TET2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tet methylcytosine dioxygenase 2|The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 54790)
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Genes

369 genes differentially expressed following the TET2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NRAP nebulin-related anchoring protein 3.58566
ATP10B ATPase, class V, type 10B 3.58566
SPI1 Spi-1 proto-oncogene 3.58566
TMPRSS4 transmembrane protease, serine 4 3.58566
PTGFR prostaglandin F receptor (FP) 3.58566
TLR2 toll-like receptor 2 3.58566
NRGN neurogranin (protein kinase C substrate, RC3) 3.58566
C7ORF57 chromosome 7 open reading frame 57 3.58566
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.58566
NANOS2 nanos homolog 2 (Drosophila) 3.58566
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 3.58566
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.58566
C11ORF96 chromosome 11 open reading frame 96 3.58566
CRYBB3 crystallin, beta B3 3.58566
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.58566
RHOXF2 Rhox homeobox family, member 2 3.58566
C1ORF141 chromosome 1 open reading frame 141 3.58566
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 3.58566
ZNF99 zinc finger protein 99 3.58566
TMEM132D transmembrane protein 132D 3.58566
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.58566
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.58566
TSPAN16 tetraspanin 16 3.58566
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.58566
MMP3 matrix metallopeptidase 3 3.58566
STAP1 signal transducing adaptor family member 1 3.58566
TRIM10 tripartite motif containing 10 3.54241
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.54241
BTC betacellulin 3.54241
PDYN prodynorphin 3.54241
PRELP proline/arginine-rich end leucine-rich repeat protein 3.54241
PGAM4 phosphoglycerate mutase family member 4 3.54241
NAPSA napsin A aspartic peptidase 3.54241
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.54241
XAF1 XIAP associated factor 1 3.54241
CELF3 CUGBP, Elav-like family member 3 3.54241
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.54241
CABP4 calcium binding protein 4 3.54241
SLC46A3 solute carrier family 46, member 3 3.54241
GNLY granulysin 3.54241
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.54241
PKP1 plakophilin 1 3.54241
TM4SF1 transmembrane 4 L six family member 1 3.54241
OR13C3 olfactory receptor, family 13, subfamily C, member 3 3.54241
ZNF556 zinc finger protein 556 3.54241
TDRD9 tudor domain containing 9 3.54241
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.54241
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.54241
OCSTAMP osteoclast stimulatory transmembrane protein 3.54241
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.54241
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 3.54241
TMEM121 transmembrane protein 121 3.54241
HBD hemoglobin, delta 3.54241
TREML1 triggering receptor expressed on myeloid cells-like 1 3.54241
C3ORF22 chromosome 3 open reading frame 22 3.54241
SFTPC surfactant protein C 3.54241
PGBDF plakoglobin binding and degradation factor 3.54241
GRXCR2 glutaredoxin, cysteine rich 2 3.54241
MYBPC3 myosin binding protein C, cardiac 3.54241
PEAR1 platelet endothelial aggregation receptor 1 3.54241
ADTRP androgen-dependent TFPI-regulating protein 3.54241
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.54241
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.54241
C6ORF58 chromosome 6 open reading frame 58 3.54241
TYRP1 tyrosinase-related protein 1 3.54241
MSC musculin 3.54241
SSTR5 somatostatin receptor 5 3.54241
CRYGA crystallin, gamma A 3.54241
IRF2-DT IRF2 divergent transcript 3.54241
OTOS otospiralin 3.54241
HTRA4 HtrA serine peptidase 4 3.54241
TCERG1L transcription elongation regulator 1-like 3.54241
KRT83 keratin 83, type II 3.54241
MLN motilin 3.54241
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.54241
TMEM40 transmembrane protein 40 3.54241
MYPN myopalladin 3.54241
GC group-specific component (vitamin D binding protein) 3.54241
TBX10 T-box 10 3.54241
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.54241
MT3 metallothionein 3 3.54241
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.54241
H1-8 H1.8 linker histone 3.54241
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.54241
SPACDR sperm acrosome developmental regulator 3.54241
JAML junction adhesion molecule like 3.54241
CCN5 cellular communication network factor 5 3.54241
DNAI7 dynein axonemal intermediate chain 7 3.54241
