TFAP2A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)|The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] (NCBI Entrez Gene Database, 7020)
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Genes

358 genes differentially expressed following the TFAP2A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FOLR1 folate receptor 1 (adult) 3.39085
ZNF560 zinc finger protein 560 3.39085
GJB4 gap junction protein, beta 4, 30.3kDa 3.39085
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.39085
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.39085
FETUB fetuin B 3.39085
C6ORF58 chromosome 6 open reading frame 58 3.39085
OLIG1 oligodendrocyte transcription factor 1 3.39085
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.39085
SIGLEC9 sialic acid binding Ig-like lectin 9 3.39085
NRAP nebulin-related anchoring protein 3.39085
SSTR1 somatostatin receptor 1 3.39085
TM4SF1 transmembrane 4 L six family member 1 3.39085
SCN2B sodium channel, voltage gated, type II beta subunit 3.39085
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.39085
CD19 CD19 molecule 3.39085
CD14 CD14 molecule 3.39085
PDIA2 protein disulfide isomerase family A, member 2 3.39085
MGAM2 maltase-glucoamylase 2 (putative) 3.39085
PRSS41 protease, serine, 41 3.39085
EPPIN epididymal peptidase inhibitor 3.39085
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.39085
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.39085
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.39085
PCDHGA12 protocadherin gamma subfamily A, 12 3.39085
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.39085
DSPP dentin sialophosphoprotein 3.39085
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 3.39085
CD22 CD22 molecule 3.39085
CD33 CD33 molecule 3.39085
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.39085
PASD1 PAS domain containing 1 3.39085
NLRP8 NLR family, pyrin domain containing 8 3.39085
FAM9B family with sequence similarity 9, member B 3.39085
MPL MPL proto-oncogene, thrombopoietin receptor 3.39085
KRT78 keratin 78, type II 3.39085
STRA8 stimulated by retinoic acid 8 3.39085
THRSP thyroid hormone responsive 3.39085
BAAT bile acid CoA:amino acid N-acyltransferase 3.39085
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.39085
C3ORF22 chromosome 3 open reading frame 22 3.39085
CLEC5A C-type lectin domain family 5, member A 3.39085
DLX4 distal-less homeobox 4 3.39085
GNRHR gonadotropin-releasing hormone receptor 3.39085
LBX2 ladybird homeobox 2 3.39085
NLRP5 NLR family, pyrin domain containing 5 3.39085
GPR75 G protein-coupled receptor 75 3.39085
DRC5 dynein regulatory complex subunit 5 3.39085
TCERG1L transcription elongation regulator 1-like 3.39085
C20ORF202 chromosome 20 open reading frame 202 3.39085
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 3.39085
WNT16 wingless-type MMTV integration site family, member 16 3.39085
DOK2 docking protein 2, 56kDa 3.39085
FCMR Fc fragment of IgM receptor 3.39085
GPR37L1 G protein-coupled receptor 37 like 1 3.39085
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.39085
SYT15 synaptotagmin XV 3.39085
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.39085
MCHR2 melanin-concentrating hormone receptor 2 3.39085
UNC93A unc-93 homolog A (C. elegans) 3.39085
CIMIP4 ciliary microtubule inner protein 4 3.39085
NOTCH2NLB notch 2 N-terminal like B 3.39085
LOC124902436 talanin 3.39085
CALHM4 calcium homeostasis modulator family member 4 3.39085
TEX13C TEX13 family member C 3.39085
CBY2 chibby family member 2 3.39085
ELOA2 elongin A2 3.39085
ERFE erythroferrone 3.39085
BNIP5 BCL2 interacting protein 5 3.39085
WDR93 WD repeat domain 93 3.39085
ASIC3 acid sensing (proton gated) ion channel 3 3.39085
MAGEB1 melanoma antigen family B1 3.39085
LGALS7B lectin, galactoside-binding, soluble, 7B 3.39085
ARL5C ADP-ribosylation factor-like 5C 3.39085
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.39085
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.39085
GUCA1C guanylate cyclase activator 1C 3.39085
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.39085
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.39085
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.39085
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.39085
AKR1D1 aldo-keto reductase family 1, member D1 3.39085
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.39085
LGSN lengsin, lens protein with glutamine synthetase domain 3.39085
