TGFBR2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description transforming growth factor, beta receptor II (70/80kDa)|This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7048)
External Link http://www.ncbi.nlm.nih.gov/gene/7048
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Genes

91 interacting proteins for TGFBR2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVRL1 activin A receptor type II-like 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNB1 cyclin B1
CCNB2 cyclin B2
CD44 CD44 molecule (Indian blood group)
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CLU clusterin
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAXX death-domain associated protein
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF3I eukaryotic translation initiation factor 3, subunit I
ENG endoglin
FBXO34 F-box protein 34
FKBP1A FK506 binding protein 1A, 12kDa
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FSTL1 follistatin-like 1
GOPC golgi-associated PDZ and coiled-coil motif containing
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IQGAP1 IQ motif containing GTPase activating protein 1
KCNK18 potassium channel, two pore domain subfamily K, member 18
LRG1 leucine-rich alpha-2-glycoprotein 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K7CL MAP3K7 C-terminal like
MED12 mediator complex subunit 12
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP1 neuropilin 1
NRP2 neuropilin 2
OCLN occludin
OSR1 odd-skipped related transciption factor 1
OXSR1 oxidative stress responsive 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PML promyelocytic leukemia
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R16B protein phosphatase 1, regulatory subunit 16B
RCVRN recoverin
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAS related RAS viral (r-ras) oncogene homolog
SCRIB scribbled planar cell polarity protein
SCUBE3 signal peptide, CUB domain, EGF-like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNX6 sorting nexin 6
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STRAP serine/threonine kinase receptor associated protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TCTEX1D4 Tctex1 domain containing 4
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR3 transforming growth factor, beta receptor III
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TRAF4 TNF receptor-associated factor 4
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAP1 TNF receptor-associated protein 1
TSC22D1 TSC22 domain family, member 1
TSSK1B testis-specific serine kinase 1B
UBC ubiquitin C
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFYVE9 zinc finger, FYVE domain containing 9