GASK1B golgi associated kinase 1B 3.54241
TCIM transcriptional and immune response regulator 3.54241
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.54241
H2BC1 H2B clustered histone 1 3.54241
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.54241
GATA2 GATA binding protein 2 3.54241
PRDM6 PR domain containing 6 3.54241
C1QL3 complement component 1, q subcomponent-like 3 3.54241
TLR8 toll-like receptor 8 3.54241
CCDC92 coiled-coil domain containing 92 3.54241
ZIC4 Zic family member 4 3.54241
MAGEB1 melanoma antigen family B1 3.54241
FAM90A12 family with sequence similarity 90 member A12 3.54241
OASL 2'-5'-oligoadenylate synthetase-like 3.54241
GRXCR1 glutaredoxin, cysteine rich 1 3.54241
CCDC116 coiled-coil domain containing 116 3.54241
SLFN11 schlafen family member 11 3.54241
CST11 cystatin 11 3.54241
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.54241
NPFF neuropeptide FF-amide peptide precursor 3.54241
SYT15 synaptotagmin XV 3.54241
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.54241
ZAR1L zygote arrest 1-like 3.54241
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.54241
PLEK2 pleckstrin 2 3.54241
FGFBP2 fibroblast growth factor binding protein 2 3.54241
OPN4 opsin 4 3.54241
PLB1 phospholipase B1 3.54241
PGLYRP2 peptidoglycan recognition protein 2 3.54241
CDKN2A cyclin-dependent kinase inhibitor 2A 3.54241
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.54241
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.54241
OXT oxytocin/neurophysin I prepropeptide 3.54241
TRIM50 tripartite motif containing 50 3.54241
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.54241
SP100 SP100 nuclear antigen 3.54241
POTEF POTE ankyrin domain family, member F 3.54241
MAGEA9B melanoma antigen family A9B 3.54241
NTN3 netrin 3 3.54241
NPAS4 neuronal PAS domain protein 4 3.54241
COL22A1 collagen, type XXII, alpha 1 3.54241
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.54241
CETP cholesteryl ester transfer protein, plasma 3.54241
DLX3 distal-less homeobox 3 3.54241
PTCRA pre T-cell antigen receptor alpha 3.54241
GRAPL GRB2-related adaptor protein-like 3.54241
LY6G5C lymphocyte antigen 6 complex, locus G5C 3.54241
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.54241
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.54241
TEX38 testis expressed 38 3.54241
TGM6 transglutaminase 6 3.54241
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 3.54241
LY96 lymphocyte antigen 96 3.54241
C11ORF16 chromosome 11 open reading frame 16 3.54241
DRD5 dopamine receptor D5 3.54241
OLFML1 olfactomedin-like 1 3.54241
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.54241
NOX1 NADPH oxidase 1 3.54241
CTAGE9 CTAGE family, member 9 3.54241
CLRN2 clarin 2 3.54241
ADGRA1 adhesion G protein-coupled receptor A1 3.54241
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.54241
TCEA3 transcription elongation factor A (SII), 3 3.54241
HAMP hepcidin antimicrobial peptide 3.54241
HBE1 hemoglobin, epsilon 1 3.54241
APLNR apelin receptor 3.54241
IL1B interleukin 1, beta 3.54241
PRR35 proline rich 35 3.54241
GFI1B growth factor independent 1B transcription repressor 3.54241
A3GALT2 alpha 1,3-galactosyltransferase 2 3.54241
TGM7 transglutaminase 7 3.54241
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.54241
NLRP8 NLR family, pyrin domain containing 8 3.54241
DKK2 dickkopf WNT signaling pathway inhibitor 2 3.54241
DCST1 DC-STAMP domain containing 1 3.54241
IL18R1 interleukin 18 receptor 1 3.54241
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.54241
MNX1 motor neuron and pancreas homeobox 1 3.54241
SCML4 sex comb on midleg-like 4 (Drosophila) 3.54241
PCDHGA11 protocadherin gamma subfamily A, 11 3.54241
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.54241
STEAP4 STEAP family member 4 3.54241
ADCY4 adenylate cyclase 4 3.54241
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.54241
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.54241
OVCH1 ovochymase 1 3.54241
SCIN scinderin 3.54241
NLRP5 NLR family, pyrin domain containing 5 3.54241
PADI6 peptidyl arginine deiminase, type VI 3.54241
IL2RB interleukin 2 receptor, beta 3.54241
TAS2R41 taste receptor, type 2, member 41 3.54241
PDCD1LG2 programmed cell death 1 ligand 2 3.54241
RGS8 regulator of G-protein signaling 8 3.54241
PLA2G2F phospholipase A2, group IIF 3.54241
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.54241
EFCC1 EF-hand and coiled-coil domain containing 1 3.54241