NPIPB7 nuclear pore complex interacting protein family, member B7 3.39085
GPR85 G protein-coupled receptor 85 3.39085
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.39085
GTSF1 gametocyte specific factor 1 3.39085
SAA1 serum amyloid A1 3.39085
UTS2 urotensin 2 3.39085
TSPO2 translocator protein 2 3.39085
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.39085
NDRG1 N-myc downstream regulated 1 3.39085
ZNF396 zinc finger protein 396 3.39085
FSHR follicle stimulating hormone receptor 3.39085
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.39085
WFDC9 WAP four-disulfide core domain 9 3.39085
WFDC8 WAP four-disulfide core domain 8 3.39085
CTAGE9 CTAGE family, member 9 3.39085
GPR12 G protein-coupled receptor 12 3.39085
CERS3 ceramide synthase 3 3.39085
CD28 CD28 molecule 3.39085
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.39085
SUPT20HL2 suppressor of Ty 20 homolog (S. cerevisiae)-like 2 3.39085
SHOX2 short stature homeobox 2 3.39085
DCT dopachrome tautomerase 3.39085
CLIC5 chloride intracellular channel 5 3.39085
CH25H cholesterol 25-hydroxylase 3.39085
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.39085
TPSAB1 tryptase alpha/beta 1 3.39085
EBF2 early B-cell factor 2 3.39085
CABP7 calcium binding protein 7 3.39085
ADAM2 ADAM metallopeptidase domain 2 3.39085
SERINC4 serine incorporator 4 3.39085
CFAP47 cilia and flagella associated protein 47 3.39085
CALR3 calreticulin 3 3.39085
MYL10 myosin, light chain 10, regulatory 3.39085
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.39085
PLA2G12B phospholipase A2, group XIIB 3.39085
HK3 hexokinase 3 (white cell) 3.39085
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.39085
IL1B interleukin 1, beta 3.39085
VWA3A von Willebrand factor A domain containing 3A 3.39085
MUC13 mucin 13, cell surface associated 3.39085
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.39085
DRD2 dopamine receptor D2 3.39085
SPHKAP SPHK1 interactor, AKAP domain containing 3.39085
NKX6-1 NK6 homeobox 1 3.39085
PAGE4 P antigen family, member 4 (prostate associated) 3.39085
NPBWR1 neuropeptides B/W receptor 1 3.39085
TREH trehalase (brush-border membrane glycoprotein) 3.39085
LGALS12 lectin, galactoside-binding, soluble, 12 3.39085
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.39085
TBC1D26 TBC1 domain family, member 26 3.39085
C9ORF57 chromosome 9 open reading frame 57 3.39085
ACKR2 atypical chemokine receptor 2 3.39085
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.39085
DMTN dematin actin binding protein 3.39085
ROM1 retinal outer segment membrane protein 1 3.39085
GJC2 gap junction protein, gamma 2, 47kDa 3.39085
PXT1 peroxisomal, testis specific 1 3.39085
DSG3 desmoglein 3 3.39085
FGF10 fibroblast growth factor 10 3.39085
LRRC74A leucine rich repeat containing 74A 3.39085
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.39085
GOLGA8K golgin A8 family, member K 3.39085
EFCAB9 EF-hand calcium binding domain 9 3.39085
CIB3 calcium and integrin binding family member 3 3.39085
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.39085
GPR150 G protein-coupled receptor 150 3.39085
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.39085
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.39085
CAPSL calcyphosine-like 3.39085
IHH indian hedgehog 3.39085
KRTAP10-6 keratin associated protein 10-6 3.39085
CA9 carbonic anhydrase IX 3.30519
TMEM187 transmembrane protein 187 3.30519
MMRN2 multimerin 2 3.30519
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 3.30519
SMCO4 single-pass membrane protein with coiled-coil domains 4 3.23993
VAV2 vav 2 guanine nucleotide exchange factor 3.14791
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 3.07941
WDR77 WD repeat domain 77 3.01087
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.92869
ADAM19 ADAM metallopeptidase domain 19 2.84567
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 2.82262
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.80215
IGSF10 immunoglobulin superfamily, member 10 2.80215
SMOC2 SPARC related modular calcium binding 2 2.78728
CDC37L1 cell division cycle 37-like 1 2.77123
SSH2 slingshot protein phosphatase 2 2.76269
ZNF365 zinc finger protein 365 2.76269
ZC3H12C zinc finger CCCH-type containing 12C 2.75453
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.70938
SAMD3 sterile alpha motif domain containing 3 2.67452
EFCAB13 EF-hand calcium binding domain 13 2.65566
LRRC3 leucine rich repeat containing 3 2.59481
PPCS phosphopantothenoylcysteine synthetase 2.59481
