TGFBR1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description transforming growth factor, beta receptor 1|The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (NCBI Entrez Gene Database, 7046)
External Link http://www.ncbi.nlm.nih.gov/gene/7046
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Genes

414 interacting proteins for TGFBR1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACTB actin, beta
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR1C activin A receptor, type IC
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ACVRL1 activin A receptor type II-like 1
ADAM28 ADAM metallopeptidase domain 28
ADCK1 aarF domain containing kinase 1
ADCK3 aarF domain containing kinase 3
ADK adenosine kinase
AFF4 AF4/FMR2 family, member 4
AHRR aryl-hydrocarbon receptor repressor
ALDOA aldolase A, fructose-bisphosphate
ALPK3 alpha-kinase 3
AMHR2 anti-Mullerian hormone receptor, type II
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANK1 ankyrin 1, erythrocytic
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP15 Rho GTPase activating protein 15
ARHGAP31 Rho GTPase activating protein 31
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL13B ADP-ribosylation factor-like 13B
ARL4D ADP-ribosylation factor-like 4D
ARL5A ADP-ribosylation factor-like 5A
ARL8B ADP-ribosylation factor-like 8B
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATAD3B ATPase family, AAA domain containing 3B
ATF2 activating transcription factor 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
AURKB aurora kinase B
AXIN1 axin 1
AZI2 5-azacytidine induced 2
BAMBI BMP and activin membrane-bound inhibitor
BCR breakpoint cluster region
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2K BMP2 inducible kinase
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD3 bromodomain containing 3
BRD4 bromodomain containing 4
BTBD2 BTB (POZ) domain containing 2
BTK Bruton agammaglobulinemia tyrosine kinase
C2CD5 C2 calcium-dependent domain containing 5
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CCNH cyclin H
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK14 cyclin-dependent kinase 14
CDK17 cyclin-dependent kinase 17
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHN1 chimerin 1
CHN2 chimerin 2
CHUK conserved helix-loop-helix ubiquitous kinase
CLK1 CDC-like kinase 1
CLU clusterin
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL5 cullin 5
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK2 death-associated protein kinase 2
DCAF12 DDB1 and CUL4 associated factor 12
DCAF6 DDB1 and CUL4 associated factor 6
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDR1 discoidin domain receptor tyrosine kinase 1
DLG5 discs, large homolog 5 (Drosophila)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DUSP10 dual specificity phosphatase 10
DUSP13 dual specificity phosphatase 13
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFNA1 ephrin-A1
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF3J eukaryotic translation initiation factor 3, subunit J
ELAVL1 ELAV like RNA binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
EP300 E1A binding protein p300
EPHA2 EPH receptor A2
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
FANCL Fanconi anemia, complementation group L
FBXL12 F-box and leucine-rich repeat protein 12
FBXO24 F-box protein 24
FBXO3 F-box protein 3
FBXO34 F-box protein 34
FBXO44 F-box protein 44
FBXW5 F-box and WD repeat domain containing 5
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNTA farnesyltransferase, CAAX box, alpha
FRK fyn-related Src family tyrosine kinase
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GDF11 growth differentiation factor 11
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRAMD1A GRAM domain containing 1A
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HIPK1 homeodomain interacting protein kinase 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HRAS Harvey rat sarcoma viral oncogene homolog
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ILKAP integrin-linked kinase-associated serine/threonine phosphatase
INPPL1 inositol polyphosphate phosphatase-like 1
IRF7 interferon regulatory factor 7
ITCH itchy E3 ubiquitin protein ligase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNK18 potassium channel, two pore domain subfamily K, member 18
KIAA0195 KIAA0195
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL1 kelch-like family member 1
KLHL35 kelch-like family member 35
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LIMS1 LIM and senescent cell antigen-like domains 1
LRG1 leucine-rich alpha-2-glycoprotein 1
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K7CL MAP3K7 C-terminal like
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MELK maternal embryonic leucine zipper kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYO3A myosin IIIA
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCK2 NCK adaptor protein 2
NEK11 NIMA-related kinase 11
NEK6 NIMA-related kinase 6