PRDM16 PR domain containing 16 3.54241
MZB1 marginal zone B and B1 cell-specific protein 3.54241
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 3.54241
IGIP IgA-inducing protein 3.54241
LGALS2 lectin, galactoside-binding, soluble, 2 3.54241
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.54241
RPS15 ribosomal protein S15 3.27397
HDAC10 histone deacetylase 10 3.23036
ZDHHC6 zinc finger, DHHC-type containing 6 3.15172
COX7B cytochrome c oxidase subunit VIIb 3.11114
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 3.03381
PTPRJ protein tyrosine phosphatase, receptor type, J 2.98008
RTL10 retrotransposon Gag like 10 2.9352
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.87412
NPIPB2 nuclear pore complex interacting protein family member B2 2.85029
STRIP2 striatin interacting protein 2 2.74887
TSPAN9 tetraspanin 9 2.74887
MOB1A MOB kinase activator 1A 2.613
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2.60856
ZNF398 zinc finger protein 398 2.60716
FAM133B family with sequence similarity 133, member B 2.53999
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.50147
CHM choroideremia (Rab escort protein 1) 2.49224
SCTR secretin receptor 2.41646
CDCP1 CUB domain containing protein 1 2.4154
PHF23 PHD finger protein 23 2.41108
ZNF136 zinc finger protein 136 2.40674
PNMA8A PNMA family member 8A 2.40123
NCBP1 nuclear cap binding protein subunit 1, 80kDa 2.40123
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.39521
INHA inhibin, alpha 2.37998
CPLX4 complexin 4 2.37355
NREP neuronal regeneration related protein 2.36868
RNF130 ring finger protein 130 2.36639
SYCP3 synaptonemal complex protein 3 2.359
PXT1 peroxisomal, testis specific 1 2.359
EFCAB12 EF-hand calcium binding domain 12 2.359
CHL1 cell adhesion molecule L1-like 2.359
SYTL3 synaptotagmin-like 3 2.359
CCL5 chemokine (C-C motif) ligand 5 2.34957
TRAPPC8 trafficking protein particle complex 8 2.31327
ADCK1 aarF domain containing kinase 1 2.29154
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 2.28854
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.27738
TERB1 telomere repeat binding bouquet formation protein 1 2.26931
JMY junction mediating and regulatory protein, p53 cofactor 2.2686
PGAP3 post-GPI attachment to proteins 3 2.25555
ATAD1 ATPase family, AAA domain containing 1 2.25555
SDF2L1 stromal cell-derived factor 2-like 1 2.24766
TMEM213 transmembrane protein 213 2.24305
CADPS2 Ca++-dependent secretion activator 2 2.20335
DSTN destrin (actin depolymerizing factor) 2.19834
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.18841
TNS1 tensin 1 2.18232
TRIML2 tripartite motif family-like 2 2.14793
TNS1-AS1 TNS1 antisense RNA 1 2.11088
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.11088
ADRA2C adrenoceptor alpha 2C 2.10883
STOX1 storkhead box 1 2.10676
TIGD7 tigger transposable element derived 7 2.10475
TAFA1 TAFA chemokine like family member 1 2.09274
AFAP1 actin filament associated protein 1 2.08618
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.0719
MAPK1 mitogen-activated protein kinase 1 2.06603
CTDNEP1 CTD nuclear envelope phosphatase 1 2.06333
SEC24D SEC24 family member D 2.05854
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 2.05615
ZNF304 zinc finger protein 304 2.04493
CBFB core-binding factor, beta subunit 2.02809
TSPAN4 tetraspanin 4 2.02209
MRPL21 mitochondrial ribosomal protein L21 2.01075
NTNG1 netrin G1 2.00678

decreased expression

Symbol Name Standardized Value
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -3.58566
SLC49A3 solute carrier family 49 member 3 -3.58566
PTGR3 prostaglandin reductase 3 -3.58566
KCNIP3 Kv channel interacting protein 3, calsenilin -3.58566
RNF222 ring finger protein 222 -3.58566
NABP1 nucleic acid binding protein 1 -3.58566
BFSP2 beaded filament structural protein 2, phakinin -3.54241
OIT3 oncoprotein induced transcript 3 -3.54241
FAM161B family with sequence similarity 161, member B -3.54241
KRTAP13-4 keratin associated protein 13-4 -3.54241
ANXA8 annexin A8 -3.54241
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -3.54241
APOL6 apolipoprotein L, 6 -3.54241
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -3.54241
CARNS1 carnosine synthase 1 -3.54241
BSX brain-specific homeobox -3.54241
BAAT bile acid CoA:amino acid N-acyltransferase -3.54241
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.54241
CCDC198 coiled-coil domain containing 198 -3.54241
NECTIN4 nectin cell adhesion molecule 4 -3.54241
SAPCD1 suppressor APC domain containing 1 -3.54241