PSRC1 proline/serine-rich coiled-coil 1 2.57791
RIT1 Ras-like without CAAX 1 2.48306
AZI2 5-azacytidine induced 2 2.48306
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.46175
TDRD1 tudor domain containing 1 2.46175
ZFP90 ZFP90 zinc finger protein 2.44623
TSSK3 testis-specific serine kinase 3 2.44623
RSRC2 arginine/serine-rich coiled-coil 2 2.4358
RGMA repulsive guidance molecule family member a 2.41293
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.40978
TEKT5 tektin 5 2.4085
LRP5 low density lipoprotein receptor-related protein 5 2.39521
RGS5 regulator of G-protein signaling 5 2.38929
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2.37855
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.37182
SNX1 sorting nexin 1 2.37016
ZNF320 zinc finger protein 320 2.35343
UBXN2B UBX domain protein 2B 2.33212
PWWP2B PWWP domain containing 2B 2.33212
UFSP2 UFM1-specific peptidase 2 2.33212
GLI2 GLI family zinc finger 2 2.33155
OTOF otoferlin 2.3254
DNAH10 dynein, axonemal, heavy chain 10 2.3254
TRIM17 tripartite motif containing 17 2.3254
LRRC61 leucine rich repeat containing 61 2.3254
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.3254
DNAH12 dynein, axonemal, heavy chain 12 2.3254
TOMM70 translocase of outer mitochondrial membrane 70 2.2866
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 2.26548
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.26362
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 2.26164
POLN polymerase (DNA directed) nu 2.26164
ENSA endosulfine alpha 2.23651
GFM1 G elongation factor, mitochondrial 1 2.23419
LRP2BP LRP2 binding protein 2.23071
ATF4 activating transcription factor 4 2.2201
CATSPERE catsper channel auxiliary subunit epsilon 2.22004
RPS17 ribosomal protein S17 2.13221
LMNB2 lamin B2 2.10953
KIFAP3 kinesin-associated protein 3 2.10953
BLM Bloom syndrome, RecQ helicase-like 2.10953
KIF16B kinesin family member 16B 2.10641
SPOUT1 SPOUT domain containing methyltransferase 1 2.0947
PUS1 pseudouridylate synthase 1 2.0947
MGMT O-6-methylguanine-DNA methyltransferase 2.08874
CTDNEP1 CTD nuclear envelope phosphatase 1 2.07579
MBD6 methyl-CpG binding domain protein 6 2.07579
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.05748
CD200 CD200 molecule 2.00217

decreased expression

Symbol Name Standardized Value
ZNF764 zinc finger protein 764 -3.39085
PLGLB1 plasminogen-like B1 -3.39085
TBC1D28 TBC1 domain family, member 28 -3.39085
ABHD1 abhydrolase domain containing 1 -3.39085
TOPAZ1 testis and ovary specific PAZ domain containing 1 -3.39085
TSGA10IP testis specific, 10 interacting protein -3.39085
CASS4 Cas scaffolding protein family member 4 -3.39085
CPO carboxypeptidase O -3.39085
FAM240C family with sequence similarity 240 member C -3.39085
C3ORF80 chromosome 3 open reading frame 80 -3.39085
PCDHGB6 protocadherin gamma subfamily B, 6 -3.39085
MEOX2 mesenchyme homeobox 2 -3.39085
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B -3.39085
SCG2 secretogranin II -3.39085
ELMOD3 ELMO/CED-12 domain containing 3 -3.39085
EBI3 Epstein-Barr virus induced 3 -3.39085
FXYD2 FXYD domain containing ion transport regulator 2 -3.39085
MROH6 maestro heat-like repeat family member 6 -3.39085
KHDC3L KH domain containing 3-like, subcortical maternal complex member -3.39085
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -3.39085
TNS4 tensin 4 -3.39085
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 -3.39085
CD86 CD86 molecule -3.39085
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -3.39085
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -3.39085
TMEM231 transmembrane protein 231 -3.39085
HSPB6 heat shock protein, alpha-crystallin-related, B6 -3.39085
ZNF70 zinc finger protein 70 -3.39085
GRAMD2A GRAM domain containing 2A -3.39085
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -3.39085
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -3.39085
TEKTIP1 tektin bundle interacting protein 1 -3.39085
SOSTDC1 sclerostin domain containing 1 -3.39085
NCR1 natural cytotoxicity triggering receptor 1 -3.39085
CFAP206 cilia and flagella associated protein 206 -3.39085
IHO1 interactor of HORMAD1 1 -3.39085
SPMIP3 sperm microtubule inner protein 3 -3.39085
TM4SF19 transmembrane 4 L six family member 19 -3.39085
EVI2A ecotropic viral integration site 2A -3.39085
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -3.39085
PLCZ1 phospholipase C, zeta 1 -3.39085
GCSAM germinal center-associated, signaling and motility -3.39085
