SREBF pathway regulator in golgi 1 -2.00549