ZFP3 ZFP3 zinc finger protein -3.54241
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -3.54241
GRHL3 grainyhead-like 3 (Drosophila) -3.54241
FAM240C family with sequence similarity 240 member C -3.54241
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -3.54241
UNC13C unc-13 homolog C (C. elegans) -3.54241
CCDC62 coiled-coil domain containing 62 -3.54241
OLIG3 oligodendrocyte transcription factor 3 -3.54241
NEU4 sialidase 4 -3.54241
H3C14 H3 clustered histone 14 -3.54241
MRLN myoregulin -3.54241
KRT222 keratin 222, type II -3.54241
GCOM1 GRINL1A complex locus 1 -3.54241
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.54241
TRIM55 tripartite motif containing 55 -3.54241
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -3.54241
ITGA11 integrin, alpha 11 -3.54241
VWA7 von Willebrand factor A domain containing 7 -3.54241
ERICH6 glutamate-rich 6 -3.54241
KLK14 kallikrein-related peptidase 14 -3.54241
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -3.54241
TRHR thyrotropin-releasing hormone receptor -3.54241
LTA4H leukotriene A4 hydrolase -3.35201
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -3.23173
MTMR1 myotubularin related protein 1 -3.08515
MROH7 maestro heat-like repeat family member 7 -3.07288
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.99363
CAB39 calcium binding protein 39 -2.97193
ARRDC3 arrestin domain containing 3 -2.90127
VWCE von Willebrand factor C and EGF domains -2.8595
TEX30 testis expressed 30 -2.82218
DNAL4 dynein, axonemal, light chain 4 -2.7184
MIMS1 mitochondrial inner membrane scaffold 1 -2.6715
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -2.63976
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -2.56721
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -2.55642
MCOLN3 mucolipin 3 -2.55429
GAB3 GRB2-associated binding protein 3 -2.55429
SNPH syntaphilin -2.55429
RASD1 RAS, dexamethasone-induced 1 -2.55429
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.55429
EIF3E eukaryotic translation initiation factor 3, subunit E -2.53568
TENT4A terminal nucleotidyltransferase 4A -2.53568
ACTN2 actinin, alpha 2 -2.53419
TTLL11 tubulin tyrosine ligase-like family member 11 -2.50864
ZNF594 zinc finger protein 594 -2.4864
IZUMO1 izumo sperm-egg fusion 1 -2.47772
TMF1 TATA element modulatory factor 1 -2.47033
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -2.44545
EPHB6 EPH receptor B6 -2.44362
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.41183
GPR82 G protein-coupled receptor 82 -2.41183
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.41183
NFX1 nuclear transcription factor, X-box binding 1 -2.36978
SPIN3 spindlin family, member 3 -2.36225
PFN1 profilin 1 -2.36225
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.36225
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.35991
KLHL12 kelch-like family member 12 -2.3517
KIF9 kinesin family member 9 -2.3225
THRB thyroid hormone receptor, beta -2.30237
TSC22D4 TSC22 domain family, member 4 -2.2951
CCDC22 coiled-coil domain containing 22 -2.29154
RIPOR1 RHO family interacting cell polarization regulator 1 -2.29154
WASF1 WAS protein family, member 1 -2.28854
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.26959
M1AP meiosis 1 associated protein -2.26959
TCF3 transcription factor 3 -2.25749
SLC25A39 solute carrier family 25, member 39 -2.23817
FBXO3 F-box protein 3 -2.23615
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.23406
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.14793
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 -2.13684
TMEM150A transmembrane protein 150A -2.11361
ZNF76 zinc finger protein 76 -2.10276
TACR3 tachykinin receptor 3 -2.10039
ZC3H12A zinc finger CCCH-type containing 12A -2.10039
DOCK1 dedicator of cytokinesis 1 -2.10039
AKR1C1 aldo-keto reductase family 1, member C1 -2.09274
MAST3 microtubule associated serine/threonine kinase 3 -2.07687
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.07613
ZNF746 zinc finger protein 746 -2.04626
SMYD2 SET and MYND domain containing 2 -2.04493
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.04212
ZNF79 zinc finger protein 79 -2.0358
ZNF624 zinc finger protein 624 -2.03044
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.02471
DOC2B double C2-like domains, beta -2.02328
C1R complement component 1, r subcomponent -2.02328
STK11 serine/threonine kinase 11 -2.01496
ZNF142 zinc finger protein 142 -2.00392
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.00392