BAHCC1 BAH domain and coiled-coil containing 1 -3.39085
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -3.39085
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 -3.39085
DUSP8 dual specificity phosphatase 8 -3.39085
PLET1 placenta expressed transcript 1 -3.39085
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -3.39085
HAL histidine ammonia-lyase -3.39085
ARG1 arginase 1 -3.39085
TEFM transcription elongation factor, mitochondrial -3.38355
ENDOD1 endonuclease domain containing 1 -3.29387
STK31 serine/threonine kinase 31 -3.24282
SAP30BP SAP30 binding protein -3.00538
PDZK1 PDZ domain containing 1 -3.00538
AIP aryl hydrocarbon receptor interacting protein -2.9625
TRIP6 thyroid hormone receptor interactor 6 -2.90052
HYAL3 hyaluronoglucosaminidase 3 -2.87788
DCTPP1 dCTP pyrophosphatase 1 -2.82262
EXOSC1 exosome component 1 -2.82092
XKR6 XK, Kell blood group complex subunit-related family, member 6 -2.80215
CHMP5 charged multivesicular body protein 5 -2.76374
TMEM45A transmembrane protein 45A -2.70251
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.69636
TTC33 tetratricopeptide repeat domain 33 -2.66134
PCDHA10 protocadherin alpha 10 -2.62339
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -2.60976
MLXIPL MLX interacting protein-like -2.60942
TGFB1 transforming growth factor, beta 1 -2.59796
CD47 CD47 molecule -2.59796
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.59481
TRIM58 tripartite motif containing 58 -2.52741
ANXA9 annexin A9 -2.50825
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 -2.48574
FTSJ3 FtsJ homolog 3 (E. coli) -2.48306
MZT1 mitotic spindle organizing protein 1 -2.47947
ARID5A AT rich interactive domain 5A (MRF1-like) -2.47599
ZNF823 zinc finger protein 823 -2.47599
COL2A1 collagen, type II, alpha 1 -2.46356
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -2.44907
PAQR5 progestin and adipoQ receptor family member V -2.42623
EMC1 ER membrane protein complex subunit 1 -2.4085
MARCHF9 membrane associated ring-CH-type finger 9 -2.40511
HAUS7 HAUS augmin-like complex, subunit 7 -2.39363
C6ORF120 chromosome 6 open reading frame 120 -2.38929
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.38479
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.37778
SCARF2 scavenger receptor class F, member 2 -2.35778
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.33846
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.33725
H4C11 H4 clustered histone 11 -2.33212
LCAT lecithin-cholesterol acyltransferase -2.33212
TSLP thymic stromal lymphopoietin -2.33212
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.33212
ZCWPW2 zinc finger, CW type with PWWP domain 2 -2.33155
GTF2B general transcription factor IIB -2.33155
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.3254
ARHGAP30 Rho GTPase activating protein 30 -2.29589
ZNF165 zinc finger protein 165 -2.29589
NLRP10 NLR family, pyrin domain containing 10 -2.29589
NXPH1 neurexophilin 1 -2.29589
IFFO1 intermediate filament family orphan 1 -2.28968
CNTN3 contactin 3 (plasmacytoma associated) -2.26362
POU3F1 POU class 3 homeobox 1 -2.26216
ZNF547 zinc finger protein 547 -2.25207
LTC4S leukotriene C4 synthase -2.25207
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.25207
ZNF790 zinc finger protein 790 -2.23651
UBE3C ubiquitin protein ligase E3C -2.22273
FLRT1 fibronectin leucine rich transmembrane protein 1 -2.22004
LHX4 LIM homeobox 4 -2.20478
TRIM38 tripartite motif containing 38 -2.19561
IQUB IQ motif and ubiquitin domain containing -2.18713
WDR6 WD repeat domain 6 -2.18298
H4C9 H4 clustered histone 9 -2.18232
NKAP NFKB activating protein -2.17616
C2 complement component 2 -2.15469
NBPF12 neuroblastoma breakpoint family, member 12 -2.15429
TMX3 thioredoxin-related transmembrane protein 3 -2.15267
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -2.13221
CNTNAP1 contactin associated protein 1 -2.12218
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -2.10953
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -2.10953
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 -2.07579
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.07292
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.06722
GTF2H5 general transcription factor IIH, polypeptide 5 -2.05858
GOLPH3L golgi phosphoprotein 3-like -2.05848
RNF19B ring finger protein 19B -2.03761
PIAS3 protein inhibitor of activated STAT, 3 -2.01342
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.01342