NEK8 NIMA-related kinase 8
NEK9 NIMA-related kinase 9
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NLK nemo-like kinase
NOXO1 NADPH oxidase organizer 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP1 neuropilin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUAK2 NUAK family, SNF1-like kinase, 2
NUP37 nucleoporin 37kDa
OCLN occludin
OSR1 odd-skipped related transciption factor 1
OXSR1 oxidative stress responsive 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD6A par-6 family cell polarity regulator alpha
PDE4A phosphodiesterase 4A, cAMP-specific
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PKN1 protein kinase N1
PKN3 protein kinase N3
PLEK pleckstrin
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK4 polo-like kinase 4
PML promyelocytic leukemia
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP6C protein phosphatase 6, catalytic subunit
PREB prolactin regulatory element binding
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF4 pre-mRNA processing factor 4
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB13 RAB13, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAB33B RAB33B, member RAS oncogene family
RAB34 RAB34, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAN RAN, member RAS oncogene family
RANBP9 RAN binding protein 9
RAP2A RAP2A, member of RAS oncogene family
RASD2 RASD family, member 2
RASL12 RAS-like, family 12
RGS19 regulator of G-protein signaling 19
RHEBL1 Ras homolog enriched in brain like 1
RHOA ras homolog family member A
RHOBTB1 Rho-related BTB domain containing 1
RHOD ras homolog family member D
RHOG ras homolog family member G
RHOH ras homolog family member H
RHOJ ras homolog family member J
RHPN2 rhophilin, Rho GTPase binding protein 2
RIPK2 receptor-interacting serine-threonine kinase 2
RNF111 ring finger protein 111
RNF130 ring finger protein 130
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF146 ring finger protein 146
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPAP3 RNA polymerase II associated protein 3
RPS27A ribosomal protein S27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAS related RAS viral (r-ras) oncogene homolog
RRH retinal pigment epithelium-derived rhodopsin homolog
RTKN rhotekin
SACK1A scaffolding CK1 anchoring protein A
SAMD8 sterile alpha motif domain containing 8
SAT2 spermidine/spermine N1-acetyltransferase family member 2
SCRIB scribbled planar cell polarity protein
SEC16A SEC16 homolog A (S. cerevisiae)
SETD2 SET domain containing 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SKAP2 src kinase associated phosphoprotein 2
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLK STE20-like kinase
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNTG1 syntrophin, gamma 1
SNX6 sorting nexin 6
SOCS6 suppressor of cytokine signaling 6
SPEG SPEG complex locus
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SSB Sjogren syndrome antigen B (autoantigen La)
STAT1 signal transducer and activator of transcription 1, 91kDa
STK16 serine/threonine kinase 16
STK35 serine/threonine kinase 35
STRAP serine/threonine kinase receptor associated protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX8 syntaxin 8
STYXL1 serine/threonine/tyrosine interacting-like 1
SYK spleen tyrosine kinase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TANK TRAF family member-associated NFKB activator
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TEC tec protein tyrosine kinase
TESK2 testis-specific kinase 2
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TNK2 tyrosine kinase, non-receptor, 2
TNNT1 troponin T type 1 (skeletal, slow)
TOLLIP toll interacting protein
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TRAF4 TNF receptor-associated factor 4
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAP1 TNF receptor-associated protein 1
TSC22D1 TSC22 domain family, member 1
TSSK1B testis-specific serine kinase 1B
TSSK4 testis-specific serine kinase 4
TTC1 tetratricopeptide repeat domain 1
TTC27 tetratricopeptide repeat domain 27
TTN titin
TTPAL tocopherol (alpha) transfer protein-like
TUBA1B tubulin, alpha 1b
TYK2 tyrosine kinase 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBD ubiquitin D
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2Z ubiquitin-conjugating enzyme E2Z
UBXN1 UBX domain protein 1
UHMK1 U2AF homology motif (UHM) kinase 1
ULK3 unc-51 like kinase 3
USP11 ubiquitin specific peptidase 11
USP15 ubiquitin specific peptidase 15
USP21 ubiquitin specific peptidase 21
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP45 ubiquitin specific peptidase 45
VEPH1 ventricular zone expressed PH domain-containing 1
WDR13 WD repeat domain 13
WDR33 WD repeat domain 33
WDR61 WD repeat domain 61
WEE1 WEE1 G2 checkpoint kinase
WISP1 WNT1 inducible signaling pathway protein 1
WSB1 WD repeat and SOCS box containing 1
WWOX WW domain containing oxidoreductase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFYVE9 zinc finger, FYVE domain containing 9